IL162357A0 - Novel chimeric tnf ligands - Google Patents

Novel chimeric tnf ligands

Info

Publication number
IL162357A0
IL162357A0 IL16235702A IL16235702A IL162357A0 IL 162357 A0 IL162357 A0 IL 162357A0 IL 16235702 A IL16235702 A IL 16235702A IL 16235702 A IL16235702 A IL 16235702A IL 162357 A0 IL162357 A0 IL 162357A0
Authority
IL
Israel
Prior art keywords
tnfα
cell
sequence encoding
chimeric
subdomain
Prior art date
Application number
IL16235702A
Other languages
English (en)
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of IL162357A0 publication Critical patent/IL162357A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
IL16235702A 2001-12-06 2002-12-05 Novel chimeric tnf ligands IL162357A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/006,305 US7786282B2 (en) 2001-12-06 2001-12-06 Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
PCT/US2002/039245 WO2003050254A2 (en) 2001-12-06 2002-12-05 Novel chimeric tnf ligands

Publications (1)

Publication Number Publication Date
IL162357A0 true IL162357A0 (en) 2005-11-20

Family

ID=21720251

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16235702A IL162357A0 (en) 2001-12-06 2002-12-05 Novel chimeric tnf ligands
IL162357A IL162357A (en) 2001-12-06 2004-06-03 Chimeric tnf ligand/cd154 molecules

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL162357A IL162357A (en) 2001-12-06 2004-06-03 Chimeric tnf ligand/cd154 molecules

Country Status (17)

Country Link
US (3) US7786282B2 (de)
EP (1) EP1465912B9 (de)
JP (1) JP4610194B2 (de)
CN (1) CN1316022C (de)
AT (1) ATE414103T1 (de)
AU (2) AU2002362205B2 (de)
CA (1) CA2469494A1 (de)
CY (1) CY1110473T1 (de)
DE (1) DE60229881D1 (de)
DK (1) DK1465912T3 (de)
ES (1) ES2316638T3 (de)
HK (1) HK1070077A1 (de)
IL (2) IL162357A0 (de)
PT (1) PT1465912E (de)
SI (1) SI1465912T1 (de)
TW (1) TWI275644B (de)
WO (1) WO2003050254A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070771B1 (en) * 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US20080318886A1 (en) * 2006-12-05 2008-12-25 Prussak Charles E Methods of Increasing Cancer Sensitivity to Chemotherapeutic Agents Using Chimeric ISF35
PL391627A1 (pl) * 2010-06-25 2012-01-02 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne
PL219845B1 (pl) * 2011-01-05 2015-07-31 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne
GB201406705D0 (en) 2014-04-15 2014-05-28 Univ Liverpool Fusion proteins,polynucleotides,expression vectors, and their uses
EP3274717B1 (de) * 2015-03-23 2020-11-25 Essen Instruments, Inc. Durchflusszytometrieverfahren zur auswertung einer probe biologischen materials in bezug auf nichtassoziierten influenzaviruspartiklen
WO2017079297A1 (en) 2015-11-02 2017-05-11 Memgen Llc Methods for treatment of cancer
HUP1600456A2 (en) 2016-07-19 2018-01-29 Richter Gedeon Nyrt Novel cell-based tnf-alpha binding assay
US11298420B2 (en) 2016-12-21 2022-04-12 Memgen, Llc Armed oncolytic viruses
EP4058559A1 (de) * 2019-11-13 2022-09-21 CRISPR Therapeutics AG Verfahren zur herstellung von car-t-zellen
EP4319782A1 (de) * 2021-04-05 2024-02-14 Implicyte, Inc. Chimere onkolytische viren mit armierten armen
WO2024064637A2 (en) * 2022-09-19 2024-03-28 Emendobio Inc. Biallelic knockout of faslg

