IL201627A - Process for Preparation of 6 - {4 - [3 - ((r) -2 - Methyl-Pyrrolidine-1-Il) -Propoxy] -Phenyl} -2H-Pyridazine-3-On - Google Patents

Process for Preparation of 6 - {4 - [3 - ((r) -2 - Methyl-Pyrrolidine-1-Il) -Propoxy] -Phenyl} -2H-Pyridazine-3-On

Info

Publication number
IL201627A
IL201627A IL201627A IL20162709A IL201627A IL 201627 A IL201627 A IL 201627A IL 201627 A IL201627 A IL 201627A IL 20162709 A IL20162709 A IL 20162709A IL 201627 A IL201627 A IL 201627A
Authority
IL
Israel
Prior art keywords
methylpyrrolidine
tartrate
methyl
phenyl
propoxy
Prior art date
Application number
IL201627A
Other languages
English (en)
Hebrew (he)
Other versions
IL201627A0 (en
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Publication of IL201627A0 publication Critical patent/IL201627A0/en
Publication of IL201627A publication Critical patent/IL201627A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Cosmetics (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL201627A 2007-05-03 2009-10-19 Process for Preparation of 6 - {4 - [3 - ((r) -2 - Methyl-Pyrrolidine-1-Il) -Propoxy] -Phenyl} -2H-Pyridazine-3-On IL201627A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92735607P 2007-05-03 2007-05-03
PCT/US2008/005702 WO2008137087A1 (en) 2007-05-03 2008-05-02 Processes for preparing (r)-2-methylpyrrolidine and (s)-2-methylpyrrolidine and tartrate salts thereof

Publications (2)

Publication Number Publication Date
IL201627A0 IL201627A0 (en) 2010-05-31
IL201627A true IL201627A (en) 2014-06-30

Family

ID=39688886

Family Applications (1)

Application Number Title Priority Date Filing Date
IL201627A IL201627A (en) 2007-05-03 2009-10-19 Process for Preparation of 6 - {4 - [3 - ((r) -2 - Methyl-Pyrrolidine-1-Il) -Propoxy] -Phenyl} -2H-Pyridazine-3-On

Country Status (14)

Country Link
EP (1) EP2152669A1 (enExample)
JP (1) JP5698887B2 (enExample)
KR (1) KR20100017565A (enExample)
CN (1) CN101679237A (enExample)
AU (1) AU2008248168B2 (enExample)
BR (1) BRPI0810330A2 (enExample)
CA (1) CA2686033A1 (enExample)
EA (1) EA019031B1 (enExample)
IL (1) IL201627A (enExample)
MX (1) MX2009011787A (enExample)
NZ (1) NZ580948A (enExample)
UA (1) UA99913C2 (enExample)
WO (1) WO2008137087A1 (enExample)
ZA (1) ZA200907643B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009000884A (es) 2006-07-25 2009-06-05 Cephalon Inc Derivados de piridizinona.
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
CA2712885A1 (en) 2008-01-30 2009-08-06 Cephalon, Inc. Substituted pyridazine derivatives which have histamine h3 antagonist activity
WO2016105529A1 (en) * 2014-12-23 2016-06-30 Cephalon, Inc. Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives
ES2923412T3 (es) * 2018-09-07 2022-09-27 Sanofi Sa Sales de 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxilato de metilo y proceso de preparación de las mismas

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329974A1 (de) 1983-08-19 1985-02-28 Bayer Ag, 5090 Leverkusen Herstellung von hydrierten nitrilkautschuken
DE3433392A1 (de) 1984-09-12 1986-03-20 Bayer Ag, 5090 Leverkusen Hydrierung nitrilgruppenhaltiger ungesaettigter polymerer
FR2714849B1 (fr) 1994-01-13 1996-04-05 Inst Francais Du Petrole Procédé de préparation d'un catalyseur d'hydrogénation soluble en phase liquide organique.
DE4403479A1 (de) 1994-02-04 1995-08-10 Basf Ag Verfahren zur Herstellung von Hydroxylammoniumsalzen
WO2004024707A2 (en) * 2002-09-16 2004-03-25 Abbott Laboratories Process for preparing amine type substituted benzofurans
US7153889B2 (en) 2002-11-12 2006-12-26 Abbott Laboratories Bicyclic-substituted amines as histamine-3 receptor ligands
EP1739104B1 (en) 2004-03-08 2014-07-09 Japan Science and Technology Agency Polymer-supported metal cluster compositions
US7145005B2 (en) 2004-05-12 2006-12-05 Abbott Laboratories 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation
CA2566526C (en) 2004-06-02 2012-10-23 F. Hoffmann-La Roche Ag Naphthaline derivatives useful as histamine-3-receptor ligands
JPWO2006059778A1 (ja) 2004-12-01 2008-06-05 萬有製薬株式会社 置換ピリドン誘導体
DE602005026169D1 (de) 2004-12-17 2011-03-10 Janssen Pharmaceutica Nv Tetrahydroisochinolinverbindungen zur behandlung von zns-erkrankungen
EP1848696A1 (en) 2005-01-21 2007-10-31 Schering Corporation Imidazole and benzimidazole derivates useful as histamine h3 antagonists
US7790720B2 (en) 2005-03-31 2010-09-07 Ucb Pharma, S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
GB0514812D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
AU2006308167A1 (en) 2005-10-27 2007-05-03 Ucb Pharma, S.A. Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses
DK1988777T3 (da) 2006-02-09 2012-01-16 Athersys Inc Pyrazoler til behandling af fedme og andre cns-lidelser
WO2007099423A1 (en) 2006-03-02 2007-09-07 Pfizer Products Inc. 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
US20090163482A1 (en) 2006-03-13 2009-06-25 Mchardy Stanton Furst Tetralines antagonists of the h-3 receptor
WO2008005338A1 (en) 2006-06-29 2008-01-10 Arena Pharmaceuticals, Inc. Modulators of the histamine h3-receptor useful for the treatment of disorders related thereto
MX2009000884A (es) * 2006-07-25 2009-06-05 Cephalon Inc Derivados de piridizinona.

Also Published As

Publication number Publication date
AU2008248168A1 (en) 2008-11-13
CN101679237A (zh) 2010-03-24
UA99913C2 (ru) 2012-10-25
EP2152669A1 (en) 2010-02-17
EA019031B1 (ru) 2013-12-30
NZ580948A (en) 2011-04-29
JP2010526142A (ja) 2010-07-29
KR20100017565A (ko) 2010-02-16
WO2008137087A1 (en) 2008-11-13
IL201627A0 (en) 2010-05-31
CA2686033A1 (en) 2008-11-13
BRPI0810330A2 (pt) 2014-10-14
JP5698887B2 (ja) 2015-04-08
ZA200907643B (en) 2014-03-26
MX2009011787A (es) 2009-11-13
AU2008248168B2 (en) 2013-03-21
EA200971019A1 (ru) 2010-04-30

Similar Documents

Publication Publication Date Title
US20100121055A1 (en) Processes for preparing (r)-2-methylpyrrolidine and (s)-2-methylpyrrolidine and tartrate salts thereof
JP6392888B2 (ja) ヒストン脱アセチル化酵素６阻害剤としての新規化合物およびこれを含む薬剤学的組成物
JP6491393B2 (ja) ヒストン脱アセチル化酵素６阻害剤としての１，３，４−オキサジアゾール誘導体化合物及びこれを含有する薬剤学的組成物
AU2006275870B2 (en) Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
ZA200603861B (en) Use of tricyclic compounds as glycine transport inhibitors
JP2023533783A (ja) ヒストン脱アセチル化酵素６阻害剤としての新規な構造の化合物およびこれを含む薬剤学的組成物
CN108718527A (zh) 用于制备4-苯基-5-烷氧羰基-2-噻唑-2-基-1，4-二氢嘧啶-6-基]甲基]-3-氧代-5，6，8，8a-四氢-1H-咪唑并[1，5-a]吡嗪-2-基]-甲酸的方法
JP2024512428A (ja) 抗ウイルス化合物
CA2791431A1 (en) Derivatives of aminoindanes, their preparation and their application in therapeutics
AU2008248168B2 (en) Processes for preparing (R)-2-methylpyrrolidine and (S)-2-methylpyrrolidine and tartrate salts thereof
Wallace et al. Development of a fit-for-purpose large-scale synthesis of an oral PARP inhibitor
CA2470236A1 (en) Lactams as tachykinin antagonists
CN113677673B (zh) Trpc6的抑制剂
WO2007102567A1 (ja) 3,4-ジ置換ピロリジン誘導体の製造方法及び製造中間体
AU2007329808A1 (en) 1,5-diphenyl-3-benzylamino-1,5-dihydropyrrolidin-2-one as CB1 receptor modulators
ES2561834T3 (es) Naftiridonas y quinolonas 7-amino alquilidenil-heterocíclicas
WO2004029048A1 (en) Heterocyclic substituted piperazines for the treatment of schizophrenia
KR20230164136A (ko) Kv1.3 칼륨 셰이커 채널 차단제로서의 아릴 헤테로시클릭 화합물
JP2010526142A5 (enExample)
WO2006082872A1 (ja) １－（ピペリジン－４－イル）－１ｈ－インドール誘導体
AU2005252178B2 (en) Histamine H3 receptor agents, preparation and therapeutic uses
ZA200700950B (en) Pyrrole derivatives, their preparation and their therapeutic use
AU2006316609A1 (en) Modulators of the H3 receptor useful for the treatment of disorders related thereto
WO2002089803A1 (fr) Composition d'ionophorese
Yoon‐Miller et al. Suzuki–Miyaura arylations of tetramic acid sulfonates: Evaluation of lactam protection, sulfonate esters, and sterics

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees