IL183634A - Polymer-von willebrand factor-conjugates - Google Patents
Polymer-von willebrand factor-conjugatesInfo
- Publication number
- IL183634A IL183634A IL183634A IL18363407A IL183634A IL 183634 A IL183634 A IL 183634A IL 183634 A IL183634 A IL 183634A IL 18363407 A IL18363407 A IL 18363407A IL 183634 A IL183634 A IL 183634A
- Authority
- IL
- Israel
- Prior art keywords
- molecule
- vwf
- life
- vivo half
- proteinaceous
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63924404P | 2004-12-27 | 2004-12-27 | |
| US66837805P | 2005-04-04 | 2005-04-04 | |
| US67190105P | 2005-04-15 | 2005-04-15 | |
| US68508605P | 2005-05-26 | 2005-05-26 | |
| PCT/US2005/046879 WO2006071801A2 (en) | 2004-12-27 | 2005-12-23 | Polymer-von willebrand factor-conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL183634A0 IL183634A0 (en) | 2007-09-20 |
| IL183634A true IL183634A (en) | 2012-02-29 |
Family
ID=36540284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL183634A IL183634A (en) | 2004-12-27 | 2007-06-04 | Polymer-von willebrand factor-conjugates |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US7884075B2 (es) |
| EP (1) | EP1835938B1 (es) |
| JP (2) | JP5022231B2 (es) |
| KR (1) | KR20070092754A (es) |
| CN (1) | CN101163506B (es) |
| AU (1) | AU2005322067B8 (es) |
| BR (1) | BRPI0519562A2 (es) |
| CA (1) | CA2591852A1 (es) |
| DK (1) | DK1835938T3 (es) |
| ES (1) | ES2434035T3 (es) |
| HK (1) | HK1105276A1 (es) |
| IL (1) | IL183634A (es) |
| MX (1) | MX2007007877A (es) |
| PL (1) | PL1835938T3 (es) |
| PT (1) | PT1835938E (es) |
| WO (1) | WO2006071801A2 (es) |
Families Citing this family (73)
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| JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプｒａｍのチエツク方法 |
| CA2591852A1 (en) | 2004-12-27 | 2006-07-06 | Baxter International Inc. | Polymer-von willebrand factor-conjugates |
| US7982010B2 (en) | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
| US7985839B2 (en) | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
| KR20080108147A (ko) | 2006-03-31 | 2008-12-11 | 백스터 인터내셔널 인코포레이티드 | 페질화된 인자 ｖｉｉｉ |
| US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| ES2531934T3 (es) | 2006-09-01 | 2015-03-20 | Novo Nordisk Health Care Ag | Glicoproteínas modificadas |
| PL2101821T3 (pl) * | 2006-12-15 | 2015-01-30 | Baxalta Inc | Koniugat czynnik viia-(poli)kwas sjalowy o przedłużonym okresie półtrwania in vivo |
| AU2007340382B2 (en) * | 2006-12-27 | 2013-06-27 | Nektar Therapeutics | Von Willebrand Factor- and Factor VIII-polymer conjugates having a releasable linkage |
| PL2152735T3 (pl) * | 2007-05-18 | 2015-08-31 | Baxalta Inc | Sposób wytwarzania dojrzałego VWF z propeptydu |
| DK2167117T3 (da) * | 2007-06-13 | 2012-11-19 | Csl Behring Gmbh | Anvendelse af VWF-stabiliserede FVIII-præparater til ekstravaskulær administration til terapeutisk og profylaktisk behandling af blødningsforstyrrelser |
| KR101654375B1 (ko) * | 2007-06-26 | 2016-09-05 | 박스알타 인코퍼레이티드 | 가수분해성 중합체 ｆｍｏｃ-링커 |
| JP2011503101A (ja) * | 2007-11-09 | 2011-01-27 | バクスター・インターナショナル・インコーポレイテッド | 修飾された組換え第ｖｉｉｉ因子およびフォンウィルブランド因子ならびにその使用方法 |
| JP5806816B2 (ja) | 2007-12-27 | 2015-11-10 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 生理学的に許容されるポリマー分子を特異的に検出するための方法および組成物 |
| ES2587742T3 (es) | 2007-12-27 | 2016-10-26 | Baxalta GmbH | Métodos para diferenciar en una muestra proteína derivada de plasma de proteína recombinante |
| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| TWI515006B (zh) | 2007-12-28 | 2016-01-01 | 巴克斯特國際公司 | 重組ｖｗｆ調配物 |
| TWI492951B (zh) | 2007-12-31 | 2015-07-21 | Baxter Int | 表現人類凝血因子的基因轉殖非人類動物及其用途 |
| CA2723746A1 (en) * | 2008-05-06 | 2009-11-12 | Aplagen Gmbh | Complex |
| JP5832285B2 (ja) * | 2008-06-24 | 2015-12-16 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 延長されたインビボ半減期を有する第ｖｉｉｉ因子、フォン・ヴィレブランド因子又はそれらの複合体 |
| CA2731546C (en) * | 2008-07-23 | 2013-11-19 | Hanmi Holdings Co., Ltd. | A polypeptide complex comprising non-peptidyl polymer having three functional ends |
| US8575102B2 (en) | 2008-08-01 | 2013-11-05 | Nektar Therapeutics | Conjugates having a releasable linkage |
| JP5785872B2 (ja) * | 2008-10-17 | 2015-09-30 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 低度の水溶性ポリマーを含む改変血液因子 |
| MX2011004195A (es) * | 2008-10-20 | 2011-09-27 | Usv Ltd | Un proceso mejorado para la pegilacion de proteinas. |
| EP2431741B1 (en) * | 2008-10-21 | 2013-08-21 | Baxter International Inc | Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation) |
| TWI508735B (zh) | 2008-10-21 | 2015-11-21 | 巴克斯特國際公司 | 凍乾的重組ｖｗｆ調配物 |
| AU2009324447B2 (en) * | 2008-12-11 | 2016-02-25 | Takeda Pharmaceutical Company Limited | Detection of physiologically acceptable polymer molecules using near infrared spectroscopy |
| ES2597954T3 (es) | 2009-07-27 | 2017-01-24 | Baxalta GmbH | Conjugados de proteína de la coagulación sanguínea |
| EP3093029A1 (en) | 2009-07-27 | 2016-11-16 | Baxalta GmbH | Blood coagulation protein conjugates |
| JP5909755B2 (ja) | 2009-07-27 | 2016-04-27 | リポクセン テクノロジーズ リミテッド | 非血液凝固タンパク質の糖ポリシアル酸化 |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| EP2462231A2 (en) * | 2009-08-04 | 2012-06-13 | Baxter International Inc | Transgenic mouse lacking endogenous fviii and vwf - a model of hemophilia a |
| CN106008697B (zh) | 2009-08-20 | 2020-08-04 | 百深公司 | 纯化vwf以增加非-脂质包封的病毒的去除 |
| JP5813641B2 (ja) | 2009-08-24 | 2015-11-17 | アムニクス オペレーティング インコーポレイテッド | 凝固第ｉｘ因子組成物ならびにそれを製造および使用する方法 |
| ES2600879T3 (es) * | 2009-11-13 | 2017-02-13 | Grifols Therapeutics Inc. | Preparaciones que contienen el factor de Von Willebrand (FvW) y procedimientos, kits y utilizaciones relacionados con las mismas |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| CN108079312A (zh) | 2010-07-30 | 2018-05-29 | 百深有限责任公司 | 用于肟键联的亲核性催化剂 |
| KR101309566B1 (ko) * | 2010-12-10 | 2013-09-17 | 포항공과대학교 산학협력단 | 히알루론산-단백질 컨쥬게이트 및 이의 제조 방법 |
| ES2800983T3 (es) | 2010-12-22 | 2021-01-07 | Baxalta GmbH | Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína |
| US20120329127A1 (en) | 2011-05-27 | 2012-12-27 | Baxter Healthcare S.A. | Therapeutic proteins with increased half-life and methods of preparing same |
| CN103732244A (zh) * | 2011-06-10 | 2014-04-16 | 巴克斯特国际公司 | 通过施用重组vwf治疗凝血疾病 |
| PL2804623T3 (pl) | 2012-01-12 | 2020-03-31 | Bioverativ Therapeutics Inc. | Chimeryczne polipeptydy czynnika viii i ich zastosowania |
| BR112014019901A8 (pt) | 2012-02-15 | 2018-01-02 | Biogen Idec Inc | Proteínas de fator viii recombinante |
| PL2814502T3 (pl) | 2012-02-15 | 2018-02-28 | Csl Behring Gmbh | Warianty czynnika von Willebranda mające ulepszone powinowactwo do wiązania czynnika VIII |
| MY188897A (en) | 2012-02-15 | 2022-01-12 | Bioverativ Therapeutics Inc | Factor viii compositions and methods of making and using same |
| AU2013204754C1 (en) | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
| BR112015000267B1 (pt) * | 2012-07-11 | 2023-01-24 | Bioverativ Therapeutics Inc. | Proteínas quiméricas, e composição farmacêutica |
| EP2796145B1 (en) | 2013-04-22 | 2017-11-01 | CSL Ltd. | A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge |
| WO2015021423A2 (en) * | 2013-08-08 | 2015-02-12 | Biogen Idec Ma Inc. | Purification of chimeric fviii molecules |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| SI4176894T1 (sl) * | 2014-01-10 | 2024-07-31 | Bioverativ Therapeutics Inc. | Himerni proteini faktorja VIII in njihova uporaba |
| CN106414719B (zh) | 2014-06-13 | 2020-02-14 | 杰特有限公司 | 生物反应器中重组von Willebrand因子的改进生产 |
| US10253088B2 (en) | 2014-07-02 | 2019-04-09 | CSL Behring Lengnau AG | Modified von Willebrand Factor |
| CN104491917B (zh) * | 2014-12-30 | 2018-01-09 | 广州市拜特凇医药科技有限公司 | 一种含有peg或其衍生物的生物材料 |
| JP2018510212A (ja) | 2015-03-06 | 2018-04-12 | ツェー・エス・エル・ベーリング・レコンビナント・ファシリティ・アクチエンゲゼルシャフト | 向上した半減期を有する改変したフォンヴィレブランド因子 |
| SG10201910896UA (en) | 2015-05-22 | 2020-01-30 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| JP6651548B2 (ja) | 2015-05-22 | 2020-02-19 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 改変フォン・ヴィルブランド因子を製造するための方法 |
| JP2015155469A (ja) * | 2015-06-01 | 2015-08-27 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 第ｆｖｉｉｉ因子ポリマー結合体 |
| TWI741992B (zh) | 2015-08-03 | 2021-10-11 | 美商百歐維拉提夫治療公司 | 因子ｉｘ融合蛋白以及其製備及使用方法 |
| ES2881701T3 (es) | 2016-01-07 | 2021-11-30 | CSL Behring Lengnau AG | Factor de von Willebrand mutado |
| US10806774B2 (en) | 2016-01-07 | 2020-10-20 | CSL Behring Lengnau AG | Mutated truncated von Willebrand Factor |
| AU2017358861B2 (en) | 2016-11-11 | 2022-02-17 | CSL Behring Lengnau AG | Truncated von Willebrand Factor polypeptides for treating hemophilia |
| DK3538134T3 (da) | 2016-11-11 | 2022-02-07 | CSL Behring Lengnau AG | Trunkeret von willebrand-faktor polypeptider til ekstravaskulær administration til behandling eller profylakse af en blodkoagulationsforstyrrelse |
| EP3648788B1 (en) | 2017-07-07 | 2024-05-22 | Takeda Pharmaceutical Company Limited | Treatment of gastrointestinal bleeding in patients with severe von willebrand disease by administration of recombinant vwf |
| AU2018298232A1 (en) | 2017-07-07 | 2020-01-30 | Takeda Pharmaceutical Company Limited | Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant VWF |
| CA3072003A1 (en) | 2017-08-23 | 2019-02-28 | Csl Behring Gmbh | Method for virus filtration of von willebrand factor |
| JP2018115170A (ja) * | 2018-03-02 | 2018-07-26 | バクスアルタ ゲーエムベーハー | 第ｆｖｉｉｉ因子ポリマー結合体 |
| WO2019183290A1 (en) | 2018-03-21 | 2019-09-26 | Baxalta Incorporated | Separation of vwf and vwf propeptide by chromatographic methods |
| KR20210020030A (ko) | 2018-05-18 | 2021-02-23 | 바이오버라티브 테라퓨틱스 인크. | A형 혈우병의 치료 방법 |
| MX2021009114A (es) | 2019-02-01 | 2021-10-13 | Takeda Pharmaceuticals Co | Métodos de tratamiento profiláctico que usan factor de von willebrand recombinante (rvwf). |
| JP2022547556A (ja) | 2019-09-11 | 2022-11-14 | 武田薬品工業株式会社 | フォン・ヴィレブランド因子と補体ｃ１ｑの複合体に関連する治療法 |
| EP4100048A1 (en) | 2020-02-04 | 2022-12-14 | Takeda Pharmaceutical Company Limited | Treatment of menorrhagia in patients with severe von willebrand disease by administration of recombinant vwf |
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-
2005
- 2005-12-23 CA CA002591852A patent/CA2591852A1/en not_active Abandoned
- 2005-12-23 BR BRPI0519562-4A patent/BRPI0519562A2/pt not_active IP Right Cessation
- 2005-12-23 WO PCT/US2005/046879 patent/WO2006071801A2/en active Application Filing
- 2005-12-23 EP EP05855442.9A patent/EP1835938B1/en active Active
- 2005-12-23 ES ES05855442T patent/ES2434035T3/es active Active
- 2005-12-23 KR KR1020077017261A patent/KR20070092754A/ko not_active Application Discontinuation
- 2005-12-23 CN CN2005800445983A patent/CN101163506B/zh active Active
- 2005-12-23 JP JP2007548552A patent/JP5022231B2/ja active Active
- 2005-12-23 US US11/317,582 patent/US7884075B2/en active Active
- 2005-12-23 DK DK05855442.9T patent/DK1835938T3/da active
- 2005-12-23 PT PT58554429T patent/PT1835938E/pt unknown
- 2005-12-23 PL PL05855442T patent/PL1835938T3/pl unknown
- 2005-12-23 AU AU2005322067A patent/AU2005322067B8/en active Active
- 2005-12-23 MX MX2007007877A patent/MX2007007877A/es active IP Right Grant
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2007
- 2007-06-04 IL IL183634A patent/IL183634A/en active IP Right Grant
- 2007-10-30 HK HK07111722.5A patent/HK1105276A1/xx unknown
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2011
- 2011-01-14 US US13/007,208 patent/US8076463B2/en active Active
- 2011-11-28 US US13/305,334 patent/US8357779B2/en active Active
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2012
- 2012-03-30 JP JP2012081700A patent/JP5715983B2/ja active Active
- 2012-12-21 US US13/724,831 patent/US8835388B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1835938B1 (en) | 2013-08-07 |
| AU2005322067B8 (en) | 2012-07-26 |
| MX2007007877A (es) | 2007-08-21 |
| US8357779B2 (en) | 2013-01-22 |
| PT1835938E (pt) | 2013-11-06 |
| KR20070092754A (ko) | 2007-09-13 |
| CA2591852A1 (en) | 2006-07-06 |
| AU2005322067B2 (en) | 2012-07-05 |
| JP2008525491A (ja) | 2008-07-17 |
| US20130190242A1 (en) | 2013-07-25 |
| US20060160948A1 (en) | 2006-07-20 |
| HK1105276A1 (en) | 2008-02-06 |
| EP1835938A2 (en) | 2007-09-26 |
| AU2005322067A1 (en) | 2006-07-06 |
| US8835388B2 (en) | 2014-09-16 |
| BRPI0519562A2 (pt) | 2009-01-27 |
| IL183634A0 (en) | 2007-09-20 |
| WO2006071801A2 (en) | 2006-07-06 |
| WO2006071801A3 (en) | 2007-08-16 |
| JP5715983B2 (ja) | 2015-05-13 |
| US7884075B2 (en) | 2011-02-08 |
| US20120135462A1 (en) | 2012-05-31 |
| CN101163506B (zh) | 2012-09-26 |
| ES2434035T3 (es) | 2013-12-13 |
| CN101163506A (zh) | 2008-04-16 |
| DK1835938T3 (da) | 2013-11-04 |
| US8076463B2 (en) | 2011-12-13 |
| US20110111455A1 (en) | 2011-05-12 |
| JP5022231B2 (ja) | 2012-09-12 |
| JP2012126750A (ja) | 2012-07-05 |
| PL1835938T3 (pl) | 2014-01-31 |
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