IL173191A - Ketoreductase polypeptides and related polynucleotides - Google Patents

Ketoreductase polypeptides and related polynucleotides

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Publication number
IL173191A
IL173191A IL173191A IL17319106A IL173191A IL 173191 A IL173191 A IL 173191A IL 173191 A IL173191 A IL 173191A IL 17319106 A IL17319106 A IL 17319106A IL 173191 A IL173191 A IL 173191A
Authority
IL
Israel
Prior art keywords
related polynucleotides
ketoreductase polypeptides
ketoreductase
polypeptides
polynucleotides
Prior art date
Application number
IL173191A
Other languages
English (en)
Other versions
IL173191A0 (en
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of IL173191A0 publication Critical patent/IL173191A0/en
Publication of IL173191A publication Critical patent/IL173191A/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
IL173191A 2003-08-11 2006-01-17 Ketoreductase polypeptides and related polynucleotides IL173191A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49419503P 2003-08-11 2003-08-11
US54568204P 2004-02-18 2004-02-18
PCT/US2004/026655 WO2005017135A1 (en) 2003-08-11 2004-08-11 Improved ketoreductase polypeptides and related polynucleotides

Publications (2)

Publication Number Publication Date
IL173191A0 IL173191A0 (en) 2006-06-11
IL173191A true IL173191A (en) 2010-12-30

Family

ID=34197992

Family Applications (1)

Application Number Title Priority Date Filing Date
IL173191A IL173191A (en) 2003-08-11 2006-01-17 Ketoreductase polypeptides and related polynucleotides

Country Status (6)

