IL166829A - Process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same - Google Patents

Process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Info

Publication number
IL166829A
IL166829A IL166829A IL16682905A IL166829A IL 166829 A IL166829 A IL 166829A IL 166829 A IL166829 A IL 166829A IL 16682905 A IL16682905 A IL 16682905A IL 166829 A IL166829 A IL 166829A
Authority
IL
Israel
Prior art keywords
formula
compounds
compound
methyl
obtaining
Prior art date
Application number
IL166829A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9944042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL166829(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL166829A publication Critical patent/IL166829A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL166829A 2002-09-13 2005-02-10 Process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same IL166829A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0221312.2A GB0221312D0 (en) 2002-09-13 2002-09-13 Organic compounds
PCT/EP2003/010171 WO2004024735A2 (en) 2002-09-13 2003-09-12 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Publications (1)

Publication Number Publication Date
IL166829A true IL166829A (en) 2011-01-31

Family

ID=9944042

Family Applications (1)

Application Number Title Priority Date Filing Date
IL166829A IL166829A (en) 2002-09-13 2005-02-10 Process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Country Status (29)

Country Link
US (1) US7470792B2 (https=)
EP (1) EP1539768B1 (https=)
JP (1) JP4628102B2 (https=)
KR (1) KR20050042500A (https=)
CN (1) CN100522968C (https=)
AR (1) AR041231A1 (https=)
AT (1) ATE373663T1 (https=)
AU (2) AU2003267349B2 (https=)
BR (1) BR0314263A (https=)
CA (1) CA2497119C (https=)
CY (1) CY1107794T1 (https=)
DE (1) DE60316456T2 (https=)
DK (1) DK1539768T3 (https=)
EC (1) ECSP055652A (https=)
ES (1) ES2290489T3 (https=)
GB (1) GB0221312D0 (https=)
IL (1) IL166829A (https=)
MX (1) MXPA05002785A (https=)
MY (1) MY140442A (https=)
NO (1) NO20051794D0 (https=)
NZ (1) NZ538612A (https=)
PE (1) PE20050052A1 (https=)
PL (1) PL375039A1 (https=)
PT (1) PT1539768E (https=)
RU (2) RU2404985C2 (https=)
SG (1) SG155770A1 (https=)
TW (1) TWI289563B (https=)
WO (1) WO2004024735A2 (https=)
ZA (1) ZA200501008B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2273083C (en) 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP2186811A1 (en) 2002-08-23 2010-05-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US20110300150A1 (en) 2010-05-18 2011-12-08 Scott Eliasof Compositions and methods for treatment of autoimmune and other disease

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU716610B2 (en) * 1996-08-30 2000-03-02 Novartis Ag Method for producing epothilones, and intermediate products obtained during the production process
US6380394B1 (en) * 1996-12-13 2002-04-30 The Scripps Research Institute Epothilone analogs
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
JP2001513098A (ja) * 1997-02-25 2001-08-28 ゲゼルシャフト フュア バイオテクノロギッシェ フォーシュンク エム ベー ハー（ゲー ベー エフ） 側鎖を修飾したエポチロン
US6498257B1 (en) * 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
GB9810659D0 (en) * 1998-05-18 1998-07-15 Ciba Geigy Ag Organic compounds
PT1140944E (pt) * 1998-12-22 2004-01-30 Novartis Pharma Gmbh Derivados de epotilona e sua utilizacao como agentes antitumorais
EP1226142A2 (en) * 1999-07-22 2002-07-31 Schering Aktiengesellschaft Process for the production of epothiolone b and derivatives as well as intermediate products for this process
US6593115B2 (en) * 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
IL155306A0 (en) 2000-10-13 2003-11-23 Univ Mississippi Methods for producing epothilone derivatives and analogs and epothilone derivatives and analogs produced thereby
BR0313043A (pt) 2002-07-31 2005-06-14 Schering Ag Conjugados efetores, processo para sua produção e seu uso farmacêutico

Also Published As

Publication number Publication date
US20060106073A1 (en) 2006-05-18
PT1539768E (pt) 2007-12-17
PL375039A1 (en) 2005-11-14
WO2004024735A2 (en) 2004-03-25
CN100522968C (zh) 2009-08-05
WO2004024735A3 (en) 2004-07-22
NZ538612A (en) 2008-01-31
US7470792B2 (en) 2008-12-30
MXPA05002785A (es) 2005-06-03
DK1539768T3 (da) 2008-01-07
SG155770A1 (en) 2009-10-29
RU2343155C2 (ru) 2009-01-10
AR041231A1 (es) 2005-05-11
GB0221312D0 (en) 2002-10-23
AU2008203451A1 (en) 2008-08-21
EP1539768B1 (en) 2007-09-19
CN1681824A (zh) 2005-10-12
ZA200501008B (en) 2006-12-27
PE20050052A1 (es) 2005-03-28
BR0314263A (pt) 2005-07-05
CY1107794T1 (el) 2013-06-19
MY140442A (en) 2009-12-31
NO20051794L (no) 2005-04-12
ECSP055652A (es) 2005-05-30
JP4628102B2 (ja) 2011-02-09
RU2005110925A (ru) 2006-01-20
ATE373663T1 (de) 2007-10-15
ES2290489T3 (es) 2008-02-16
HK1078853A1 (en) 2006-03-24
JP2006511469A (ja) 2006-04-06
KR20050042500A (ko) 2005-05-09
CA2497119A1 (en) 2004-03-25
AU2003267349B2 (en) 2008-05-01
EP1539768A2 (en) 2005-06-15
NO20051794D0 (no) 2005-04-12
DE60316456D1 (de) 2007-10-31
TW200413388A (en) 2004-08-01
CA2497119C (en) 2011-08-02
RU2008129613A (ru) 2010-01-27
TWI289563B (en) 2007-11-11
DE60316456T2 (de) 2008-06-19
RU2404985C2 (ru) 2010-11-27
AU2003267349A1 (en) 2004-04-30

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Legal Events

Date Code Title Description
ERR Corrigendum

Free format text: CORRECT PRIORITY NUMBER GB 13.9.2002 0221312.2

FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees