IL185277A - Use of Roflomylast or Ropromylast n-Oxide for the preparation of a type 2 diabetes drug - Google Patents
Use of Roflomylast or Ropromylast n-Oxide for the preparation of a type 2 diabetes drugInfo
- Publication number
- IL185277A IL185277A IL185277A IL18527707A IL185277A IL 185277 A IL185277 A IL 185277A IL 185277 A IL185277 A IL 185277A IL 18527707 A IL18527707 A IL 18527707A IL 185277 A IL185277 A IL 185277A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutically acceptable
- diabetes mellitus
- acceptable salt
- type
- roflumilast
- Prior art date
Links
- 201000000083 maturity-onset diabetes of the young type 1 Diseases 0.000 title claims description 76
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title claims description 46
- 229960002586 roflumilast Drugs 0.000 title claims description 42
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 34
- 238000004519 manufacturing process Methods 0.000 title claims description 13
- 150000003839 salts Chemical class 0.000 claims description 145
- 239000003814 drug Substances 0.000 claims description 11
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- PCGSQNPMMSALEJ-UHFFFAOYSA-N roflumilast n-oxide Chemical compound ClC1=C[N+]([O-])=CC(Cl)=C1NC(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 PCGSQNPMMSALEJ-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 134
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 68
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- KHXXMSARUQULRI-UHFFFAOYSA-N 3-(cyclopropylmethoxy)-n-(3,5-dichloro-1-hydroxypyridin-4-ylidene)-4-(difluoromethoxy)benzamide Chemical compound ClC1=CN(O)C=C(Cl)C1=NC(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 KHXXMSARUQULRI-UHFFFAOYSA-N 0.000 description 39
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (2)
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| EP05101772 | 2005-03-08 | ||
| PCT/EP2006/060418 WO2006094933A1 (en) | 2005-03-08 | 2006-03-03 | Roflumilast for the treatment of diabetes mellitus |
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| IL185277A0 IL185277A0 (en) | 2008-02-09 |
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| IL221006A IL221006A0 (en) | 2005-03-08 | 2012-07-18 | Pharmaceutical composition, kits and combinations comprising roflumilast and/of its n-oxide derivative together with other component active in treating diabetes |
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| JP5216328B2 (ja) | 2005-01-24 | 2013-06-19 | アンタレス ファーマ インコーポレイテッド | あらかじめ充填された針補助シリンジジェット式注射器 |
| AU2006222060B2 (en) * | 2005-03-08 | 2011-09-01 | Takeda Gmbh | Roflumilast for the treatment of diabetes mellitus |
| TW200738266A (en) * | 2005-09-29 | 2007-10-16 | Sankyo Co | Pharmaceutical agent containing insulin resistance improving agent |
| US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
| WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| JP2010502670A (ja) * | 2006-09-07 | 2010-01-28 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 真性糖尿病のための組合せ治療 |
| EP2268342B1 (en) | 2008-03-10 | 2015-09-16 | Antares Pharma, Inc. | Injector safety device |
| CN101548972B (zh) * | 2008-04-03 | 2012-10-17 | 万特制药(海南)有限公司 | 一种含有瑞格列奈的固体药物组合物 |
| EP3581224A1 (en) | 2008-08-05 | 2019-12-18 | Antares Pharma, Inc. | Multiple dosage injector |
| CN102612381B (zh) | 2009-03-20 | 2015-09-09 | 安塔瑞斯制药公司 | 危险试剂注入系统 |
| US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
| US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| US20130172303A1 (en) * | 2012-01-03 | 2013-07-04 | Forest Laboratories Holdings Ltd. | Roflumilast compositions for the treatment of copd |
| WO2013134244A2 (en) | 2012-03-06 | 2013-09-12 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
| KR20150011346A (ko) | 2012-04-06 | 2015-01-30 | 안타레스 팔마, 인코퍼레이티드 | 테스토스테론 조성물의 바늘-보조식 젯 주입 투여 장치 및 방법 |
| US9364610B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| ES2969984T3 (es) | 2013-02-11 | 2024-05-23 | Antares Pharma Inc | Dispositivo de inyección por chorro asistido por aguja que tiene fuerza de disparo reducida |
| WO2014124860A1 (en) | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Specific pde4b-inhibitors for the treatment of diabetes mellitus |
| JP6030803B2 (ja) | 2013-03-11 | 2016-11-24 | アンタレス・ファーマ・インコーポレーテッド | ピニオンシステムを有する用量注射器 |
| WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
| EP3165224A1 (en) * | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
| WO2017182873A2 (en) | 2016-04-19 | 2017-10-26 | Ureka Sarl | Peptide-oligourea foldamer compounds and methods of their use |
| GB202306663D0 (en) * | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
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| US3174901A (en) * | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
| JPS5869812A (ja) | 1981-10-22 | 1983-04-26 | Chugai Pharmaceut Co Ltd | 血糖降下剤 |
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| NZ225447A (en) | 1987-07-20 | 1991-12-23 | Merck & Co Inc | Piperazinyl derivatives of purine and purine isosteres and pharmaceutical compositions |
| US5698711A (en) | 1991-01-28 | 1997-12-16 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group |
| GB9215633D0 (en) | 1992-07-23 | 1992-09-09 | Smithkline Beecham Plc | Novel treatment |
| CZ14795A3 (en) | 1992-07-28 | 1996-07-17 | Rhone Poulenc Rorer Ltd | Benzene derivative containing phenyl group bound to aryl or heteroaryl fraction through an aliphatic or hetero atom containing group, process of its preparation and pharmaceutical composition containing thereof |
| EP0671936A1 (en) | 1992-10-15 | 1995-09-20 | Dana-Farber Cancer Institute, Inc. | TREATMENT OF INSULIN RESISTANCE IN OBESITY LINKED TYPE II DIABETES USING ANTAGONISTS TO TNF-$g(a) FUNCTION |
| ES2176252T3 (es) | 1993-07-02 | 2002-12-01 | Altana Pharma Ag | Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. |
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-
2006
- 2006-03-03 AU AU2006222060A patent/AU2006222060B2/en not_active Ceased
- 2006-03-03 KR KR1020077022434A patent/KR101302838B1/ko not_active Expired - Fee Related
- 2006-03-03 NZ NZ560269A patent/NZ560269A/en not_active IP Right Cessation
- 2006-03-03 US US11/885,450 patent/US8017633B2/en not_active Expired - Fee Related
- 2006-03-03 BR BRPI0609371-0A patent/BRPI0609371A2/pt not_active IP Right Cessation
- 2006-03-03 EA EA200701845A patent/EA015382B1/ru not_active IP Right Cessation
- 2006-03-03 JP JP2008500172A patent/JP5091106B2/ja not_active Expired - Fee Related
- 2006-03-03 MX MX2007010560A patent/MX2007010560A/es not_active Application Discontinuation
- 2006-03-03 WO PCT/EP2006/060418 patent/WO2006094933A1/en not_active Ceased
- 2006-03-03 CA CA2599376A patent/CA2599376C/en not_active Expired - Fee Related
- 2006-03-03 EP EP06708617A patent/EP1874308A1/en not_active Withdrawn
- 2006-03-03 CN CN2012100579547A patent/CN102600144A/zh active Pending
- 2006-03-03 CN CN2006800072465A patent/CN101137368B/zh not_active Expired - Fee Related
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2007
- 2007-07-27 ZA ZA200706294A patent/ZA200706294B/xx unknown
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- 2007-10-01 NO NO20074943A patent/NO20074943L/no not_active Application Discontinuation
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- 2012-06-07 JP JP2012129982A patent/JP5611275B2/ja not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2006222060A1 (en) | 2006-09-14 |
| JP2012188448A (ja) | 2012-10-04 |
| CN101137368A (zh) | 2008-03-05 |
| JP5611275B2 (ja) | 2014-10-22 |
| US8017633B2 (en) | 2011-09-13 |
| NZ560269A (en) | 2010-12-24 |
| ZA200706294B (en) | 2008-09-25 |
| BRPI0609371A2 (pt) | 2010-03-30 |
| CA2599376C (en) | 2014-05-13 |
| CA2599376A1 (en) | 2006-09-14 |
| US20080214625A1 (en) | 2008-09-04 |
| US8541456B2 (en) | 2013-09-24 |
| AU2006222060B2 (en) | 2011-09-01 |
| KR20070111539A (ko) | 2007-11-21 |
| NO20074943L (no) | 2007-10-01 |
| US20110269750A1 (en) | 2011-11-03 |
| CN101137368B (zh) | 2012-05-16 |
| JP2008532974A (ja) | 2008-08-21 |
| MX2007010560A (es) | 2008-02-21 |
| IL185277A0 (en) | 2008-02-09 |
| HK1116077A1 (en) | 2008-12-19 |
| IL221006A0 (en) | 2012-08-30 |
| EP1874308A1 (en) | 2008-01-09 |
| EA015382B1 (ru) | 2011-08-30 |
| EA200701845A1 (ru) | 2008-02-28 |
| JP5091106B2 (ja) | 2012-12-05 |
| KR101302838B1 (ko) | 2013-09-03 |
| WO2006094933A1 (en) | 2006-09-14 |
| CN102600144A (zh) | 2012-07-25 |
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