IL163996A0 - N3 alkylated benzimidazole derivatives as mek inhibitors - Google Patents

N3 alkylated benzimidazole derivatives as mek inhibitors

Info

Publication number
IL163996A0
IL163996A0 IL16399603A IL16399603A IL163996A0 IL 163996 A0 IL163996 A0 IL 163996A0 IL 16399603 A IL16399603 A IL 16399603A IL 16399603 A IL16399603 A IL 16399603A IL 163996 A0 IL163996 A0 IL 163996A0
Authority
IL
Israel
Prior art keywords
benzimidazole derivatives
mek inhibitors
alkylated benzimidazole
alkylated
mek
Prior art date
Application number
IL16399603A
Other languages
English (en)
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of IL163996A0 publication Critical patent/IL163996A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL16399603A 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as mek inhibitors IL163996A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36416402P 2002-03-13 2002-03-13
PCT/US2003/007565 WO2003077855A2 (en) 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as mek inhibitors

Publications (1)

Publication Number Publication Date
IL163996A0 true IL163996A0 (en) 2005-12-18

Family

ID=28041882

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16399603A IL163996A0 (en) 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as mek inhibitors

Country Status (18)

Country Link
US (2) US20030216460A1 (sh)
EP (1) EP1482944A4 (sh)
JP (1) JP2005526076A (sh)
KR (1) KR20040098013A (sh)
CN (1) CN1652792A (sh)
AR (1) AR038972A1 (sh)
AU (1) AU2003220202A1 (sh)
CA (1) CA2478534A1 (sh)
CO (1) CO5611145A2 (sh)
DO (1) DOP2003000614A (sh)
IL (1) IL163996A0 (sh)
MX (1) MXPA04008894A (sh)
PA (1) PA8569201A1 (sh)
PL (1) PL378635A1 (sh)
RU (1) RU2300528C2 (sh)
TW (1) TW200406203A (sh)
UA (1) UA76837C2 (sh)
WO (1) WO2003077855A2 (sh)

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ATE442847T1 (de) 2003-07-24 2009-10-15 Warner Lambert Co Benzimidazol-derivate als mek-hemmer
US7538120B2 (en) * 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US7144907B2 (en) * 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7781595B2 (en) * 2003-09-22 2010-08-24 S*Bio Pte Ltd. Benzimidazole derivatives: preparation and pharmaceutical applications
US7732616B2 (en) * 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
WO2005051302A2 (en) * 2003-11-19 2005-06-09 Array Biopharma Inc. Bicyclic inhibitors of mek and methods of use thereof
US7517994B2 (en) * 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
CN1882347A (zh) * 2003-11-21 2006-12-20 阿雷生物药品公司 Akt蛋白激酶抑制剂
EP1699477A2 (en) * 2003-12-11 2006-09-13 Theravance, Inc. Compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
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ES2567133T3 (es) 2005-06-23 2016-04-20 Array Biopharma, Inc. Proceso para preparar compuestos de benzoimidazol
US8101799B2 (en) 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
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JP2009520780A (ja) * 2005-12-21 2009-05-28 アストラゼネカ アクチボラグ 癌の治療において有用なｍｅｋ阻害剤である６−（４−ブロモ−２−クロロフェニルアミノ）−７−フルオロ−ｎ−（２−ヒドロキシエトキシ）−３−メチル−３ｈ−ベンゾイミダゾール−５−カルボキシアミドのトシル酸塩
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AU2007286808B2 (en) * 2006-08-21 2012-12-06 Genentech, Inc. Aza-benzofuranyl compounds and methods of use
CN111643496A (zh) 2006-12-14 2020-09-11 埃克塞利希斯股份有限公司 使用mek抑制剂的方法
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US8258152B2 (en) 2007-06-12 2012-09-04 Genentech, Inc. N-substituted azaindoles and methods of use
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Also Published As

Publication number Publication date
RU2300528C2 (ru) 2007-06-10
US20030216460A1 (en) 2003-11-20
UA76837C2 (uk) 2006-09-15
WO2003077855A2 (en) 2003-09-25
AU2003220202A1 (en) 2003-09-29
MXPA04008894A (es) 2005-06-20
TW200406203A (en) 2004-05-01
RU2004127925A (ru) 2005-05-27
EP1482944A2 (en) 2004-12-08
PA8569201A1 (es) 2004-05-21
WO2003077855A3 (en) 2004-03-04
CN1652792A (zh) 2005-08-10
JP2005526076A (ja) 2005-09-02
KR20040098013A (ko) 2004-11-18
CO5611145A2 (es) 2006-02-28
EP1482944A4 (en) 2006-04-19
CA2478534A1 (en) 2003-09-25
PL378635A1 (pl) 2006-05-15
AR038972A1 (es) 2005-02-02
DOP2003000614A (es) 2009-09-30
US20060106225A1 (en) 2006-05-18

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