IL156779A0 - Purine derivatives as purinergic receptor antagonists - Google Patents
Purine derivatives as purinergic receptor antagonistsInfo
- Publication number
- IL156779A0 IL156779A0 IL15677902A IL15677902A IL156779A0 IL 156779 A0 IL156779 A0 IL 156779A0 IL 15677902 A IL15677902 A IL 15677902A IL 15677902 A IL15677902 A IL 15677902A IL 156779 A0 IL156779 A0 IL 156779A0
- Authority
- IL
- Israel
- Prior art keywords
- sub
- alkyl
- aryl
- conr
- disorder
- Prior art date
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 239000000111 purinergic antagonist Substances 0.000 title 1
- 229940121374 purinergic receptor antagonist Drugs 0.000 title 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- -1 0thioalkyl Chemical group 0.000 abstract 1
- 102000009346 Adenosine receptors Human genes 0.000 abstract 1
- 108050000203 Adenosine receptors Proteins 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 208000016285 Movement disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 102000000033 Purinergic Receptors Human genes 0.000 abstract 1
- 108010080192 Purinergic Receptors Proteins 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 206010027175 memory impairment Diseases 0.000 abstract 1
- 201000003631 narcolepsy Diseases 0.000 abstract 1
- 230000004112 neuroprotection Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000005000 thioaryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0100623.8A GB0100623D0 (en) | 2001-01-10 | 2001-01-10 | Chemical compounds IV |
| PCT/GB2002/000076 WO2002055521A1 (en) | 2001-01-10 | 2002-01-10 | Purine derivatives as purinergic receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL156779A0 true IL156779A0 (en) | 2004-02-08 |
Family
ID=9906570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15677902A IL156779A0 (en) | 2001-01-10 | 2002-01-10 | Purine derivatives as purinergic receptor antagonists |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7452894B2 (cs) |
| EP (1) | EP1349857B1 (cs) |
| JP (1) | JP4284069B2 (cs) |
| KR (1) | KR20030079945A (cs) |
| CN (1) | CN1617871A (cs) |
| AT (1) | ATE471323T1 (cs) |
| AU (1) | AU2002217331B2 (cs) |
| BR (1) | BR0206561A (cs) |
| CA (1) | CA2433858C (cs) |
| CZ (1) | CZ20031956A3 (cs) |
| DE (1) | DE60236719D1 (cs) |
| GB (1) | GB0100623D0 (cs) |
| HU (1) | HUP0402504A2 (cs) |
| IL (1) | IL156779A0 (cs) |
| MX (1) | MXPA03006163A (cs) |
| NO (1) | NO20033145L (cs) |
| NZ (1) | NZ527249A (cs) |
| PL (1) | PL363172A1 (cs) |
| RU (1) | RU2003124653A (cs) |
| WO (1) | WO2002055521A1 (cs) |
| YU (1) | YU55603A (cs) |
| ZA (1) | ZA200305116B (cs) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4222837B2 (ja) * | 2001-04-05 | 2009-02-12 | 住友化学株式会社 | 2,6−ジハロゲノプリンの製法 |
| EP1440072A4 (en) | 2001-10-30 | 2005-02-02 | Conforma Therapeutic Corp | PURINE ANALOGS HAVING HSP90 INHIBITORY ACTIVITY |
| US7414036B2 (en) | 2002-01-25 | 2008-08-19 | Muscagen Limited | Compounds useful as A3 adenosine receptor agonists |
| DE10252650A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
| NZ546611A (en) * | 2003-09-18 | 2010-02-26 | Conforma Therapeutics Corp | Novel heterocyclic compounds as HSP90-inhibitors |
| JPWO2005085210A1 (ja) * | 2004-03-10 | 2008-01-17 | 小野薬品工業株式会社 | ニトリル化合物およびその化合物を有効成分として含有する医薬組成物 |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| BRPI0609509A2 (pt) | 2005-03-30 | 2010-04-13 | Conforma Therapeutics Corp | composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável |
| WO2007035873A1 (en) * | 2005-09-21 | 2007-03-29 | Pharmacopeia, Inc. | Purinone derivatives for treating neurodegenerative diseases |
| CN1947717B (zh) * | 2005-10-14 | 2012-09-26 | 卓敏 | 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用 |
| US7989459B2 (en) | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
| US7902187B2 (en) | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| CL2007002867A1 (es) | 2006-10-04 | 2008-06-27 | Pharmacopeia Inc | Compuestos derivados de 2-(bencimidazolil)purina, inhibidores de janus quinasa 3; composicion farmaceutica que los contiene; y su uso para tratar enfermedades autoinmune, inflamatorias, cardiovasculares, rechazo de implante, entre otras. |
| CL2007002866A1 (es) | 2006-10-04 | 2008-07-04 | Pharmacopeia Inc | Compuestos derivados de 6-sustituidos-2-(bencimidazolil) purina y purinona; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades autoinmunes, enfermedad inflamatoria, enfermedad mediada por m |
| US20090054468A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
| DK2209786T3 (da) * | 2007-10-05 | 2013-06-03 | Verastem Inc | Pyrimidinsubstituerede purinderivater |
| GB0906579D0 (en) * | 2009-04-16 | 2009-05-20 | Vernalis R&D Ltd | Pharmaceuticals, compositions and methods of making and using the same |
| CN102428085B (zh) | 2009-04-03 | 2015-07-15 | 维拉斯通股份有限公司 | 作为激酶抑制剂的嘧啶取代的嘌呤化合物 |
| ES2572915T3 (es) | 2011-06-02 | 2016-06-03 | The University Of Louisville Research Foundation, Inc. | Nanopartículas conjugadas a un agente antinucleolina |
| WO2012172043A1 (en) * | 2011-06-15 | 2012-12-20 | Laboratoire Biodim | Purine derivatives and their use as pharmaceuticals for prevention or treatment of bacterial infections |
| CN104284895B (zh) * | 2012-04-17 | 2016-08-31 | 安斯泰来制药株式会社 | 含氮双环式芳香族杂环化合物 |
| WO2018093758A1 (en) * | 2016-11-18 | 2018-05-24 | The Procter & Gamble Company | Fabric treatment compositions and methods for providing a benefit |
| US10870816B2 (en) | 2016-11-18 | 2020-12-22 | The Procter & Gamble Company | Fabric treatment compositions having low calculated cationic charge density polymers and fabric softening actives and methods for providing a benefit |
| JP7137225B2 (ja) * | 2017-08-21 | 2022-09-14 | 国立大学法人三重大学 | 非ヒト哺乳類の脳梗塞モデルによる観察方法及び非ヒト哺乳類の脳梗塞モデルによる観察装置 |
| CN107903274A (zh) * | 2017-12-28 | 2018-04-13 | 窦玉玲 | 一种胺类化合物及其在抗肿瘤药物中的应用 |
| CN114025758B (zh) * | 2019-07-01 | 2026-05-08 | 钱立刚 | P2x7r拮抗剂 |
| KR20210061202A (ko) * | 2019-11-19 | 2021-05-27 | 일동제약(주) | 벤조나이트릴이 치환된 축합 피리미딘 유도체 및 그의 의약 용도 |
| US11787775B2 (en) * | 2020-07-24 | 2023-10-17 | Genentech, Inc. | Therapeutic compounds and methods of use |
| US11806350B2 (en) | 2020-11-19 | 2023-11-07 | Ildong Pharmaceutical Co., Ltd. | Prevention and/or treatment of CNS disorders |
| CN116589464B (zh) * | 2022-02-14 | 2025-10-31 | 上海科技大学 | 嘧啶并环类化合物、其制备方法和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3630997A (en) * | 1970-05-04 | 1971-12-28 | Paul M Craven | Curable epoxy resin compositions and method of preparing same |
| US5064745A (en) * | 1988-02-25 | 1991-11-12 | Mitsubishi Paper Mills, Ltd. | Method for making lithographic printing plate |
| US5403932A (en) * | 1988-05-25 | 1995-04-04 | Research Corporation Technologies, Inc. | Phosphoramidates useful as antitumor agents |
| US5968989A (en) * | 1991-12-18 | 1999-10-19 | The Salk Institute For Biological Studies | Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor |
| IL108523A0 (en) * | 1993-02-03 | 1994-05-30 | Gensia Inc | Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain |
| DE4330735A1 (de) * | 1993-09-10 | 1995-03-16 | Wacker Chemie Gmbh | Hydrophile Gruppen aufweisende Organopolysiloxane |
| US5789416B1 (en) | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| JP2002507996A (ja) | 1997-07-03 | 2002-03-12 | デュポン ファーマシューティカルズ カンパニー | 神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類 |
| WO1999026627A1 (en) * | 1997-11-26 | 1999-06-03 | Cerebrus Limited | (-)-mefloquine to block purinergic receptors and to treat movement or neurodegenerative disorders |
| CA2315736A1 (en) | 1998-01-05 | 1999-07-15 | Eisai Co., Ltd. | Purine compounds and adenosine a2 receptor antagonist as preventive or therapeutic for diabetes mellitus |
| JPH11279193A (ja) * | 1998-03-24 | 1999-10-12 | Akira Matsuda | アデノシン誘導体 |
| GB9819382D0 (en) * | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds I |
| GB9819384D0 (en) * | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| GB9915437D0 (en) * | 1999-07-01 | 1999-09-01 | Cerebrus Ltd | Chemical compounds III |
| DE60022366T2 (de) | 1999-07-02 | 2006-06-14 | Eisai Co Ltd | Kondensierte imidazolderivate und arzneimittel gegen diabetes mellitus |
| AU2001255620A1 (en) * | 2000-04-26 | 2001-11-07 | Warner-Lambert Company | Cyclohexylamine derivative as subtype selective NMDA receptor antagonists |
| US6903238B2 (en) * | 2001-12-13 | 2005-06-07 | Wyeth | Substituted indenones as estrogenic agents |
| US6946005B2 (en) * | 2002-03-27 | 2005-09-20 | L'oreal S.A. | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers |
| DE10326303A1 (de) * | 2003-06-11 | 2004-12-30 | Celares Gmbh | Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung |
| US20060211698A1 (en) * | 2005-01-14 | 2006-09-21 | Genelabs, Inc. | Bicyclic heteroaryl derivatives for treating viruses |
| JP5190364B2 (ja) * | 2005-09-09 | 2013-04-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 大環状ペプチドの調製の為の閉環メタセシス工程 |
| EP1965805B1 (en) * | 2005-11-25 | 2009-12-02 | Galapagos SAS | Urea derivatives useful as calcium receptor modulators |
| US8143236B2 (en) * | 2005-12-13 | 2012-03-27 | Bionumerik Pharmaceuticals, Inc. | Chemoprotective methods |
| US20080045498A1 (en) * | 2006-07-20 | 2008-02-21 | Genelabs Technologies, Inc. | Polycyclic viral inhibitors |
-
2001
- 2001-01-10 GB GBGB0100623.8A patent/GB0100623D0/en not_active Ceased
-
2002
- 2002-01-10 IL IL15677902A patent/IL156779A0/xx unknown
- 2002-01-10 RU RU2003124653/04A patent/RU2003124653A/ru not_active Application Discontinuation
- 2002-01-10 AU AU2002217331A patent/AU2002217331B2/en not_active Ceased
- 2002-01-10 WO PCT/GB2002/000076 patent/WO2002055521A1/en not_active Ceased
- 2002-01-10 DE DE60236719T patent/DE60236719D1/de not_active Expired - Lifetime
- 2002-01-10 BR BR0206561-4A patent/BR0206561A/pt not_active Application Discontinuation
- 2002-01-10 JP JP2002556190A patent/JP4284069B2/ja not_active Expired - Fee Related
- 2002-01-10 YU YU55603A patent/YU55603A/sh unknown
- 2002-01-10 PL PL02363172A patent/PL363172A1/xx not_active Application Discontinuation
- 2002-01-10 CN CNA028062582A patent/CN1617871A/zh active Pending
- 2002-01-10 AT AT02729444T patent/ATE471323T1/de not_active IP Right Cessation
- 2002-01-10 CZ CZ20031956A patent/CZ20031956A3/cs unknown
- 2002-01-10 US US10/250,941 patent/US7452894B2/en not_active Expired - Fee Related
- 2002-01-10 NZ NZ527249A patent/NZ527249A/xx unknown
- 2002-01-10 CA CA2433858A patent/CA2433858C/en not_active Expired - Fee Related
- 2002-01-10 MX MXPA03006163A patent/MXPA03006163A/es unknown
- 2002-01-10 EP EP02729444A patent/EP1349857B1/en not_active Expired - Lifetime
- 2002-01-10 KR KR10-2003-7009241A patent/KR20030079945A/ko not_active Withdrawn
- 2002-01-10 HU HU0402504A patent/HUP0402504A2/hu unknown
-
2003
- 2003-07-01 ZA ZA200305116A patent/ZA200305116B/xx unknown
- 2003-07-09 NO NO20033145A patent/NO20033145L/no not_active Application Discontinuation
-
2006
- 2006-07-19 US US11/488,750 patent/US20060270691A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200305116B (en) | 2004-07-01 |
| US7452894B2 (en) | 2008-11-18 |
| NZ527249A (en) | 2005-04-29 |
| NO20033145D0 (no) | 2003-07-09 |
| MXPA03006163A (es) | 2003-09-16 |
| DE60236719D1 (de) | 2010-07-29 |
| CA2433858C (en) | 2010-12-14 |
| US20040102459A1 (en) | 2004-05-27 |
| HUP0402504A2 (hu) | 2005-04-28 |
| BR0206561A (pt) | 2004-06-22 |
| CA2433858A1 (en) | 2002-07-18 |
| US20060270691A1 (en) | 2006-11-30 |
| EP1349857A1 (en) | 2003-10-08 |
| PL363172A1 (en) | 2004-11-15 |
| EP1349857B1 (en) | 2010-06-16 |
| KR20030079945A (ko) | 2003-10-10 |
| NO20033145L (no) | 2003-09-09 |
| CZ20031956A3 (cs) | 2003-11-12 |
| ATE471323T1 (de) | 2010-07-15 |
| AU2002217331B2 (en) | 2006-06-29 |
| RU2003124653A (ru) | 2005-01-10 |
| YU55603A (sh) | 2006-05-25 |
| GB0100623D0 (en) | 2001-02-21 |
| WO2002055521A1 (en) | 2002-07-18 |
| JP4284069B2 (ja) | 2009-06-24 |
| JP2004517874A (ja) | 2004-06-17 |
| CN1617871A (zh) | 2005-05-18 |
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