IL221820B - Use of a compound selected from 21-methoxy-17α-acetoxy-11β-(4 n,n- dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione and 17α-acetoxy-11β-(4 n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione in the manufacture of a medicament - Google Patents

Use of a compound selected from 21-methoxy-17α-acetoxy-11β-(4 n,n- dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione and 17α-acetoxy-11β-(4 n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione in the manufacture of a medicament

Info

Publication number
IL221820B
IL221820B IL221820A IL22182012A IL221820B IL 221820 B IL221820 B IL 221820B IL 221820 A IL221820 A IL 221820A IL 22182012 A IL22182012 A IL 22182012A IL 221820 B IL221820 B IL 221820B
Authority
IL
Israel
Prior art keywords
norparagne
dimethylaminophenyl
acetoxy
dione
diene
Prior art date
Application number
IL221820A
Other languages
English (en)
Hebrew (he)
Inventor
Therapeutics Inc Repros
Original Assignee
Therapeutics Inc Repros
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44343114&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL221820(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Therapeutics Inc Repros filed Critical Therapeutics Inc Repros
Publication of IL221820B publication Critical patent/IL221820B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL221820A 2010-03-22 2012-09-06 Use of a compound selected from 21-methoxy-17α-acetoxy-11β-(4 n,n- dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione and 17α-acetoxy-11β-(4 n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione in the manufacture of a medicament IL221820B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31626310P 2010-03-22 2010-03-22
PCT/US2010/062068 WO2011119194A1 (en) 2010-03-22 2010-12-23 Compositions and methods for non-toxic delivery of antiprogestins

Publications (1)

Publication Number Publication Date
IL221820B true IL221820B (en) 2018-06-28

Family

ID=44343114

Family Applications (2)

Application Number Title Priority Date Filing Date
IL221820A IL221820B (en) 2010-03-22 2012-09-06 Use of a compound selected from 21-methoxy-17α-acetoxy-11β-(4 n,n- dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione and 17α-acetoxy-11β-(4 n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione in the manufacture of a medicament
IL255679A IL255679A (en) 2010-03-22 2017-11-15 A dose of 1 mg per 100 mg of a selective progesterone receptor modulator (SPRM) for the treatment of endometriosis or uterine fibroids

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL255679A IL255679A (en) 2010-03-22 2017-11-15 A dose of 1 mg per 100 mg of a selective progesterone receptor modulator (SPRM) for the treatment of endometriosis or uterine fibroids

Country Status (25)

Country Link
US (3) US20130018027A1 (enExample)
EP (2) EP3865502A1 (enExample)
JP (4) JP5894143B2 (enExample)
KR (2) KR20130009990A (enExample)
CN (3) CN107260746A (enExample)
AR (1) AR080692A1 (enExample)
AU (4) AU2010348967C1 (enExample)
BR (2) BR112012023281A2 (enExample)
CA (1) CA2793712A1 (enExample)
CL (1) CL2012002544A1 (enExample)
CO (1) CO6602170A2 (enExample)
CR (1) CR20120514A (enExample)
EA (1) EA023743B1 (enExample)
EC (1) ECSP12012226A (enExample)
IL (2) IL221820B (enExample)
MX (1) MX2012010327A (enExample)
MY (1) MY164622A (enExample)
NI (2) NI201200142A (enExample)
NZ (1) NZ602525A (enExample)
PH (2) PH12012501812A1 (enExample)
SG (3) SG10201504913UA (enExample)
TW (1) TWI581797B (enExample)
UA (1) UA110030C2 (enExample)
WO (1) WO2011119194A1 (enExample)
ZA (1) ZA201207688B (enExample)

Families Citing this family (6)

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MX384159B (es) * 2014-05-05 2025-03-14 Repros Therapeutics Inc Formulaciones y métodos para el suministro vaginal de antiprogestinas.
CA2966753A1 (en) * 2014-11-17 2016-05-26 Arno Therapeutics, Inc. Onapristone extended-release compositions and methods
AU2016326657B2 (en) 2015-09-25 2019-10-24 Context Biopharma, Inc. Methods of making onapristone intermediates
CA3008422A1 (en) 2015-12-15 2017-06-22 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
JP2019506443A (ja) 2016-02-24 2019-03-07 イースタン バージニア メディカル スクール 改良された持効性注射用デポ型ブタン酸レボノルゲストレル懸濁製剤
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

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EA023743B1 (ru) 2016-07-29
KR20130009990A (ko) 2013-01-24
SG183924A1 (en) 2012-10-30
UA110030C2 (uk) 2015-11-10
SG10201510568WA (en) 2016-01-28
JP2013522361A (ja) 2013-06-13
JP5894143B2 (ja) 2016-03-23
ECSP12012226A (es) 2012-11-30
CN107260746A (zh) 2017-10-20
AU2010348967A1 (en) 2012-09-27
TWI581797B (zh) 2017-05-11
TW201200135A (en) 2012-01-01
IL255679A (en) 2018-01-31
JP2016029083A (ja) 2016-03-03
ZA201207688B (en) 2013-07-31
EP2550288A1 (en) 2013-01-30
JP2019123756A (ja) 2019-07-25
AR080692A1 (es) 2012-05-02
NZ602525A (en) 2014-01-31
CO6602170A2 (es) 2013-01-18
CR20120514A (es) 2013-02-11
WO2011119194A1 (en) 2011-09-29
NI201200142A (es) 2013-04-12
AU2010348967C1 (en) 2016-04-28
AU2017251837A1 (en) 2017-11-16
PH12012501812A1 (en) 2012-12-10
US20190127413A1 (en) 2019-05-02
MY164622A (en) 2018-01-30
US20130018027A1 (en) 2013-01-17
CN107260745A (zh) 2017-10-20
AU2016200575A1 (en) 2016-02-18
EA201390959A1 (ru) 2013-11-29
CN102906103A (zh) 2013-01-30
US20150203526A1 (en) 2015-07-23
PH12013501176A1 (en) 2021-06-02
AU2010348967B2 (en) 2015-10-29
AU2020200027A1 (en) 2020-01-30
CL2012002544A1 (es) 2012-11-23
SG10201504913UA (en) 2015-07-30
MX2012010327A (es) 2012-11-16
CA2793712A1 (en) 2011-09-29
KR20180104180A (ko) 2018-09-19
AU2016200575B2 (en) 2017-11-16
KR102166867B1 (ko) 2020-10-19
BR112013015509A2 (pt) 2016-09-13
NI201300059A (es) 2014-06-06
JP2018016655A (ja) 2018-02-01
EP3865502A1 (en) 2021-08-18
AU2017251837B2 (en) 2019-10-03
BR112012023281A2 (pt) 2016-05-17

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