AR038041A1 - Metodo para el tratamiento de trastornos oseos - Google Patents
Metodo para el tratamiento de trastornos oseosInfo
- Publication number
- AR038041A1 AR038041A1 ARP020104997A ARP020104997A AR038041A1 AR 038041 A1 AR038041 A1 AR 038041A1 AR P020104997 A ARP020104997 A AR P020104997A AR P020104997 A ARP020104997 A AR P020104997A AR 038041 A1 AR038041 A1 AR 038041A1
- Authority
- AR
- Argentina
- Prior art keywords
- during
- bisphosphonate
- period
- disorders
- oseos
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940122361 Bisphosphonate Drugs 0.000 abstract 3
- 150000004663 bisphosphonates Chemical class 0.000 abstract 3
- 210000000988 bone and bone Anatomy 0.000 abstract 3
- 238000012423 maintenance Methods 0.000 abstract 2
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 abstract 1
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 abstract 1
- DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004343 alendronic acid Drugs 0.000 abstract 1
- 229960002286 clodronic acid Drugs 0.000 abstract 1
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229940015872 ibandronate Drugs 0.000 abstract 1
- LWRDQHOZTAOILO-UHFFFAOYSA-N incadronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)NC1CCCCCC1 LWRDQHOZTAOILO-UHFFFAOYSA-N 0.000 abstract 1
- 229950006971 incadronic acid Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 abstract 1
- 229940046231 pamidronate Drugs 0.000 abstract 1
- 229940089617 risedronate Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940019375 tiludronate Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Kit o conjunto para aumentar la masa ósea según un régimen que comprende dosis unitarias de bisfosfonato, como ser risedronato, ácido alendrónico, pamidronato, tiludronato, clodronato, cimadronato, ibandronato, zolendronato, sus sales y ésteres, durante un periodo de carga de 7 a 180 días, seguido de dosis unitarias menores de bisfosfonato durante un período de mantenimiento, con un medio para facilitar su cumplimiento. El uso de un bisfosfonato para fabricar un kit útil para un método que comprende su administración durante un período de carga y en menor dosis, durante un período de mantenimiento. Se aplica para aumentar la masa ósea, reducción de fracturas en osteoporosis y tratar trastornos metabólicos óseos, con mayor rapidez.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34487501P | 2001-12-21 | 2001-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR038041A1 true AR038041A1 (es) | 2004-12-22 |
Family
ID=23352430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020104997A AR038041A1 (es) | 2001-12-21 | 2002-12-19 | Metodo para el tratamiento de trastornos oseos |
Country Status (24)
Country | Link |
---|---|
US (5) | US20030118634A1 (es) |
EP (1) | EP1455796A1 (es) |
JP (1) | JP2005514400A (es) |
KR (1) | KR100638122B1 (es) |
CN (1) | CN100479823C (es) |
AR (1) | AR038041A1 (es) |
AU (1) | AU2002360619B2 (es) |
CA (1) | CA2469779C (es) |
CZ (1) | CZ2004690A3 (es) |
HK (1) | HK1087039A1 (es) |
HU (1) | HUP0402267A3 (es) |
IL (2) | IL162053A0 (es) |
MA (1) | MA27157A1 (es) |
MX (1) | MXPA04006027A (es) |
MY (1) | MY147886A (es) |
NO (1) | NO340249B1 (es) |
NZ (1) | NZ532994A (es) |
PE (1) | PE20030743A1 (es) |
PL (1) | PL371264A1 (es) |
RU (1) | RU2294203C2 (es) |
SK (1) | SK2532004A3 (es) |
TW (1) | TWI349553B (es) |
WO (1) | WO2003055496A1 (es) |
ZA (1) | ZA200404007B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005514400A (ja) * | 2001-12-21 | 2005-05-19 | ザ プロクター アンド ギャンブル カンパニー | 骨疾患の治療方法 |
ATE376444T1 (de) * | 2002-05-10 | 2007-11-15 | Hoffmann La Roche | Ibandronsäure zur behandlung und vorbeugung von osteoporose |
US20040097468A1 (en) * | 2002-11-20 | 2004-05-20 | Wimalawansa Sunil J. | Method of treating osteoporosis and other bone disorders with upfront loading of bisphosphonates, and kits for such treatment |
BR0309691A (pt) * | 2002-12-20 | 2005-08-02 | Hoffmann La Roche | Formulação de ibandronato em alta dose |
CA2566798A1 (en) * | 2004-05-24 | 2005-12-08 | The Procter & Gamble Company | Enteric solid oral dosage form of bisphosphonate containing a chelating agent |
WO2006020009A1 (en) * | 2004-07-23 | 2006-02-23 | The Procter & Gamble Company | Solid oral dosage form of a bisphosphonate containing a chelating agent |
US20070191315A1 (en) * | 2006-02-16 | 2007-08-16 | Bengt Bergstrom | Method for administering ibandronate |
Family Cites Families (68)
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CA777769A (en) * | 1963-03-18 | 1968-02-06 | H. Roy Clarence | Substituted methylene diphosphonic acid compounds and detergent compositions |
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DE2534391C2 (de) * | 1975-08-01 | 1983-01-13 | Henkel KGaA, 4000 Düsseldorf | 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren |
DE2745083C2 (de) * | 1977-10-07 | 1985-05-02 | Henkel KGaA, 4000 Düsseldorf | Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung |
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DE2943498C2 (de) * | 1979-10-27 | 1983-01-27 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure |
DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
IT1201087B (it) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
DE3434667A1 (de) * | 1984-09-21 | 1986-04-03 | Henkel KGaA, 4000 Düsseldorf | 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung |
IT1196315B (it) * | 1984-10-29 | 1988-11-16 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici |
IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
US4812311A (en) * | 1984-12-21 | 1989-03-14 | The Procter & Gamble Company | Kit for use in the treatment of osteoporosis |
DE3512536A1 (de) * | 1985-04-06 | 1986-10-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
US4761406A (en) * | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
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US6638920B2 (en) * | 2000-07-21 | 2003-10-28 | Merck & Co., Inc. | Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses |
ES2243457T3 (es) * | 2001-01-23 | 2005-12-01 | Gador S.A. | Composicion que comprende bifosfonatos para la prevencion y/o tratamiento de trastornos metabolicos de huesos, procedimiento de preparacion de dicha composicion y usos de la misma. |
AR034199A1 (es) * | 2001-02-01 | 2004-02-04 | Riderway Corp | Composicion farmacologica liquida para el tratamiento de enfermedades oseas y procedimientos para su elaboracion |
SK9862003A3 (en) * | 2001-02-06 | 2004-02-03 | Royal Alexandra Hosp Children | A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis |
CN1492763B (zh) * | 2001-03-01 | 2012-05-23 | 艾米斯菲尔技术有限公司 | 用于递送二膦酸盐的组合物 |
CA2445922A1 (en) * | 2001-05-10 | 2002-11-21 | Merck & Co., Inc. | Estrogen receptor modulators |
WO2003051373A1 (en) * | 2001-12-13 | 2003-06-26 | Merck & Co., Inc. | Liquid bisphosphonate formulations for bone disorders |
US20050070504A1 (en) * | 2001-12-21 | 2005-03-31 | The Procter & Gamble Co. | Risedronate compositions and their methods of use |
JP2005514400A (ja) * | 2001-12-21 | 2005-05-19 | ザ プロクター アンド ギャンブル カンパニー | 骨疾患の治療方法 |
US7488496B2 (en) * | 2002-03-06 | 2009-02-10 | Christer Rosen | Effervescent compositions comprising bisphosphonates and methods related thereto |
CA2480814A1 (en) * | 2002-04-05 | 2003-10-23 | Merck & Co., Inc. | Method for inhibiting bone resorption with an alendronate and vitamin d formulation |
ATE376444T1 (de) * | 2002-05-10 | 2007-11-15 | Hoffmann La Roche | Ibandronsäure zur behandlung und vorbeugung von osteoporose |
US20040188316A1 (en) * | 2003-03-26 | 2004-09-30 | The Procter & Gamble Company | Kit for pharmaceutical use |
-
2002
- 2002-12-16 JP JP2003556073A patent/JP2005514400A/ja active Pending
- 2002-12-16 KR KR1020047009393A patent/KR100638122B1/ko active IP Right Grant
- 2002-12-16 WO PCT/US2002/040234 patent/WO2003055496A1/en active Application Filing
- 2002-12-16 CZ CZ2004690A patent/CZ2004690A3/cs unknown
- 2002-12-16 AU AU2002360619A patent/AU2002360619B2/en not_active Expired
- 2002-12-16 SK SK253-2004A patent/SK2532004A3/sk unknown
- 2002-12-16 RU RU2004122433/14A patent/RU2294203C2/ru active
- 2002-12-16 CA CA002469779A patent/CA2469779C/en not_active Expired - Lifetime
- 2002-12-16 NZ NZ532994A patent/NZ532994A/en not_active IP Right Cessation
- 2002-12-16 MX MXPA04006027A patent/MXPA04006027A/es not_active Application Discontinuation
- 2002-12-16 IL IL16205302A patent/IL162053A0/xx unknown
- 2002-12-16 CN CNB028256271A patent/CN100479823C/zh not_active Expired - Lifetime
- 2002-12-16 HU HU0402267A patent/HUP0402267A3/hu not_active Application Discontinuation
- 2002-12-16 PL PL02371264A patent/PL371264A1/xx not_active Application Discontinuation
- 2002-12-16 TW TW091136276A patent/TWI349553B/zh not_active IP Right Cessation
- 2002-12-16 EP EP20020795891 patent/EP1455796A1/en not_active Ceased
- 2002-12-17 US US10/321,208 patent/US20030118634A1/en not_active Abandoned
- 2002-12-19 AR ARP020104997A patent/AR038041A1/es not_active Application Discontinuation
- 2002-12-20 MY MYPI20024837A patent/MY147886A/en unknown
-
2003
- 2003-01-06 PE PE2003000007A patent/PE20030743A1/es not_active Application Discontinuation
-
2004
- 2004-05-19 IL IL162053A patent/IL162053A/en active IP Right Grant
- 2004-05-24 ZA ZA2004/04007A patent/ZA200404007B/en unknown
- 2004-06-15 MA MA27736A patent/MA27157A1/fr unknown
- 2004-07-20 NO NO20043113A patent/NO340249B1/no not_active IP Right Cessation
-
2006
- 2006-06-30 HK HK06107438.9A patent/HK1087039A1/xx not_active IP Right Cessation
-
2007
- 2007-03-20 US US11/725,896 patent/US20070166237A1/en not_active Abandoned
-
2008
- 2008-03-20 US US12/077,623 patent/US20080214505A1/en not_active Abandoned
- 2008-06-27 US US12/163,155 patent/US20080261924A1/en not_active Abandoned
- 2008-06-27 US US12/163,278 patent/US20080260827A1/en not_active Abandoned
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