IL161903A0 - Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs - Google Patents

Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs

Info

Publication number
IL161903A0
IL161903A0 IL16190304A IL16190304A IL161903A0 IL 161903 A0 IL161903 A0 IL 161903A0 IL 16190304 A IL16190304 A IL 16190304A IL 16190304 A IL16190304 A IL 16190304A IL 161903 A0 IL161903 A0 IL 161903A0
Authority
IL
Israel
Prior art keywords
endodermally
usein
organs
disease
treatment
Prior art date
Application number
IL16190304A
Other languages
English (en)
Original Assignee
Gamida Cell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamida Cell Ltd filed Critical Gamida Cell Ltd
Priority to IL16190304A priority Critical patent/IL161903A0/xx
Priority to US10/564,760 priority patent/US20070082397A1/en
Priority to EP04744984A priority patent/EP1648397A4/fr
Priority to PCT/IL2004/000644 priority patent/WO2005007073A2/fr
Publication of IL161903A0 publication Critical patent/IL161903A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • C12N5/0672Stem cells; Progenitor cells; Precursor cells; Oval cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0647Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/20Transition metals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/44Thiols, e.g. mercaptoethanol
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/11Epidermal growth factor [EGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/113Acidic fibroblast growth factor (aFGF, FGF-1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/12Hepatocyte growth factor [HGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/125Stem cell factor [SCF], c-kit ligand [KL]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/135Platelet-derived growth factor [PDGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/145Thrombopoietin [TPO]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/2306Interleukin-6 (IL-6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/235Leukemia inhibitory factor [LIF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/237Oncostatin M [OSM]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/385Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/39Steroid hormones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/14Coculture with; Conditioned medium produced by hepatocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL16190304A 2003-07-17 2004-05-10 Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs IL161903A0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IL16190304A IL161903A0 (en) 2003-07-17 2004-05-10 Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
US10/564,760 US20070082397A1 (en) 2003-07-17 2004-07-15 Ex vivo progenitor and stem cell expansion for use in the treatment of disease of endodermally-derived organs
EP04744984A EP1648397A4 (fr) 2003-07-17 2004-07-15 Expansion ex vivo de cellules progenitrices et de cellules souches destinees au traitement de maladies d'organes derives de l'endoderme
PCT/IL2004/000644 WO2005007073A2 (fr) 2003-07-17 2004-07-15 Expansion ex vivo de cellules progenitrices et de cellules souches destinees au traitement de maladies d'organes derives de l'endoderme

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48762303P 2003-07-17 2003-07-17
US50388403P 2003-09-22 2003-09-22
IL16190304A IL161903A0 (en) 2003-07-17 2004-05-10 Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs

Publications (1)

Publication Number Publication Date
IL161903A0 true IL161903A0 (en) 2005-11-20

Family

ID=34084199

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16190304A IL161903A0 (en) 2003-07-17 2004-05-10 Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs

Country Status (4)

Country Link
US (1) US20070082397A1 (fr)
EP (1) EP1648397A4 (fr)
IL (1) IL161903A0 (fr)
WO (1) WO2005007073A2 (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1117762A4 (fr) 1998-09-29 2004-02-25 Gamida Cell Ltd Procedes de regulation de la proliferation et de la differentiation de cellules souches et precurseurs
WO2006030442A2 (fr) * 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methodes de culture ex vivo de cellules souches et de precurseur par co-culture avec des cellules mesenchymales
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
WO2006079107A2 (fr) * 2005-01-22 2006-07-27 Kronos Longevity Research Institute Compositions pour transplantation et procedes de traitement des diabetes
EP1888123B1 (fr) 2005-06-08 2013-01-09 Janssen Biotech, Inc. Thérapie cellulaire pour la dégénérescence oculaire
KR101441843B1 (ko) 2005-10-18 2014-09-17 내셔날 쥬이쉬 헬스 조건부 불멸화 장기 줄기 세포 및 상기 세포의 제조 및 사용 방법
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
BRPI0620523A2 (pt) * 2005-11-29 2011-11-16 Gamida Cell Ltd método de aumentar o potencial de implante e de atração celular, método de preparar células para transplante em um sujeito, população de células e composição farmacêutica
US8741643B2 (en) * 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
WO2008063675A2 (fr) * 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Cellules progénitrices endothermiques
JP5339533B2 (ja) * 2007-05-18 2013-11-13 国立大学法人旭川医科大学 血管内皮前駆細胞の移植による抗がん療法
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
EP2185693B1 (fr) 2007-07-31 2019-07-03 Lifescan, Inc. Différenciation de cellules souches embryonnaires humaines
ATE523585T1 (de) 2007-11-27 2011-09-15 Lifescan Inc Differenzierung menschlicher embryonaler stammzellen
CA2959401C (fr) 2008-02-21 2021-12-07 Centocor Ortho Biotech Inc. Procedes, plaques a surface modifiee et compositions permettant la fixation, la culture et le detachement de cellules
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
AU2009246876B2 (en) 2008-05-16 2015-04-02 Htyr Acquisition Llc Antibodies and processes for preparing the same
CN102159703B (zh) 2008-06-30 2015-11-25 森托科尔奥索生物科技公司 多能干细胞的分化
RU2011103183A (ru) * 2008-06-30 2012-08-10 Сентокор Орто Байотек Инк. (Us) Дифференцирование плюрипотентных стволовых клеток
US8962290B2 (en) 2008-08-26 2015-02-24 Intelligentnano Inc. Enhanced animal cell growth using ultrasound
US9012192B2 (en) 2008-08-26 2015-04-21 Intelligentnano Inc. Ultrasound enhanced growth of microorganisms
CA2735415A1 (fr) * 2008-08-26 2010-03-04 Intelligentnano Inc. Acceleration de la croissance de micro-organismes grace aux ultrasons
AU2009285547B2 (en) 2008-08-28 2012-05-31 Taiga Biotechnologies (Abc), Llc Modulators of MYC, methods of using the same, and methods of identifying agents that modulate MYC
EP2346988B1 (fr) 2008-10-31 2017-05-31 Janssen Biotech, Inc. Différenciation de cellules souches embryonnaires humaines en la lignée endocrine pancréatique
US9012218B2 (en) 2008-10-31 2015-04-21 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
EP3260534A1 (fr) 2008-11-20 2017-12-27 Janssen Biotech, Inc. Culture de cellules souches pluripotentes sur des micro-supports
BRPI0921996A2 (pt) 2008-11-20 2015-08-18 Centocor Ortho Biotech Inc Métodos e composições para cultura e ligação de células em substratos planos.
CN101768571B (zh) * 2009-01-07 2012-06-06 复旦大学 一种体外诱导、分化胚胎干细胞的方法
SG177481A1 (en) 2009-07-20 2012-02-28 Janssen Biotech Inc Differentiation of human embryonic stem cells
KR101786735B1 (ko) 2009-07-20 2017-10-18 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
CA2768644A1 (fr) 2009-07-20 2011-01-27 Janssen Biotech, Inc. Differenciation de cellules souches embryonnaires humaines
WO2011047289A1 (fr) * 2009-10-16 2011-04-21 University Of Medicine And Dentistry Of New Jersey Séparation en système fermé de cellules-souches de la moelle osseuse adhérentes pour des applications en médecine régénérative
RU2701335C2 (ru) * 2009-12-23 2019-09-25 Янссен Байотек, Инк. Способ получения популяции панкреатических эндокринных клеток, соэкспрессирующих nkx6.1 и инсулин, и способ лечения диабета
SG181822A1 (en) * 2009-12-23 2012-08-30 Centocor Ortho Biotech Inc Differentiation of human embryonic stem cells
BR112012016203A2 (pt) 2009-12-29 2019-09-24 Gamida Cell Ltd "métodos para melhoria da proliferaçõ e atividade das células exterminadoras naturais"
BR112012022145A2 (pt) 2010-03-01 2020-10-06 Janssen Biotech, Inc. métodos para purificar células derivadas de células-tronco pluripotentes
US8415149B2 (en) 2010-05-06 2013-04-09 Gwo Xi Stem Cell Applied Technology Co., Ltd. Hepatic progenitor cells and uses thereof
KR101903562B1 (ko) 2010-05-12 2018-10-02 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
EP2853589B1 (fr) 2010-08-31 2017-12-27 Janssen Biotech, Inc. Différenciation de cellules souches embryonnaires humaines
KR101851956B1 (ko) 2010-08-31 2018-04-25 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
ES2585028T3 (es) 2010-08-31 2016-10-03 Janssen Biotech, Inc. Diferenciación de células madre pluripotentes
US20140205582A1 (en) * 2011-07-06 2014-07-24 Cellerant Therapeutics, Inc. Megakaryocyte progenitor cells for production of platelets
KR20140063861A (ko) * 2011-09-22 2014-05-27 사이토메트릭스 피티와이 리미티드 조혈줄기세포 및 조혈전구세포의 생체 외 증식 방법
KR102203056B1 (ko) 2011-12-22 2021-01-14 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 단일 인슐린 호르몬 양성 세포로의 분화
CN104204192A (zh) 2012-02-13 2014-12-10 加米达细胞有限公司 间充质干细胞调理的基质及其产生和使用方法
US9434920B2 (en) 2012-03-07 2016-09-06 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
CN108103005A (zh) 2012-06-08 2018-06-01 詹森生物科技公司 人胚胎干细胞向胰腺内分泌细胞的分化
US9789135B2 (en) * 2012-07-20 2017-10-17 Taiga Biotechnologies, Inc. Enhanced reconstitution and autoreconstitution of the hematopoietic compartment
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
CN105008518B (zh) 2012-12-31 2020-08-07 詹森生物科技公司 在空气-液体界面处培养人胚胎干细胞以用于分化成胰腺内分泌细胞
JP6529440B2 (ja) 2012-12-31 2019-06-12 ヤンセン バイオテツク,インコーポレーテツド 膵内分泌細胞への分化のためのヒト多能性細胞の懸濁及びクラスタリング
CN105073979B (zh) 2012-12-31 2020-03-06 詹森生物科技公司 使用hb9调节子使人胚胎干细胞分化为胰腺内分泌细胞的方法
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
MX2016015004A (es) 2014-05-16 2017-06-27 Janssen Biotech Inc Uso de moleculas pequeñas para mejorar la expresion de mafa en celulas endocrinas pancreaticas.
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
CA3045017A1 (fr) 2016-12-02 2018-06-07 Taiga Biotechnologies, Inc. Formulations de nanoparticules
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
CN110833551B (zh) * 2018-08-15 2023-03-24 广西梧州制药(集团)股份有限公司 吡唑并嘧啶衍生物在治疗急性胰腺炎的用途
CN110833550B (zh) * 2018-08-15 2023-03-24 广西梧州制药(集团)股份有限公司 吡唑并嘧啶衍生物在治疗急性胰腺炎致肝损伤的用途

