IL159475A0 - Spherical protein particles, compositions containing the same and methods for the production thereof - Google Patents
Spherical protein particles, compositions containing the same and methods for the production thereofInfo
- Publication number
- IL159475A0 IL159475A0 IL15947502A IL15947502A IL159475A0 IL 159475 A0 IL159475 A0 IL 159475A0 IL 15947502 A IL15947502 A IL 15947502A IL 15947502 A IL15947502 A IL 15947502A IL 159475 A0 IL159475 A0 IL 159475A0
- Authority
- IL
- Israel
- Prior art keywords
- production
- methods
- same
- compositions containing
- protein particles
- Prior art date
Links
- 102000034238 globular proteins Human genes 0.000 title 1
- 108091005896 globular proteins Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/60—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape characterised by shape
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
- C30B7/02—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent
- C30B7/06—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent using non-aqueous solvents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29998901P | 2001-06-21 | 2001-06-21 | |
PCT/US2002/019870 WO2003000014A2 (en) | 2001-06-21 | 2002-06-21 | Spherical protein particles and methods of making and using them |
Publications (1)
Publication Number | Publication Date |
---|---|
IL159475A0 true IL159475A0 (en) | 2004-06-01 |
Family
ID=23157185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15947502A IL159475A0 (en) | 2001-06-21 | 2002-06-21 | Spherical protein particles, compositions containing the same and methods for the production thereof |
Country Status (8)
Country | Link |
---|---|
US (2) | US7998477B2 (xx) |
EP (1) | EP1492554B1 (xx) |
JP (1) | JP2005500304A (xx) |
AU (1) | AU2002322295C1 (xx) |
CA (1) | CA2451185A1 (xx) |
IL (1) | IL159475A0 (xx) |
NZ (1) | NZ530700A (xx) |
WO (1) | WO2003000014A2 (xx) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100923514B1 (ko) * | 2000-12-28 | 2009-10-27 | 알투스 파마슈티컬스 인코포레이티드 | 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법 |
JP2005500304A (ja) | 2001-06-21 | 2005-01-06 | アルタス バイオロジックス インコーポレイテッド | 球状タンパク質粒子およびそれらの作製方法および使用方法 |
JP4161101B2 (ja) * | 2002-06-21 | 2008-10-08 | 独立行政法人 日本原子力研究開発機構 | 生体高分子の結晶育成装置 |
SG135204A1 (en) | 2003-07-18 | 2007-09-28 | Baxter Int | Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation |
JP2005241389A (ja) * | 2004-02-25 | 2005-09-08 | Ochiyanomizu Jiyoshi Univ | 蛍光標識糖鎖の特異的固定化試薬および固定化方法 |
PT1758558E (pt) | 2004-05-12 | 2013-12-05 | Baxter Healthcare Sa | Microesferas contendo oligonucleótidos, sua utilização para o fabrico de um medicamento para o tratamento de diabetes do tipo 1 |
US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
EP1765294B1 (en) | 2004-05-12 | 2008-09-24 | Baxter International Inc. | Nucleic acid microspheres, production and delivery thereof |
MXPA06012992A (es) | 2004-05-12 | 2007-02-12 | Baxter Int | Microesferas que comprenden proteina y que muestran inyectabilidad en altas concentraciones de este agente. |
BRPI0517457A (pt) | 2004-10-22 | 2008-10-07 | Amgen Inc | métodos para reenovelamento de anticorpos recombinantes |
US7956160B2 (en) * | 2005-07-22 | 2011-06-07 | Amgen Inc. | Concentrated protein lyophilates, methods, and uses |
SI1948259T1 (sl) * | 2005-10-26 | 2017-07-31 | Genesis Technologies Limited | Acelularni bioabsorbljivi tkivni regeneracijski matriksi, proizvedeni z inkubiranjem acelularnih proizvodov krvi |
