CA777769A
(en)
*
|
1963-03-18 |
1968-02-06 |
H. Roy Clarence |
Substituted methylene diphosphonic acid compounds and detergent compositions
|
DE2405254C2
(de)
*
|
1974-02-04 |
1982-05-27 |
Henkel KGaA, 4000 Düsseldorf |
Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
|
DE2534391C2
(de)
*
|
1975-08-01 |
1983-01-13 |
Henkel KGaA, 4000 Düsseldorf |
1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
|
DE2745083C2
(de)
*
|
1977-10-07 |
1985-05-02 |
Henkel KGaA, 4000 Düsseldorf |
Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
|
US4252742A
(en)
*
|
1979-07-13 |
1981-02-24 |
Ciba-Geigy Corporation |
Chemical process for the preparation of 2,6-dialkylcyclohexylamines from 2,6-dialkylphenols
|
DE2943498C2
(de)
*
|
1979-10-27 |
1983-01-27 |
Henkel KGaA, 4000 Düsseldorf |
Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
|
DE3016289A1
(de)
*
|
1980-04-28 |
1981-10-29 |
Henkel KGaA, 4000 Düsseldorf |
Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
|
IT1201087B
(it)
*
|
1982-04-15 |
1989-01-27 |
Gentili Ist Spa |
Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
|
FR2531088B1
(fr)
*
|
1982-07-29 |
1987-08-28 |
Sanofi Sa |
Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
|
DE3434667A1
(de)
*
|
1984-09-21 |
1986-04-03 |
Henkel KGaA, 4000 Düsseldorf |
4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
|
IT1196315B
(it)
*
|
1984-10-29 |
1988-11-16 |
Gentili Ist Spa |
Procedimento per la preparazione di acidi difosfonici
|
IL77243A
(en)
*
|
1984-12-21 |
1996-11-14 |
Procter & Gamble |
Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
|
US4812311A
(en)
*
|
1984-12-21 |
1989-03-14 |
The Procter & Gamble Company |
Kit for use in the treatment of osteoporosis
|
DE3512536A1
(de)
*
|
1985-04-06 |
1986-10-16 |
Boehringer Mannheim Gmbh, 6800 Mannheim |
Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
|
US4761406A
(en)
*
|
1985-06-06 |
1988-08-02 |
The Procter & Gamble Company |
Regimen for treating osteoporosis
|
DE3540150A1
(de)
*
|
1985-11-13 |
1987-05-14 |
Boehringer Mannheim Gmbh |
Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
|
DE3623397A1
(de)
*
|
1986-07-11 |
1988-01-14 |
Boehringer Mannheim Gmbh |
Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
|
DE3626058A1
(de)
*
|
1986-08-01 |
1988-02-11 |
Boehringer Mannheim Gmbh |
Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
|
DE3640938A1
(de)
*
|
1986-11-29 |
1988-06-01 |
Boehringer Mannheim Gmbh |
Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
|
CA1339805C
(en)
*
|
1988-01-20 |
1998-04-07 |
Yasuo Isomura |
(cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active
|
EP0333082A3
(en)
*
|
1988-03-15 |
1991-05-02 |
Takeda Chemical Industries, Ltd. |
Cephem compounds, their production and use
|
GB2217988B
(en)
*
|
1988-04-11 |
1992-04-01 |
Gould Leonard W |
Regimen for increasing bone density in humans
|
DE3822650A1
(de)
*
|
1988-07-05 |
1990-02-01 |
Boehringer Mannheim Gmbh |
Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
|
US5018651A
(en)
*
|
1988-12-27 |
1991-05-28 |
Hull Harold L |
Side or end dump article carrier
|
DE3917153A1
(de)
*
|
1989-05-26 |
1990-11-29 |
Boehringer Mannheim Gmbh |
Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
|
US4922007A
(en)
*
|
1989-06-09 |
1990-05-01 |
Merck & Co., Inc. |
Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
|
NL8902727A
(nl)
*
|
1989-11-06 |
1991-06-03 |
Philips Nv |
Objecthouder voor ondersteuning van een object in een geladen deeltjesbundelsysteem.