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US158831A (en) * 1875-01-19 Improvement in washing-machines
EP0251037B1 (de) * 1986-06-20 1994-06-15 Dainippon Pharmaceutical Co., Ltd. Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS
DE3879395T2 (de) 1987-05-29 1993-06-24 Central Glass Co Ltd Fusionsprotein, enthaltend lymphotoxin.
JP2930713B2 (ja) 1989-08-16 1999-08-03 カイロン コーポレイション タンパク質ホルモン形成の抑制用の組成物およびその使用法
US5519119A (en) * 1990-09-21 1996-05-21 Ishihara Sangyo Kaisha Ltd. Muteins of TNF pharmaceutical compositions and a method of making
CA2055168A1 (en) * 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins
US5962406A (en) * 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
US5716805A (en) * 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins
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ATE242322T1 (de) 1992-03-30 2003-06-15 Immunex Corp Fusionsprotein , das zwei rezeptoren des tumornekrose-faktors enthält
SK376492A3 (en) * 1992-04-02 1995-06-07 Hoffmann La Roche Tnf - muteins and method of their production
DK0615451T3 (da) 1992-05-26 2006-04-24 Immunex Corp Hidtil ukendt cytokin der binder til CD30
CA2142860A1 (en) 1992-08-21 1994-03-03 Gregorio Aversa Human interleukin-13
WO1994004570A1 (en) 1992-08-21 1994-03-03 Schering Corporation Cd40 ligand, anti cd40 antibodies, and soluble cd40
US5540926A (en) 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
US5573924A (en) * 1992-09-08 1996-11-12 Immunex Corporation CD27 ligand
JP4242447B2 (ja) * 1993-01-22 2009-03-25 イミュネックス・コーポレーション Ｃｄ４０リガンド遺伝子の突然変異の検出および治療
DK0679191T3 (da) 1993-01-22 2004-04-13 Immunex Corp Påvisning og behandling af mutationer i et CD40-ligand-gen
US5830463A (en) 1993-07-07 1998-11-03 University Technology Corporation Yeast-based delivery vehicles
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AU680102B2 (en) 1993-12-23 1997-07-17 Immunex Corporation Method of preventing or treating disease characterized by neoplastic cells expressing CD40
JPH09508009A (ja) 1994-01-07 1997-08-19 イミュネックス・コーポレーション Ｆａｓ抗原を結合するリガンド
DK0763057T3 (da) * 1994-04-28 2006-03-27 Boehringer Ingelheim Pharma Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf
US5606023A (en) * 1994-05-24 1997-02-25 Thomas Jefferson University Mutant tumor necrosis factor proteins
US5759536A (en) 1994-05-27 1998-06-02 University Technology Corporation Use of fas ligand to supress T-lymphocyte-mediated immune responses
WO1996003141A1 (en) 1994-07-22 1996-02-08 F. Hoffmann-La Roche Ag Pharmaceutical compositions comprising a chimaeric tnf binding protein
GB9425060D0 (en) 1994-12-13 1995-02-08 Univ Birmingham Carcinoma treatment
US5888764A (en) 1995-01-20 1999-03-30 Uab Research Foundation Human fas gene promoter region
US6017527A (en) * 1996-07-10 2000-01-25 Immunex Corporation Activated dendritic cells and methods for their activation
US6544523B1 (en) * 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
US7070771B1 (en) * 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
US6016832A (en) * 1997-04-16 2000-01-25 Woodward Governor Company Valve for controlling gas mass flow
CA2304130C (en) 1997-09-17 2008-10-28 Mochida Pharmaceutical Co., Ltd. Novel fas ligand derivative
US6451759B1 (en) * 1998-01-14 2002-09-17 The Regents Of The University Of California Noncleavable Fas ligand
US7300774B1 (en) * 1999-12-09 2007-11-27 The Regents Of The University Of California Multimeric fusion proteins of the TNF superfamily ligands
US20020022017A1 (en) 2000-04-12 2002-02-21 Hua Yu Regulation of systemic immune responses utilizing soluble CD40
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US7495090B2 (en) * 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
GB2392158B (en) 2002-08-21 2005-02-16 Proimmune Ltd Chimeric MHC protein and oligomer thereof

Also Published As

Publication number Publication date
US7786282B2 (en) 2010-08-31
US7964712B2 (en) 2011-06-21
DK1465912T3 (da) 2009-03-16
CN1612890A (zh) 2005-05-04
EP1465912B1 (de) 2008-11-12
EP1465912A4 (de) 2005-04-13
SI1465912T1 (sl) 2009-04-30
JP2005511086A (ja) 2005-04-28
AU2002362205A1 (en) 2003-06-23
AU2002362205B2 (en) 2009-12-10
US20120116052A1 (en) 2012-05-10
DE60229881D1 (de) 2008-12-24
CN1316022C (zh) 2007-05-16
WO2003050254A2 (en) 2003-06-19
US20110008842A1 (en) 2011-01-13
HK1070077A1 (en) 2005-06-10
IL162357A (en) 2010-12-30
CA2469494A1 (en) 2003-06-19
ATE414103T1 (de) 2008-11-15
TWI275644B (en) 2007-03-11
ES2316638T3 (es) 2009-04-16
EP1465912A2 (de) 2004-10-13
CY1110473T1 (el) 2015-04-29
TW200301777A (en) 2003-07-16
JP4610194B2 (ja) 2011-01-12
WO2003050254A3 (en) 2004-03-04
PT1465912E (pt) 2009-02-19
US20050048476A1 (en) 2005-03-03
EP1465912B9 (de) 2009-08-12
AU2010200912A1 (en) 2010-04-01

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