JP5147699B2 (ja) * | 2005-12-20 | 2013-02-20 | 富士フイルム株式会社 | タンパク質ナノ粒子およびその使用 |
WO2007114262A1 (ja) | 2006-03-29 | 2007-10-11 | Fujifilm Corporation | カゼインナノ粒子 |
US7964574B2 (en) | 2006-08-04 | 2011-06-21 | Baxter International Inc. | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
US20080299182A1 (en) * | 2007-03-01 | 2008-12-04 | Shuyuan Zhang | Methods and formulations for topical gene therapy |
US8808747B2 (en) | 2007-04-17 | 2014-08-19 | Baxter International Inc. | Nucleic acid microparticles for pulmonary delivery |
JP2008285432A (ja) | 2007-05-16 | 2008-11-27 | Fujifilm Corp | 皮膚外用剤 |
EP2170283B1 (en) | 2007-06-22 | 2019-01-09 | Board of Regents, The University of Texas System | Formation of stable submicron peptide or protein particles by thin film freezing |
WO2009005709A1 (en) * | 2007-06-28 | 2009-01-08 | Surmodics, Inc. | Polypeptide microparticles |
US20090022805A1 (en) * | 2007-06-28 | 2009-01-22 | Joram Slager | Polypeptide microparticles having sustained release characteristics, methods and uses |
KR100845009B1 (ko) * | 2007-08-07 | 2008-07-08 | 한국생명공학연구원 | 전하를 띠는 물질이 고착된 다공성 고분자 입자 및 그제조방법 |
EA020753B1 (ru) | 2008-06-16 | 2015-01-30 | Бинд Терапьютикс, Инк. | Терапевтические полимерные наночастицы, содержащие алкалоиды vinca, и их применение |
WO2010005726A2 (en) | 2008-06-16 | 2010-01-14 | Bind Biosciences Inc. | Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same |
DK2774608T3 (da) | 2008-06-16 | 2020-01-13 | Pfizer | Lægemiddelladede polymere nanopartikler og fremgangsmåder til fremstilling og anvendelse deraf |
US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
EP2376522A4 (en) * | 2008-11-16 | 2013-12-25 | Univ Texas | LOW VISCOSIS HIGHLY CONCENTRATED SUSPENSIONS |
FR2938542B1 (fr) | 2008-11-18 | 2013-06-14 | Sang Bourgogne Franche Comte Ets Franc | Proteine cd20 tronquee, deltacd20 |
US8563041B2 (en) | 2008-12-12 | 2013-10-22 | Bind Therapeutics, Inc. | Therapeutic particles suitable for parenteral administration and methods of making and using same |
JP2012512175A (ja) | 2008-12-15 | 2012-05-31 | バインド バイオサイエンシズ インコーポレイテッド | 治療薬を徐放するための長時間循環性ナノ粒子 |
US8529933B2 (en) | 2009-07-27 | 2013-09-10 | Warsaw Orthopedic, Inc. | Biphasic calcium phosphate cement for drug delivery |
JP5491119B2 (ja) | 2009-10-02 | 2014-05-14 | 日東電工株式会社 | 薬物含有微粒子を含む医薬組成物およびその製造方法 |
CN102811743B (zh) | 2009-12-11 | 2015-11-25 | 佰恩德治疗股份有限公司 | 冻干治疗颗粒的稳定制剂 |
EA201290499A1 (ru) | 2009-12-15 | 2013-01-30 | Байнд Байосайенсиз, Инк. | Композиции терапевтических полимерных наночастиц с высокой температурой стеклования и высокомолекулярными сополимерами |
MX336473B (es) | 2010-02-11 | 2016-01-20 | Hoffmann La Roche | Ensayo mediante adcc nk facs tridimensional. |
US9643996B2 (en) | 2011-11-04 | 2017-05-09 | Battelle Memorial Institute | Processes for producing protein microparticles |
CN105688188A (zh) | 2011-11-18 | 2016-06-22 | 瑞泽恩制药公司 | 聚合物蛋白微粒 |
US20150177115A1 (en) | 2012-04-06 | 2015-06-25 | Slingshot Biosciences | Hydrogel particles with tunable optical properties |
US9803010B2 (en) | 2012-06-27 | 2017-10-31 | Merck Sharp & Dohme Corp. | Crystalline anti-human IL-23p19 antibodies |
HUE043998T2 (hu) | 2012-09-17 | 2019-09-30 | Pfizer | Eljárás terápiás nanorészecskék elõállítására |
US9474803B2 (en) | 2012-11-27 | 2016-10-25 | Alteogen Inc. | Composition for stabilizing fusion protein in which protein and FC domain are fused |
CN103018446B (zh) * | 2012-12-24 | 2014-08-20 | 青岛汉唐生物科技有限公司 | 用于检测甲型肝炎病毒抗体的方法、检测用的试剂盒及其制备方法 |
BR112016004054A2 (pt) * | 2013-08-26 | 2017-09-12 | Ps Therapies Ltd | composições e métodos para o tratamento de condições nasais |
WO2015058173A1 (en) * | 2013-10-18 | 2015-04-23 | Abbvie Inc. | Stable solid units and methods of making the same |
CA2942859A1 (en) | 2014-03-14 | 2015-09-17 | Pfizer Inc. | Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same |
US10525122B2 (en) | 2014-07-18 | 2020-01-07 | Km Biologics Co., Ltd. | Vaccine containing virus-like particles |
EP3179985A1 (en) * | 2014-08-14 | 2017-06-21 | Brown University | Compositions for stabilizing and delivering proteins |
US9821059B2 (en) | 2014-10-17 | 2017-11-21 | Alteogen Inc. | Composition for stabilizing protein and pharmaceutical formulation comprising the same |
KR102436976B1 (ko) | 2015-02-09 | 2022-08-25 | 슬링샷 바이오사이언시즈 인코포레이티드 | 튜닝가능한 광 특성을 갖는 하이드로겔 입자 및 이를 사용하기 위한 방법 |
AR103726A1 (es) | 2015-02-27 | 2017-05-31 | Merck Sharp & Dohme | Cristales de anticuerpos monoclonales anti-pd-1 humanos |
EP3278102B1 (en) | 2015-04-24 | 2021-12-29 | Colgate-Palmolive Company | Porous protein particles as carriers for actives |
WO2017219974A1 (zh) | 2016-06-22 | 2017-12-28 | 本康生物制药(深圳)有限公司 | 用于肿瘤治疗的双特异性抗体和抗体偶联物及其应用 |
CN108504638B (zh) * | 2017-02-28 | 2021-09-17 | 中国科学院过程工程研究所 | 一种口蹄疫灭活病毒抗原纯化或储存的方法 |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
MX2019013072A (es) | 2017-05-02 | 2019-12-16 | Merck Sharp & Dohme | Formulaciones de anticuerpos anti-lag3 y coformulaciones de anticuerpos anti-lag3 y anticuerpos anti-pd-1. |
CN113238039B (zh) * | 2018-03-07 | 2023-03-31 | 深圳市伯劳特生物制品有限公司 | 一种检测试剂盒 |
KR20210124228A (ko) * | 2018-12-31 | 2021-10-14 | 라니 테라퓨틱스, 엘엘씨 | 삼킬 수 있는 약물 전달 장치를 사용하여 장관의 내강으로 약물을 전달하기 위한 치료제 제제 및 방법 |
US10993459B2 (en) | 2019-09-23 | 2021-05-04 | Ralph Yoder | Method for unlocking bioactive proteins |
KR20220104797A (ko) | 2019-11-25 | 2022-07-26 | 리제너론 파마슈티칼스 인코포레이티드 | 비수성 에멀전을 이용한 지속 방출 제형 |
WO2021150838A1 (en) | 2020-01-24 | 2021-07-29 | Slingshot Biosciences, Inc. | Compositions and methods for cell-like calibration particles |
WO2021177996A1 (en) * | 2020-03-02 | 2021-09-10 | Northwestern University | Fit-flares for detection of intracellular analytes in live cells |
KR20230029612A (ko) | 2020-05-04 | 2023-03-03 | 슬링샷 바이오사이언시즈 인코포레이티드 | 다중 검정을 위한 수동 광학 바코딩용 조성물 및 방법 |
TW202237070A (zh) | 2020-11-25 | 2022-10-01 | 美商再生元醫藥公司 | 使用非水性膜乳化之持續釋放調配物 |
EP4262757A1 (en) | 2020-12-17 | 2023-10-25 | Regeneron Pharmaceuticals, Inc. | Fabrication of protein-encapsulating microgels |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4334024A (en) | 1980-11-03 | 1982-06-08 | Sarjit Johal | Preparation and crystallization of fraction I protein from plant sources |
DE3327709A1 (de) | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
DE3419782C1 (de) | 1984-05-26 | 1985-11-14 | Gödecke AG, 1000 Berlin | Sphaerische Proteinpartikel mit immunadsorbierenden Eigenschaften und Verfahren zu deren Herstellung |
US6727278B1 (en) * | 1986-08-27 | 2004-04-27 | Dms Pharmaceutical Inc. | Pharmaceutically active agents that impede amyloid formation in vivo |
EP0506866B1 (en) | 1989-12-21 | 1993-10-20 | Novo Nordisk A/S | Method for crystallization of enzymes |
US5780599A (en) | 1990-07-13 | 1998-07-14 | Novo Nordisk A/S | Growth hormone crystals and a process for production of growth hormone crystals |
US5618710A (en) | 1990-08-03 | 1997-04-08 | Vertex Pharmaceuticals, Inc. | Crosslinked enzyme crystals |
US6063910A (en) * | 1991-11-14 | 2000-05-16 | The Trustees Of Princeton University | Preparation of protein microparticles by supercritical fluid precipitation |
US5751453A (en) * | 1991-12-06 | 1998-05-12 | Ncr Corporation | Liquid crystal display with pen-input capability |
EP0646000A4 (en) * | 1992-11-16 | 1997-05-02 | Univ Mercer | COMPOSITIONS CONTAINING MICRO-ENCODED NEUTRALIZING ANTIBODIES. |
US6794357B1 (en) * | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
US5904935A (en) | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
AU6960696A (en) | 1995-08-30 | 1997-03-19 | Ariad Pharmaceuticals, Inc. | Crystalline zap family proteins |
US5972331A (en) | 1995-12-22 | 1999-10-26 | Schering Corporation | Crystalline interferon alpha for pulmonary delivery and method for producing the same |
US5932212A (en) | 1996-05-24 | 1999-08-03 | Altus Biologics, Inc. | Crosslinked protein crystal formulations and their use as catalysts in organic solvents |
US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6652837B1 (en) * | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
US6310038B1 (en) | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
US6140475A (en) | 1997-04-11 | 2000-10-31 | Altus Biologics Inc. | Controlled dissolution crosslinked protein crystals |
EP2311436A1 (en) * | 1998-04-27 | 2011-04-20 | Altus Pharmaceuticals Inc. | Stabilized protein crystals, formulations containing them and methods of making them |
US6956021B1 (en) * | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
ATE325868T1 (de) | 1999-03-05 | 2006-06-15 | Genencor Int | Verfahren zur schnellen herstellung von crystallen mit wünschenswerter morphologie |
AU782916B2 (en) * | 1999-06-09 | 2005-09-08 | Robert E. Sievers | Supercritical fluid-assisted nebulization and bubble drying |
ES2184716T3 (es) | 1999-06-10 | 2003-04-16 | Max Planck Gesellschaft | Encapsulacion de cristales por medio de recubrimientos multicapa. |
GB9915975D0 (en) * | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
FR2802445B1 (fr) * | 1999-12-15 | 2002-02-15 | Separex Sa | Procede et dispositif de captage de fines particules par piegeage au sein d'un melange solide de type neige carbonique |
US6562952B1 (en) * | 2000-10-31 | 2003-05-13 | The University Of Kansas | Precipitation of proteins from organic solutions |
US6756062B2 (en) * | 2000-11-03 | 2004-06-29 | Board Of Regents University Of Texas System | Preparation of drug particles using evaporation precipitation into aqueous solutions |
KR100923514B1 (ko) * | 2000-12-28 | 2009-10-27 | 알투스 파마슈티컬스 인코포레이티드 | 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법 |
EP1801123A3 (en) * | 2000-12-28 | 2007-11-21 | Altus Pharmaceuticals Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
JP2005500304A (ja) | 2001-06-21 | 2005-01-06 | アルタス バイオロジックス インコーポレイテッド | 球状タンパク質粒子およびそれらの作製方法および使用方法 |
US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
-
2002
- 2002-06-21 JP JP2003506470A patent/JP2005500304A/ja active Pending
- 2002-06-21 IL IL15947502A patent/IL159475A0/xx unknown
- 2002-06-21 AU AU2002322295A patent/AU2002322295C1/en not_active Ceased
- 2002-06-21 WO PCT/US2002/019870 patent/WO2003000014A2/en active Search and Examination
- 2002-06-21 CA CA002451185A patent/CA2451185A1/en not_active Abandoned
- 2002-06-21 EP EP02756275.0A patent/EP1492554B1/en not_active Expired - Lifetime
- 2002-06-21 NZ NZ530700A patent/NZ530700A/en not_active IP Right Cessation
-
2003
- 2003-12-19 US US10/741,861 patent/US7998477B2/en not_active Expired - Fee Related
-
2011
- 2011-07-27 US US13/192,345 patent/US20120282464A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2451185A1 (en) | 2003-01-03 |
AU2002322295C1 (en) | 2008-12-18 |
EP1492554B1 (en) | 2019-08-21 |
EP1492554A2 (en) | 2005-01-05 |
US7998477B2 (en) | 2011-08-16 |
JP2005500304A (ja) | 2005-01-06 |
WO2003000014A2 (en) | 2003-01-03 |
US20120282464A1 (en) | 2012-11-08 |
NZ530700A (en) | 2009-02-28 |
EP1492554A4 (en) | 2012-07-11 |
WO2003000014A3 (en) | 2004-10-21 |
US20040219224A1 (en) | 2004-11-04 |
AU2002322295B2 (en) | 2008-07-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL159475A0 (en) | Spherical protein particles, compositions containing the same and methods for the production thereof | |
AU2002330959A1 (en) | Abrasive particles, abrasive articles, and methods of making and using the same | |
IL162228A0 (en) | Shaped nanocrystal particles and methods for making the same | |
AU2002321872A1 (en) | Abrasive particles, and methods of making and using the same | |
HK1098737A1 (en) | Process for the preparation of 1,1,1,3,3-pentafluoro-2-chloropropene and 1,1,1,3,3,3-hexafluoro-2-chloropropane | |
IL165977A (en) | Substituted pyrimidinylaminobenzamides , process for the preparation thereof and pharmaceutical compositions comprising the same | |
IL164021A (en) | Anti-αvβ6 antibodies and their pharmaceutical preparations | |
HK1079213A1 (en) | Anti-il-6 antibodies, compositions, methods and uses | |
AU2001234693A1 (en) | Fused al2o3-y2o3 eutectic abrasive particles, abrasive articles, and methods of making and using the same | |
IL152918A0 (en) | Stabilized tetrazolium-phenazine reagent compositions and methods for using the same | |
EP1660638A4 (en) | LIPOPARTICLES COMPRISING PROTEINS, AND METHODS OF MAKING AND USING SAME LIPOPARTICLES | |
EP1439017B8 (en) | Monodisperse spherical metal particles | |
AU3281902A (en) | Methods for the production of multimeric proteins, and related compositions | |
AU2002232819A1 (en) | Methods for the production of multimeric proteins, and related compositions | |
IL157846A0 (en) | Stable astaxanthin-containing powdery compositions and process for producing the same | |
IL161893A0 (en) | 5-Phenylpyrimidines, agents comprising the same, method for production and use thereof | |
IL161428A0 (en) | Oligoamine derivatives, methods for the production thereof and pharmaceutical compositions containing the same | |
IL157890A0 (en) | P-thienylbenzyl-amides serving as agonists of angiotensin-(1-7)-receptors, method for the production thereof, their use and pharmaceutical preparations containing the same | |
HK1061008A1 (en) | Spherical alumina particles and production process thereof | |
EP1539792A4 (en) | CNGH0005 POLYPEPTIDES, ANTIBODIES, COMPOSITIONS, METHODS AND USES | |
AU2002365269A1 (en) | Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses | |
HUP0401577A3 (en) | Process for the preparation of 2,4-didezoxyhexoses and 2,4,6-tridezoxyhexoses | |
HK1061009A1 (en) | Spherical alumina particles and production process thereof | |
EP1501870A4 (en) | RSV PROTEINS, ANTIBODIES, COMPOSITIONS, PROCESSES AND USES | |
AU2001234687A1 (en) | Fused -al2o3-mgo-y2o3 eutectic abrasive particles, abrasive articles, and methods of making and using the same |