CA2533838A1 - Improved ketoreductase polypeptides and related polynucleotides - Google Patents
Improved ketoreductase polypeptides and related polynucleotides Download PDFInfo
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- CA2533838A1 CA2533838A1 CA002533838A CA2533838A CA2533838A1 CA 2533838 A1 CA2533838 A1 CA 2533838A1 CA 002533838 A CA002533838 A CA 002533838A CA 2533838 A CA2533838 A CA 2533838A CA 2533838 A1 CA2533838 A1 CA 2533838A1
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
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- Engineering & Computer Science (AREA)
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
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| US60/545,682 | 2004-02-18 | ||
| PCT/US2004/026655 WO2005017135A1 (en) | 2003-08-11 | 2004-08-11 | Improved ketoreductase polypeptides and related polynucleotides |
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| CA2533838A1 true CA2533838A1 (en) | 2005-02-24 |
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| IL (1) | IL173191A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005017135A1 (cg-RX-API-DMAC7.html) |
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| EP1660669A4 (en) | 2003-08-11 | 2008-10-01 | Codexis Inc | ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS |
| WO2007010944A1 (ja) * | 2005-07-20 | 2007-01-25 | Kaneka Corporation | 光学活性２－（ｎ－置換アミノメチル）－３－ヒドロキシ酪酸エステル類の製造方法 |
| AT502395B1 (de) * | 2005-07-27 | 2007-03-15 | Iep Gmbh | Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen |
| WO2008100251A1 (en) | 2007-02-13 | 2008-08-21 | Ls9, Inc. | Modified microorganism uses therefor |
| DE102006010994A1 (de) * | 2006-03-09 | 2007-09-13 | Wacker Chemie Ag | Verfahren zur enzymatischen Herstellung von chiralen Alkoholen |
| AT503486B1 (de) * | 2006-04-11 | 2008-05-15 | Iep Gmbh | Verfahren zur enantioselektiven reduktion von steroiden |
| MX344588B (es) | 2006-05-19 | 2016-12-20 | Reg Life Sciences Llc | Produccion de acidos grasos y derivados de los mismos. |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| US20100274033A1 (en) | 2009-04-27 | 2010-10-28 | Ls9, Inc. | Production of fatty acid esters |
| US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
| CN101528917B (zh) | 2006-10-02 | 2015-07-29 | 科德克希思公司 | 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法 |
| US7820421B2 (en) | 2007-02-08 | 2010-10-26 | Codexis, Inc. | Ketoreductases and uses thereof |
| AU2008230735A1 (en) | 2007-03-28 | 2008-10-02 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| WO2009029554A2 (en) | 2007-08-24 | 2009-03-05 | Codexis, Inc. | Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane |
| CN101855342B (zh) * | 2007-09-13 | 2013-07-10 | 科德克希思公司 | 用于还原苯乙酮的酮还原酶多肽 |
| JP2010539948A (ja) | 2007-09-28 | 2010-12-24 | コデクシス， インコーポレイテッド | ケトレダクターゼポリペプチドおよびその使用 |
| JP5646328B2 (ja) * | 2007-10-01 | 2014-12-24 | コデクシス， インコーポレイテッド | アゼチジノンの生産のためのケトレダクターゼポリペプチド |
| WO2009045507A2 (en) * | 2007-10-03 | 2009-04-09 | Teva Pharmaceutical Industries Ltd. | Processes for preparing an intermediate of sitagliptin via enzymatic reduction |
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| DK3023494T3 (en) | 2008-06-13 | 2019-02-25 | Codexis Inc | PROCEDURE FOR SYNTHESIS OF POLYNUCLEOTIDE VARIETIES |
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