IL169869A - Thienopyrimidine compounds and use thereof - Google Patents

Thienopyrimidine compounds and use thereof

Info

Publication number
IL169869A
IL169869A IL169869A IL16986905A IL169869A IL 169869 A IL169869 A IL 169869A IL 169869 A IL169869 A IL 169869A IL 16986905 A IL16986905 A IL 16986905A IL 169869 A IL169869 A IL 169869A
Authority
IL
Israel
Prior art keywords
compound
methyl
mmol
phenyl
alkyl
Prior art date
Application number
IL169869A
Other languages
English (en)
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of IL169869A publication Critical patent/IL169869A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL169869A 2003-01-29 2005-07-25 Thienopyrimidine compounds and use thereof IL169869A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003020854 2003-01-29
PCT/JP2004/000741 WO2004067535A1 (ja) 2003-01-29 2004-01-28 チエノピリミジン化合物およびその用途

Publications (1)

Publication Number Publication Date
IL169869A true IL169869A (en) 2011-10-31

Family

ID=32820637

Family Applications (1)

Application Number Title Priority Date Filing Date
IL169869A IL169869A (en) 2003-01-29 2005-07-25 Thienopyrimidine compounds and use thereof

Country Status (26)

Country Link
US (4) US7300935B2 (enExample)
EP (1) EP1591446B1 (enExample)
KR (1) KR101074462B1 (enExample)
CN (2) CN100360538C (enExample)
AU (1) AU2004207706B2 (enExample)
BE (1) BE2022C501I2 (enExample)
BR (1) BRPI0407082C1 (enExample)
CA (1) CA2514407C (enExample)
CO (1) CO5590921A2 (enExample)
CY (2) CY1114008T1 (enExample)
DK (1) DK1591446T3 (enExample)
ES (1) ES2410814T3 (enExample)
FR (1) FR21C1056I2 (enExample)
HU (1) HUS2100052I1 (enExample)
IL (1) IL169869A (enExample)
LT (1) LTC1591446I2 (enExample)
MX (1) MXPA05007990A (enExample)
NL (1) NL301158I2 (enExample)
NO (2) NO331981B1 (enExample)
NZ (1) NZ541772A (enExample)
PL (1) PL214756B1 (enExample)
PT (1) PT1591446E (enExample)
RU (1) RU2331648C2 (enExample)
SI (1) SI1591446T1 (enExample)
WO (1) WO2004067535A1 (enExample)
ZA (1) ZA200506611B (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
NZ566038A (en) * 2005-07-22 2011-06-30 Takeda Pharmaceutical The use of thieno(2,3-d)pyrimidine-2,4-dione derivatives which are gonadotropin releasing hormone (GnRH) antagonists as premature ovulation preventive agent
US20100061976A1 (en) * 2008-07-24 2010-03-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
WO2010026993A1 (ja) 2008-09-03 2010-03-11 武田薬品工業株式会社 製剤における吸収性改善方法および吸収性が改善された製剤
ES2550032T3 (es) * 2009-01-08 2015-11-04 Curis, Inc. Inhibidores de fosfoinosítido 3-quinasa con un resto de unión a cinc
US9265739B2 (en) 2010-06-02 2016-02-23 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to HER2/neu receptor complex
US8993634B2 (en) 2010-06-02 2015-03-31 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to Her2/neu receptor complex
ME03523B (me) 2011-04-01 2020-04-20 Curis Inc Inhibitori fosfoinozitid 3 kinaze sa dijelom koji vezuje cink
