BRPI0718841A2 - Derivados 5,6 ou 7 substituídos de s-(hetero) arilisoquinolinamina como agentes antitumor - Google Patents

Info

Publication number

BRPI0718841A2

BRPI0718841A2 BRPI0718841-2A BRPI0718841A BRPI0718841A2 BR PI0718841 A2 BRPI0718841 A2 BR PI0718841A2 BR PI0718841 A BRPI0718841 A BR PI0718841A BR PI0718841 A2 BRPI0718841 A2 BR PI0718841A2

Authority

BR

Brazil

Prior art keywords

methyl

methoxy

compound

dimethoxy

dimethylamino

Prior art date

2006-11-17

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• 239000002246 antineoplastic agent Substances 0.000 title description 8
• 150000001875 compounds Chemical class 0.000 claims description 149
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 39
• 206010028980 Neoplasm Diseases 0.000 claims description 33
• 150000003839 salts Chemical class 0.000 claims description 30
• 238000000034 method Methods 0.000 claims description 26
• 230000003463 hyperproliferative effect Effects 0.000 claims description 25
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 24
• 239000000203 mixture Substances 0.000 claims description 23
• 208000035475 disorder Diseases 0.000 claims description 17
• -1 3, 4-methylenedioxy Chemical group 0.000 claims description 14
• 230000008685 targeting Effects 0.000 claims description 12
• 208000029742 colonic neoplasm Diseases 0.000 claims description 9
• 229910052739 hydrogen Inorganic materials 0.000 claims description 8
• 239000001257 hydrogen Substances 0.000 claims description 8
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 8
• 229910052736 halogen Inorganic materials 0.000 claims description 7
• 150000002367 halogens Chemical class 0.000 claims description 7
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• 239000011230 binding agent Substances 0.000 claims description 6
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• 201000001441 melanoma Diseases 0.000 claims description 6
• YKYIFUROKBDHCY-ONEGZZNKSA-N (e)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one Chemical group CCO\C=C\C(=O)C(F)(F)F YKYIFUROKBDHCY-ONEGZZNKSA-N 0.000 claims description 5
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 5
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• 125000001424 substituent group Chemical group 0.000 claims description 5
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• 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 claims description 3
• 229910052799 carbon Inorganic materials 0.000 claims description 3
• 229910052731 fluorine Inorganic materials 0.000 claims description 3
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
• 239000008194 pharmaceutical composition Substances 0.000 claims description 3
• 229910052760 oxygen Inorganic materials 0.000 claims description 2
• 229910052717 sulfur Inorganic materials 0.000 claims description 2
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 16
• 125000001309 chloro group Chemical group Cl* 0.000 claims 4
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