AR080692A1 - Compuestos, composiciones y metodos para la administracion no toxica de antiprogestinas - Google Patents
Compuestos, composiciones y metodos para la administracion no toxica de antiprogestinasInfo
- Publication number
- AR080692A1 AR080692A1 ARP110100899A ARP110100899A AR080692A1 AR 080692 A1 AR080692 A1 AR 080692A1 AR P110100899 A ARP110100899 A AR P110100899A AR P110100899 A ARP110100899 A AR P110100899A AR 080692 A1 AR080692 A1 AR 080692A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- acyl
- alkoxy
- hydrogen
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El objeto es pertinente para el campo del tratamiento de las afecciones dependientes de hormonas. Se divulgan compuestos y métodos para tratar estas afecciones. Se divulgan métodos para tratar la endometriosis, la dismenorrea, el cáncer del seno, los fibromas uterinos y la hiperproliferacion endometrial. Reivindicacion 1: Un compuesto caracterizado porque tiene la formula general (1) o una sal aceptable desde el punto de vista farmacéutico de este, donde R1 se selecciona del grupo que incluye: alquilo; alquenilo; cicloalquilo; cicloalquenilo; arilo; H; CH3SO; CH3SO2 acilo; alcoxi; tioalcoxi; tioalquilo, aciloxi; Si(CH3)3; el resto de formula (2) donde X e Y son acilo; aziridinilo, azirinilo, azetidinilo, pirrolidinilo, etoxipirrolidinilo, metoxipirrolidinilo, piperidinilo, etoxipiperidinilo, morfolinilo, etoximorfolinilo, oxazinilo, piperazinilo, metilpiperazinilo, etilpiperazinilo y diazinilo; R2 se selecciona del grupo que incluye: hidrogeno, halogeno, alquilo, acilo, hidroxilo, alcoxi, aciloxi, carbonato de alquilo, cipioniloxi, S-alquilo, S-CN, S-acilo y -OC(O)R6 donde R6 es alquilo, alcoxialquilo o alcoxi; R3 se selecciona del grupo que incluye: alquilo, hidroxi, alcoxi y aciloxi con la condicion de que sea distinto de acetoxi o propinilo; R4 es hidrogeno o alquilo; y X se selecciona del grupo que incluye: =O, N-OR5 donde R5 es hidrogeno o alquilo, OH, CH2, OAIk1 y OCOAlk2, donde Alk1 y Alk2 son alquilo C1-8 o aralalquilo C7-15, con la condicion de que si R1 está en la posicion para y es -OCH3, -SCH3, -NC4H8, -NC5H10, -NC4H8O, -CHO, -CH(OH)CH3, -COCH3, -O(CH2)2NC4H8 o -O(CH2)2NC5H10, X sea distinto de =O o =N-OR5, donde R5 es hidrogeno o alquilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31626310P | 2010-03-22 | 2010-03-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR080692A1 true AR080692A1 (es) | 2012-05-02 |
Family
ID=44343114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110100899A AR080692A1 (es) | 2010-03-22 | 2011-03-18 | Compuestos, composiciones y metodos para la administracion no toxica de antiprogestinas |
Country Status (24)
Country | Link |
---|---|
US (3) | US20130018027A1 (es) |
EP (2) | EP3865502A1 (es) |
JP (4) | JP5894143B2 (es) |
KR (2) | KR20130009990A (es) |
CN (3) | CN107260746A (es) |
AR (1) | AR080692A1 (es) |
AU (4) | AU2010348967C1 (es) |
BR (2) | BR112012023281A2 (es) |
CA (1) | CA2793712A1 (es) |
CL (1) | CL2012002544A1 (es) |
CO (1) | CO6602170A2 (es) |
CR (1) | CR20120514A (es) |
EA (1) | EA023743B1 (es) |
EC (1) | ECSP12012226A (es) |
IL (2) | IL221820B (es) |
MX (1) | MX2012010327A (es) |
MY (1) | MY164622A (es) |
NI (2) | NI201200142A (es) |
NZ (1) | NZ602525A (es) |
SG (3) | SG183924A1 (es) |
TW (1) | TWI581797B (es) |
UA (1) | UA110030C2 (es) |
WO (1) | WO2011119194A1 (es) |
ZA (1) | ZA201207688B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10064815B2 (en) * | 2014-05-05 | 2018-09-04 | Repros Therapeutics Inc. | Formulations and methods for vaginal delivery of antiprogestins |
RU2017112748A (ru) | 2014-11-17 | 2018-12-19 | Арно Терапьютикс, Инк. | Композиции онапристона пролонгированного действия и способы |
EP3353148A4 (en) | 2015-09-25 | 2019-04-24 | Context Biopharma Inc. | PROCESS FOR THE PRODUCTION OF ONAPRISTONE INTERMEDIATE PRODUCTS |
AU2016370499B2 (en) | 2015-12-15 | 2022-06-30 | Context Biopharma Inc. | Amorphous onapristone compositions and methods of making the same |
AU2017223595B2 (en) * | 2016-02-24 | 2022-11-24 | Eastern Virginia Medical School | An improved formulation of long-acting levonorgestrel butanoate injectable depot suspension |
US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2377418A1 (fr) * | 1977-01-13 | 1978-08-11 | Roussel Uclaf | Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments |
ZA8231B (en) | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
FR2521565B1 (fr) | 1982-02-17 | 1985-07-05 | Dior Sa Parfums Christian | Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees |
FR2522328B1 (fr) * | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
FR2534487B1 (fr) | 1982-10-15 | 1988-06-10 | Dior Christian Parfums | Procede d'homogeneisation de dispersions de phases lamellaires lipidiques hydratees, et suspensions obtenues par ce procede |
EP0116974B1 (de) | 1983-02-18 | 1986-10-29 | Schering Aktiengesellschaft | 11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate |
US4780461A (en) | 1983-06-15 | 1988-10-25 | Schering Aktiengesellschaft | 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same |
EP0501523B1 (en) | 1983-11-14 | 1997-04-09 | Columbia Laboratories, Inc. | Bioadhesive compositions |
DE3347126A1 (de) | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3506785A1 (de) | 1985-02-22 | 1986-08-28 | Schering AG, Berlin und Bergkamen, 1000 Berlin | 11ss-n,n-dimethylaminophenyl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
FR2598421B1 (fr) * | 1986-05-06 | 1988-08-19 | Roussel Uclaf | Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
DE3625315A1 (de) | 1986-07-25 | 1988-01-28 | Schering Ag | 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3708942A1 (de) | 1987-03-18 | 1988-09-29 | Schering Ag | 19,11ss-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
US5446178A (en) | 1987-03-18 | 1995-08-29 | Schering Aktiengesellschaft | Process for preparing 19,11β-bridged steroids |
DE3866410D1 (de) | 1987-04-24 | 1992-01-09 | Akzo Nv | 11-arylestranderivate und 11-arylpregnanderivate. |
ES2053714T3 (es) | 1987-12-12 | 1994-08-01 | Akzo Nv | Proceso para la preparacion de 11-arilesteroides. |
DE3820948A1 (de) | 1988-06-16 | 1989-12-21 | Schering Ag | 10ss, 11ss-ueberbrueckte steroide |
US4954490A (en) * | 1988-06-23 | 1990-09-04 | Research Triangle Institute | 11 β-substituted progesterone analogs |
DE3822770A1 (de) | 1988-07-01 | 1990-01-04 | Schering Ag | 13-alkyl-11ss-phenylgonane |
US5077211A (en) | 1988-07-06 | 1991-12-31 | Applied Genetics, Inc. | Purification and administration of dna repair enzymes |
DE3832303A1 (de) | 1988-09-20 | 1990-04-12 | Schering Ag | 11ss-phenyl-14ssh-steroide |
DE3917274A1 (de) | 1989-05-24 | 1990-11-29 | Schering Ag | 9(alpha)-hydroxy-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3921059A1 (de) | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
DE4042007A1 (de) | 1990-12-22 | 1992-06-25 | Schering Ag | 6,7-modifizierte-11(beta)-aryl-4-estrene |
US5407928A (en) | 1990-08-15 | 1995-04-18 | Schering Aktiengesellschaft | 11β-aryl-gona-4,9-dien-3-ones |
DE4038128A1 (de) | 1990-11-27 | 1992-06-04 | Schering Ag | 8-en-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
JPH0735335B2 (ja) * | 1991-02-28 | 1995-04-19 | 五十嵐 正雄 | 子宮内膜症の治療薬 |
ZA929315B (en) | 1991-12-20 | 1993-05-24 | Akzo Nv | 17-spirofuran-3'-ylidene steroids. |
US5439913A (en) | 1992-05-12 | 1995-08-08 | Schering Aktiengesellschaft | Contraception method using competitive progesterone antagonists and novel compounds useful therein |
DE4216004B4 (de) | 1992-05-12 | 2008-03-27 | Bayer Schering Pharma Akiengesellschaft | Verwendung kompetitiver Progesteronantagonisten |
DE4216003A1 (de) | 1992-05-12 | 1993-11-18 | Schering Ag | Dissoziierte kompetitive Progesteronantagonisten |
US5684151A (en) | 1992-07-01 | 1997-11-04 | Ortho Pharmaceutical Corporation | 1-arylsulphonyl, arylcarbonyl and 1-arylphosphonyl-3-phenyl-1,4,5,6-tetrahydropyridazines |
US5543150A (en) * | 1993-09-15 | 1996-08-06 | Columbia Laboratories, Inc. | Method of progesterone delivery and affect thereof |
DE4332284C2 (de) | 1993-09-20 | 1997-05-28 | Jenapharm Gmbh | 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE4332283A1 (de) | 1993-09-20 | 1995-04-13 | Jenapharm Gmbh | Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE4434488A1 (de) | 1994-09-14 | 1996-03-21 | Schering Ag | Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
US5576310A (en) | 1994-09-20 | 1996-11-19 | Jenapharm Gmbh | 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds |
US5688810A (en) | 1994-12-22 | 1997-11-18 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
WO1997041145A1 (en) | 1996-05-01 | 1997-11-06 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
US6900193B1 (en) * | 1996-05-01 | 2005-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
WO1998008471A1 (en) * | 1996-08-30 | 1998-03-05 | The Population Council, Inc. | Vaginal application mifepristone |
US5753655A (en) | 1996-10-10 | 1998-05-19 | Ortho Pharmaceutical Corporation | 1-arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and methods of preparation |
DE19652408C2 (de) | 1996-12-06 | 2002-04-18 | Schering Ag | Steroidester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneimitteln |
US5993856A (en) * | 1997-01-24 | 1999-11-30 | Femmepharma | Pharmaceutical preparations and methods for their administration |
DE19706061A1 (de) | 1997-02-07 | 1998-08-13 | Schering Ag | Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette |
US6197327B1 (en) * | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
DE19809845A1 (de) | 1998-03-03 | 1999-09-09 | Jenapharm Gmbh | S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
US6172052B1 (en) * | 1998-12-04 | 2001-01-09 | Research Triangle Institute | 17β-acyl-17α-propynyl-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US6369056B1 (en) | 1999-05-04 | 2002-04-09 | American Home Products Corporation | Cyclic urea and cyclic amide derivatives |
US6380235B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Benzimidazolones and analogues |
US6306851B1 (en) | 1999-05-04 | 2001-10-23 | American Home Products Corporation | Cyclocarbamate and cyclic amide derivatives |
US6339098B1 (en) | 1999-05-04 | 2002-01-15 | American Home Products Corporation | 2,1-benzisothiazoline 2,2-dioxides |
US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
US6417214B1 (en) | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
US6358948B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
US6740645B1 (en) * | 1999-09-03 | 2004-05-25 | Research Triangle Institute | 17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties |
UA74168C2 (uk) * | 1999-10-05 | 2005-11-15 | Коламбіа Леборетеріс (Бермуда) Лімітед | Лікування ендометріозу або безпліддя, або покращення плідності та застосування бета-адренергічного агоніста для виробництва лікарського засобу |
US6476079B1 (en) * | 1999-12-23 | 2002-11-05 | Leiras Oy | Devices for the delivery of drugs having antiprogestinic properties |
EP1328276B1 (en) * | 2000-10-18 | 2005-11-23 | Schering Aktiengesellschaft | Use of antiprogestins for prophylaxis and treatment of hormone-dependent diseases |
CN1210079C (zh) * | 2001-04-25 | 2005-07-13 | 上海市计划生育科学研究所 | 阴道环制剂及其应用 |
CN101080205B (zh) * | 2004-07-09 | 2011-10-12 | 人口委员会股份有限公司 | 含孕酮受体调节剂的缓释组合物 |
CN1846703A (zh) * | 2006-02-13 | 2006-10-18 | 程定超 | 米非司酮阴道给药制剂及其组成和制备方法 |
PL2148681T3 (pl) * | 2007-04-20 | 2016-09-30 | Selektywny modulator progesteronu w leczeniu krwawienia z macicy | |
DK2197415T3 (da) * | 2007-09-20 | 2014-05-26 | Lapidot Medical Imp And Marketing Ltd | Sammensætninger og midler til at behandle uterusleiomyomer, leiomyom, myom, uterusfibroid, endometriose, adenomyose og beslægtede forstyrrelser med mifepriston |
US8299050B2 (en) * | 2008-01-29 | 2012-10-30 | Laboratoire Hra-Pharma | Method for treating uterine fibroids |
-
2010
- 2010-12-23 AU AU2010348967A patent/AU2010348967C1/en not_active Ceased
- 2010-12-23 KR KR1020127027413A patent/KR20130009990A/ko active Application Filing
- 2010-12-23 KR KR1020187026211A patent/KR102166867B1/ko active IP Right Grant
- 2010-12-23 CN CN201710457607.6A patent/CN107260746A/zh active Pending
- 2010-12-23 US US13/636,119 patent/US20130018027A1/en not_active Abandoned
- 2010-12-23 SG SG2012065801A patent/SG183924A1/en unknown
- 2010-12-23 BR BR112012023281A patent/BR112012023281A2/pt not_active IP Right Cessation
- 2010-12-23 UA UAA201212075A patent/UA110030C2/uk unknown
- 2010-12-23 NZ NZ602525A patent/NZ602525A/en not_active IP Right Cessation
- 2010-12-23 EP EP21167932.9A patent/EP3865502A1/en not_active Withdrawn
- 2010-12-23 JP JP2013501240A patent/JP5894143B2/ja not_active Expired - Fee Related
- 2010-12-23 WO PCT/US2010/062068 patent/WO2011119194A1/en active Application Filing
- 2010-12-23 CA CA2793712A patent/CA2793712A1/en not_active Abandoned
- 2010-12-23 EP EP10807575A patent/EP2550288A1/en not_active Ceased
- 2010-12-23 SG SG10201504913UA patent/SG10201504913UA/en unknown
- 2010-12-23 CN CN2010800669434A patent/CN102906103A/zh active Pending
- 2010-12-23 MX MX2012010327A patent/MX2012010327A/es unknown
- 2010-12-23 CN CN201710457367.XA patent/CN107260745A/zh active Pending
- 2010-12-23 MY MYPI2012004016A patent/MY164622A/en unknown
-
2011
- 2011-03-11 TW TW100108248A patent/TWI581797B/zh not_active IP Right Cessation
- 2011-03-18 AR ARP110100899A patent/AR080692A1/es unknown
- 2011-09-08 EA EA201390959A patent/EA023743B1/ru not_active IP Right Cessation
- 2011-09-08 SG SG10201510568WA patent/SG10201510568WA/en unknown
- 2011-09-08 BR BR112013015509A patent/BR112013015509A2/pt not_active IP Right Cessation
-
2012
- 2012-09-06 IL IL221820A patent/IL221820B/en active IP Right Grant
- 2012-09-13 CL CL2012002544A patent/CL2012002544A1/es unknown
- 2012-09-20 NI NI201200142A patent/NI201200142A/es unknown
- 2012-09-20 CO CO12163077A patent/CO6602170A2/es not_active Application Discontinuation
- 2012-10-05 EC ECSP12012226 patent/ECSP12012226A/es unknown
- 2012-10-11 CR CR20120514A patent/CR20120514A/es not_active Application Discontinuation
- 2012-10-12 ZA ZA2012/07688A patent/ZA201207688B/en unknown
-
2013
- 2013-06-21 NI NI201300059A patent/NI201300059A/es unknown
-
2015
- 2015-03-20 US US14/664,518 patent/US20150203526A1/en not_active Abandoned
- 2015-10-13 JP JP2015201752A patent/JP2016029083A/ja not_active Withdrawn
-
2016
- 2016-01-29 AU AU2016200575A patent/AU2016200575B2/en not_active Ceased
-
2017
- 2017-10-27 AU AU2017251837A patent/AU2017251837B2/en not_active Ceased
- 2017-11-06 JP JP2017213755A patent/JP2018016655A/ja not_active Withdrawn
- 2017-11-15 IL IL255679A patent/IL255679A/en unknown
-
2018
- 2018-05-14 US US15/978,988 patent/US20190127413A1/en not_active Abandoned
-
2019
- 2019-05-09 JP JP2019088915A patent/JP2019123756A/ja not_active Withdrawn
-
2020
- 2020-01-02 AU AU2020200027A patent/AU2020200027A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR080692A1 (es) | Compuestos, composiciones y metodos para la administracion no toxica de antiprogestinas | |
AR108812A1 (es) | Proceso para preparar un derivado de piridona policíclica sustituida y cristal del mismo | |
PE20181045A1 (es) | Compuestos utiles como inmunomoduladores | |
BR112017005767A2 (pt) | composições de limpeza contendo uma polieteramina | |
JP2019514955A5 (es) | ||
CY1120821T1 (el) | Παραγωγα ταμοξιφαινης για θεραπεια νεοπλασματικων ασθενειων, ειδικα με υψηλο επιπεδο πρωτεϊνης her2 | |
BR112017001599A2 (pt) | ?sal de amônio quaternário, método para sua preparação, composições, método de melhoria do desempenho de um motor, uso de aditivo e método de preparação de uma composição combustível?. | |
BR112015026410A2 (pt) | derivados de dolastatina 10 e auristatinas | |
CO6251243A2 (es) | Nuevos inhibidores macrocíclicos de la replicación del virus de hepatitis c | |
BR112018013174A2 (pt) | composição e método para crescimento de cabelo | |
AR086829A1 (es) | Compuestos heterociclicos fusionados como moduladores del canal ionico | |
AR090993A1 (es) | Pirazol indanil carboxamidas | |
BR112016026046A8 (pt) | uso de compostos de tienotriazolodiazepina | |
RU2018113718A (ru) | Новые соединения | |
BR112017013715A2 (pt) | composição de líquido refrigerante, método de operação de motor de combustão interna usando a mesma, e uso da mesma | |
PE20141201A1 (es) | Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv) | |
RU2016133471A (ru) | Композиции и способы для лечения диабета и заболеваний печени | |
AR090618A1 (es) | Proceso para la preparacion de inhibidores de sglt2 de derivados de bencilbenceno | |
WO2014186571A1 (en) | Benzoxazole-based materials for vulcanization accelerator applications | |
BR112015017740A2 (pt) | composto heterocíclico condensado | |
BR112016024238A2 (pt) | uso de composições aquosas de redução de desvio | |
AR090323A1 (es) | Imidazopiridazinas sustituidas, procesos e intermediarios para su obtencion y su uso en el tratamiento de enfermedades mediadas por la quinasa mps-1 | |
AR105540A1 (es) | Inhibidores de fucosidasas | |
AR109387A1 (es) | INHIBIDORES DEL FACTOR XIa | |
BR112014030034A2 (pt) | método para a estabilização de gesso beta semi-hidratado |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |