IL228072A - Quinazoline compound is converted to alkyl and methods of use - Google Patents

Info

Publication number

IL228072A

IL228072A IL228072A IL22807213A IL228072A IL 228072 A IL228072 A IL 228072A IL 228072 A IL228072 A IL 228072A IL 22807213 A IL22807213 A IL 22807213A IL 228072 A IL228072 A IL 228072A

Authority

IL

Israel

Prior art keywords

compound

cancer

alkyl

chloro

cycloalkyl

Prior art date

2011-03-04

Links

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• 238000000034 method Methods 0.000 title description 43
• 150000001345 alkine derivatives Chemical group 0.000 title description 6
• 150000001875 compounds Chemical class 0.000 claims description 164
• 150000003839 salts Chemical class 0.000 claims description 46
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 30
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 30
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 24
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 22
• 229910052736 halogen Inorganic materials 0.000 claims description 22
• 150000002367 halogens Chemical group 0.000 claims description 20
• 125000004043 oxo group Chemical group O=* 0.000 claims description 20
• 239000008194 pharmaceutical composition Substances 0.000 claims description 18
• 239000012453 solvate Substances 0.000 claims description 18
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
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