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3715345A (en) * 1970-08-03 1973-02-06 Lilly Co Eli Glucagon separation process
US3876623A (en) * 1973-05-09 1975-04-08 Lilly Co Eli Process for purifying insulin
US3863008A (en) * 1973-06-11 1975-01-28 American Home Prod Somatostatin as stimulant of luteinizing hormone secretion
US4476301A (en) * 1982-04-29 1984-10-09 Centre National De La Recherche Scientifique Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5550111A (en) * 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4806484A (en) * 1987-08-07 1989-02-21 Igb Products, Ltd. Perfusion airlift bioreactor
WO1989009221A1 (fr) * 1988-03-25 1989-10-05 University Of Virginia Alumni Patents Foundation N-alkylphosphoramidates oligonucleotides
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5264564A (en) * 1989-10-24 1993-11-23 Gilead Sciences Oligonucleotide analogs with novel linkages
US5264562A (en) * 1989-10-24 1993-11-23 Gilead Sciences, Inc. Oligonucleotide analogs with novel linkages
US5321131A (en) * 1990-03-08 1994-06-14 Hybridon, Inc. Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
US5612211A (en) * 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US5623070A (en) * 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5661016A (en) * 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) * 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
EP0814159B1 (fr) * 1990-08-29 2005-07-27 GenPharm International, Inc. Souris transgéniques capables de produire des anticorps hétérologues
US5545806A (en) * 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) * 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5714331A (en) * 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5320963A (en) * 1992-11-25 1994-06-14 National Research Council Of Canada Bioreactor for the perfusion culture of cells
US5476925A (en) * 1993-02-01 1995-12-19 Northwestern University Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
GB9304618D0 (en) * 1993-03-06 1993-04-21 Ciba Geigy Ag Chemical compounds
US5342781A (en) * 1993-07-15 1994-08-30 Su Wei Wen W External-loop perfusion air-lift bioreactor
US5378725A (en) * 1993-07-19 1995-01-03 The Arizona Board Of Regents Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof
US5807718A (en) * 1994-12-02 1998-09-15 The Scripps Research Institute Enzymatic DNA molecules
US5925567A (en) * 1995-05-19 1999-07-20 T. Breeders, Inc. Selective expansion of target cell populations
US5674750A (en) * 1995-05-19 1997-10-07 T. Breeders Continuous selective clonogenic expansion of relatively undifferentiated cells
US5712154A (en) * 1995-06-07 1998-01-27 W.R. Grace & Co.-Conn. Dual fiber bioreactor
US6680166B1 (en) * 1995-06-07 2004-01-20 Claudy Jean Paul Mullon Dual fiber bioreactor
US6440734B1 (en) * 1998-09-25 2002-08-27 Cytomatrix, Llc Methods and devices for the long-term culture of hematopoietic progenitor cells
US6962698B1 (en) * 1998-02-17 2005-11-08 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
CA2320073C (fr) * 1998-02-17 2011-11-01 Gamida Cell Ltd. Procede de lutte contre la proliferation et la differenciation de cellules souches et parentes
US6886568B2 (en) * 1998-04-08 2005-05-03 The Johns Hopkins University Method for fabricating cell-containing implants
EP1117762A4 (fr) * 1998-09-29 2004-02-25 Gamida Cell Ltd Procedes de regulation de la proliferation et de la differentiation de cellules souches et precurseurs
US6541249B2 (en) * 1999-12-22 2003-04-01 Human Genome Sciences, Inc. Immortalized human stromal cell lines
US6303374B1 (en) * 2000-01-18 2001-10-16 Isis Pharmaceuticals Inc. Antisense modulation of caspase 3 expression
WO2001094549A2 (fr) * 2000-06-05 2001-12-13 The Burnham Institute Procedes de differenciation et de protection des cellules par modulation du chemin p38/mef2
IL154159A0 (en) * 2000-08-01 2003-07-31 Yissum Res Dev Co Directed differentiation of ebryonic cells
US7198940B2 (en) * 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
US6642019B1 (en) * 2000-11-22 2003-11-04 Synthecan, Inc. Vessel, preferably spherical or oblate spherical for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same
JP3750548B2 (ja) * 2001-03-19 2006-03-01 セイコーエプソン株式会社 液晶表示装置、液晶表示装置の駆動方法、液晶表示装置の駆動回路および電子機器
CA2442177A1 (fr) * 2001-03-29 2002-10-10 Ixion Biotechnology, Inc. Procede de transdifferentiation de cellules souches non pancreatiques dans la voie de differentiation du pancreas
DE10131388B4 (de) * 2001-06-28 2004-07-08 Infineon Technologies Ag Integrierter dynamischer Speicher und Verfahren zum Betrieb desselben
WO2003035618A2 (fr) * 2001-10-24 2003-05-01 Iconix Pharmaceuticals, Inc. Modulateurs de la phosphoinositide 3-kinase
US6887401B2 (en) * 2001-11-05 2005-05-03 Essilor International Compagnie General D'optique Method for making transparent polythiourethane substrates in particular optical substrates
IL152904A0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
JP2005520511A (ja) * 2002-03-18 2005-07-14 ガミダ セル リミテッド エクスビボ拡大培養された幹細胞における分化を誘導する方法
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
US7247477B2 (en) * 2002-04-16 2007-07-24 Technion Research & Development Foundation Ltd. Methods for the in-vitro identification, isolation and differentiation of vasculogenic progenitor cells
WO2005007799A2 (fr) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Procedes de multiplication ex-vivo de cellules souches / progenitrices

Also Published As

Publication number Publication date
EP1648397A4 (fr) 2008-05-21
WO2005007073A3 (fr) 2007-05-03
EP1648397A2 (fr) 2006-04-26
US20070082397A1 (en) 2007-04-12
WO2005007073A2 (fr) 2005-01-27

Similar Documents

Publication Publication Date Title
IL161903A0 (en) Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
EP1459759A4 (fr) Medicament mobilisant les cellules souches totipotentes d'un tissu dans le sang peripherique
AU2003220424A8 (en) Adipose stromal stem cells for tissue and vascular modification
PL1641914T3 (pl) Komórki pochodzące z poporodowej tkanki łożyska oraz sposoby uzyskiwania i zastosowania tych komórek
EP1485464A4 (fr) Procedes permettant d'induire la differenciation dans des cellules souches expansees ex vivo
GB2429013C (en) Peptides for treatment and diagnosis of autoimmunedisease
HK1160393A1 (zh) 治療炎症相關疾病的方法
EP1872741A4 (fr) Instrument d'expansion d'organes corporels
GB2464652B (en) Improved methods for the generation of hepatocyte-like cells from human blastocyst-derived stem (hBS)
IL218504A0 (en) Lkktet and/or lkktnt peptides for treatment of elevated intraocular pressure
SI1546088T1 (sl) Spojine za uporabo v zdravljenju avtoimunskih bolezni, imunoalergijskih bolezni in zavrnitve transpalantata organa ali tkiva
EP1805210A4 (fr) Nouveaux peptides et procédés pour le traitement de maladie inflammatoire
EP1838260A4 (fr) Systeme et procede destines au traitement du tissu cardiaque
ZA200702651B (en) Arrangement and method for the treatment of compressed gas
AU2002352100A8 (en) Method for carrying out the ex vivo expansion and ex vivo differentiation of multipotent stem cells
HK1104235A1 (en) S-mirtazapine for the treatment of hot flush
EP1637589A4 (fr) Nouvelle cellule souche derivee d'une tissu adulte et son utilisation
EP1765331A4 (fr) Procedes et compositions destines au traitement de maladies pulmonaires
GB2414688B (en) System for drying gas and use of the system
EP1759720A4 (fr) Vaisseau sanguin artificiel et procédé de production de ce vaisseau
ZA200711163B (en) Use of anti-MAdCAM antibodies for the treatment of coeliac disease and tropical sprue
EP1819722A4 (fr) Modulation de l'ovulation
ZA200610628B (en) Composition for diagnosing and treating circulatory system diseases
EP1636341A4 (fr) Cellules souches a des fins cliniques et commerciales
GB0228588D0 (en) Method for the genetic reconstruction of human organs