ES2185985T3 - Derivados de 4-aminoetoxiindolona como agonistas del receptor d2 de dopamina. - Google Patents

Derivados de 4-aminoetoxiindolona como agonistas del receptor d2 de dopamina.

Info

Publication number
ES2185985T3
ES2185985T3 ES97938630T ES97938630T ES2185985T3 ES 2185985 T3 ES2185985 T3 ES 2185985T3 ES 97938630 T ES97938630 T ES 97938630T ES 97938630 T ES97938630 T ES 97938630T ES 2185985 T3 ES2185985 T3 ES 2185985T3
Authority
ES
Spain
Prior art keywords
hydrogen
dopamine
aminoetoxiindolone
agenists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97938630T
Other languages
English (en)
Inventor
Richard Eric Mewshaw
Michael Byron Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of ES2185985T3 publication Critical patent/ES2185985T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE Y ES HIDROGENO, HALOGENO O ALCOXI; R ES HIDROGENO O ALQUILTIO; R 1 ES HIDROGENO O ALQUILO; X ES HIDROGENO, HALOGENO, ALCOXI, ALQUILO O FENILO; N ES UNO DE LOS ENTEROS 1, 2, 3 O 4; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. DICHOS COMPUESTOS SON INHIBIDORES DE LA SINTESIS Y LIBERACION DE DOPAMINA, UTILES PARA EL TRATAMIENTO DE LA ESQUIZOFRENIA, LA ENFERMEDAD DE PARKINSON, EL SINDROME DE GILLES DE LA TOURETTE, LA ADICCION AL ALCOHOL, A LA COCAINA Y A DROGAS ANALOGAS.
ES97938630T 1996-08-27 1997-08-26 Derivados de 4-aminoetoxiindolona como agonistas del receptor d2 de dopamina. Expired - Lifetime ES2185985T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70360696A 1996-08-27 1996-08-27

Publications (1)

Publication Number Publication Date
ES2185985T3 true ES2185985T3 (es) 2003-05-01

Family

ID=24826054

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97938630T Expired - Lifetime ES2185985T3 (es) 1996-08-27 1997-08-26 Derivados de 4-aminoetoxiindolona como agonistas del receptor d2 de dopamina.

Country Status (12)

Country Link
EP (1) EP0923576B1 (es)
JP (1) JP2000517318A (es)
KR (1) KR20000035822A (es)
CN (1) CN1077890C (es)
AT (1) ATE227284T1 (es)
AU (1) AU4091797A (es)
CA (1) CA2264072A1 (es)
DE (1) DE69716932T2 (es)
DK (1) DK0923576T3 (es)
ES (1) ES2185985T3 (es)
PT (1) PT923576E (es)
WO (1) WO1998008843A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2278747A1 (en) * 1997-02-18 1998-08-20 James Albert Nelson 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives, their preparation and their use as dopamine autoreceptor (d2) agonists
US5990144A (en) * 1997-02-18 1999-11-23 American Home Products Corporation 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one dopamine autoreceptor agonists
CN114507162A (zh) * 2020-11-16 2022-05-17 尚科生物医药（上海）有限公司 一种制备2-氟-5-甲氧基苯磺酰氯的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
IL119483A (en) * 1995-11-06 1999-06-20 American Home Prod 2-(Aminomethyl)-3,4,7,9- tetrahydro- 2H-pyrano-2[3,3-e]indol-8-ones their derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PT923576E (pt) 2003-02-28
JP2000517318A (ja) 2000-12-26
DE69716932T2 (de) 2003-03-27
DK0923576T3 (da) 2003-03-03
CN1234033A (zh) 1999-11-03
AU4091797A (en) 1998-03-19
EP0923576A1 (en) 1999-06-23
CN1077890C (zh) 2002-01-16
EP0923576B1 (en) 2002-11-06
CA2264072A1 (en) 1998-03-05
WO1998008843A1 (en) 1998-03-05
DE69716932D1 (de) 2002-12-12
KR20000035822A (ko) 2000-06-26
ATE227284T1 (de) 2002-11-15

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