IL156843A0 - Combined use of factor vii polypeptides and factor viii polypeptides - Google Patents
Combined use of factor vii polypeptides and factor viii polypeptidesInfo
- Publication number
- IL156843A0 IL156843A0 IL15684302A IL15684302A IL156843A0 IL 156843 A0 IL156843 A0 IL 156843A0 IL 15684302 A IL15684302 A IL 15684302A IL 15684302 A IL15684302 A IL 15684302A IL 156843 A0 IL156843 A0 IL 156843A0
- Authority
- IL
- Israel
- Prior art keywords
- factor
- polypeptides
- factor viii
- factor vii
- combined use
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200100186 | 2001-02-05 | ||
PCT/DK2002/000081 WO2002062377A2 (en) | 2001-02-05 | 2002-02-05 | Combined use of factor vii polypeptides and factor viii polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
IL156843A0 true IL156843A0 (en) | 2004-02-08 |
Family
ID=8160159
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15684202A IL156842A0 (en) | 2001-02-05 | 2002-02-05 | Combined use of factor vii polypeptides and factor ix polypeptides |
IL15684302A IL156843A0 (en) | 2001-02-05 | 2002-02-05 | Combined use of factor vii polypeptides and factor viii polypeptides |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15684202A IL156842A0 (en) | 2001-02-05 | 2002-02-05 | Combined use of factor vii polypeptides and factor ix polypeptides |
Country Status (16)
Country | Link |
---|---|
US (5) | US20030199444A1 (xx) |
EP (2) | EP1359936B1 (xx) |
JP (2) | JP2004517950A (xx) |
KR (2) | KR20030088430A (xx) |
CN (2) | CN1592632A (xx) |
AT (1) | ATE386538T1 (xx) |
AU (1) | AU2002229510A1 (xx) |
BR (2) | BR0207007A (xx) |
CA (2) | CA2436807A1 (xx) |
DE (1) | DE60225118T2 (xx) |
ES (1) | ES2301624T3 (xx) |
HU (2) | HUP0303130A2 (xx) |
IL (2) | IL156842A0 (xx) |
PL (2) | PL365293A1 (xx) |
RU (2) | RU2311923C2 (xx) |
WO (2) | WO2002062376A1 (xx) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050032690A1 (en) * | 1997-09-10 | 2005-02-10 | Rojkjaer Lisa Payne | Factor VII polypeptides for preventing formation of inhibitors in subjects with haemophilia |
US7786070B2 (en) | 1997-09-10 | 2010-08-31 | Novo Nordisk Healthcare A/G | Subcutaneous administration of coagulation factor VII |
US6905683B2 (en) | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
US7015194B2 (en) | 2000-05-10 | 2006-03-21 | Novo Nordisk A/S | Pharmaceutical composition comprising factor VIIa and anti-TFPI |
EP1282438B1 (en) * | 2000-05-10 | 2005-08-03 | Novo Nordisk Health Care AG | Use of pharmaceutical composition comprising a factor viia and a factor xiii |
CN101486761A (zh) | 2000-09-13 | 2009-07-22 | 诺沃挪第克健康护理股份公司 | 人凝血因子vii变体 |
AU2002218029A1 (en) | 2000-11-09 | 2002-05-21 | The Scripps Research Institute | Modified factor viia |
JP4537059B2 (ja) * | 2001-09-27 | 2010-09-01 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | ヒト凝固第vii因子ポリペプチド |
US7052868B2 (en) | 2001-09-27 | 2006-05-30 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
US6960657B2 (en) | 2001-11-02 | 2005-11-01 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
JP2006510568A (ja) * | 2001-11-09 | 2006-03-30 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Vii因子ポリペプチドおよびイプシロン―アミノカプロン酸を含む薬学的組成物 |
US20030119723A1 (en) * | 2001-11-09 | 2003-06-26 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and PAI-1 polypeptides |
US7291587B2 (en) | 2001-11-09 | 2007-11-06 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides |
US6911323B2 (en) | 2002-09-25 | 2005-06-28 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
CN101870729A (zh) | 2003-09-09 | 2010-10-27 | 诺和诺德医疗保健公司 | 凝固因子ⅶ多肽 |
PT1748781E (pt) * | 2004-05-27 | 2013-01-22 | Baxter Int | Processos para o tratamento de distúrbios de hemorragias utilizando polissacarídeos sulfatados |
EP1761274B1 (en) * | 2004-06-21 | 2009-09-02 | Novo Nordisk Health Care AG | Factor viia or factor viia equivalents for preventing or attentuating haemorrhage growth, and/or oedema generation following intracerebral haemorrhage (ich) |
JP5236952B2 (ja) * | 2005-02-28 | 2013-07-17 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 改善された特性を有するfxiiiバリアント |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
EP2046372A2 (en) * | 2006-07-17 | 2009-04-15 | Novo Nordisk Health Care AG | Factor viia analogues with increased activity for treating thrombocytopenia |
