IL232652A - A method for the preparation and isolation of Vardenafil salts with acids - Google Patents

A method for the preparation and isolation of Vardenafil salts with acids

Info

Publication number
IL232652A
IL232652A IL232652A IL23265214A IL232652A IL 232652 A IL232652 A IL 232652A IL 232652 A IL232652 A IL 232652A IL 23265214 A IL23265214 A IL 23265214A IL 232652 A IL232652 A IL 232652A
Authority
IL
Israel
Prior art keywords
vardenafil
isolation
salts
acids
preparation
Prior art date
Application number
IL232652A
Other languages
English (en)
Hebrew (he)
Other versions
IL232652A0 (en
Inventor
Halama Ales
Strelec Ivo
Dammer Ondrej
Original Assignee
Zentiva Ks
Halama Ales
Strelec Ivo
Dammer Ondrej
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks, Halama Ales, Strelec Ivo, Dammer Ondrej filed Critical Zentiva Ks
Publication of IL232652A0 publication Critical patent/IL232652A0/en
Publication of IL232652A publication Critical patent/IL232652A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
IL232652A 2011-11-24 2014-05-15 A method for the preparation and isolation of Vardenafil salts with acids IL232652A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20110767A CZ2011767A3 (cs) 2011-11-24 2011-11-24 Zpusob prípravy a izolace solí vardenafilu s kyselinami
PCT/CZ2012/000120 WO2013075680A1 (en) 2011-11-24 2012-11-26 A method for the preparation and isolation of salts of vardenafil with acids

Publications (2)

Publication Number Publication Date
IL232652A0 IL232652A0 (en) 2014-06-30
IL232652A true IL232652A (en) 2017-05-29

Family

ID=47435673

Family Applications (1)

Application Number Title Priority Date Filing Date
IL232652A IL232652A (en) 2011-11-24 2014-05-15 A method for the preparation and isolation of Vardenafil salts with acids

Country Status (7)

Country Link
CN (1) CN103946225B (cs)
BR (1) BR112014012430A2 (cs)
CZ (1) CZ2011767A3 (cs)
HU (1) HUP1400334A3 (cs)
IL (1) IL232652A (cs)
IN (1) IN2014KN01308A (cs)
WO (1) WO2013075680A1 (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3082428A4 (en) 2013-12-09 2017-08-02 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
PL223869B1 (pl) 2013-12-16 2016-11-30 Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna Sposób otrzymywania wardenafilu i jego soli
CN107445964A (zh) * 2017-07-29 2017-12-08 合肥创新医药技术有限公司 一种盐酸伐地那非杂质的合成方法
BR112020012239A2 (pt) 2017-12-20 2020-11-24 Klaria Pharma Holding Ab método para preparar um filme mucoadesivo, e, filme mucoadesivo
EP3887376A1 (en) * 2018-11-28 2021-10-06 Topadur Pharma AG Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
CN114085225A (zh) * 2021-06-04 2022-02-25 广东西捷药业有限公司 一种伐地那非类似物及其合成方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230154B1 (hu) * 1997-11-12 2015-09-28 Bayer Intellectual Property Gmbh Eljárás 2-es helyzetben fenil-szubszituenst hordozó imidazo-triazinon-származékok előállítására
DE10063108A1 (de) 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE102004023069A1 (de) 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
US7977478B2 (en) 2006-03-13 2011-07-12 Dr. Reddy's Laboratories Limited Polymorphic forms of vardenafil
DE102007027067A1 (de) 2007-06-12 2008-12-18 Ratiopharm Gmbh Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat
CN101965348B (zh) 2007-09-06 2013-11-13 上海特化医药科技有限公司 伐地那非的制备方法及其中间体
JP5411161B2 (ja) 2007-12-28 2014-02-12 上海特化医薬科技有限公司 Ｎ−｛１−［３−（２−エトキシ−５−（４−エチルピペラジニル）スルホニルフェニル）−４，５−ジヒドロ−５−オキソ−１，２，４−トリアジン−６−イル］エチル｝ブチルアミド、その調製方法及び用途
DE102009020888A1 (de) 2009-05-12 2010-11-18 Ratiopharm Gmbh Schmelztablette, enthaltend ein Vardenafil-Salz
PL390079A1 (pl) * 2009-12-30 2011-07-04 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli
CN101870698B (zh) * 2010-04-02 2012-10-17 漆又毛 磺酰苯基咪唑并三嗪衍生物及制备方法

Also Published As

Publication number Publication date
HUP1400334A2 (hu) 2014-10-28
CZ303877B6 (cs) 2013-06-05
BR112014012430A2 (pt) 2017-06-06
CN103946225A (zh) 2014-07-23
HUP1400334A3 (en) 2014-12-29
CZ2011767A3 (cs) 2013-06-05
WO2013075680A1 (en) 2013-05-30
IL232652A0 (en) 2014-06-30
IN2014KN01308A (cs) 2015-10-16
CN103946225B (zh) 2016-06-15

Similar Documents

Publication Publication Date Title
ZA201305972B (en) Method for the preparation of biphephos
EP2707510A4 (en) ISOLATION OF NUCLEIC ACIDS
PL2734536T3 (pl) Sposób wytwarzania estetrolu
ZA201306758B (en) Process for the preparation of an accelerator solution
IL232652A (en) A method for the preparation and isolation of Vardenafil salts with acids
SG11201400939YA (en) Process for the preparation of methoxymelonal
EP2875348A4 (en) METHOD OF ISOLATING MICROVESICLES
PL2757878T3 (pl) Sposób wytwarzania i udoskonalenia podków
HK1194733A1 (zh) 製備 -酰基- -苯基磺酰基脯氨酰胺衍生物的方法及中間體
SI2736909T1 (sl) Proces za pripravo sitagliptina in njegovih farmacevtsko sprejemljivih soli
EP2663646A4 (en) METHOD FOR PRODUCING NICOTIC ACID
IL231645A0 (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
HK1200458A1 (en) Methods of isolating 4-chloro-2-fluoro-3-substituted-phenylboronic acids 4--2--3--
HK1186172A1 (zh) 製備 -氟- -羥基亞甲基－ -氧代丁酸酯的烯醇鹽方法
EP2751074A4 (en) 5-SULPHISOPHTHALIC ACID SALTS AND PROCESS FOR THE PREPARATION THEREOF
PL2673282T3 (pl) Nowy sposób wytwarzania kwasów dronowych
PL396622A1 (pl) Pochodne diestrów 4-metylotiofenylowych kwasów 1-amino-2-metylo-propanofosfonowych, sposób wytwarzania pochodnych diestrów 4-metylotiofenylowych kwasów 1-amino-2-metylo-propanofosfonowych oraz zastosowanie pochodnych diestrów 4-metylotiofenylowych kwasów 1-amino-2-metylo-propanofosfonowych
IL229602A0 (en) Method for the production of fluoromethyl esters of androstene-17-beta carboxylic acids
PL396137A1 (pl) Sposób otrzymywania tadalafilu
PL394420A1 (pl) Sposób wytwarzania dilauroilofluoresceiny
PL394378A1 (pl) Sposób otrzymywania E-2-amino-4-nitrostilbenów
PL396818A1 (pl) Sposób wytwarzania kwasów dialkiloaminometylo(hydroksymetylo)fosfinowych

Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees