IL159540A0 - Heterocyclic compounds as selective bacterial dhfr inhibitors and the uses thereof - Google Patents

Heterocyclic compounds as selective bacterial dhfr inhibitors and the uses thereof

Info

Publication number
IL159540A0
IL159540A0 IL15954002A IL15954002A IL159540A0 IL 159540 A0 IL159540 A0 IL 159540A0 IL 15954002 A IL15954002 A IL 15954002A IL 15954002 A IL15954002 A IL 15954002A IL 159540 A0 IL159540 A0 IL 159540A0
Authority
IL
Israel
Prior art keywords
heterocyclic compounds
dhfr inhibitors
bacterial dhfr
selective bacterial
selective
Prior art date
Application number
IL15954002A
Other languages
English (en)
Original Assignee
Pliva D D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva D D filed Critical Pliva D D
Publication of IL159540A0 publication Critical patent/IL159540A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL15954002A 2001-06-28 2002-06-28 Heterocyclic compounds as selective bacterial dhfr inhibitors and the uses thereof IL159540A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30168501P 2001-06-28 2001-06-28
PCT/US2002/020479 WO2003002064A2 (en) 2001-06-28 2002-06-28 Fused pyrimidine dhfr inhibitors as antibacterials

Publications (1)

Publication Number Publication Date
IL159540A0 true IL159540A0 (en) 2004-06-01

Family

ID=23164426

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15953802A IL159538A0 (en) 2001-06-28 2002-06-28 8/17 heterocyclic compounds and uses thereof as d-alanyl-d-alanine ligase inhibitors
IL15954002A IL159540A0 (en) 2001-06-28 2002-06-28 Heterocyclic compounds as selective bacterial dhfr inhibitors and the uses thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL15953802A IL159538A0 (en) 2001-06-28 2002-06-28 8/17 heterocyclic compounds and uses thereof as d-alanyl-d-alanine ligase inhibitors

Country Status (16)

Country Link
US (3) US7345048B2 (cs)
EP (2) EP1432713A4 (cs)
CN (2) CN1547472A (cs)
BG (1) BG108548A (cs)
BR (1) BR0211310A (cs)
CA (2) CA2451800A1 (cs)
CZ (2) CZ200442A3 (cs)
EA (1) EA200400094A1 (cs)
EE (2) EE200400043A (cs)
HU (2) HUP0700040A2 (cs)
IL (2) IL159538A0 (cs)
MX (1) MXPA04000159A (cs)
PL (2) PL374589A1 (cs)
SK (1) SK302004A3 (cs)
WO (2) WO2003002064A2 (cs)
YU (2) YU102503A (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0217703D0 (en) * 2002-07-31 2002-09-11 Univ Liverpool Pharmaceutical composition
AU2005304040B2 (en) * 2004-11-09 2009-04-23 F. Hoffmann-La Roche Ag Aminoquinazolines compounds
EP1910359B1 (en) * 2005-07-21 2009-11-18 F. Hoffmann-Roche AG PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS
GB0608822D0 (en) * 2006-05-04 2006-06-14 Chroma Therapeutics Ltd Inhibitors of DHFR
SI22338A (sl) * 2006-08-18 2008-02-29 Univerza V Ljubljani, Fakulteta Za Farmacijo Diazendikarboksamidi kot inhibitorji d-alanil-d-alanin ligaze
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
CN101084901B (zh) * 2007-06-22 2011-12-21 复旦大学 一种葡萄球菌抑制剂
AU2009208947B2 (en) * 2008-02-01 2014-02-06 Takeda Pharmaceutical Company Limited Oxim derivatives as HSP90 inhibitors
WO2010107977A2 (en) * 2009-03-20 2010-09-23 Board Of Regents Of The University Of Texas System Method for imparting antimicrobial activity to a medical device
AU2009351623B2 (en) * 2009-08-31 2014-12-11 Dow Agrosciences Llc Pteridines and their use as agrochemicals
HUE038059T2 (hu) 2015-03-04 2018-10-29 Gilead Sciences Inc Toll-like receptor moduláló 4,6-diamino-pirido[3,2-D]pirimidin vegyületek
CN106316966A (zh) * 2015-06-15 2017-01-11 董运勤 医药中间体n-(2-吡嗪甲基)苄胺磷酸盐化合物制备方法
US10370342B2 (en) 2016-09-02 2019-08-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
SG10201912128SA (en) 2017-02-01 2020-02-27 Univ Yale Treatment of diuretic resistance
MX2020006882A (es) 2018-01-05 2020-09-07 Novo Nordisk As Metodos para tratar inflamacion mediada por interleucina-6 sin inmunosupresion.
KR20210124292A (ko) * 2019-02-01 2021-10-14 에프엠씨 코포레이션 제초제로서 디아미노-치환된 피리딘 및 피리미딘
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
GB2626567A (en) * 2023-01-26 2024-07-31 De Montfort Univ Quinazoline derivatives for use as a medicament

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949466A (en) * 1958-03-04 1960-08-16 Parke Davis & Co Pyrimidine compounds and means of producing the same
US3134778A (en) * 1963-08-20 1964-05-26 Smith Kline French Lab 2,5,7-triamino-4-phenyl (or thienyl)-pyrimido[4,5-d]pyrimidines
RO56210A2 (cs) 1970-12-28 1974-08-01
US4079056A (en) * 1975-03-31 1978-03-14 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making pteridine compounds
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3445298A1 (de) * 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
WO1992017478A1 (en) 1991-04-08 1992-10-15 Duquesne University Of The Holy Ghost 5-ALKYL-6-[[AMINO]METHYL]PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING AND USING THESE DERIVATIVES
US5547954A (en) 1994-05-26 1996-08-20 Fmc Corporation 2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides
DK0728758T3 (da) * 1995-02-27 2004-02-23 Hoffmann La Roche Dioxopyrrolo-pyrrolderivater
AU2960599A (en) * 1998-03-30 1999-10-18 Akira Karasawa Quinazoline derivatives
JP2000239277A (ja) 1999-02-19 2000-09-05 Kyowa Hakko Kogyo Co Ltd イミダゾキナゾリン誘導体
GB0219893D0 (en) 2002-08-27 2002-10-02 Melacure Therapeutics Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
WO2003001887A3 (en) 2003-08-21
EP1411949A4 (en) 2004-11-24
EP1411949A2 (en) 2004-04-28
WO2003002064A3 (en) 2003-10-23
CZ200443A3 (cs) 2004-08-18
SK302004A3 (sk) 2005-07-01
EA200400094A1 (ru) 2005-08-25
US20030176436A1 (en) 2003-09-18
YU102303A (sh) 2006-08-17
US20030181470A1 (en) 2003-09-25
US20080090847A1 (en) 2008-04-17
US7345048B2 (en) 2008-03-18
CN1547472A (zh) 2004-11-17
HUP0700040A2 (en) 2007-05-29
EE200400042A (et) 2004-10-15
CA2451840A1 (en) 2003-01-09
EP1432713A4 (en) 2005-05-11
WO2003001887A2 (en) 2003-01-09
HUP0700061A2 (en) 2007-05-02
CA2451800A1 (en) 2003-01-09
PL374589A1 (en) 2005-10-31
IL159538A0 (en) 2004-06-01
PL374259A1 (en) 2005-10-03
EP1432713A2 (en) 2004-06-30
WO2003002064A2 (en) 2003-01-09
EE200400043A (et) 2004-10-15
BG108548A (bg) 2005-05-31
BR0211310A (pt) 2006-10-31
MXPA04000159A (es) 2005-01-07
CZ200442A3 (cs) 2004-10-13
CN1543465A (zh) 2004-11-03
YU102503A (sh) 2006-08-17

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