IL204763A - Kinazolinone derivatives preserved at position 6, 7, or 8, their composition and @ methods of use @ them - Google Patents
Kinazolinone derivatives preserved at position 6, 7, or 8, their composition and @ methods of use @ themInfo
- Publication number
- IL204763A IL204763A IL204763A IL20476310A IL204763A IL 204763 A IL204763 A IL 204763A IL 204763 A IL204763 A IL 204763A IL 20476310 A IL20476310 A IL 20476310A IL 204763 A IL204763 A IL 204763A
- Authority
- IL
- Israel
- Prior art keywords
- methods
- compositions
- same
- quinazolinone derivatives
- substituted quinazolinone
- Prior art date
Links
- -1 8- substituted quinazolinone Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99567607P | 2007-09-26 | 2007-09-26 | |
| PCT/US2008/011124 WO2009042177A1 (en) | 2007-09-26 | 2008-09-25 | 6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL204763A0 IL204763A0 (en) | 2010-11-30 |
| IL204763A true IL204763A (en) | 2013-07-31 |
Family
ID=40225265
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL204763A IL204763A (en) | 2007-09-26 | 2010-03-25 | Kinazolinone derivatives preserved at position 6, 7, or 8, their composition and @ methods of use @ them |
| IL226870A IL226870A (en) | 2007-09-26 | 2013-06-11 | Quinazolinone derivatives are preserved at position 6, 7 or 8, containing and using their compositions |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL226870A IL226870A (en) | 2007-09-26 | 2013-06-11 | Quinazolinone derivatives are preserved at position 6, 7 or 8, containing and using their compositions |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US8492395B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2200999B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5637852B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101593242B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN101952272B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008305581C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0817525A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2704710C (cg-RX-API-DMAC7.html) |
| CO (1) | CO6270228A2 (cg-RX-API-DMAC7.html) |
| CR (1) | CR11355A (cg-RX-API-DMAC7.html) |
| ES (1) | ES2523925T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL204763A (cg-RX-API-DMAC7.html) |
| MX (1) | MX347987B (cg-RX-API-DMAC7.html) |
| MY (1) | MY157495A (cg-RX-API-DMAC7.html) |
| NI (1) | NI201000041A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ584425A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2476432C2 (cg-RX-API-DMAC7.html) |
| SG (2) | SG176442A1 (cg-RX-API-DMAC7.html) |
| UA (1) | UA102078C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009042177A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201002303B (cg-RX-API-DMAC7.html) |
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| JP5388854B2 (ja) | 2006-09-26 | 2014-01-15 | セルジーン コーポレイション | ５−置換キナゾリノン誘導体、それを含む組成物、及びその使用方法 |
| US8354417B2 (en) * | 2007-09-26 | 2013-01-15 | Celgene Corporation | Solid forms comprising 3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the same, and methods of using the same |
| BR112012003464B8 (pt) * | 2009-08-31 | 2021-05-25 | Merck Sharp & Dohme | compostos de piranil aril metil benzoquinaozlinona, uso dos mesmos, e, composição farmacêutica |
| US8895580B2 (en) | 2009-10-21 | 2014-11-25 | Merck Sharp & Dohme Corp. | Quinolinone-pyrazolone M1 receptor positive allosteric modulators |
| SMT201800032T1 (it) | 2011-03-11 | 2018-03-08 | Celgene Corp | Forme solide di 3-(5-ammino-2-metil-4-osso-4h-chinazolin-3-il)-piperidina-2,6-dione, e loro composizioni farmaceutiche e usi |
| EP2683384B1 (en) * | 2011-03-11 | 2015-12-09 | Celgene Corporation | Methods of treating cancer using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione |
| AU2012236655B2 (en) | 2011-03-28 | 2016-09-22 | Deuterx, Llc, | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
| WO2014110558A1 (en) | 2013-01-14 | 2014-07-17 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
| EP2968334A4 (en) * | 2013-03-14 | 2016-08-03 | Deuterx Llc | 3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES |
| KR102240356B1 (ko) | 2013-04-17 | 2021-04-14 | 시그날 파마소티칼 엘엘씨 | Ｔｏｒ 키나제 억제제와 5-치환된 퀴나졸리논 화합물을 포함하는 암 치료용 조합 요법 |
| US9119854B2 (en) | 2013-05-03 | 2015-09-01 | Celgene Corporation | Methods for treating cancer using combination therapy |
| FI3182996T3 (fi) | 2014-08-22 | 2023-03-28 | Celgene Corp | Menetelmiä multippelin myelooman hoitamiseksi immuunivastetta muuntavilla yhdisteillä yhdistelmässä vasta-aineiden kanssa |
| US10973822B2 (en) | 2015-07-02 | 2021-04-13 | Celgene Corporation | Combination therapy for treatment of hematological cancers and solid tumors |
| US9809603B1 (en) | 2015-08-18 | 2017-11-07 | Deuterx, Llc | Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same |
| KR102331013B1 (ko) * | 2016-01-14 | 2021-11-26 | 강푸 바이오파마슈티칼즈 리미티드 | 퀴나졸리논 유도체, 이의 제조방법, 약학 조성물 및 적용 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| EP3455219A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| WO2018208123A1 (ko) * | 2017-05-12 | 2018-11-15 | 한국화학연구원 | 신규한 피페리딘-2,6-디온 유도체 및 이의 용도 |
| KR102014478B1 (ko) | 2017-05-12 | 2019-08-26 | 한국화학연구원 | 신규한 피페리딘-2,6-디온 유도체 및 이의 용도 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| WO2019043217A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROBENZIMIDAZOLONES |
| WO2019043208A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROQUINOLINONES |
| WO2019043214A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | glutarimide |
| CA3079959A1 (en) * | 2017-10-27 | 2018-10-26 | Transfusion Health, Llc | Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene |
| CN111372585A (zh) | 2017-11-16 | 2020-07-03 | C4医药公司 | 用于靶蛋白降解的降解剂和降解决定子 |
| KR20210018199A (ko) | 2018-03-26 | 2021-02-17 | 씨4 테라퓨틱스, 인코포레이티드 | 이카로스의 분해를 위한 세레블론 결합제 |
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| WO2006053160A2 (en) | 2004-11-12 | 2006-05-18 | Celgene Corporation | Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases |
| WO2006058008A1 (en) | 2004-11-23 | 2006-06-01 | Celgene Corporation | Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury |
| MX2007006439A (es) | 2004-12-01 | 2007-07-20 | Celgene Corp | Metodos y composiciones que usan compuestos inmunomoduladores para el tratamiento de trastornos de inmunodeficiencia. |
| KR20080042158A (ko) | 2005-08-31 | 2008-05-14 | 셀진 코포레이션 | 이소인돌-이미드 화합물과 이를 포함하는 조성물 및 이를이용한 방법 |
| WO2007028047A2 (en) | 2005-09-01 | 2007-03-08 | Celgene Corporation | Immunological uses of immunodulatory compounds for vaccine and anti-infections disease therapy |
| JP5388854B2 (ja) * | 2006-09-26 | 2014-01-15 | セルジーン コーポレイション | ５−置換キナゾリノン誘導体、それを含む組成物、及びその使用方法 |
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