IL187947A0 - Novel forms of tiotropium bromide and processes for preparation thereof - Google Patents
Novel forms of tiotropium bromide and processes for preparation thereofInfo
- Publication number
- IL187947A0 IL187947A0 IL187947A IL18794707A IL187947A0 IL 187947 A0 IL187947 A0 IL 187947A0 IL 187947 A IL187947 A IL 187947A IL 18794707 A IL18794707 A IL 18794707A IL 187947 A0 IL187947 A0 IL 187947A0
- Authority
- IL
- Israel
- Prior art keywords
- processes
- preparation
- tiotropium bromide
- novel forms
- novel
- Prior art date
Links
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229960000257 tiotropium bromide Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75267205P | 2005-12-19 | 2005-12-19 | |
| US75453005P | 2005-12-27 | 2005-12-27 | |
| US76143706P | 2006-01-23 | 2006-01-23 | |
| US77405106P | 2006-02-15 | 2006-02-15 | |
| US78031006P | 2006-03-07 | 2006-03-07 | |
| US83218906P | 2006-07-20 | 2006-07-20 | |
| US85122306P | 2006-10-12 | 2006-10-12 | |
| US85274006P | 2006-10-18 | 2006-10-18 | |
| PCT/US2006/048734 WO2007075858A2 (en) | 2005-12-19 | 2006-12-19 | Novel forms of tiotropium bromide and processes for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL187947A0 true IL187947A0 (en) | 2008-03-20 |
Family
ID=38115166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL187947A IL187947A0 (en) | 2005-12-19 | 2007-12-06 | Novel forms of tiotropium bromide and processes for preparation thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US8163913B2 (OSRAM) |
| EP (2) | EP2123650B1 (OSRAM) |
| JP (3) | JP5086267B2 (OSRAM) |
| KR (1) | KR101395881B1 (OSRAM) |
| CN (1) | CN102731494A (OSRAM) |
| AT (1) | ATE552256T1 (OSRAM) |
| BR (1) | BRPI0608427A2 (OSRAM) |
| CA (1) | CA2627729A1 (OSRAM) |
| DK (1) | DK1869035T4 (OSRAM) |
| ES (2) | ES2384486T3 (OSRAM) |
| IL (1) | IL187947A0 (OSRAM) |
| MX (1) | MX2007009988A (OSRAM) |
| PL (2) | PL2123650T3 (OSRAM) |
| PT (1) | PT1869035E (OSRAM) |
| RS (1) | RS52663B2 (OSRAM) |
| TW (1) | TW200732340A (OSRAM) |
| WO (1) | WO2007075858A2 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9108962B2 (en) * | 2005-12-19 | 2015-08-18 | Sicor, Inc. | Forms of tiotropium bromide and processes for preparation thereof |
| JP5086267B2 (ja) * | 2005-12-19 | 2012-11-28 | シコール インコーポレイティド | 臭化チオトロピウムの新規な形態およびそれを製造する方法 |
| GB0716026D0 (en) * | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
| PT2240477E (pt) * | 2008-01-10 | 2014-11-19 | Generics Uk Ltd | Um novo processo para a preparação de ésteres de escopina |
| EP2172190A1 (en) * | 2008-10-02 | 2010-04-07 | Laboratorios Liconsa, S.A. | Inhalable particles comprising tiotropium |
| KR101557633B1 (ko) * | 2008-11-04 | 2015-10-06 | 시플라 리미티드 | 낮은 결정화도를 갖는 티오트로피움 브로마이드 |
| JP2012507574A (ja) * | 2008-11-04 | 2012-03-29 | シプラ・リミテッド | 医薬エアロゾル組成物 |
| AU2010280497B2 (en) * | 2009-08-07 | 2015-10-22 | Generics [Uk] Limited | Anhydrate of tiotropium bromide |
| WO2011015883A1 (en) | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Dichloromethane solvate of tiotropium bromide and its use |
| TR201111589A2 (tr) * | 2011-03-03 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür susuz kristal formu. |
| CZ304368B6 (cs) | 2011-11-28 | 2014-04-02 | Zentiva, K.S. | Směsný solvát tiotropium bromidu a způsob jeho přípravy |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| PT106142B (pt) * | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | Processo para a preparação de brometo de tiotrópio |
| EP2705838A1 (en) * | 2012-09-06 | 2014-03-12 | Xspray Microparticles Ab | Tiotropium preparations |
| EP2897955B1 (en) * | 2012-09-11 | 2019-11-06 | Bilgic, Mahmut | New tiotropium bromide crystalline form |
| SI2914593T1 (sl) | 2012-11-05 | 2017-05-31 | Zentiva, K.S. | Stabilizacija tiotropijevih solvatov |
| MX2015013845A (es) | 2013-04-01 | 2016-05-09 | Pulmatrix Inc | Polvos secos de tiotropio. |
| EP2789611A1 (en) * | 2013-04-08 | 2014-10-15 | Cerbios-Pharma S.A. | A crystalline form of tiotropium bromide |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
| RU2567539C1 (ru) * | 2015-02-04 | 2015-11-10 | Индивидуальный предприниматель Михайлов Олег Ростиславович | КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ |
| WO2017138896A1 (en) * | 2016-02-11 | 2017-08-17 | Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti | Crystalline form of tiotropium bromide anhydrate |
| WO2020013330A1 (ja) * | 2018-07-13 | 2020-01-16 | 協和発酵バイオ株式会社 | ユーコミン酸の非溶媒和物結晶及びその製造方法 |
| PT115583B (pt) | 2019-06-17 | 2022-05-02 | Hovione Farm S A | Processo contínuo para a preparação de medicamentos anticolinérgicos |
| EP4108230A1 (en) | 2021-06-24 | 2022-12-28 | Laboratoires SMB | New dry powder composition of tiotropium for inhalation |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610163A (en) * | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| US6736830B2 (en) | 2000-08-22 | 2004-05-18 | Deborah M. Roust | Baby pacifier |
| CA2425539C (en) | 2000-10-12 | 2007-04-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline monohydrate, processes for the preparation thereof and the use thereof for preparing a pharmaceutical composition |
| US6908928B2 (en) | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
| BR0107304A (pt) * | 2000-10-12 | 2002-08-13 | Boehringer Ingelheim Pharma | Pó para inalação contendo tiotrópio |
| DE10064816A1 (de) | 2000-12-22 | 2002-06-27 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung eines Anticholinergikums |
| US6608055B2 (en) | 2001-06-22 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition |
| HUP0400333A3 (en) * | 2001-06-22 | 2012-10-29 | Boehringer Ingelheim Pharma | Crystalline anticholinergic, method for its production, and use thereof in the production of pharmaceutical composition |
| US6890291B2 (en) | 2001-06-25 | 2005-05-10 | Mission Medical, Inc. | Integrated automatic blood collection and processing unit |
| US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
| DE10212264A1 (de) | 2002-03-20 | 2003-10-02 | Boehringer Ingelheim Pharma | Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels |
| BR0317340A (pt) * | 2002-12-16 | 2005-11-08 | Boehringer Ingelheim Pharma | Formulações de hfc em solução contendo tiotrópio |
| UA83813C2 (ru) * | 2002-12-20 | 2008-08-26 | Бёрингер Ингельхайм Фарма Гмбх & Ко. Кг | Порошковое лекарственное средство, которое содержит соль тиотропия и ксинафоат салметерола |
| DE10351196B4 (de) | 2003-10-28 | 2016-08-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verwendung einer anodisch mit Silizium bondbaren Glas-Keramik (LTCC) |
| KR101285571B1 (ko) | 2003-11-03 | 2013-07-15 | 베링거 인겔하임 인터내셔날 게엠베하 | 항콜린성 효과를 지닌 신규한 무수 결정 |
| SG149876A1 (en) * | 2003-11-03 | 2009-02-27 | Boehringer Ingelheim Int | Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same |
| UY28590A1 (es) | 2003-11-03 | 2005-06-30 | Boehringer Ingelheim Int | Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen. |
| US7968717B2 (en) * | 2003-11-03 | 2011-06-28 | Boehringer Ingelhein International Gmbh | Crystalline anhydrate with anticholinergic efficacy |
| CN1271073C (zh) * | 2004-10-26 | 2006-08-23 | 江苏正大天晴药业股份有限公司 | 结晶性抗胆碱能药噻托溴铵晶体 |
| DK1881980T3 (da) * | 2005-05-02 | 2012-10-01 | Boehringer Ingelheim Int | Nye krystalline former af tiotropiumbromid |
| AU2006243239A1 (en) * | 2005-05-02 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Crystalline forms of tiotropium bromide |
| SI1869035T2 (sl) * | 2005-12-19 | 2015-12-31 | Sicor, Inc. | Nove kristalne oblike tiotropij bromida in postopek njihove priprave |
| JP5086267B2 (ja) * | 2005-12-19 | 2012-11-28 | シコール インコーポレイティド | 臭化チオトロピウムの新規な形態およびそれを製造する方法 |
| EP1923393A1 (en) | 2006-11-17 | 2008-05-21 | Boehringer Ingelheim Pharma GmbH & Co. KG | Crystalline form of tiotropium bromide and urea |
| EP2020403A1 (en) * | 2007-08-02 | 2009-02-04 | Esteve Quimica, S.A. | Process for the resolution of zopiclone and intermediate compounds |
| WO2011015883A1 (en) | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Dichloromethane solvate of tiotropium bromide and its use |
| AU2010280497B2 (en) * | 2009-08-07 | 2015-10-22 | Generics [Uk] Limited | Anhydrate of tiotropium bromide |
-
2006
- 2006-12-19 JP JP2008538130A patent/JP5086267B2/ja active Active
- 2006-12-19 ES ES09010563T patent/ES2384486T3/es active Active
- 2006-12-19 KR KR1020077018777A patent/KR101395881B1/ko active Active
- 2006-12-19 MX MX2007009988A patent/MX2007009988A/es unknown
- 2006-12-19 CA CA002627729A patent/CA2627729A1/en not_active Abandoned
- 2006-12-19 US US11/643,001 patent/US8163913B2/en active Active
- 2006-12-19 CN CN201210232788XA patent/CN102731494A/zh active Pending
- 2006-12-19 AT AT09010563T patent/ATE552256T1/de active
- 2006-12-19 EP EP09010563A patent/EP2123650B1/en active Active
- 2006-12-19 BR BRPI0608427-3A patent/BRPI0608427A2/pt not_active IP Right Cessation
- 2006-12-19 DK DK06847887.4T patent/DK1869035T4/en active
- 2006-12-19 PL PL09010563T patent/PL2123650T3/pl unknown
- 2006-12-19 TW TW095147754A patent/TW200732340A/zh unknown
- 2006-12-19 ES ES06847887.4T patent/ES2396978T5/es active Active
- 2006-12-19 PT PT68478874T patent/PT1869035E/pt unknown
- 2006-12-19 RS RS20120583A patent/RS52663B2/sr unknown
- 2006-12-19 PL PL06847887T patent/PL1869035T5/pl unknown
- 2006-12-19 EP EP06847887.4A patent/EP1869035B2/en active Active
- 2006-12-19 WO PCT/US2006/048734 patent/WO2007075858A2/en not_active Ceased
-
2007
- 2007-12-06 IL IL187947A patent/IL187947A0/en unknown
-
2011
- 2011-12-28 US US13/339,042 patent/US8846926B2/en active Active
-
2012
- 2012-02-23 JP JP2012037796A patent/JP5567610B2/ja active Active
- 2012-03-05 US US13/412,586 patent/US20120165364A1/en not_active Abandoned
- 2012-06-04 JP JP2012127232A patent/JP2012176975A/ja active Pending
-
2013
- 2013-10-31 US US14/068,998 patent/US20140057935A1/en not_active Abandoned
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