IL198571A - 5,6 or 7-substituted-s-(hetero)arylisoquinolinamine derivatives as antitumor agents - Google Patents
5,6 or 7-substituted-s-(hetero)arylisoquinolinamine derivatives as antitumor agentsInfo
- Publication number
- IL198571A IL198571A IL198571A IL19857109A IL198571A IL 198571 A IL198571 A IL 198571A IL 198571 A IL198571 A IL 198571A IL 19857109 A IL19857109 A IL 19857109A IL 198571 A IL198571 A IL 198571A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- tumors
- dimethylamino
- salt
- methoxy
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86626906P | 2006-11-17 | 2006-11-17 | |
| PCT/US2007/024041 WO2008063548A2 (en) | 2006-11-17 | 2007-11-16 | 5, 6, or 7-substituted-s- (hetero)arylisoquinolinamine derivatives as antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL198571A0 IL198571A0 (en) | 2010-02-17 |
| IL198571A true IL198571A (en) | 2013-02-28 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL198571A IL198571A (en) | 2006-11-17 | 2009-05-05 | 5,6 or 7-substituted-s-(hetero)arylisoquinolinamine derivatives as antitumor agents |
| IL223327A IL223327A0 (en) | 2006-11-17 | 2012-11-28 | 5,6 or 7-substituted-s- (hetero) arylisoquinolinamine derivatives as antitumor agents |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL223327A IL223327A0 (en) | 2006-11-17 | 2012-11-28 | 5,6 or 7-substituted-s- (hetero) arylisoquinolinamine derivatives as antitumor agents |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8034829B2 (enExample) |
| EP (2) | EP2423196A1 (enExample) |
| JP (2) | JP5270564B2 (enExample) |
| KR (1) | KR101464591B1 (enExample) |
| CN (2) | CN102532020B (enExample) |
| AU (2) | AU2007322068B2 (enExample) |
| BR (1) | BRPI0718841A2 (enExample) |
| CA (1) | CA2669083C (enExample) |
| ES (1) | ES2392361T3 (enExample) |
| IL (2) | IL198571A (enExample) |
| MX (1) | MX2009005242A (enExample) |
| PL (1) | PL2099765T3 (enExample) |
| WO (1) | WO2008063548A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8034829B2 (en) * | 2006-11-17 | 2011-10-11 | Rexahn Pharmaceuticals, Inc. | 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof |
| FR2956816B1 (fr) * | 2010-03-01 | 2012-05-18 | Univ Joseph Fourier | Utilisation de quinolones pour la preparation de medicaments, nouvelles quinolones et leur procede de synthese |
| KR101641196B1 (ko) * | 2014-09-18 | 2016-07-21 | 전남대학교산학협력단 | 헤테로아릴이소퀴놀린계 유도체 및 이를 포함하는 항암 조성물 |
| US10341135B2 (en) * | 2015-12-30 | 2019-07-02 | Nova-Tron Controls Corp. | Zone control system for conveyor system |
| WO2019189554A1 (ja) | 2018-03-30 | 2019-10-03 | 国立大学法人京都大学 | 心筋細胞成熟促進剤 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788608A (fr) * | 1971-09-09 | 1973-03-08 | Koninklijke Pharma Fab Nv | Aminoisoquinoleines |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US4942163A (en) * | 1989-03-07 | 1990-07-17 | E. I. Du Pont De Nemours And Company | 1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents |
| KR100412319B1 (ko) | 2001-03-20 | 2003-12-31 | 양지화학 주식회사 | 항암제로 유용한 3-아릴이소퀴놀린 유도체 및 그의 염 |
| TW200536830A (en) | 2004-02-06 | 2005-11-16 | Chugai Pharmaceutical Co Ltd | 1-(2H)-isoquinolone derivative |
| WO2005075432A1 (ja) | 2004-02-06 | 2005-08-18 | Chugai Seiyaku Kabushiki Kaisha | １−（２ｈ）−イソキノロン誘導体およびその抗ガン剤としての使用 |
| US8034829B2 (en) * | 2006-11-17 | 2011-10-11 | Rexahn Pharmaceuticals, Inc. | 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof |
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2007
- 2007-11-15 US US11/984,288 patent/US8034829B2/en not_active Expired - Fee Related
- 2007-11-16 EP EP11190786A patent/EP2423196A1/en not_active Withdrawn
- 2007-11-16 CA CA2669083A patent/CA2669083C/en not_active Expired - Fee Related
- 2007-11-16 BR BRPI0718841-2A patent/BRPI0718841A2/pt not_active IP Right Cessation
- 2007-11-16 WO PCT/US2007/024041 patent/WO2008063548A2/en not_active Ceased
- 2007-11-16 CN CN201110411212.5A patent/CN102532020B/zh not_active Expired - Fee Related
- 2007-11-16 MX MX2009005242A patent/MX2009005242A/es active IP Right Grant
- 2007-11-16 AU AU2007322068A patent/AU2007322068B2/en not_active Ceased
- 2007-11-16 ES ES07840063T patent/ES2392361T3/es active Active
- 2007-11-16 JP JP2009537215A patent/JP5270564B2/ja not_active Expired - Fee Related
- 2007-11-16 CN CN2007800425993A patent/CN101573337B/zh not_active Expired - Fee Related
- 2007-11-16 PL PL07840063T patent/PL2099765T3/pl unknown
- 2007-11-16 KR KR1020097012207A patent/KR101464591B1/ko not_active Expired - Fee Related
- 2007-11-16 EP EP07840063A patent/EP2099765B1/en not_active Not-in-force
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2009
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2011
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- 2012-05-31 AU AU2012203232A patent/AU2012203232B2/en not_active Ceased
- 2012-11-28 IL IL223327A patent/IL223327A0/en unknown
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| Publication number | Publication date |
|---|---|
| US20080182871A1 (en) | 2008-07-31 |
| KR101464591B1 (ko) | 2014-11-27 |
| KR20090098821A (ko) | 2009-09-17 |
| AU2012203232B2 (en) | 2014-10-09 |
| ES2392361T3 (es) | 2012-12-10 |
| US20120029012A1 (en) | 2012-02-02 |
| CN101573337A (zh) | 2009-11-04 |
| IL198571A0 (en) | 2010-02-17 |
| BRPI0718841A2 (pt) | 2014-02-04 |
| WO2008063548A2 (en) | 2008-05-29 |
| EP2099765A2 (en) | 2009-09-16 |
| CA2669083A1 (en) | 2008-05-29 |
| JP2010510217A (ja) | 2010-04-02 |
| WO2008063548A3 (en) | 2009-01-08 |
| IL223327A0 (en) | 2013-02-03 |
| AU2007322068A1 (en) | 2008-05-29 |
| EP2423196A1 (en) | 2012-02-29 |
| JP5668092B2 (ja) | 2015-02-12 |
| PL2099765T3 (pl) | 2013-01-31 |
| CN102532020A (zh) | 2012-07-04 |
| JP5270564B2 (ja) | 2013-08-21 |
| CN102532020B (zh) | 2015-02-25 |
| AU2012203232A1 (en) | 2012-06-21 |
| MX2009005242A (es) | 2009-08-19 |
| JP2013151546A (ja) | 2013-08-08 |
| US8034829B2 (en) | 2011-10-11 |
| AU2007322068B2 (en) | 2012-07-12 |
| EP2099765B1 (en) | 2012-08-29 |
| US8314123B2 (en) | 2012-11-20 |
| CA2669083C (en) | 2014-10-28 |
| CN101573337B (zh) | 2012-02-08 |
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