|
US5356887A
(en)
*
|
1990-01-31 |
1994-10-18 |
Merck & Co., Inc. |
Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
|
US5019651A
(en)
*
|
1990-06-20 |
1991-05-28 |
Merck & Co., Inc. |
Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
|
TW237386B
(ja)
*
|
1992-04-15 |
1995-01-01 |
Ciba Geigy |
|
CA2136825C
(en)
*
|
1992-05-29 |
1997-10-28 |
Frank H. Ebetino |
Quaternary nitrogen-containing phosphonate compounds, for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque
|
US5391743A
(en)
*
|
1992-05-29 |
1995-02-21 |
Procter & Gamble Pharmaceuticals, Inc. |
Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
|
RU2119794C1
(ru)
*
|
1992-06-30 |
1998-10-10 |
Проктер энд Гэмбл Фармасьютикалз, Инк. |
Использование фосфонатов и нестероидных противовоспалительных лекарственных средств для лечения артрита, способ лечения
|
US5358941A
(en)
*
|
1992-12-02 |
1994-10-25 |
Merck & Co., Inc. |
Dry mix formulation for bisphosphonic acids with lactose
|
FR2703590B1
(fr)
*
|
1993-04-05 |
1995-06-30 |
Sanofi Elf |
Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
|
US5431920A
(en)
*
|
1993-09-21 |
1995-07-11 |
Merck Frosst, Canada, Inc. |
Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents
|
US5646134A
(en)
*
|
1994-04-21 |
1997-07-08 |
Merck & Co., Inc. |
Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
|
US20010007863A1
(en)
*
|
1998-06-18 |
2001-07-12 |
Merck & Co., Inc. |
Wet granulation formulation for bisphosphonic acids
|
US5462932A
(en)
*
|
1994-05-17 |
1995-10-31 |
Merck & Co., Inc. |
Oral liquid alendronate formulations
|
US6008206A
(en)
*
|
1994-09-21 |
1999-12-28 |
Merck & Co., Inc. |
Sodium alendronate preparation for local administration
|
US20010051616A1
(en)
*
|
1995-02-17 |
2001-12-13 |
David B. Karpf |
Method of lessening the risk of vertebral fractures
|
JPH11506010A
(ja)
*
|
1995-06-07 |
1999-06-02 |
コドン・ゲーエムベーハー・ゲゼルシャフト・フュア・モレキュラーレ・メディツィーン・ウント・バイオテクノロジー |
骨粗鬆症患者からの標準化された一次骨芽細胞培養物、および骨粗鬆症の診断および潜在的骨粗鬆症治療薬の試験におけるその使用
|
DE19615812A1
(de)
*
|
1996-04-20 |
1997-10-23 |
Boehringer Mannheim Gmbh |
Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
|
GB2324726A
(en)
*
|
1997-05-01 |
1998-11-04 |
Merck & Co Inc |
Combination Therapy for the Treatment of Osteoporosis
|
US5994329A
(en)
*
|
1997-07-22 |
1999-11-30 |
Merck & Co., Inc. |
Method for inhibiting bone resorption
|
US6432932B1
(en)
*
|
1997-07-22 |
2002-08-13 |
Merck & Co., Inc. |
Method for inhibiting bone resorption
|
US6124314A
(en)
*
|
1997-10-10 |
2000-09-26 |
Pfizer Inc. |
Osteoporosis compounds
|
AU757104B2
(en)
*
|
1998-06-24 |
2003-01-30 |
Merck & Co., Inc. |
Compositions and methods for inhibiting bone resorption
|
IT1303672B1
(it)
*
|
1998-07-28 |
2001-02-23 |
Nicox Sa |
Sali nitrati di farmaci attivi nei disordini ossei
|
EP0998932A1
(de)
*
|
1998-10-09 |
2000-05-10 |
Boehringer Mannheim Gmbh |
Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
|
EP0998933A1
(de)
*
|
1998-10-09 |
2000-05-10 |
Boehringer Mannheim Gmbh |
Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation
|
BR9915927A
(pt)
*
|
1998-12-04 |
2001-08-21 |
Roche Diagnostics Gmbh |
Uso de ácido ibandrÈnico ou seus sais ou ésteres fisiologicamente compatìveis
|
US6468559B1
(en)
*
|
2000-04-28 |
2002-10-22 |
Lipocine, Inc. |
Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods
|
HUP0303700A3
(en)
*
|
2000-07-17 |
2006-07-28 |
Astellas Pharma Inc Chuo Ku |
Pharmaceutical composition improved in peroral absorbability
|
AU2001272916A1
(en)
*
|
2000-07-19 |
2002-02-05 |
Eli Lilly And Company |
Method for enhancing bone mineral density gain by administration of raloxifene
|
US6638920B2
(en)
*
|
2000-07-21 |
2003-10-28 |
Merck & Co., Inc. |
Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses
|
US7560490B2
(en)
*
|
2001-01-23 |
2009-07-14 |
Gador S.A. |
Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof
|
AR034199A1
(es)
*
|
2001-02-01 |
2004-02-04 |
Riderway Corp |
Composicion farmacologica liquida para el tratamiento de enfermedades oseas y procedimientos para su elaboracion
|
BR0116862A
(pt)
*
|
2001-02-06 |
2004-01-13 |
Royal Alexandra Hosp Children |
Medicamento, métodos para tratar um paciente com osteonecrose e/ou osteocondrite dissecans, para prevenir a osteonecrose e/ou osteocondrite dissecans em um paciente em risco de cada uma das ditas doenças, uso de um medicamento, e, método para prevenir a destruição da cartilagem ou condrólise associadas com osteonecrose e/ou osteocondrite dissecans
|
JP4354698B2
(ja)
*
|
2001-03-01 |
2009-10-28 |
エミスフェアー・テクノロジーズ・インク |
ビスホスホネートデリバリー用組成物
|
US6838584B2
(en)
*
|
2001-05-10 |
2005-01-04 |
Merck & Co., Inc. |
Estrogen receptor modulators
|
US20030139378A1
(en)
*
|
2001-12-13 |
2003-07-24 |
Daifotis Anastasia G. |
Liquid bisphosphonate formulations for bone disorders
|
US20050070504A1
(en)
*
|
2001-12-21 |
2005-03-31 |
The Procter & Gamble Co. |
Risedronate compositions and their methods of use
|
SK2532004A3
(en)
*
|
2001-12-21 |
2004-11-03 |
Procter & Gamble |
Method for the treatment of bone disorders
|
US7488496B2
(en)
*
|
2002-03-06 |
2009-02-10 |
Christer Rosen |
Effervescent compositions comprising bisphosphonates and methods related thereto
|
CA2480814A1
(en)
*
|
2002-04-05 |
2003-10-23 |
Merck & Co., Inc. |
Method for inhibiting bone resorption with an alendronate and vitamin d formulation
|
KR20120065435A
(ko)
*
|
2002-05-10 |
2012-06-20 |
에프. 호프만-라 로슈 아게 |
골다공증 치료 및 예방용 비스포스폰산
|
US20040188316A1
(en)
*
|
2003-03-26 |
2004-09-30 |
The Procter & Gamble Company |
Kit for pharmaceutical use
|