SI2776038T1 (en) * 2011-11-11 2018-06-29 Gilead Apollo, Llc ACC INHIBITORS AND THEIR USE
CN104703992B (zh) * 2012-09-28 2019-03-05 武田药品工业株式会社 噻吩并嘧啶衍生物的制备方法
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
EP2881391A1 (en) 2013-12-05 2015-06-10 Bayer Pharma Aktiengesellschaft Spiroindoline carbocycle derivatives and pharmaceutical compositions thereof
PL4233847T3 (pl) * 2015-02-26 2024-11-18 Takeda Pharmaceutical Company Limited Tabletka zawierająca pochodną metoksymocznika i cząstki mannitolu
ES2980216T3 (es) 2015-07-01 2024-09-30 California Inst Of Techn Sistemas de administración basados en polímeros de ácido múcico catiónicos
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
JP2019503338A (ja) 2015-11-25 2019-02-07 ギリアド アポロ， エルエルシー ２，４−ジオキソ−１，４−ジヒドロチエノ［２，３−ｄ］ピリミジンの誘導体を含む殺真菌組成物
PT3380479T (pt) 2015-11-25 2023-03-13 Gilead Apollo Llc Inhibidores de triazol acc e seus usos
AU2016361414A1 (en) 2015-11-25 2018-05-24 Gilead Apollo, Llc Ester ACC inhibitors and uses thereof
JP2019502660A (ja) 2015-11-25 2019-01-31 ギリアド アポロ， エルエルシー ピラゾールａｃｃ阻害剤およびその使用
RU2610281C1 (ru) * 2016-02-26 2017-02-08 ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ НАУКИ ИНСТИТУТ ОРГАНИЧЕСКОЙ ХИМИИ им. Н.Д. ЗЕЛИНСКОГО РОССИЙСКОЙ АКАДЕМИИ НАУК (ИОХ РАН) Способ получения 2-фтор-3-метилбут-2-ениламина или его гидрохлорида (Варианты)
SG11201807077RA (en) 2016-03-02 2018-09-27 Gilead Apollo Llc Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
FI3518933T4 (fi) * 2016-09-30 2025-05-14 Sumitomo Pharma Switzerland Gmbh Menetelmiä kohtumyooman ja endometrioosin hoitamiseksi
MX2019003733A (es) 2016-09-30 2019-09-26 Myovant Sciences Gmbh Tratamiento de cancer de prostata.
US20180280394A1 (en) 2017-03-28 2018-10-04 Gilead Sciences, Inc. Methods of treating liver disease
WO2018224498A1 (en) 2017-06-05 2018-12-13 ObsEva S.A. Gonadotropin-releasing hormone antagonist dosing regimens for the treatment of endometriosis
WO2019178304A1 (en) * 2018-03-14 2019-09-19 Teva Pharmaceuticals International Gmbh Solid state forms of relugolix
US12441738B2 (en) 2018-03-14 2025-10-14 Assia Chemical Industries Ltd. Solid state forms of Relugolix
US20190381188A1 (en) 2018-06-13 2019-12-19 California Institute Of Technology Nanoparticles For Crossing The Blood Brain Barrier And Methods Of Treatment Using The Same
WO2020055840A1 (en) 2018-09-11 2020-03-19 Curis Inc. Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety
AU2019373349B2 (en) 2018-10-29 2025-01-09 Kissei Pharmaceutical Co., Ltd. Compositions and methods for the treatment of adenomyosis and rectovaginal endometriosis
SG11202104053TA (en) 2018-11-07 2021-05-28 ObsEva SA Compositions and methods for the treatment of estrogen-dependent disorders
EP3666776A1 (en) * 2018-12-11 2020-06-17 Sandoz AG Hydrate of a gonadotropin-releasing hormone receptor antagonist
EP3969455A4 (en) * 2019-05-15 2023-07-05 Dr. Reddy's Laboratories Limited AMORPHOUS AND CRYSTALLINE FORMS OF RELUGOLIX
CN110194776B (zh) * 2019-06-27 2021-05-28 四川伊诺达博医药科技有限公司 一种瑞卢戈利的合成方法
CN111943960B (zh) * 2019-07-29 2022-02-15 广东东阳光药业有限公司 取代的嘧啶二酮类化合物及其用途
CN114174302A (zh) * 2019-08-02 2022-03-11 庄信万丰股份有限公司 瑞卢戈利的固态形式
CN112321602A (zh) * 2019-08-05 2021-02-05 苏州鹏旭医药科技有限公司 一种瑞卢戈利药物中间体的制备方法
CA3150089A1 (en) 2019-08-08 2021-02-11 ObsEva S.A. Gnrh antagonists for the treatment of estrogen-dependent disorders
JP2022543308A (ja) 2019-08-08 2022-10-11 オブセヴァ エス．エー． エストロゲン依存性障害の治療のための組成物及び方法
CN112390812A (zh) * 2019-08-14 2021-02-23 苏州鹏旭医药科技有限公司 瑞卢戈利化合物的晶型和无定型固体及其制备方法
CN112771052B (zh) * 2019-08-21 2023-04-07 深圳仁泰医药科技有限公司 促性腺素释放激素拮抗剂的晶型及其制备方法和用途
JP2022551316A (ja) 2019-10-10 2022-12-08 ミオバント サイエンシズ ゲーエムベーハー Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶形
JP7713934B2 (ja) * 2019-10-10 2025-07-28 スミトモ ファーマ スウィッツァーランド ゲーエムベーハー Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶溶媒和形
CN112745304A (zh) * 2019-10-29 2021-05-04 上海度德医药科技有限公司 一种Relugolix的制备方法及中间体化合物
CN113444105A (zh) * 2020-03-27 2021-09-28 南京海润医药有限公司 一种Relugolix的制备方法
CN111333633B (zh) * 2020-04-01 2023-10-20 江西科睿药业有限公司 一种瑞卢戈利的中间体化合物及其制备方法和用途
CN111574534B (zh) * 2020-05-25 2021-06-04 东莞市东阳光新药研发有限公司 苯基取代的噻吩并[2,3-d]嘧啶-2,4(1H,3H)-二酮类化合物及其用途
CN115666531B (zh) 2020-05-29 2025-08-19 住友制药瑞士有限公司 促性腺激素释放激素拮抗剂的组合固体口服剂型
CN111875614B (zh) * 2020-07-03 2022-04-29 东莞市东阳光新药研发有限公司 杂环基取代的噻吩并[2,3-d]嘧啶-2,4(1H,3H)-二酮类化合物及其用途
CN111793078B (zh) * 2020-07-03 2022-02-01 东莞市东阳光新药研发有限公司 双环含氮杂芳基取代的嘧啶二酮类化合物及其用途
CN111909168B (zh) * 2020-07-31 2022-02-01 广东东阳光药业有限公司 含氮杂环基取代的嘧啶二酮类化合物及其用途
CN111925379B (zh) * 2020-07-31 2022-02-15 广东东阳光药业有限公司 含氮杂芳基取代的嘧啶二酮类化合物及其用途
CN113754679B (zh) * 2020-09-09 2023-04-07 广东东阳光药业有限公司 取代的嘧啶二酮类化合物及其用途
CN112047957B (zh) * 2020-09-09 2022-02-01 广东东阳光药业有限公司 取代的嘧啶二酮类化合物及其用途
CN112142757B (zh) * 2020-09-29 2022-02-15 广东东阳光药业有限公司 五元含氮杂芳基取代的嘧啶二酮类化合物及其用途
WO2022101303A1 (en) 2020-11-11 2022-05-19 Myovant Sciences Gmbh Methods of administering relugolix
CN112552312B (zh) * 2020-12-07 2022-08-05 杭州科巢生物科技有限公司 一种瑞卢戈利或其盐的合成方法
CN113620972A (zh) * 2021-02-02 2021-11-09 奥锐特药业(天津)有限公司 瑞卢戈利新晶型及其制备方法
CN114907370B (zh) 2021-02-10 2023-11-03 奥锐特药业(天津)有限公司 高纯度的噻吩并嘧啶化合物及其制备方法
CN115073491A (zh) * 2021-03-12 2022-09-20 上海医药工业研究院 一种瑞卢戈利中间体、其制备方法及其应用
WO2022214645A1 (en) 2021-04-09 2022-10-13 Farmhispania Group, S.L. Processes and intermediates for the preparation of relugolix
CN113135934A (zh) * 2021-04-28 2021-07-20 北京海美源医药科技有限公司 用于制备瑞卢戈利的中间体化合物及其制备方法和瑞卢戈利的制备方法
CN115260211B (zh) * 2021-04-29 2024-02-06 长春金赛药业有限责任公司 含噻吩稠环类衍生物、药物组合物及其制备方法和应用
JP2024540922A (ja) 2021-10-18 2024-11-06 スミトモ ファーマ スウィッツァーランド ゲーエムベーハー Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素のエタノール溶媒和物の結晶形
EP4428137A1 (en) * 2021-11-01 2024-09-11 Shandong Luye Pharmaceutical Co., Ltd. Gonadotropin-releasing hormone antagonist, and preparation method therefor and use thereof
CN114230576A (zh) * 2021-12-21 2022-03-25 伊诺药物研究(南京)有限公司 一种瑞卢戈利的制备方法
CN117285506A (zh) * 2022-07-14 2023-12-26 江西同和药业股份有限公司 一种瑞卢戈利中间体及其制备方法
CN115417883B (zh) * 2022-09-16 2024-08-27 浙江科聚生物医药有限公司 一种瑞卢戈利的晶型及其制备方法
WO2024126674A1 (en) 2022-12-15 2024-06-20 Medichem, S.A. Process for the preparation of relugolix
WO2024222827A1 (zh) * 2023-04-27 2024-10-31 山东绿叶制药有限公司 一种噻吩并嘧啶类化合物的盐型、晶型及其制备方法和应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048863A (en) 1994-04-19 2000-04-11 Takeda Chemical Industries, Ltd. Condensed-ring thiophene derivatives and thienopyrimidine derivatives, their production and use
UY23948A1 (es) 1995-02-08 2001-10-25 Takeda Chemical Industries Ltd Derivados de anillos condensados de tiofeno su producción y uso.
TWI225863B (en) 1999-03-24 2005-01-01 Takeda Chemical Industries Ltd Thienopyrimidine compounds, their production and use
US6297379B1 (en) * 1999-03-24 2001-10-02 Takeda Chemical Industries, Ltd. Thienopyrimidine compounds, their production and use
JP2001316391A (ja) * 2000-02-29 2001-11-13 Takeda Chem Ind Ltd チエノピリミジン誘導体の製造法
CA2401379A1 (en) 2000-02-29 2001-09-07 Junichi Kawakami Processes for the production of thienopyrimidine derivatives
AU2001248760A1 (en) 2000-04-13 2001-10-30 Takeda Chemical Industries Ltd. Preventives/remedies for alzheimer's disease
JP2001354588A (ja) * 2000-04-13 2001-12-25 Takeda Chem Ind Ltd アルツハイマー病予防・治療剤
JP2002068982A (ja) * 2000-06-14 2002-03-08 Takeda Chem Ind Ltd 徐放性組成物
WO2001095940A1 (en) 2000-06-14 2001-12-20 Takeda Chemical Industries, Ltd. Sustained release compositions
JP2002080397A (ja) * 2000-07-05 2002-03-19 Takeda Chem Ind Ltd 性ホルモン依存性疾患の治療用医薬製剤
WO2002002144A1 (fr) 2000-07-05 2002-01-10 Takeda Chemical Industries, Ltd. Preparations medicinales pour le traitement des maladies dependant des hormones sexuelles
US20040034039A1 (en) 2000-09-22 2004-02-19 Yoshinori Nakano Solid preparations
JP2002167327A (ja) * 2000-09-22 2002-06-11 Takeda Chem Ind Ltd 固形製剤
AU2002218494A1 (en) * 2000-11-29 2002-06-11 Takeda Chemical Industries Ltd. Medicinal compositions and process for producing the same
WO2002047722A1 (en) 2000-12-15 2002-06-20 Takeda Chemical Industries, Ltd. Medicinal compositions of nonpeptidyl gonadotropin-releasing hormone agonist or antagonist, process for producing the same and use thereof
JP2004518732A (ja) 2001-02-14 2004-06-24 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー マトリックスメタロプロテイナーゼ阻害剤としてのチエノ’２，３−ｄピリミジンジオン誘導体
EP1479684A4 (en) 2002-01-30 2006-01-04 Takeda Pharmaceutical THIENOPYRIMIDINES, METHODS OF MAKING AND USING SAME
JP5072166B2 (ja) * 2002-01-30 2012-11-14 武田薬品工業株式会社 チエノピリミジン化合物、その製造法および用途
JP2004002321A (ja) * 2002-03-11 2004-01-08 Takeda Chem Ind Ltd 性ホルモン依存性疾患治療剤
WO2003075958A1 (fr) 2002-03-11 2003-09-18 Takeda Chemical Industries, Ltd. Medicaments permettant de traiter une maladie dependant d'une hormone sexuelle
JP2004002377A (ja) * 2002-04-12 2004-01-08 Takeda Chem Ind Ltd ホットフラッシュ予防・治療剤
WO2003086464A1 (en) 2002-04-12 2003-10-23 Takeda Pharmaceutical Company Limited. Preventives/remedies for hotflash

