IL158385A0 - Modified cyclosporin which can be used as a pro-drug and use thereof - Google Patents

Modified cyclosporin which can be used as a pro-drug and use thereof

Info

Publication number
IL158385A0
IL158385A0 IL15838502A IL15838502A IL158385A0 IL 158385 A0 IL158385 A0 IL 158385A0 IL 15838502 A IL15838502 A IL 15838502A IL 15838502 A IL15838502 A IL 15838502A IL 158385 A0 IL158385 A0 IL 158385A0
Authority
IL
Israel
Prior art keywords
pro
drug
modified cyclosporin
cyclosporin
modified
Prior art date
Application number
IL15838502A
Other languages
English (en)
Original Assignee
Debiopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa filed Critical Debiopharm Sa
Publication of IL158385A0 publication Critical patent/IL158385A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL15838502A 2001-04-20 2002-04-22 Modified cyclosporin which can be used as a pro-drug and use thereof IL158385A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH7202001 2001-04-20
PCT/CH2002/000222 WO2002085928A2 (fr) 2001-04-20 2002-04-22 Cyclosporine modifiee utilisable en tant que pro-drogue et son utilisation

Publications (1)

Publication Number Publication Date
IL158385A0 true IL158385A0 (en) 2004-05-12

Family

ID=4531478

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15838502A IL158385A0 (en) 2001-04-20 2002-04-22 Modified cyclosporin which can be used as a pro-drug and use thereof

Country Status (17)

Country Link
US (1) US6995139B2 (de)
EP (1) EP1379547B1 (de)
JP (1) JP4588979B2 (de)
KR (1) KR100932859B1 (de)
CN (1) CN1507451A (de)
AT (1) ATE313557T1 (de)
AU (1) AU2002245996B8 (de)
BR (1) BR0208923A (de)
CA (1) CA2444278C (de)
DE (1) DE60208180T2 (de)
ES (1) ES2256450T3 (de)
IL (1) IL158385A0 (de)
MX (1) MXPA03009586A (de)
RU (1) RU2290196C2 (de)
UA (1) UA75136C2 (de)
WO (1) WO2002085928A2 (de)
ZA (1) ZA200307794B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7354574B2 (en) 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
AU2004222306A1 (en) 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US7087237B2 (en) 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006039163A2 (en) 2004-09-29 2006-04-13 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008514702A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
CA2615990A1 (en) 2005-07-18 2007-01-25 Minu, L.L.C. Enhanced ocular neuroprotection/neurostimulation
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
WO2008013860A2 (en) 2006-07-28 2008-01-31 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of alpha-amino acids, methods of synthesis and use
WO2009042892A1 (en) 2007-09-26 2009-04-02 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) * 2008-02-08 2009-08-13 Debiopharm Sa Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
GB0912584D0 (en) * 2009-07-20 2009-08-26 Ucl Business Plc Cyclosporin conjugates
LT2651965T (lt) 2010-12-15 2019-01-10 Contravir Pharmaceuticals, Inc. Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis
AR090964A1 (es) * 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
CN113388002A (zh) * 2021-06-10 2021-09-14 梯尔希（南京）药物研发有限公司 一种环孢菌素相关化合物的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
ATE43335T1 (de) * 1980-02-14 1989-06-15 Sandoz Ag Peptide die einen (1s,2r,3r)- oder (1r,2s,3s)-1nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder hept-5-en-rest enthalten brauchbar in totaler synsthese von cyclosporinen, und verfahren zu ihrer herstellung.
US5169773A (en) * 1984-10-04 1992-12-08 Sandoz Ltd. Monoclonal antibodies to cyclosporins
DE3478398D1 (en) * 1984-10-10 1989-07-06 Ile De France Synergistic contraceptive mixture
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
DE69124459T3 (de) * 1990-11-02 2001-05-31 Novartis Ag, Basel Zyklosporine
GB9116836D0 (en) * 1991-08-05 1991-09-18 Sandoz Ltd Organic compounds
GB9204466D0 (en) * 1992-03-02 1992-04-15 Sandoz Ltd Improvements in or relating to organic compounds
US6187547B1 (en) * 1993-09-08 2001-02-13 Novartis Ag Assay kit
GB9624038D0 (en) * 1996-11-19 1997-01-08 Sandoz Ltd Organic compounds
US6017879A (en) * 1998-04-03 2000-01-25 B.M.R.A. Corporation B.V. Template associated NPY Y2-receptor agonists
USRE40987E1 (en) 1998-07-01 2009-11-17 Debiopharm S.A. Cyclosporin with improved activity profile
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
WO2000046239A1 (fr) * 1999-02-05 2000-08-10 Debiopharm S.A. Derives de cyclosporine et procede de preparation desdits derives
US6765019B1 (en) * 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
WO2001005819A1 (en) * 1999-07-15 2001-01-25 Kuhnil Pharm. Co., Ltd. Novel water soluble-cyclosporine conjugated compounds
EP2269654A3 (de) * 1999-08-24 2011-04-13 Cellgate Inc. Verbesserung des Verabreichung von Arzneimitteln durch und in epitheliale Gewebe rch Verwendung von Oligoarginin-Gruppen

Also Published As

Publication number Publication date
KR20030094357A (ko) 2003-12-11
MXPA03009586A (es) 2004-05-24
AU2002245996B8 (en) 2005-07-14
ZA200307794B (en) 2004-07-19
RU2003133742A (ru) 2005-03-20
AU2002245996B2 (en) 2005-06-30
EP1379547A2 (de) 2004-01-14
JP2004536051A (ja) 2004-12-02
KR100932859B1 (ko) 2009-12-23
US6995139B2 (en) 2006-02-07
EP1379547B1 (de) 2005-12-21
CA2444278A1 (en) 2002-10-31
RU2290196C2 (ru) 2006-12-27
CA2444278C (en) 2011-11-22
DE60208180T2 (de) 2006-08-17
BR0208923A (pt) 2004-04-27
ATE313557T1 (de) 2006-01-15
ES2256450T3 (es) 2006-07-16
WO2002085928A3 (fr) 2003-04-17
CN1507451A (zh) 2004-06-23
DE60208180D1 (de) 2006-01-26
WO2002085928A2 (fr) 2002-10-31
JP4588979B2 (ja) 2010-12-01
US20040138108A1 (en) 2004-07-15
UA75136C2 (en) 2006-03-15

Similar Documents

Publication Publication Date Title
IL158385A0 (en) Modified cyclosporin which can be used as a pro-drug and use thereof
AP2000001856A0 (en) Prodrugs of aspartyl protease inhibitors.
YU9404A (sh) Multimerna, usmerena kontrastna sredstva na bazi peptida
PL350456A1 (en) N−cyanomethylamides as protease inhibitors
EP1545483A4 (de) Nichtnukleosidische reverse-transkriptase-hemmer
ATE274330T1 (de) Gleitschutz fur einen gehäusekopf medizinischer instrumente
MY144318A (en) Methods of treating hiv infection.
AU3780901A (en) Pharmaceutical composition for muscular anabolism
SI1546127T1 (sl) Novi pirimidinamidni derivati in njihova uporaba
WO2002094189A3 (en) Compositions and methods for treating or preventing convulsions or seizures
PL366800A1 (en) Tablet comprising cetirizine and pseudoephedrine
WO2003092632A3 (en) Cyclic peptide anti-cancer agents and methods
BG108452A (en) Tablet comprising cetirizine and pseudoephedrine
AU2002246983A1 (en) 1,2-disubstituted cyclic inhibitors of matrix metallorproteases and tnf-alpha
DK1268522T3 (da) LH-RH-antagonister samt fremstilling deraf og anvendelse deraf som lægemidler
PL1603584T3 (pl) Aplidyna do leczenia szpiczaka mnogiego
MY128529A (en) Use of cilobradine or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
AU3739500A (en) Protease resistant flint analogs
HK1043534A1 (zh) 蛋白酶抑制剂
MXPA05009626A (es) Sistema de liberacion subcutanea, su proceso de preparacion y uso para el tratamiento de trastornos de deficiencia colinergica.
MXPA05009428A (es) Composiciones y metodos para prevenir y tratar enfermedades relacionadas con endotoxinas.
NZ533738A (en) Synthetic peptides and uses thereof for the prevention and therapy of cancer invasion and metastasis
GB0221169D0 (en) Crystal
ATE281522T1 (de) Sentrin-spezifische menschliche protease senp1
IL165996A0 (en) Novel thiophene acyl hydrazino derivatives method for preparing same use thereof as medicines pharmaceutical compositions and novel use

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees