IL205501A - Preparation of preparations for the treatment of arthritis - Google Patents

Info

Publication number

IL205501A

IL205501A IL205501A IL20550110A IL205501A IL 205501 A IL205501 A IL 205501A IL 205501 A IL205501 A IL 205501A IL 20550110 A IL20550110 A IL 20550110A IL 205501 A IL205501 A IL 205501A

Authority

IL

Israel

Prior art keywords

methyl

amino

piperazin

fused

unfused

Prior art date

2007-11-16

Links

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• 238000002360 preparation method Methods 0.000 title description 7
• 239000003814 drug Substances 0.000 title description 6
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 382
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 324
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• KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims description 167
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• -1 aziridin-l-yl Chemical group 0.000 claims description 133
• 150000002390 heteroarenes Chemical class 0.000 claims description 101
• 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 80
• 150000001925 cycloalkenes Chemical class 0.000 claims description 71
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 67
• 125000000217 alkyl group Chemical group 0.000 claims description 53
• 150000001924 cycloalkanes Chemical class 0.000 claims description 50
• 150000001875 compounds Chemical class 0.000 claims description 48
• 125000001072 heteroaryl group Chemical group 0.000 claims description 42
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• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 35
• 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims description 28
• 125000000304 alkynyl group Chemical group 0.000 claims description 22
• 125000003342 alkenyl group Chemical group 0.000 claims description 20
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