ES2317335T3 - Derivados de fenilpiperazina con una combinacion de agonismo parcial de receptor de dopamina-d2 e inhibicion de la recaptacion de serotonina. - Google Patents

Derivados de fenilpiperazina con una combinacion de agonismo parcial de receptor de dopamina-d2 e inhibicion de la recaptacion de serotonina. Download PDF

Info

Publication number
ES2317335T3
ES2317335T3 ES05816322T ES05816322T ES2317335T3 ES 2317335 T3 ES2317335 T3 ES 2317335T3 ES 05816322 T ES05816322 T ES 05816322T ES 05816322 T ES05816322 T ES 05816322T ES 2317335 T3 ES2317335 T3 ES 2317335T3
Authority
ES
Spain
Prior art keywords
mmol
scheme
stage
dopamine
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05816322T
Other languages
English (en)
Spanish (es)
Inventor
Roelof W. Solvay Pharmaceuticals B.V. FEENSTRA
Axel Solvay Pharmaceuticals B.V. STOIT
Jan-Willem Solvay Pharmaceuticals B.V. TERPSTRA
Maria L. Solvay Pharmaceuticals B.V. PRAS-RAVES
Andrew C. Solvay Pharmaceuticals B.V. MCCREARY
Bernard J. Solvay Pharmaceuticals B.V. VAN VLIET
Mayke B. Solvay Pharmaceuticals B.V. HESSELINK
Cornelis G. Solvay Pharmaceuticals B.V. KRUSE
G.J.M. Solvay Pharmaceuticals BV VAN SCHARRENBURG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Healthcare Products BV
Original Assignee
Solvay Pharmaceuticals BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals BV filed Critical Solvay Pharmaceuticals BV
Application granted granted Critical
Publication of ES2317335T3 publication Critical patent/ES2317335T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES05816322T 2004-12-08 2005-12-06 Derivados de fenilpiperazina con una combinacion de agonismo parcial de receptor de dopamina-d2 e inhibicion de la recaptacion de serotonina. Expired - Lifetime ES2317335T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US63407404P 2004-12-08 2004-12-08
US634074P 2004-12-08
EP04106394 2004-12-08
EP04106394 2004-12-08

Publications (1)

Publication Number Publication Date
ES2317335T3 true ES2317335T3 (es) 2009-04-16

Family

ID=35744728

Family Applications (2)

Application Number Title Priority Date Filing Date
ES05816322T Expired - Lifetime ES2317335T3 (es) 2004-12-08 2005-12-06 Derivados de fenilpiperazina con una combinacion de agonismo parcial de receptor de dopamina-d2 e inhibicion de la recaptacion de serotonina.
ES05850037T Expired - Lifetime ES2311245T3 (es) 2004-12-08 2005-12-06 Derivados de ariloxietilamina con una combinacion de agonismo parcial del receptor de dopamina-d2 e inhibicion de la reabsorcion de serotonina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES05850037T Expired - Lifetime ES2311245T3 (es) 2004-12-08 2005-12-06 Derivados de ariloxietilamina con una combinacion de agonismo parcial del receptor de dopamina-d2 e inhibicion de la reabsorcion de serotonina.

Country Status (18)

Country Link
EP (4) EP1827426A1 (enExample)
JP (4) JP2008537725A (enExample)
KR (4) KR20070085975A (enExample)
AT (2) ATE413173T1 (enExample)
AU (4) AU2005313391A1 (enExample)
BR (1) BRPI0518613A2 (enExample)
CA (4) CA2587202A1 (enExample)
DE (2) DE602005008471D1 (enExample)
DK (2) DK1824479T3 (enExample)
ES (2) ES2317335T3 (enExample)
HR (2) HRP20090015T3 (enExample)
IL (4) IL183062A0 (enExample)
NO (4) NO20072977L (enExample)
PL (2) PL1827427T3 (enExample)
PT (2) PT1827427E (enExample)
RU (4) RU2007125661A (enExample)
SI (2) SI1827427T1 (enExample)
WO (4) WO2006061379A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR059227A1 (es) * 2006-01-30 2008-03-19 Speedel Experimenta Ag Proceso para la preparacion de compuestos organicos
US8063062B2 (en) 2006-12-20 2011-11-22 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition
CA2671554A1 (en) * 2007-01-10 2008-07-17 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
US8138174B2 (en) 2007-01-10 2012-03-20 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
JP2010525013A (ja) * 2007-04-23 2010-07-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体
JP5431305B2 (ja) * 2007-04-23 2014-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
RU2489431C2 (ru) * 2007-04-23 2013-08-10 Янссен Фармацевтика Н.В. Тиа(диа)золы как быстро диссоциирующие антагонисты рецептора допамина 2
CN103360342B (zh) * 2012-04-09 2015-12-16 江苏恩华药业股份有限公司 3-氰基苯胺烷基芳基哌嗪衍生物及在制备药物中的应用
CN103570698B (zh) * 2012-08-01 2016-08-03 江苏恩华药业股份有限公司 用于制备维拉佐酮的化合物及其中间体和应用
ITMI20130392A1 (it) * 2013-03-15 2014-09-16 Dipharma Francis Srl Sintesi di un inibitore della ricaptazione della serotonina
EP3010586A1 (en) 2013-06-21 2016-04-27 Lupin Limited Substituted heterocyclic compounds as crac modulators
WO2014207648A1 (en) 2013-06-24 2014-12-31 Lupin Limited Chromane and chromene derivatives and their use as crac modulators
WO2015014256A1 (en) 2013-07-29 2015-02-05 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
CN1304403A (zh) * 1998-04-08 2001-07-18 美国家用产品公司 用于治疗抑郁症的n－芳氧基乙基－吲哚基－烷基胺(5－ht1a受体活化剂)
AU765317C (en) * 1998-06-19 2004-05-20 H. Lundbeck A/S 4,5,6 and 7-indole and indoline derivatives, their preparation and use
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
MXPA02001919A (es) * 1999-08-23 2003-07-21 Solvay Pharm Bv Fenilpiperazinas novedosas.
ATE350381T1 (de) * 2002-12-10 2007-01-15 Merck Patent Gmbh Indolderivate und deren verwendung als 5-ht liganden

