IN2014KN01308A - - Google Patents
Info
- Publication number
- IN2014KN01308A IN2014KN01308A IN1308KON2014A IN2014KN01308A IN 2014KN01308 A IN2014KN01308 A IN 2014KN01308A IN 1308KON2014 A IN1308KON2014 A IN 1308KON2014A IN 2014KN01308 A IN2014KN01308 A IN 2014KN01308A
- Authority
- IN
- India
- Prior art keywords
- salts
- vardenafil
- acids
- water
- isolation
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical class CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 abstract 4
- 150000007513 acids Chemical class 0.000 abstract 4
- 238000002425 crystallisation Methods 0.000 abstract 3
- 230000008025 crystallization Effects 0.000 abstract 3
- 238000002955 isolation Methods 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- 229960002381 vardenafil Drugs 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- FBCDRHDULQYRTB-UHFFFAOYSA-N 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1h-imidazo[5,1-f][1,2,4]triazin-4-one;trihydrate;hydrochloride Chemical compound O.O.O.Cl.CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 FBCDRHDULQYRTB-UHFFFAOYSA-N 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960004573 vardenafil hydrochloride trihydrate Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20110767A CZ303877B6 (cs) | 2011-11-24 | 2011-11-24 | Zpusob prípravy a izolace solí vardenafilu s kyselinami |
| PCT/CZ2012/000120 WO2013075680A1 (en) | 2011-11-24 | 2012-11-26 | A method for the preparation and isolation of salts of vardenafil with acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014KN01308A true IN2014KN01308A (cs) | 2015-10-16 |
Family
ID=47435673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1308KON2014 IN2014KN01308A (cs) | 2011-11-24 | 2012-11-26 |
Country Status (7)
| Country | Link |
|---|---|
| CN (1) | CN103946225B (cs) |
| BR (1) | BR112014012430A2 (cs) |
| CZ (1) | CZ303877B6 (cs) |
| HU (1) | HUP1400334A3 (cs) |
| IL (1) | IL232652A (cs) |
| IN (1) | IN2014KN01308A (cs) |
| WO (1) | WO2013075680A1 (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3082428A4 (en) | 2013-12-09 | 2017-08-02 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| PL223869B1 (pl) | 2013-12-16 | 2016-11-30 | Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna | Sposób otrzymywania wardenafilu i jego soli |
| CN107445964A (zh) * | 2017-07-29 | 2017-12-08 | 合肥创新医药技术有限公司 | 一种盐酸伐地那非杂质的合成方法 |
| CA3085219A1 (en) | 2017-12-20 | 2019-06-27 | Klaria Pharma Holding Ab | Film formulation comprising vardenafil, method for its preparation, and use thereof |
| BR112021009958A2 (pt) * | 2018-11-28 | 2021-08-17 | Topadur Pharma Ag | modo duplo de ação de ativadores de guanilato ciclase solúveis e inibidores de fosfodiesterase e seus usos |
| CN114085225A (zh) * | 2021-06-04 | 2022-02-25 | 广东西捷药业有限公司 | 一种伐地那非类似物及其合成方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK287161B6 (sk) * | 1997-11-12 | 2010-02-08 | Bayer Healthcare Ag | 2-Fenylsubstituované imidazotriazinóny, spôsob ich výroby, liečivá obsahujúce tieto látky a ich použitie |
| DE10063108A1 (de) * | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
| DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
| DE102004023069A1 (de) | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
| US7977478B2 (en) | 2006-03-13 | 2011-07-12 | Dr. Reddy's Laboratories Limited | Polymorphic forms of vardenafil |
| DE102007027067A1 (de) | 2007-06-12 | 2008-12-18 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat |
| WO2009030095A1 (en) | 2007-09-06 | 2009-03-12 | Topharman Shanghai Co., Ltd. | Process for preparing vardenafil and its intermediates |
| EP2228370B1 (en) | 2007-12-28 | 2012-05-23 | Topharman Shanghai Co., Ltd. | N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)benzenesulfonyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof |
| DE102009020888A1 (de) | 2009-05-12 | 2010-11-18 | Ratiopharm Gmbh | Schmelztablette, enthaltend ein Vardenafil-Salz |
| PL390079A1 (pl) * | 2009-12-30 | 2011-07-04 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli |
| CN101870698B (zh) * | 2010-04-02 | 2012-10-17 | 漆又毛 | 磺酰苯基咪唑并三嗪衍生物及制备方法 |
-
2011
- 2011-11-24 CZ CZ20110767A patent/CZ303877B6/cs not_active IP Right Cessation
-
2012
- 2012-11-26 WO PCT/CZ2012/000120 patent/WO2013075680A1/en active Application Filing
- 2012-11-26 CN CN201280057517.3A patent/CN103946225B/zh active Active
- 2012-11-26 IN IN1308KON2014 patent/IN2014KN01308A/en unknown
- 2012-11-26 BR BR112014012430A patent/BR112014012430A2/pt not_active Application Discontinuation
- 2012-11-26 HU HU1400334A patent/HUP1400334A3/hu unknown
-
2014
- 2014-05-15 IL IL232652A patent/IL232652A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN103946225A (zh) | 2014-07-23 |
| CZ2011767A3 (cs) | 2013-06-05 |
| IL232652A (en) | 2017-05-29 |
| HUP1400334A2 (hu) | 2014-10-28 |
| CZ303877B6 (cs) | 2013-06-05 |
| WO2013075680A1 (en) | 2013-05-30 |
| HUP1400334A3 (en) | 2014-12-29 |
| CN103946225B (zh) | 2016-06-15 |
| IL232652A0 (en) | 2014-06-30 |
| BR112014012430A2 (pt) | 2017-06-06 |
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