Also Published As

Publication number Publication date
CN101153042A (zh) 2008-04-02
HK1084665A1 (en) 2006-08-04
BRPI0407082A (pt) 2006-01-24
EP1591446B1 (en) 2013-03-06
HUS2100052I1 (hu) 2021-12-28
CY2021039I2 (el) 2022-03-24
NO331981B1 (no) 2012-05-21
AU2004207706A1 (en) 2004-08-12
SI1591446T1 (sl) 2013-07-31
AU2004207706B2 (en) 2010-03-04
BRPI0407082C1 (pt) 2021-05-25
KR101074462B1 (ko) 2011-10-18
US7300935B2 (en) 2007-11-27
FR21C1056I1 (enExample) 2022-01-21
WO2004067535A1 (ja) 2004-08-12
CY2021039I1 (el) 2022-03-24
US9346822B2 (en) 2016-05-24
ZA200506611B (en) 2006-12-27
KR20050096171A (ko) 2005-10-05
BRPI0407082B1 (pt) 2019-06-04
CN1768065A (zh) 2006-05-03
NO2021052I1 (no) 2021-12-16
US8735401B2 (en) 2014-05-27
RU2005127052A (ru) 2006-02-10
LTPA2021529I1 (enExample) 2021-12-10
DK1591446T3 (da) 2013-06-10
PL378002A1 (pl) 2006-02-20
US20140221381A1 (en) 2014-08-07
US20120071486A1 (en) 2012-03-22
PL214756B1 (pl) 2013-09-30
CN100360538C (zh) 2008-01-09
RU2331648C2 (ru) 2008-08-20
US8058280B2 (en) 2011-11-15
NO20053974L (no) 2005-10-27
FR21C1056I2 (fr) 2022-11-18
NL301158I2 (nl) 2022-05-25
ES2410814T3 (es) 2013-07-03
CA2514407A1 (en) 2004-08-12
CO5590921A2 (es) 2005-12-30
US20060160829A1 (en) 2006-07-20
NO20053974D0 (no) 2005-08-25
CY1114008T1 (el) 2016-07-27
CA2514407C (en) 2012-01-03
EP1591446A1 (en) 2005-11-02
NZ541772A (en) 2009-10-30
PT1591446E (pt) 2013-06-12
MXPA05007990A (es) 2005-09-20
US20080108623A1 (en) 2008-05-08
BRPI0407082B8 (pt) 2019-06-25
LTC1591446I2 (enExample) 2023-04-25
BE2022C501I2 (enExample) 2023-03-07
EP1591446A4 (en) 2008-04-30

Similar Documents

Publication Publication Date Title
EP1591446B1 (en) Thienopyrimidine compounds and use thereof
US7569570B2 (en) Thienopyrimidines, process for preparing the same and use thereof
EP1042325B1 (en) Nitrogen-containing heterocyclic compounds, their production and use
US20090062258A1 (en) Fused pyrimidine derivative and use thereof
AU2006270749A1 (en) Premature ovulation preventive agent
JP2008195728A (ja) ホットフラッシュ予防・治療剤
JP4039574B2 (ja) チエノピリミジン化合物およびその用途
JP5072166B2 (ja) チエノピリミジン化合物、その製造法および用途
HK1084665B (en) Thienopyrimidine compounds and use thereof
JP2008094846A (ja) チエノピリミジン化合物およびその用途
JP2004002377A (ja) ホットフラッシュ予防・治療剤

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed