IL183062A0 - Phenylpiperazine derivatives with a combination of partial dopamine d2 receptor agonism and serotonin reuptake in inhibition - Google Patents
Phenylpiperazine derivatives with a combination of partial dopamine d2 receptor agonism and serotonin reuptake in inhibitionInfo
- Publication number
- IL183062A0 IL183062A0 IL183062A IL18306207A IL183062A0 IL 183062 A0 IL183062 A0 IL 183062A0 IL 183062 A IL183062 A IL 183062A IL 18306207 A IL18306207 A IL 18306207A IL 183062 A0 IL183062 A0 IL 183062A0
- Authority
- IL
- Israel
- Prior art keywords
- serotonin reuptake
- inhibition
- combination
- phenylpiperazine derivatives
- receptor agonism
- Prior art date
Links
- 102000004980 Dopamine D2 Receptors Human genes 0.000 title abstract 2
- 108090001111 Dopamine D2 Receptors Proteins 0.000 title abstract 2
- 230000008484 agonism Effects 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000697 serotonin reuptake Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63407404P | 2004-12-08 | 2004-12-08 | |
| EP04106394 | 2004-12-08 | ||
| PCT/EP2005/056507 WO2006061378A1 (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL183062A0 true IL183062A0 (en) | 2007-09-20 |
Family
ID=35744728
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL183062A IL183062A0 (en) | 2004-12-08 | 2007-05-08 | Phenylpiperazine derivatives with a combination of partial dopamine d2 receptor agonism and serotonin reuptake in inhibition |
| IL183061A IL183061A0 (en) | 2004-12-08 | 2007-05-08 | Aryloxyethylamine derivatives with a combination of partial dopamine d2 receptor agonism and serotonin reuptake inhibition |
| IL183064A IL183064A0 (en) | 2004-12-08 | 2007-05-08 | Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition |
| IL183063A IL183063A0 (en) | 2004-12-08 | 2007-05-08 | Phenylpiperazine derivatives with a combination of partial dopamine d2 receptor agonism and serotonin reuptake inhibition |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL183061A IL183061A0 (en) | 2004-12-08 | 2007-05-08 | Aryloxyethylamine derivatives with a combination of partial dopamine d2 receptor agonism and serotonin reuptake inhibition |
| IL183064A IL183064A0 (en) | 2004-12-08 | 2007-05-08 | Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition |
| IL183063A IL183063A0 (en) | 2004-12-08 | 2007-05-08 | Phenylpiperazine derivatives with a combination of partial dopamine d2 receptor agonism and serotonin reuptake inhibition |
Country Status (18)
| Country | Link |
|---|---|
| EP (4) | EP1827426A1 (enExample) |
| JP (4) | JP2008537725A (enExample) |
| KR (4) | KR20070085975A (enExample) |
| AT (2) | ATE413173T1 (enExample) |
| AU (4) | AU2005313391A1 (enExample) |
| BR (1) | BRPI0518613A2 (enExample) |
| CA (4) | CA2587202A1 (enExample) |
| DE (2) | DE602005008471D1 (enExample) |
| DK (2) | DK1824479T3 (enExample) |
| ES (2) | ES2317335T3 (enExample) |
| HR (2) | HRP20090015T3 (enExample) |
| IL (4) | IL183062A0 (enExample) |
| NO (4) | NO20072977L (enExample) |
| PL (2) | PL1827427T3 (enExample) |
| PT (2) | PT1827427E (enExample) |
| RU (4) | RU2007125661A (enExample) |
| SI (2) | SI1827427T1 (enExample) |
| WO (4) | WO2006061379A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059227A1 (es) * | 2006-01-30 | 2008-03-19 | Speedel Experimenta Ag | Proceso para la preparacion de compuestos organicos |
| US8063062B2 (en) | 2006-12-20 | 2011-11-22 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition |
| CA2671554A1 (en) * | 2007-01-10 | 2008-07-17 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition |
| US8138174B2 (en) | 2007-01-10 | 2012-03-20 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition |
| JP2010525013A (ja) * | 2007-04-23 | 2010-07-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体 |
| JP5431305B2 (ja) * | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体 |
| RU2489431C2 (ru) * | 2007-04-23 | 2013-08-10 | Янссен Фармацевтика Н.В. | Тиа(диа)золы как быстро диссоциирующие антагонисты рецептора допамина 2 |
| CN103360342B (zh) * | 2012-04-09 | 2015-12-16 | 江苏恩华药业股份有限公司 | 3-氰基苯胺烷基芳基哌嗪衍生物及在制备药物中的应用 |
| CN103570698B (zh) * | 2012-08-01 | 2016-08-03 | 江苏恩华药业股份有限公司 | 用于制备维拉佐酮的化合物及其中间体和应用 |
| ITMI20130392A1 (it) * | 2013-03-15 | 2014-09-16 | Dipharma Francis Srl | Sintesi di un inibitore della ricaptazione della serotonina |
| EP3010586A1 (en) | 2013-06-21 | 2016-04-27 | Lupin Limited | Substituted heterocyclic compounds as crac modulators |
| WO2014207648A1 (en) | 2013-06-24 | 2014-12-31 | Lupin Limited | Chromane and chromene derivatives and their use as crac modulators |
