IL176745A - Process for the purification of antibodies - Google Patents
Process for the purification of antibodiesInfo
- Publication number
- IL176745A IL176745A IL176745A IL17674506A IL176745A IL 176745 A IL176745 A IL 176745A IL 176745 A IL176745 A IL 176745A IL 17674506 A IL17674506 A IL 17674506A IL 176745 A IL176745 A IL 176745A
- Authority
- IL
- Israel
- Prior art keywords
- chromatography
- antibodies
- resin
- ligands
- modal
- Prior art date
Links
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- 125000001624 naphthyl group Chemical group 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 description 1
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
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- QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
- B01J20/3253—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure not containing any of the heteroatoms nitrogen, oxygen or sulfur, e.g. aromatic structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3847—Multimodal interactions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
- B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400501A SE0400501D0 (sv) | 2004-02-27 | 2004-02-27 | Antibody purification |
| SE0402558A SE0402558D0 (sv) | 2004-10-21 | 2004-10-21 | A process for the purification of antibodies |
| PCT/SE2005/000293 WO2005082483A1 (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL176745A0 IL176745A0 (en) | 2006-10-31 |
| IL176745A true IL176745A (en) | 2012-10-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL176745A IL176745A (en) | 2004-02-27 | 2006-07-06 | Process for the purification of antibodies |
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| Country | Link |
|---|---|
| US (1) | US7750129B2 (enExample) |
| EP (1) | EP1718386A1 (enExample) |
| JP (1) | JP4848356B2 (enExample) |
| KR (1) | KR101150050B1 (enExample) |
| AU (1) | AU2005216847B2 (enExample) |
| CA (1) | CA2552639C (enExample) |
| IL (1) | IL176745A (enExample) |
| NZ (1) | NZ548126A (enExample) |
| WO (1) | WO2005082483A1 (enExample) |
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| WO2006043895A1 (en) | 2004-10-21 | 2006-04-27 | Ge Healthcare Bio-Sciences Ab | A method of antibody purification |
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| WO2007108955A1 (en) * | 2006-03-20 | 2007-09-27 | Medarex, Inc. | Protein purification |
| EP2738178A1 (en) | 2006-04-05 | 2014-06-04 | AbbVie Biotechnology Ltd | Antibody purification |
| EP2043767B1 (en) | 2006-07-14 | 2020-03-25 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
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| CA2682333C (en) | 2007-03-28 | 2015-05-05 | Upfront Chromatography A/S | Expanded bed column and disposable chromatography |
| EP2027875A1 (en) * | 2007-08-23 | 2009-02-25 | Octapharma AG | A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC) |
| US8653246B2 (en) * | 2007-10-26 | 2014-02-18 | Asahi Kasei Chemicals Corporation | Method for purifying protein |
| HUE043863T2 (hu) * | 2007-12-31 | 2019-09-30 | Baxalta GmbH | Lényegében állati fehérjétõl mentes rekombináns furin és eljárás elõállítására |
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| SI2300497T1 (sl) * | 2008-06-24 | 2013-02-28 | Octapharma Ag | Postopek za äťiĺˇäťenje koagulacijskega faktorja viii |
| EP2326658A4 (en) * | 2008-09-12 | 2013-04-10 | Ge Healthcare Bio Sciences Ab | REMOVAL OF REINFORCED PROTEIN AGGREGATES WITH MULTIMODAL ANION DERIVATIVES IN THE PRESENCE OF TWITTERS WITHOUT PROTEINS |
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| JP4425994B2 (ja) | 1996-08-30 | 2010-03-03 | ウプフロント クロマトグラフィー アクティーゼルスカブ | 免疫グロブリンの単離 |
| AU9040098A (en) * | 1997-09-10 | 1999-03-29 | University Of Florida | Compounds and method for the prevention and treatment of diabetic retinopathy |
| SE9904197D0 (sv) | 1999-11-22 | 1999-11-22 | Amersham Pharm Biotech Ab | A method for anion exchange adsorption on matrices carrying mixed mode ligands |
| SE0002688D0 (sv) | 2000-07-17 | 2000-07-17 | Amersham Pharm Biotech Ab | Adsorption method and ligands |
| AU2002235795A1 (en) * | 2000-12-31 | 2002-07-16 | Amersham Biosciences Ab | A method for the manufacture of compositions containing low concentrations of salts |
| EP1355710A4 (en) * | 2001-01-05 | 2005-01-26 | Pro Chem Inc | DEVICES AND METHODS FOR PURIFICATION |
| WO2002057498A1 (en) * | 2001-01-22 | 2002-07-25 | Emergen, Inc. | Isotopically enriched nucleic acids and associated methods for the production and purification thereof |
| US6652853B2 (en) * | 2001-03-08 | 2003-11-25 | Ludwig Institute For Cancer Research | Method for treating cancer using A33 specific antibodies and chemotherapeutic agents |
| SE0103084D0 (sv) | 2001-09-14 | 2001-09-14 | Amersham Pharm Biotech Ab | Generation of ion exchange media |
-
2005
- 2005-02-25 WO PCT/SE2005/000293 patent/WO2005082483A1/en not_active Ceased
- 2005-02-25 JP JP2007500725A patent/JP4848356B2/ja not_active Expired - Lifetime
- 2005-02-25 US US10/589,717 patent/US7750129B2/en not_active Expired - Lifetime
- 2005-02-25 NZ NZ548126A patent/NZ548126A/en not_active IP Right Cessation
- 2005-02-25 AU AU2005216847A patent/AU2005216847B2/en not_active Expired
- 2005-02-25 EP EP05722175A patent/EP1718386A1/en not_active Ceased
- 2005-02-25 KR KR1020067017113A patent/KR101150050B1/ko not_active Expired - Lifetime
- 2005-02-25 CA CA2552639A patent/CA2552639C/en not_active Expired - Lifetime
-
2006
- 2006-07-06 IL IL176745A patent/IL176745A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2552639A1 (en) | 2005-09-09 |
| US7750129B2 (en) | 2010-07-06 |
| NZ548126A (en) | 2009-10-30 |
| AU2005216847B2 (en) | 2010-04-01 |
| JP4848356B2 (ja) | 2011-12-28 |
| WO2005082483A1 (en) | 2005-09-09 |
| EP1718386A1 (en) | 2006-11-08 |
| US20070167613A1 (en) | 2007-07-19 |
| KR101150050B1 (ko) | 2012-07-05 |
| KR20070001968A (ko) | 2007-01-04 |
| AU2005216847A1 (en) | 2005-09-09 |
| JP2007525501A (ja) | 2007-09-06 |
| CA2552639C (en) | 2012-05-01 |
| IL176745A0 (en) | 2006-10-31 |
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| MM9K | Patent not in force due to non-payment of renewal fees |