Country Link
US (2) US7629157B2 (cg-RX-API-DMAC7.html)
EP (1) EP1654354A1 (cg-RX-API-DMAC7.html)
JP (1) JP2007502124A (cg-RX-API-DMAC7.html)
CA (1) CA2533838A1 (cg-RX-API-DMAC7.html)
IL (1) IL173191A (cg-RX-API-DMAC7.html)
WO (1) WO2005017135A1 (cg-RX-API-DMAC7.html)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003258187A1 (en) 2002-08-09 2004-02-25 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
EP1660669A4 (en) 2003-08-11 2008-10-01 Codexis Inc ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS
WO2007010944A1 (ja) * 2005-07-20 2007-01-25 Kaneka Corporation 光学活性2-(n-置換アミノメチル)-3-ヒドロキシ酪酸エステル類の製造方法
AT502395B1 (de) * 2005-07-27 2007-03-15 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
WO2008100251A1 (en) 2007-02-13 2008-08-21 Ls9, Inc. Modified microorganism uses therefor
DE102006010994A1 (de) * 2006-03-09 2007-09-13 Wacker Chemie Ag Verfahren zur enzymatischen Herstellung von chiralen Alkoholen
AT503486B1 (de) * 2006-04-11 2008-05-15 Iep Gmbh Verfahren zur enantioselektiven reduktion von steroiden
MX344588B (es) 2006-05-19 2016-12-20 Reg Life Sciences Llc Produccion de acidos grasos y derivados de los mismos.
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US20100274033A1 (en) 2009-04-27 2010-10-28 Ls9, Inc. Production of fatty acid esters
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
US7820421B2 (en) 2007-02-08 2010-10-26 Codexis, Inc. Ketoreductases and uses thereof
AU2008230735A1 (en) 2007-03-28 2008-10-02 Ls9, Inc. Enhanced production of fatty acid derivatives
WO2009029554A2 (en) 2007-08-24 2009-03-05 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
CN101855342B (zh) * 2007-09-13 2013-07-10 科德克希思公司 用于还原苯乙酮的酮还原酶多肽
JP2010539948A (ja) 2007-09-28 2010-12-24 コデクシス, インコーポレイテッド ケトレダクターゼポリペプチドおよびその使用
JP5646328B2 (ja) * 2007-10-01 2014-12-24 コデクシス, インコーポレイテッド アゼチジノンの生産のためのケトレダクターゼポリペプチド
WO2009045507A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Processes for preparing an intermediate of sitagliptin via enzymatic reduction
WO2009111513A1 (en) 2008-03-03 2009-09-11 Joule Biotechnologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
DK3023494T3 (en) 2008-06-13 2019-02-25 Codexis Inc PROCEDURE FOR SYNTHESIS OF POLYNUCLEOTIDE VARIETIES
ES2438576T3 (es) 2008-06-24 2014-01-17 Codexis, Inc. Procesos biocatalíticos para la preparación de compuestos de prolina bicíclica fusionada considerablemente pura estereoméricamente
EP2329013B1 (en) * 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
US8288141B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
SG10201404330VA (en) 2008-08-29 2014-10-30 Codexis Inc Ketoreductase Polypeptides For The Stereoselective Production Of (4S)-3[(5S)-5(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-Phenyl-1,3-Oxazolidin-2-One
EP2998402A1 (en) 2008-10-17 2016-03-23 Joule Unlimited Technologies, Inc. Ethanol production by microorganisms
CN110129296A (zh) 2008-12-23 2019-08-16 Reg生命科学有限责任公司 硫酯酶相关的方法和组合物
ES2840000T3 (es) 2009-01-08 2021-07-06 Codexis Inc Polipéptidos de transaminasa
EP2401369B1 (en) 2009-02-26 2014-12-24 Codexis, Inc. Beta-glucosidase variant enzymes and related polynucleotides
SG173815A1 (en) 2009-02-26 2011-09-29 Codexis Inc Transaminase biocatalysts
US8263601B2 (en) 2009-02-27 2012-09-11 Concert Pharmaceuticals, Inc. Deuterium substituted xanthine derivatives
CA2754580C (en) 2009-03-17 2014-06-17 Codexis, Inc. Variant endoglucanases and related polynucleotides
US20100298612A1 (en) 2009-05-22 2010-11-25 Codexis, Inc. Engineered biosynthesis of fatty alcohols
EP2446026B1 (en) 2009-06-22 2017-08-09 Codexis, Inc. Transaminase reactions
EP3409765B1 (en) * 2009-06-22 2021-08-04 Codexis, Inc. Ketoreductase-mediated stereoselective route to alpha chloroalcohols
US8216815B2 (en) 2009-06-30 2012-07-10 Codexis, Inc. Production of fatty alcohols with fatty alcohol forming acyl-CoA reductases (FAR)
SG178456A1 (en) 2009-08-19 2012-04-27 Codexis Inc Ketoreductase polypeptides for the preparation of phenylephrine
EP2478137B1 (en) 2009-09-18 2017-09-13 Codexis, Inc. Reduced codon mutagenesis
US20110082055A1 (en) * 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
EP2510089B1 (en) 2009-12-08 2015-10-21 Codexis, Inc. Synthesis of prazole compounds
US8986965B2 (en) 2010-03-31 2015-03-24 Codexis, Inc. Production of monoterpenes
WO2011140219A1 (en) 2010-05-04 2011-11-10 Codexis, Inc. Biocatalysts for ezetimibe synthesis
CN102906258B (zh) * 2010-05-21 2015-06-17 明治制果药业株式会社 酮还原酶突变体
US8852900B2 (en) * 2010-06-17 2014-10-07 Codexis, Inc. Biocatalysts and methods for the synthesis of (S)-3-(1-aminoethyl)-phenol
WO2012006114A2 (en) 2010-06-28 2012-01-12 Codexis, Inc. Fatty alcohol forming acyl reductases (fars) and methods of use thereof
CA2808098C (en) 2010-08-16 2020-03-10 Merck Sharp & Dohme Corp. Process for preparing aminocyclohexyl ether compounds
EP2606139B1 (en) 2010-08-16 2015-07-15 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
US9322027B2 (en) 2010-08-20 2016-04-26 Shell Oil Company Expression constructs comprising fungal promoters
US9085788B2 (en) 2010-09-01 2015-07-21 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
US9074233B2 (en) 2010-09-01 2015-07-07 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
US9364797B2 (en) * 2010-09-14 2016-06-14 Council Of Scientific & Industrial Research High flux hollow fiber ultrafiltration membranes and process for the preparation thereof
CN103228658A (zh) * 2010-10-08 2013-07-31 卡迪拉保健有限公司 用于通过酶促转化制备西他列汀的中间体的方法
US9267159B2 (en) 2010-12-08 2016-02-23 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
HUE042817T2 (hu) 2011-06-28 2019-07-29 Codexis Inc Fehérjevariánsok elõállítása régiókeveréssel
EP2753640B1 (en) 2011-09-08 2016-03-09 Codexis, Inc. Biocatalysts and methods for the synthesis of substituted lactams
KR20140091700A (ko) * 2011-10-19 2014-07-22 시플라 리미티드 엔도텔린 수용체 길항제의 제조방법
US9139819B2 (en) 2011-11-18 2015-09-22 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
WO2013096082A1 (en) 2011-12-20 2013-06-27 Codexis, Inc. Fatty alcohol forming acyl reductase (far) variants and methods of use
DK2828385T3 (en) 2012-03-23 2018-03-12 Codexis Inc BIOCATALIZATORS AND METHODS FOR SYNTHETIZING DERIVATIVES AND TRYPTAMIN AND TRYPTAMINE ANALOGS
SI2828256T1 (sl) 2012-03-23 2019-11-29 Novartis Ag Kemijski postopek za pripravo spiroindolonov in njihovih vmesnih spojin
WO2013159055A1 (en) 2012-04-20 2013-10-24 Codexis, Inc. Production of fatty alcohols from engineered microorganisms
CN104428412B (zh) 2012-05-08 2017-09-08 科德克希思公司 用于化合物的羟基化的生物催化剂和方法
HUE036947T2 (hu) 2012-05-11 2018-08-28 Codexis Inc Átalakított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására
WO2014015278A1 (en) 2012-07-20 2014-01-23 Codexis, Inc. Production of fatty alcohols from engineered microorganisms
US9512447B2 (en) 2012-12-14 2016-12-06 Codexis, Inc. Modified native beta-ketoacyl-ACP synthases and engineered microorganisms
DK2935572T3 (da) 2012-12-21 2020-11-16 Codexis Inc Modificerede biokatalysatorer og fremgangsmåder til syntetisering af chirale aminer
CN105051180B (zh) 2013-01-18 2020-06-12 科德克希思公司 用于碳青霉烯类合成的工程化的生物催化剂
ES2694327T3 (es) 2013-02-28 2018-12-19 Codexis, Inc. Polipéptidos de transaminasa modificados por biocatálisis industrial
WO2014150633A1 (en) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
CN105358687B (zh) * 2013-04-17 2018-10-09 科学与工业研究委员会 在有效生产对映体富集的醇中用于酮的对映体选择性还原的设计师细胞及其应用
JP6643987B2 (ja) 2013-11-13 2020-02-12 コデクシス, インコーポレイテッド ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法
US9133488B2 (en) 2013-12-30 2015-09-15 University Of Alaska Fairbanks Synthetic methods and compounds related thereto
ES2686695T3 (es) 2014-04-22 2018-10-19 C-Lecta Gmbh Cetorreductasas
US10696953B2 (en) 2015-02-10 2020-06-30 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN104659287B (zh) * 2015-03-12 2017-05-31 京东方科技集团股份有限公司 像素界定层及制备方法、显示基板及制备方法、显示装置
EP3292136B1 (en) 2015-05-07 2021-02-17 Codexis, Inc. Penicillin-g acylases
MX389364B (es) 2016-05-05 2025-03-19 Codexis Inc Penicilina g acilasas
EP3469088B1 (en) 2016-06-09 2023-09-06 Codexis, Inc. Biocatalysts and methods for hydroxylation of chemical compounds
JP2019517801A (ja) 2016-06-15 2019-06-27 コデクシス, インコーポレイテッド 操作されたβ−グルコシダーゼおよびグルコシル化方法
SG10202111589RA (en) 2016-08-26 2021-11-29 Codexis Inc Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
WO2018129130A1 (en) 2017-01-05 2018-07-12 Codexis, Inc. Penicillin-g acylases
WO2018144675A1 (en) 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
CN110831618B (zh) 2017-04-27 2023-08-25 科德克希思公司 酮还原酶多肽及多核苷酸
CN110914415B (zh) 2017-05-08 2024-09-17 科德克希思公司 工程化连接酶变体
JP7122009B2 (ja) 2017-06-14 2022-08-19 コデクシス, インコーポレイテッド 産業上の生体触媒作用のための操作されたトランスアミナーゼポリペプチド
CA3064577A1 (en) 2017-06-27 2019-01-03 Codexis, Inc. Penicillin-g acylases
JP2020530267A (ja) 2017-06-30 2020-10-22 コデクシス, インコーポレイテッド T7 rnaポリメラーゼバリアント
EP3645711A4 (en) 2017-06-30 2021-04-21 Codexis, Inc. T7 RNA POLYMERASE VARIANTS
CN110914446B (zh) * 2017-07-14 2024-02-06 C-乐克塔股份有限公司 酮还原酶
SG11202003094PA (en) 2017-11-07 2020-05-28 Codexis Inc Transglutaminase variants
MX2020006222A (es) 2017-12-13 2020-08-31 Codexis Inc Polipeptidos de carboxiesterasa para acoplamiento de amidas.
EP4471137A3 (en) 2017-12-13 2025-02-19 GlaxoSmithKline Intellectual Property Development Ltd Carboxyesterase biocatalysts
GB201802383D0 (en) * 2018-02-14 2018-03-28 Givaudan Sa Process
ES2975412T3 (es) 2018-06-21 2024-07-05 Fis Fabbrica Italiana Sintetici Spa Proceso enzimático para la preparación de droxidopa
MX2021000326A (es) 2018-07-09 2021-03-25 Codexis Inc Desoxirribosa-fosfato aldolasas modificadas geneticamente.
CA3106124A1 (en) 2018-07-16 2020-01-23 Novartis Ag Chemical process for preparing phenylpiperidinyl indole derivatives
JP7584401B2 (ja) 2018-07-30 2024-11-15 テイト アンド ライル ソリューションズ ユー・エス・エー エル・エル・シー 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
JP7261874B2 (ja) 2018-09-26 2023-04-20 カラマズー・ホールディングス・インコーポレイテッド 変性されたホップ生成物の製造のための酵素的方法
CN113286876A (zh) * 2018-10-26 2021-08-20 T·巴尔 用于生物降解酒精的组合物和方法
KR20210084590A (ko) 2018-10-29 2021-07-07 코덱시스, 인코포레이티드 조작된 dna 중합효소 변이체
AU2019397401A1 (en) 2018-12-14 2021-06-17 Codexis, Inc. Engineered tyrosine ammonia lyase
WO2020150125A1 (en) 2019-01-15 2020-07-23 Codexis, Inc. Engineered transaminase polypeptides
JP7677630B2 (ja) 2019-05-01 2025-05-15 コデクシス, インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法
US12215368B2 (en) 2019-05-01 2025-02-04 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
WO2020248186A1 (zh) 2019-06-13 2020-12-17 凯莱英医药集团(天津)股份有限公司 酮还原酶突变体及生产手性醇的方法
BR112021026326A2 (pt) 2019-07-02 2022-02-08 Codexis Inc Sacarose fosforilase engenheirada, composição, sequência de polinucleotídeo, vetor de expressão, célula hospedeira, e, método para produzir uma sacarose fosforilase engenheirada
ES3007439T3 (en) 2019-08-30 2025-03-20 Nestle Sa Engineered lipase variants
US12012620B2 (en) 2019-09-12 2024-06-18 Codexis, Inc. Peroxidase activity towards 10-acetyl-3,7-dihydroxyphenoxazine
JP7715045B2 (ja) * 2019-11-22 2025-07-30 Ube株式会社 カルボニル還元酵素、これをコードする核酸、及びこれらを利用した光学活性化合物の製造方法
JP7720098B2 (ja) 2019-11-26 2025-08-07 コデクシス, インコーポレイテッド 化合物のヒドロキシル化のための生体触媒および方法
PH12022551776A1 (en) 2020-02-04 2023-11-29 Codexis Inc Engineered leucine decarboxylases
US11788071B2 (en) 2020-04-10 2023-10-17 Codexis, Inc. Engineered transaminase polypeptides
WO2022047264A1 (en) 2020-08-28 2022-03-03 Codexis, Inc. Engineered amylase variants
CA3191867A1 (en) 2020-08-28 2022-03-03 Codexis, Inc. Engineered protease variants
WO2022066155A1 (en) 2020-09-24 2022-03-31 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
CN112410276B (zh) * 2020-11-27 2023-03-21 江苏阿尔法药业股份有限公司 一种2-氯-1-(3,4-二氟苯基)乙酮还原酶重组菌株及构建方法和应用
EP4262804A4 (en) 2020-12-18 2025-02-12 Codexis, Inc. Engineered uridine phosphorylase variant enzymes
TW202313969A (zh) 2021-05-21 2023-04-01 美商克迪科思股份有限公司 經工程化的甲硫胺酸γ解離酶變異體
IL310621A (en) * 2021-08-13 2024-04-01 Codexis Inc Enzymes from a transgenic variant of nucleoside deoxyribosyltransferase
JP2024539636A (ja) 2021-10-15 2024-10-29 コデクシス, インコーポレイテッド 操作されたdnaポリメラーゼバリアント
WO2023077169A2 (en) 2021-11-01 2023-05-04 Codexis, Inc. Engineered leucine decarboxylases
EP4577644A1 (en) 2022-08-26 2025-07-02 Tesaro, Inc. Biocatalysts and methods thereof
TW202440911A (zh) 2022-12-20 2024-10-16 瑞士商諾華公司 工程化連接酶及其用途
AR131406A1 (es) 2022-12-20 2025-03-19 Novartis Ag Método de ligación de ácidos nucleicos
EP4649143A1 (en) 2023-01-12 2025-11-19 Novartis AG Engineered ketoreductase polypeptides
WO2025235589A1 (en) 2024-05-08 2025-11-13 Codexis, Inc. Dna polymerase variants

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
SI20120A (sl) * 1997-02-07 2000-06-30 Kaneka Corporation Nova karbonil reduktaza, gen, ki omenjeno kodira in postopek za uporabo take reduktaze in gena
EP0918090A3 (en) * 1997-11-04 2002-08-28 Eli Lilly And Company Ketoreductase gene and protein from yeast
US6531308B2 (en) * 1997-11-04 2003-03-11 Eli Lilly And Company Ketoreductase gene and protein from yeast
WO1999032434A1 (en) * 1997-12-19 1999-07-01 Warner-Lambert Export Limited Process for the synthesis of 1,3-diols
HUP0103659A3 (en) * 1998-04-30 2003-01-28 Kaneka Corp Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
CA2305564C (en) * 1998-08-05 2008-06-17 Kaneka Corporation Process for the preparation of optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives
AU766843B2 (en) * 1998-11-12 2003-10-23 Larry Kirn Multi-reference, high-accuracy switching amplifier
EP1194582A1 (de) * 1999-07-09 2002-04-10 Forschungszentrum Jülich Gmbh Verfahren zur reduktion von keto-carbonsäuren und deren estern
KR100512080B1 (ko) * 1999-12-03 2005-09-02 카네카 코포레이션 신규 카르보닐 환원효소, 그의 유전자, 및 그의 이용 방법
US6492868B2 (en) * 2000-08-14 2002-12-10 Larry Kirn Dynamic range enhancement technique
US20040248250A1 (en) 2001-07-02 2004-12-09 Takahisa Nakai Method for modifying enzyme and oxidoreductive variant
EP1485471B1 (en) 2002-03-18 2007-08-29 BioCatalytics Inc. Alcohol dehydrogenases with high solvent and temperature stability
AU2003258187A1 (en) 2002-08-09 2004-02-25 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
EP1660669A4 (en) * 2003-08-11 2008-10-01 Codexis Inc ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS
DE102004029112B4 (de) 2004-06-11 2007-06-21 Julich Chiral Solutions Gmbh Alkoholdehydrogenase zur stereoselektiven Gewinnung von Hydroxyverbindungen

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IL173191A0 (en) 2006-06-11
US20060195947A1 (en) 2006-08-31
US7629157B2 (en) 2009-12-08
JP2007502124A (ja) 2007-02-08
US7833767B2 (en) 2010-11-16
CA2533838A1 (en) 2005-02-24
WO2005017135A1 (en) 2005-02-24
EP1654354A1 (en) 2006-05-10
WO2005017135A8 (en) 2012-06-14

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