KR101464591B1 - 5, 6, 또는 7-치환-3-(헤테로)아릴이소퀴놀린아민 유도체 및 그 치료 용도 - Google Patents

5, 6, 또는 7-치환-3-(헤테로)아릴이소퀴놀린아민 유도체 및 그 치료 용도 Download PDF

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Publication number
KR101464591B1
KR101464591B1 KR1020097012207A KR20097012207A KR101464591B1 KR 101464591 B1 KR101464591 B1 KR 101464591B1 KR 1020097012207 A KR1020097012207 A KR 1020097012207A KR 20097012207 A KR20097012207 A KR 20097012207A KR 101464591 B1 KR101464591 B1 KR 101464591B1
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South Korea
Prior art keywords
compound
cancer
tumors
amine
hetero
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KR1020097012207A
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English (en)
Korean (ko)
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KR20090098821A (ko
Inventor
이영복
안창호
조원재
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렉산 파마슈티컬스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020097012207A 2006-11-17 2007-11-16 5, 6, 또는 7-치환-3-(헤테로)아릴이소퀴놀린아민 유도체 및 그 치료 용도 Expired - Fee Related KR101464591B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86626906P 2006-11-17 2006-11-17
US60/866,269 2006-11-17
PCT/US2007/024041 WO2008063548A2 (en) 2006-11-17 2007-11-16 5, 6, or 7-substituted-s- (hetero)arylisoquinolinamine derivatives as antitumor agents

Publications (2)

Publication Number Publication Date
KR20090098821A KR20090098821A (ko) 2009-09-17
KR101464591B1 true KR101464591B1 (ko) 2014-11-27

Family

ID=39430327

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097012207A Expired - Fee Related KR101464591B1 (ko) 2006-11-17 2007-11-16 5, 6, 또는 7-치환-3-(헤테로)아릴이소퀴놀린아민 유도체 및 그 치료 용도

Country Status (13)

Country Link
US (2) US8034829B2 (enExample)
EP (2) EP2423196A1 (enExample)
JP (2) JP5270564B2 (enExample)
KR (1) KR101464591B1 (enExample)
CN (2) CN102532020B (enExample)
AU (2) AU2007322068B2 (enExample)
BR (1) BRPI0718841A2 (enExample)
CA (1) CA2669083C (enExample)
ES (1) ES2392361T3 (enExample)
IL (2) IL198571A (enExample)
MX (1) MX2009005242A (enExample)
PL (1) PL2099765T3 (enExample)
WO (1) WO2008063548A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034829B2 (en) * 2006-11-17 2011-10-11 Rexahn Pharmaceuticals, Inc. 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof
FR2956816B1 (fr) * 2010-03-01 2012-05-18 Univ Joseph Fourier Utilisation de quinolones pour la preparation de medicaments, nouvelles quinolones et leur procede de synthese
KR101641196B1 (ko) * 2014-09-18 2016-07-21 전남대학교산학협력단 헤테로아릴이소퀴놀린계 유도체 및 이를 포함하는 항암 조성물
US10341135B2 (en) * 2015-12-30 2019-07-02 Nova-Tron Controls Corp. Zone control system for conveyor system
WO2019189554A1 (ja) 2018-03-30 2019-10-03 国立大学法人京都大学 心筋細胞成熟促進剤

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020074568A (ko) * 2001-03-20 2002-10-04 양지화학 주식회사 항암제로 유용한 3-아릴이소퀴놀린 유도체 및 그의 염

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788608A (fr) * 1971-09-09 1973-03-08 Koninklijke Pharma Fab Nv Aminoisoquinoleines
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US4942163A (en) * 1989-03-07 1990-07-17 E. I. Du Pont De Nemours And Company 1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents
TW200536830A (en) 2004-02-06 2005-11-16 Chugai Pharmaceutical Co Ltd 1-(2H)-isoquinolone derivative
WO2005075432A1 (ja) 2004-02-06 2005-08-18 Chugai Seiyaku Kabushiki Kaisha １−（２ｈ）−イソキノロン誘導体およびその抗ガン剤としての使用
US8034829B2 (en) * 2006-11-17 2011-10-11 Rexahn Pharmaceuticals, Inc. 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020074568A (ko) * 2001-03-20 2002-10-04 양지화학 주식회사 항암제로 유용한 3-아릴이소퀴놀린 유도체 및 그의 염

Also Published As

Publication number Publication date
US20080182871A1 (en) 2008-07-31
KR20090098821A (ko) 2009-09-17
AU2012203232B2 (en) 2014-10-09
ES2392361T3 (es) 2012-12-10
US20120029012A1 (en) 2012-02-02
IL198571A (en) 2013-02-28
CN101573337A (zh) 2009-11-04
IL198571A0 (en) 2010-02-17
BRPI0718841A2 (pt) 2014-02-04
WO2008063548A2 (en) 2008-05-29
EP2099765A2 (en) 2009-09-16
CA2669083A1 (en) 2008-05-29
JP2010510217A (ja) 2010-04-02
WO2008063548A3 (en) 2009-01-08
IL223327A0 (en) 2013-02-03
AU2007322068A1 (en) 2008-05-29
EP2423196A1 (en) 2012-02-29
JP5668092B2 (ja) 2015-02-12
PL2099765T3 (pl) 2013-01-31
CN102532020A (zh) 2012-07-04
JP5270564B2 (ja) 2013-08-21
CN102532020B (zh) 2015-02-25
AU2012203232A1 (en) 2012-06-21
MX2009005242A (es) 2009-08-19
JP2013151546A (ja) 2013-08-08
US8034829B2 (en) 2011-10-11
AU2007322068B2 (en) 2012-07-12
EP2099765B1 (en) 2012-08-29
US8314123B2 (en) 2012-11-20
CA2669083C (en) 2014-10-28
CN101573337B (zh) 2012-02-08

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