Also Published As

Publication number Publication date
WO2006061377A1 (en) 2006-06-15
PL1824479T3 (pl) 2009-04-30
KR20070085975A (ko) 2007-08-27
BRPI0518613A2 (pt) 2008-11-25
DK1824479T3 (da) 2009-03-09
HRP20090015T3 (en) 2009-02-28
RU2007125658A (ru) 2009-01-20
ES2311245T3 (es) 2009-02-01
JP2008537725A (ja) 2008-09-25
HRP20080538T3 (en) 2008-12-31
WO2006061376A1 (en) 2006-06-15
NO20072981L (no) 2007-09-05
AU2005313390A1 (en) 2006-06-15
NO20072969L (no) 2007-08-31
NO20072977L (no) 2007-09-05
EP1827427B1 (en) 2008-07-23
DE602005008471D1 (de) 2008-09-04
NO20072974L (no) 2007-08-23
EP1824479A1 (en) 2007-08-29
EP1827426A1 (en) 2007-09-05
CA2587559A1 (en) 2006-06-15
IL183061A0 (en) 2007-09-20
IL183063A0 (en) 2007-09-20
JP2008523030A (ja) 2008-07-03
IL183064A0 (en) 2007-09-20
EP1824479B1 (en) 2008-11-05
AU2005313312A1 (en) 2006-06-15
WO2006061379A1 (en) 2006-06-15
DE602005010902D1 (de) 2008-12-18
RU2007125660A (ru) 2009-01-20
CA2587357A1 (en) 2006-06-15
DK1827427T3 (da) 2008-11-24
ATE401883T1 (de) 2008-08-15
IL183062A0 (en) 2007-09-20
AU2005313391A1 (en) 2006-06-15
SI1827427T1 (sl) 2008-12-31
RU2007125661A (ru) 2009-01-20
WO2006061378A1 (en) 2006-06-15
KR20070085988A (ko) 2007-08-27
CA2587202A1 (en) 2006-06-15
AU2005313311A1 (en) 2006-06-15
RU2007125659A (ru) 2009-01-20
SI1824479T1 (sl) 2009-04-30
JP2008523029A (ja) 2008-07-03
EP1827427A1 (en) 2007-09-05
KR20070085916A (ko) 2007-08-27
PT1824479E (pt) 2009-01-30
JP2008523031A (ja) 2008-07-03
PL1827427T3 (pl) 2009-01-30
CA2587381A1 (en) 2006-06-15
KR20070085959A (ko) 2007-08-27
EP1824480A1 (en) 2007-08-29
ATE413173T1 (de) 2008-11-15
PT1827427E (pt) 2008-11-03

Similar Documents

Publication Publication Date Title
EP1218352B1 (en) Benzimidazolone derivatives having mixed serotonine and dopamine receptors affinity
ES2317335T3 (es) Derivados de fenilpiperazina con una combinacion de agonismo parcial de receptor de dopamina-d2 e inhibicion de la recaptacion de serotonina.
US8101619B2 (en) Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
AU2005313388A1 (en) Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
MX2007006817A (es) Derivados de fenilpiperazina con una combinacion de agonismo parcial del receptor de dopamina-d2 e inhibicion de la reabsorcion de serotonina.
US20060247256A1 (en) Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
KR20070091646A (ko) 도파민-ｄ2 수용체 및 세로토닌 재흡수 위치에 대한친화도를 함께 갖는 페닐피페라진
US7371769B2 (en) Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20060122175A1 (en) Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
HK1113903A (en) Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
CA2587936A1 (en) Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-d2 receptors and serotonin reuptake sites
HK1109343A (en) Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
HK1109622A (en) Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-d2 receptors and serotonin reuptake sites