| WO2015014256A1 (en) | 2013-07-29 | 2015-02-05 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| EP0900792B1 (en) * | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
| CN1304403A (zh) * | 1998-04-08 | 2001-07-18 | 美国家用产品公司 | 用于治疗抑郁症的n－芳氧基乙基－吲哚基－烷基胺(5－ht1a受体活化剂) |
| AU765317C (en) * | 1998-06-19 | 2004-05-20 | H. Lundbeck A/S | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
| AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
| MXPA02001919A (es) * | 1999-08-23 | 2003-07-21 | Solvay Pharm Bv | Fenilpiperazinas novedosas. |
| ATE350381T1 (de) * | 2002-12-10 | 2007-01-15 | Merck Patent Gmbh | Indolderivate und deren verwendung als 5-ht liganden |
-
2005
- 2005-12-06 CA CA002587202A patent/CA2587202A1/en not_active Abandoned
- 2005-12-06 AU AU2005313391A patent/AU2005313391A1/en not_active Abandoned
- 2005-12-06 DE DE602005008471T patent/DE602005008471D1/de not_active Expired - Fee Related
- 2005-12-06 KR KR1020077013041A patent/KR20070085975A/ko not_active Withdrawn
- 2005-12-06 DE DE602005010902T patent/DE602005010902D1/de not_active Expired - Fee Related
- 2005-12-06 CA CA002587381A patent/CA2587381A1/en not_active Abandoned
- 2005-12-06 EP EP05813645A patent/EP1827426A1/en not_active Withdrawn
- 2005-12-06 JP JP2007544898A patent/JP2008537725A/ja not_active Withdrawn
- 2005-12-06 KR KR1020077012935A patent/KR20070085916A/ko not_active Withdrawn
- 2005-12-06 PL PL05850037T patent/PL1827427T3/pl unknown
- 2005-12-06 JP JP2007544896A patent/JP2008523030A/ja not_active Withdrawn
- 2005-12-06 AU AU2005313311A patent/AU2005313311A1/en not_active Abandoned
- 2005-12-06 RU RU2007125661/04A patent/RU2007125661A/ru not_active Application Discontinuation
- 2005-12-06 BR BRPI0518613-7A patent/BRPI0518613A2/pt not_active IP Right Cessation
- 2005-12-06 AT AT05816322T patent/ATE413173T1/de not_active IP Right Cessation
- 2005-12-06 EP EP05850037A patent/EP1827427B1/en not_active Expired - Lifetime
- 2005-12-06 PT PT05850037T patent/PT1827427E/pt unknown
- 2005-12-06 AU AU2005313312A patent/AU2005313312A1/en not_active Abandoned
- 2005-12-06 EP EP05816324A patent/EP1824480A1/en not_active Withdrawn
- 2005-12-06 DK DK05816322T patent/DK1824479T3/da active
- 2005-12-06 ES ES05816322T patent/ES2317335T3/es not_active Expired - Lifetime
- 2005-12-06 ES ES05850037T patent/ES2311245T3/es not_active Expired - Lifetime
- 2005-12-06 WO PCT/EP2005/056508 patent/WO2006061379A1/en not_active Ceased
- 2005-12-06 KR KR1020077013063A patent/KR20070085988A/ko not_active Withdrawn
- 2005-12-06 AT AT05850037T patent/ATE401883T1/de not_active IP Right Cessation
- 2005-12-06 WO PCT/EP2005/056506 patent/WO2006061377A1/en not_active Ceased
- 2005-12-06 WO PCT/EP2005/056505 patent/WO2006061376A1/en not_active Ceased
- 2005-12-06 JP JP2007544895A patent/JP2008523029A/ja not_active Withdrawn
- 2005-12-06 CA CA002587357A patent/CA2587357A1/en not_active Abandoned
- 2005-12-06 WO PCT/EP2005/056507 patent/WO2006061378A1/en not_active Ceased
- 2005-12-06 CA CA002587559A patent/CA2587559A1/en not_active Abandoned
- 2005-12-06 HR HR20090015T patent/HRP20090015T3/xx unknown
- 2005-12-06 AU AU2005313390A patent/AU2005313390A1/en not_active Abandoned
- 2005-12-06 HR HR20080538T patent/HRP20080538T3/xx unknown
- 2005-12-06 PL PL05816322T patent/PL1824479T3/pl unknown
- 2005-12-06 EP EP05816322A patent/EP1824479B1/en not_active Expired - Lifetime
- 2005-12-06 RU RU2007125659/04A patent/RU2007125659A/ru not_active Application Discontinuation
- 2005-12-06 SI SI200530416T patent/SI1827427T1/sl unknown
- 2005-12-06 DK DK05850037T patent/DK1827427T3/da active
- 2005-12-06 RU RU2007125660/04A patent/RU2007125660A/ru not_active Application Discontinuation
- 2005-12-06 JP JP2007544897A patent/JP2008523031A/ja not_active Withdrawn
- 2005-12-06 KR KR1020077013015A patent/KR20070085959A/ko not_active Withdrawn
- 2005-12-06 SI SI200530566T patent/SI1824479T1/sl unknown
- 2005-12-06 RU RU2007125658/04A patent/RU2007125658A/ru not_active Application Discontinuation
- 2005-12-06 PT PT05816322T patent/PT1824479E/pt unknown
-
2007
- 2007-05-08 IL IL183062A patent/IL183062A0/en unknown
- 2007-05-08 IL IL183061A patent/IL183061A0/en unknown
- 2007-05-08 IL IL183064A patent/IL183064A0/en unknown
- 2007-05-08 IL IL183063A patent/IL183063A0/en unknown
- 2007-06-11 NO NO20072977A patent/NO20072977L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072981A patent/NO20072981L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072969A patent/NO20072969L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072974A patent/NO20072974L/no not_active Application Discontinuation
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