WO2008081024A1 (en) * | 2007-01-03 | 2008-07-10 | Novo Nordisk Health Care Ag | Subcutaneous administration of coagulation factor viia-related popypeptdes |
WO2008119815A1 (en) * | 2007-04-02 | 2008-10-09 | Novo Nordisk A/S | Subcutaneous administration of coagulation factor ix |
EP1988101A1 (en) * | 2007-05-04 | 2008-11-05 | Novo Nordisk A/S | Improvement of factor VIII polypeptide titers in cell cultures |
WO2009051717A2 (en) * | 2007-10-15 | 2009-04-23 | The University Of North Carolina At Chapel Hill | Human factor ix variants with an extended half life |
US8354377B2 (en) | 2008-01-18 | 2013-01-15 | Novo Nordisk Health Care Ag | Use of factor VIIa or factor VIIa equivalents for preventing or attenuating haemorrhage growth, and/or oedema generation following intracerebral haemorrhage (ICH) in a selected subpopulation of ICH patients |
TWI538916B (zh) | 2008-04-11 | 2016-06-21 | 介控生化科技公司 | 經修飾的因子vii多肽和其用途 |
SI2393828T1 (sl) | 2009-02-03 | 2017-01-31 | Amunix Operating Inc. | Podaljšani rekombinantni polipetidi in sestavki, ki jih obsegajo |
US8716448B2 (en) * | 2009-02-03 | 2014-05-06 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
WO2011020866A2 (en) * | 2009-08-20 | 2011-02-24 | Csl Behring Gmbh | Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders |
RS56957B1 (sr) * | 2009-12-06 | 2018-05-31 | Bioverativ Therapeutics Inc | Himerni i hibridni polipeptidi faktora viii-fc, i postupci za njihovu upotrebu |
JP2013517782A (ja) * | 2010-01-28 | 2013-05-20 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 因子vii融合ポリペプチド |
PL2624859T3 (pl) | 2010-10-06 | 2017-09-29 | Medimmune Limited | Czynnik ii samodzielnie lub w skojarzeniu z dalszymi czynnikami do leczenia zaburzeń hemostazy powiązanych z koagulopatią z rozcieńczenia |
US9175280B2 (en) * | 2010-10-12 | 2015-11-03 | Sangamo Biosciences, Inc. | Methods and compositions for treating hemophilia B |
DK2822577T3 (en) | 2012-02-15 | 2019-04-01 | Bioverativ Therapeutics Inc | RECOMBINANT FACTOR VIII PROTEINS |
EP3564260B1 (en) | 2012-02-15 | 2022-10-19 | Bioverativ Therapeutics Inc. | Factor viii compositions and methods of making and using same |
TWI667255B (zh) | 2013-08-14 | 2019-08-01 | 美商生物化學醫療公司 | 因子viii-xten融合物及其用途 |
GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
EP3331608A4 (en) | 2015-08-03 | 2019-05-01 | Bioverativ Therapeutics Inc. | FUSION XI FUSION PROTEINS AND METHODS OF MAKING AND USING THE SAME |
US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
US20210355231A1 (en) * | 2018-09-06 | 2021-11-18 | Board Of Regents, The University Of Texas System | Treatment and prevention of hemophilic arthropathy with an antibody against endothelial cell protein c receptor (epcr) |
EP3833381B1 (en) * | 2019-08-15 | 2022-08-03 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2550011C2 (de) * | 1975-11-07 | 1982-11-25 | Behringwerke Ag, 3550 Marburg | Verfahren zur Herstellung eines antihämophilen Mittels |
DE2759053A1 (de) * | 1977-12-30 | 1979-07-12 | Uhlin | Verfahren zum herstellen von genprodukten von plasmid-dns |
DE3165600D1 (en) * | 1980-01-28 | 1984-09-27 | Baxter Travenol Lab | Prothrombin-containing therapeutic compositions and methods of producing enzymatically active blood clotting factors from prothrombin-containing blood fractions |
US4381119A (en) * | 1980-12-17 | 1983-04-26 | Burroughs Corporation | Multipart continuous form |
US4501731A (en) * | 1983-06-27 | 1985-02-26 | Tishkoff Garson H | Treatment of disparate bleeding disorders with factor X zymogen |
DK525384D0 (da) * | 1984-11-05 | 1984-11-05 | Nordisk Insulinlab | Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat |
US5451521A (en) * | 1986-05-29 | 1995-09-19 | Genetics Institute, Inc. | Procoagulant proteins |
DE19531637A1 (de) * | 1995-08-28 | 1997-03-06 | Immuno Ag | Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung |
EP1282438B1 (en) * | 2000-05-10 | 2005-08-03 | Novo Nordisk Health Care AG | Use of pharmaceutical composition comprising a factor viia and a factor xiii |
US7015194B2 (en) * | 2000-05-10 | 2006-03-21 | Novo Nordisk A/S | Pharmaceutical composition comprising factor VIIa and anti-TFPI |
US6825323B2 (en) * | 2001-01-10 | 2004-11-30 | The United States Of America As Represented By The Secretary Of The Army | Compositions for treatment of hemorrhaging with activated factor VIIa in combination with fibrinogen and methods of using same |
