IL159873A0 - Substituted 4-aminocyclohexanol derivatives - Google Patents

Substituted 4-aminocyclohexanol derivatives

Info

Publication number
IL159873A0
IL159873A0 IL15987302A IL15987302A IL159873A0 IL 159873 A0 IL159873 A0 IL 159873A0 IL 15987302 A IL15987302 A IL 15987302A IL 15987302 A IL15987302 A IL 15987302A IL 159873 A0 IL159873 A0 IL 159873A0
Authority
IL
Israel
Prior art keywords
substituted
aminocyclohexanol derivatives
aminocyclohexanol
derivatives
Prior art date
Application number
IL15987302A
Other languages
English (en)
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10135635A external-priority patent/DE10135635A1/de
Priority claimed from DE10135637A external-priority patent/DE10135637A1/de
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of IL159873A0 publication Critical patent/IL159873A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL15987302A 2001-07-17 2002-07-15 Substituted 4-aminocyclohexanol derivatives IL159873A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10135635A DE10135635A1 (de) 2001-07-17 2001-07-17 Analgetische substituierte 4-Aminocyclohexanolderivate
DE10135637A DE10135637A1 (de) 2001-07-17 2001-07-17 Substituierte 4-Aminocyclohexanolderivate
PCT/EP2002/007849 WO2003008371A1 (de) 2001-07-17 2002-07-15 Substituierte 4-aminocyclohexanolderivate

Publications (1)

Publication Number Publication Date
IL159873A0 true IL159873A0 (en) 2004-06-20

Family

ID=26009751

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15987302A IL159873A0 (en) 2001-07-17 2002-07-15 Substituted 4-aminocyclohexanol derivatives
IL159873A IL159873A (en) 2001-07-17 2004-01-15 Transformed derivatives of 4-aminocyclohexanol, the process for their preparation and preparations containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL159873A IL159873A (en) 2001-07-17 2004-01-15 Transformed derivatives of 4-aminocyclohexanol, the process for their preparation and preparations containing them

Country Status (27)

Country Link
US (1) US7678834B2 (xx)
EP (1) EP1406859B1 (xx)
JP (1) JP4126271B2 (xx)
KR (1) KR100886579B1 (xx)
CN (1) CN100584819C (xx)
AR (1) AR036171A1 (xx)
AT (1) ATE382601T1 (xx)
AU (1) AU2002328894B2 (xx)
BR (1) BR0211223A (xx)
CA (1) CA2453843C (xx)
CO (1) CO5550425A2 (xx)
CY (1) CY1107231T1 (xx)
DE (1) DE50211466D1 (xx)
DK (1) DK1406859T3 (xx)
ES (1) ES2298389T3 (xx)
HK (1) HK1065305A1 (xx)
HU (1) HU229121B1 (xx)
IL (2) IL159873A0 (xx)
MX (1) MXPA04000272A (xx)
NO (1) NO328672B1 (xx)
NZ (1) NZ531112A (xx)
PE (1) PE20030320A1 (xx)
PL (1) PL208792B1 (xx)
PT (1) PT1406859E (xx)
RU (1) RU2315750C2 (xx)
SI (1) SI1406859T1 (xx)
WO (1) WO2003008371A1 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186310A1 (en) * 2001-06-22 2004-09-23 Kim Keun-Sik Process for preparation of cyclohexanol derivatives
JP2007204409A (ja) * 2006-02-01 2007-08-16 Sumitomo Chemical Co Ltd アルキルベンゼン化合物の製造方法
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
EP3101018B1 (en) * 2007-08-31 2019-03-06 Purdue Pharma L.P. Substituted-quinoxaline-type-piperidine compounds and the uses thereof
US20090215725A1 (en) * 2008-02-26 2009-08-27 Grunenthal Gmbh Substituted 4-aminocyclohexane derivatives
AU2009228637B2 (en) * 2008-03-27 2013-12-19 Grunenthal Gmbh (Hetero-)aryl cyclohexane derivatives
EP2502907B1 (de) 2008-03-27 2018-08-29 Grünenthal GmbH Substituierte 4-Aminocyclohexan-Derivate
WO2010032322A1 (ja) * 2008-09-22 2010-03-25 日清ファルマ株式会社 抗炎症性ペプチド

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE160007C (xx) 1900-01-01
FR2135883A6 (en) 1971-04-29 1972-12-22 Gryspeerdt Andre Jacquard mechanism - using upper and lower frames carrying punched plates
US4115589A (en) * 1977-05-17 1978-09-19 The Upjohn Company Compounds, compositions and method of use
US4366172A (en) * 1977-09-29 1982-12-28 The Upjohn Company 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use
US4212878A (en) * 1978-01-26 1980-07-15 The Upjohn Company Phenylacetamide derivative analgesics
US4346101A (en) * 1980-12-08 1982-08-24 The Upjohn Company Benzamide derivative analgesics
FR2603612B1 (fr) * 1986-09-05 1988-12-09 Brochier Soieries J Dispositif de variation de la densite des fils de chaine dans un metier a tisser
DE3924304A1 (de) 1989-07-22 1991-01-31 Bayer Ag Neue fluorierte cyclohexanderivate, verfahren und zwischenprodukte zu deren herstellung und die verwendung der neuen fluorierten cyclohexanderivate als fungizide und zwischenprodukte
DE4031515C1 (xx) 1990-08-22 1991-10-10 Schroers Jacquard Papierind
US5304479A (en) * 1991-12-06 1994-04-19 Diagnostic Reagents, Inc. Phencyclidine compounds and assays for its determination
FR2685015B1 (fr) * 1991-12-12 1994-04-01 Staubli Verdol Sa Attache rapide pour la liaison d'au moins un element funiculaire par rapport a l'extremite d'un cordon.
US5239110A (en) * 1992-12-30 1993-08-24 Sterling Winthrop, Inc. Phenylcyclohexanol derivatives as agents for treating CNS disorders
FR2726011B1 (fr) 1994-10-25 1996-12-20 Staubli Sa Ets Nouvel harnais demontable pour mecaniques jacquard
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
DE19963175A1 (de) * 1999-12-27 2001-07-12 Gruenenthal Gmbh Verwendung von substituierten 4-Amino-1-phenylbutan-2-ol-Verbindungen als Arzneimittel
IL151018A0 (en) * 2000-03-17 2003-02-12 Bristol Myers Squibb Pharma Co Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha
DE10135636A1 (de) * 2001-07-17 2003-02-06 Gruenenthal Gmbh Substituierte 4-Aminocyclohexanole
DE20118363U1 (de) 2001-11-13 2002-01-17 Textilma Ag, Hergiswil Chorbrett für Webmaschinen

Also Published As

Publication number Publication date
CO5550425A2 (es) 2005-08-31
CA2453843C (en) 2011-11-29
JP2005504742A (ja) 2005-02-17
EP1406859A1 (de) 2004-04-14
NO328672B1 (no) 2010-04-19
MXPA04000272A (es) 2004-05-04
NZ531112A (en) 2005-09-30
RU2315750C2 (ru) 2008-01-27
ATE382601T1 (de) 2008-01-15
SI1406859T1 (sl) 2008-04-30
CA2453843A1 (en) 2003-01-30
WO2003008371A1 (de) 2003-01-30
DK1406859T3 (da) 2008-02-18
BR0211223A (pt) 2004-08-10
CN100584819C (zh) 2010-01-27
JP4126271B2 (ja) 2008-07-30
RU2004104628A (ru) 2005-07-10
NO20040162L (no) 2004-03-11
AU2002328894B2 (en) 2007-06-14
DE50211466D1 (de) 2008-02-14
HU229121B1 (en) 2013-08-28
PL208792B1 (pl) 2011-06-30
EP1406859B1 (de) 2008-01-02
US20040214822A1 (en) 2004-10-28
HUP0400207A2 (hu) 2004-08-30
PE20030320A1 (es) 2003-04-03
US7678834B2 (en) 2010-03-16
PL368040A1 (en) 2005-03-21
PT1406859E (pt) 2008-01-24
CN1555355A (zh) 2004-12-15
HUP0400207A3 (en) 2008-03-28
HK1065305A1 (en) 2005-02-18
IL159873A (en) 2009-02-11
KR20040029369A (ko) 2004-04-06
CY1107231T1 (el) 2012-11-21
ES2298389T3 (es) 2008-05-16
AR036171A1 (es) 2004-08-18
KR100886579B1 (ko) 2009-03-05

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