IL162132A0 - Chondrocyte precursors derived from human embryonic stem cells - Google Patents

Chondrocyte precursors derived from human embryonic stem cells

Info

Publication number
IL162132A0
IL162132A0 IL16213202A IL16213202A IL162132A0 IL 162132 A0 IL162132 A0 IL 162132A0 IL 16213202 A IL16213202 A IL 16213202A IL 16213202 A IL16213202 A IL 16213202A IL 162132 A0 IL162132 A0 IL 162132A0
Authority
IL
Israel
Prior art keywords
stem cells
embryonic stem
human embryonic
precursors derived
chondrocyte precursors
Prior art date
Application number
IL16213202A
Other languages
English (en)
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Publication of IL162132A0 publication Critical patent/IL162132A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/44—Thiols, e.g. mercaptoethanol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/395—Thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
IL16213202A 2001-12-07 2002-12-06 Chondrocyte precursors derived from human embryonic stem cells IL162132A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33904301P 2001-12-07 2001-12-07
PCT/US2002/039090 WO2003050250A2 (en) 2001-12-07 2002-12-06 Chondrocyte precursors derived from human embryonic stem cells

Publications (1)

Publication Number Publication Date
IL162132A0 true IL162132A0 (en) 2005-11-20

Family

ID=23327241

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16213202A IL162132A0 (en) 2001-12-07 2002-12-06 Chondrocyte precursors derived from human embryonic stem cells

Country Status (10)

Country Link
US (5) US20030109038A1 (zh)
EP (1) EP1463800A4 (zh)
JP (1) JP2005511083A (zh)
KR (1) KR100973453B1 (zh)
CN (1) CN1599793A (zh)
AU (1) AU2002366602B2 (zh)
CA (1) CA2468335C (zh)
GB (1) GB2399348A (zh)
IL (1) IL162132A0 (zh)
WO (1) WO2003050250A2 (zh)

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US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
CA2468335C (en) * 2001-12-07 2014-07-08 Geron Corporation Chondrocyte precursors derived from human embryonic stem cells
ES2571355T3 (es) 2002-12-16 2016-05-24 Technion Res & Dev Foundation Sistema de cultivo sin células alimentadoras ni xenocontaminantes para células madre embrionarias humanas
US20050106725A1 (en) * 2003-11-19 2005-05-19 Palecek Sean P. Method of reducing cell differentiation
US8637065B2 (en) 2004-07-09 2014-01-28 William Marsh Rice University Dermis-derived cells for tissue engineering applications
GB2431165B (en) 2004-07-13 2009-04-01 Geron Corp Medium for growing human embryonic stem cells
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
EP3599277A1 (en) 2005-06-22 2020-01-29 Asterias Biotherapeutics, Inc. Suspension culture of human embryonic stem cells
GB0513777D0 (en) * 2005-07-06 2005-08-10 Univ Bristol Methods for tissue engineering
EP1962719A4 (en) 2005-08-29 2011-05-04 Technion Res And Dev Of Foundation Ltd MEDIA FOR BREEDING STEM CELLS
JP4977854B2 (ja) * 2005-10-21 2012-07-18 国立大学法人名古屋大学 組織形成用複合材料およびその製造方法
US8343762B2 (en) * 2006-01-11 2013-01-01 Technion Research & Development Foundation Ltd. Human embryonic stem cell-derived connective tissue progenitors for tissue engineering
CA2648327A1 (en) * 2006-04-05 2007-10-11 William Marsh Rice University Tissue engineering with human embryonic stem cells
DK2733203T3 (en) 2006-08-02 2019-02-04 Technion Res & Dev Foundation PROCEDURES FOR EXPANSION OF EMBRYONAL STEM CELLS IN A SUSPENSION CULTURE
KR101503939B1 (ko) 2007-01-23 2015-03-18 고리츠다이가쿠호진 요코하마시리츠다이가쿠 연골 세포 조제 방법
WO2008096842A1 (ja) * 2007-02-09 2008-08-14 Osaka University 退行性疾患の予防用又は治療用の薬剤のスクリーニング方法
US8574567B2 (en) 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
EP2155860B1 (en) 2007-05-03 2014-08-27 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
CN102123745A (zh) 2008-02-29 2011-07-13 科洛普拉斯特公司 用于受试者中活组织的增加和再生的组合物和方法
CA2713118A1 (en) * 2008-02-29 2009-09-03 Interface Biotech A/S Biosynthetic cartilaginous matrix and methods for their production
CA3123228A1 (en) * 2008-03-27 2009-10-01 Asterias Biotherapeutics, Inc. Differentiation of primate pluripotent stem cells to hematopoietic lineage cells
KR101812817B1 (ko) * 2009-06-25 2017-12-27 제론 코포레이션 무관계 표현형이 고갈된 분화된 다능성 줄기 세포 자손
KR101135636B1 (ko) * 2009-10-27 2012-04-17 서울대학교산학협력단 인간 만능줄기세포로부터 중배엽 줄기세포를 생산하는 방법 및 이에 의해 생성된 중배엽 줄기세포
CA3174901A1 (en) 2009-11-12 2011-05-19 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
JP6263329B2 (ja) * 2009-11-24 2018-01-17 ザ ユニバーシティ オブ コネチカット ヒト胚性および人工多能性幹細胞の分化
US9029145B2 (en) 2010-04-08 2015-05-12 The University Court Of The University Of Edinburgh Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof
ES2370794B1 (es) * 2010-05-25 2012-10-31 Servicio Andaluz De Salud Biomarcador de células cartilaginosas humanas.
US20110312001A1 (en) 2010-06-15 2011-12-22 Emile Nuwaysir Compendium of ready-built stem cell models for interrogation of biological response
US20130122589A1 (en) * 2010-07-26 2013-05-16 The University Of Manchester Targeted differentiation of stem cells
DE102010033565B4 (de) * 2010-07-27 2012-06-21 Tetec Tissue Engineering Technologies Ag Marker zur Bestimmung von Chondrozyten
AU2012236707B2 (en) 2011-03-29 2017-07-20 Asterias Biotherapeutics, Inc. Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
US10350277B2 (en) 2011-09-07 2019-07-16 Icahn School Of Medicine At Mount Sinai Ceramidase and cell differentiation
CA2918486C (en) * 2012-07-20 2020-12-08 The Regents Of The University Of California Methods for producing cartilage and bone
JP6635505B2 (ja) * 2013-11-01 2020-01-29 国立大学法人京都大学 新規軟骨細胞誘導方法
CN106967686B (zh) * 2017-03-31 2019-11-08 北昊干细胞与再生医学研究院有限公司 软骨细胞体外端粒延长增殖培养的方法及人源组织工程化再生软骨
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KR102307115B1 (ko) * 2021-05-12 2021-10-01 주식회사 스마트셀랩 시프로플록사신에 의한 줄기세포의 연골전구세포로의 유도 및 연골세포로의 분화
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Also Published As

Publication number Publication date
WO2003050250A3 (en) 2004-02-12
US20060148077A1 (en) 2006-07-06
GB2399348A (en) 2004-09-15
US7906330B2 (en) 2011-03-15
AU2002366602A1 (en) 2003-06-23
US20110129867A1 (en) 2011-06-02
US20190024053A1 (en) 2019-01-24
GB0414956D0 (en) 2004-08-04
AU2002366602B2 (en) 2008-07-03
EP1463800A2 (en) 2004-10-06
CA2468335A1 (en) 2003-06-19
US8546101B2 (en) 2013-10-01
CA2468335C (en) 2014-07-08
JP2005511083A (ja) 2005-04-28
WO2003050250A2 (en) 2003-06-19
CN1599793A (zh) 2005-03-23
US20140134721A1 (en) 2014-05-15
US20030109038A1 (en) 2003-06-12
KR20050044733A (ko) 2005-05-12
KR100973453B1 (ko) 2010-08-02
EP1463800A4 (en) 2006-04-26
WO2003050250B1 (en) 2004-04-15

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