DOP2013000169A - Compuesto para uso en el tratamiento de la artritis - Google Patents

Compuesto para uso en el tratamiento de la artritis

Info

Publication number
DOP2013000169A
DOP2013000169A DO2013000169A DO2013000169A DOP2013000169A DO P2013000169 A DOP2013000169 A DO P2013000169A DO 2013000169 A DO2013000169 A DO 2013000169A DO 2013000169 A DO2013000169 A DO 2013000169A DO P2013000169 A DOP2013000169 A DO P2013000169A
Authority
DO
Dominican Republic
Prior art keywords
methyl
arthritis
composite
treatment
phenylsulfanyl
Prior art date
Application number
DO2013000169A
Other languages
English (en)
Inventor
Philip Bardwell
Tariq Ghayur
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of DOP2013000169A publication Critical patent/DOP2013000169A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

La presente invención se relaciona con compuesto N—(4—(4—((4'-cloro(1,1'-bifenil)—2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitrobencensulfonamida y compuesto N—(4—(4—((2—(4-clorofenil)—5, 5-dimetil-1-ciclohex-1-en-1-il)metil)piperazin-1-il)benzoil)-4- (((1R)-3-(morfolin-4-il)-1 -((fenilsulfanil)metil)propil)amino)-3-((trifluorometil) sulfonil) bencensulfonamida para uso en el tratamiento de la artritis en un mamífero.
DO2013000169A 2007-11-16 2013-07-23 Compuesto para uso en el tratamiento de la artritis DOP2013000169A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98847907P 2007-11-16 2007-11-16

Publications (1)

Publication Number Publication Date
DOP2013000169A true DOP2013000169A (es) 2013-12-15

Family

ID=40291332

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2013000169A DOP2013000169A (es) 2007-11-16 2013-07-23 Compuesto para uso en el tratamiento de la artritis

Country Status (14)

Country Link
US (2) US20090176785A1 (es)
EP (1) EP2231159A1 (es)
JP (2) JP5450434B2 (es)
KR (1) KR101585848B1 (es)
CN (1) CN101969951B (es)
AU (1) AU2008322595B2 (es)
CA (1) CA2705294C (es)
DO (1) DOP2013000169A (es)
IL (2) IL205501A (es)
MX (1) MX2010005395A (es)
NZ (2) NZ601350A (es)
RU (2) RU2526201C2 (es)
WO (1) WO2009064938A1 (es)
ZA (1) ZA201003434B (es)

Families Citing this family (16)

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US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2568611C2 (ru) * 2010-03-25 2015-11-20 Эббви Инк. Средства, индуцирующие апоптоз, для лечения рака, иммунных и аутоиммунных заболеваний
TWI520960B (zh) 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
EP2632436B1 (en) 2010-10-29 2018-08-29 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
US8722657B2 (en) 2010-11-23 2014-05-13 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
WO2012071374A1 (en) 2010-11-23 2012-05-31 Abbott Laboratories Methods of treatment using selective bcl-2 inhibitors
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA3073446A1 (en) 2017-08-23 2019-02-28 Newave Pharmaceutical Inc. Bcl-2 inhibitors
US11903950B2 (en) 2018-08-22 2024-02-20 Newave Pharmaceutical Inc. BCL-2 inhibitors
WO2020140005A2 (en) 2018-12-29 2020-07-02 Newave Pharmaceutical Inc. Bcl-2 inhibitors
WO2021066873A1 (en) 2019-10-03 2021-04-08 Newave Pharmaceutical Inc. Condensed heterocycles as bcl-2 inhibitors
KR20220098755A (ko) 2019-11-05 2022-07-12 애브비 인코포레이티드 나비토클락스를 사용한 골수섬유증 및 mpn 관련 장애 치료에 사용하기 위한 투약 레지멘
WO2021133817A1 (en) 2019-12-27 2021-07-01 Guangzhou Lupeng Pharmaceutical Company Ltd. 1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
US20230295183A1 (en) 2020-02-24 2023-09-21 Newave Pharmaceutical Inc. Hot melt extruded solid dispersions containing a bcl2 inhibitor
WO2022140224A1 (en) 2020-12-22 2022-06-30 Newave Pharmaceutical Inc. 1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases

Family Cites Families (12)

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GB9200275D0 (en) * 1992-01-08 1992-02-26 Roussel Lab Ltd Chemical compounds
JP3020612B2 (ja) * 1995-10-10 2000-03-15 ファイザー インク． ロイコトリエンアンタゴニストとしてのインドールカルバメート類
KR20020081465A (ko) * 2000-03-21 2002-10-26 더 프록터 앤드 갬블 캄파니 헤테로시클릭 측쇄 함유, ｎ-치환된 메탈로프로테아제저해제
EP1415987B1 (en) * 2000-10-20 2007-02-28 Eisai R&D Management Co., Ltd. Nitrogenous aromatic ring compounds as anti cancer agents
GB0217431D0 (en) * 2002-07-27 2002-09-04 Astrazeneca Ab Novel compounds
BRPI0413072A (pt) * 2003-07-28 2006-10-03 Janssen Pharmaceutica Nv moduladores de lta4h
ES2441206T3 (es) * 2003-09-03 2014-02-03 Raqualia Pharma Inc. Compuestos de fenil o piridilamida como antagonistas de la prostaglandina E2
WO2005049593A2 (en) * 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
ES2257929B1 (es) * 2004-07-16 2007-05-01 Laboratorios Del Dr. Esteve, S.A. Derivados de pirazolina, procedimiento para su obtencion y utilizacion de los mismos como agentes terapeuticos.
PT1888550E (pt) * 2005-05-12 2014-09-03 Abbvie Bahamas Ltd Promotores de apoptose
US20060276464A1 (en) * 2005-05-13 2006-12-07 Wyeth Diarylsulfone sulfonamides and use thereof
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Also Published As

Publication number Publication date
KR101585848B1 (ko) 2016-01-15
RU2012143212A (ru) 2014-04-20
CA2705294A1 (en) 2009-05-22
KR20100099172A (ko) 2010-09-10
RU2472509C2 (ru) 2013-01-20
CA2705294C (en) 2016-05-17
ZA201003434B (en) 2011-10-26
JP5667684B2 (ja) 2015-02-12
AU2008322595B2 (en) 2014-01-30
AU2008322595A1 (en) 2009-05-22
IL205501A0 (en) 2010-12-30
NZ585085A (en) 2012-08-31
MX2010005395A (es) 2010-06-02
WO2009064938A1 (en) 2009-05-22
IL205501A (en) 2013-08-29
CN101969951A (zh) 2011-02-09
JP2011503199A (ja) 2011-01-27
US20160101109A1 (en) 2016-04-14
EP2231159A1 (en) 2010-09-29
JP5450434B2 (ja) 2014-03-26
NZ601350A (en) 2013-08-30
RU2526201C2 (ru) 2014-08-20
IL227641A0 (en) 2013-09-30
CN101969951B (zh) 2012-10-31
WO2009064938A9 (en) 2009-08-06
RU2010123796A (ru) 2011-12-27
JP2014065716A (ja) 2014-04-17
US20090176785A1 (en) 2009-07-09

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