US20030203845A1 (en) * | 2001-02-05 | 2003-10-30 | Knudsen Jens Bjerre | Combined use of factor VII polypeptides and factor IX polypeptides |
US20030119741A1 (en) * | 2001-11-09 | 2003-06-26 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and aprotinin polypeptides |
US20060025336A1 (en) * | 2001-07-16 | 2006-02-02 | Novo Nordisk A/S | Pharmaceutical compositions comprising combinations of factor VII polypeptides and aprotinin polypeptides |
US7419949B2 (en) * | 2001-07-16 | 2008-09-02 | Novo Noridsk Healthcare A/G | Single-dose administration of factor VIIa |
US20030040480A1 (en) * | 2001-07-20 | 2003-02-27 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides |
US7291587B2 (en) * | 2001-11-09 | 2007-11-06 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides |
JP2006510568A (ja) * | 2001-11-09 | 2006-03-30 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Vii因子ポリペプチドおよびイプシロン―アミノカプロン酸を含む薬学的組成物 |
EP1446150A1 (en) * | 2001-11-09 | 2004-08-18 | Novo Nordisk Health Care AG | Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors |
US20030119723A1 (en) * | 2001-11-09 | 2003-06-26 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and PAI-1 polypeptides |
JP2005526004A (ja) * | 2001-11-09 | 2005-09-02 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第vii因子ポリペプチドおよびトラネキサム酸を含む薬学的組成物 |
US20030119743A1 (en) * | 2001-11-09 | 2003-06-26 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and tissue plasminogen inhibitors |
US7125846B2 (en) * | 2001-11-09 | 2006-10-24 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides |
US20030124118A1 (en) * | 2001-11-27 | 2003-07-03 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and protein S inhibitors |
US20030118580A1 (en) * | 2001-11-09 | 2003-06-26 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and thrombomodulin polypeptides |
US7078479B2 (en) * | 2001-11-09 | 2006-07-18 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and alpha2-antiplasmin polypeptides |
-
2002
- 2002-02-05 EP EP02710762A patent/EP1359936B1/en not_active Expired - Lifetime
- 2002-02-05 RU RU2003127018/15A patent/RU2311923C2/ru not_active IP Right Cessation
- 2002-02-05 KR KR10-2003-7010192A patent/KR20030088430A/ko not_active Application Discontinuation
- 2002-02-05 AU AU2002229510A patent/AU2002229510A1/en not_active Abandoned
- 2002-02-05 BR BR0207007-3A patent/BR0207007A/pt not_active IP Right Cessation
- 2002-02-05 HU HU0303130A patent/HUP0303130A2/hu unknown
- 2002-02-05 WO PCT/DK2002/000080 patent/WO2002062376A1/en active Application Filing
- 2002-02-05 DE DE60225118T patent/DE60225118T2/de not_active Expired - Lifetime
- 2002-02-05 PL PL02365293A patent/PL365293A1/xx not_active Application Discontinuation
- 2002-02-05 HU HU0303143A patent/HUP0303143A2/hu unknown
- 2002-02-05 JP JP2002562383A patent/JP2004517950A/ja active Pending
- 2002-02-05 IL IL15684202A patent/IL156842A0/xx unknown
- 2002-02-05 CA CA002436807A patent/CA2436807A1/en not_active Abandoned
- 2002-02-05 RU RU2003126911/15A patent/RU2292909C2/ru not_active IP Right Cessation
- 2002-02-05 ES ES02710762T patent/ES2301624T3/es not_active Expired - Lifetime
- 2002-02-05 JP JP2002562382A patent/JP2004517949A/ja active Pending
- 2002-02-05 CN CNA028076184A patent/CN1592632A/zh active Pending
- 2002-02-05 EP EP02710761A patent/EP1359935A1/en not_active Ceased
- 2002-02-05 WO PCT/DK2002/000081 patent/WO2002062377A2/en active IP Right Grant
- 2002-02-05 CA CA002437015A patent/CA2437015A1/en not_active Abandoned
- 2002-02-05 KR KR10-2003-7010193A patent/KR20030078901A/ko not_active Application Discontinuation
- 2002-02-05 CN CNA028076192A patent/CN1499981A/zh active Pending
- 2002-02-05 BR BR0207006-5A patent/BR0207006A/pt not_active IP Right Cessation
- 2002-02-05 AT AT02710762T patent/ATE386538T1/de not_active IP Right Cessation
- 2002-02-05 IL IL15684302A patent/IL156843A0/xx unknown
- 2002-02-05 PL PL02365290A patent/PL365290A1/xx not_active Application Discontinuation
-
2003
- 2003-01-08 US US10/338,471 patent/US20030199444A1/en not_active Abandoned
-
2006
- 2006-05-18 US US11/436,491 patent/US20060211621A1/en not_active Abandoned
- 2006-07-25 US US11/492,461 patent/US20060276398A1/en not_active Abandoned
-
2007
- 2007-10-04 US US11/867,336 patent/US20080076702A1/en not_active Abandoned
- 2007-10-04 US US11/867,140 patent/US20080075711A1/en not_active Abandoned
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