IL156314A0 - Arylated furane and thiophene carboxylic acid amides with potassium channel blocking effect - Google Patents

Arylated furane and thiophene carboxylic acid amides with potassium channel blocking effect

Info

Publication number
IL156314A0
IL156314A0 IL15631401A IL15631401A IL156314A0 IL 156314 A0 IL156314 A0 IL 156314A0 IL 15631401 A IL15631401 A IL 15631401A IL 15631401 A IL15631401 A IL 15631401A IL 156314 A0 IL156314 A0 IL 156314A0
Authority
IL
Israel
Prior art keywords
arylated
furane
carboxylic acid
acid amides
potassium channel
Prior art date
Application number
IL15631401A
Other languages
English (en)
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of IL156314A0 publication Critical patent/IL156314A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL15631401A 2000-12-12 2001-11-29 Arylated furane and thiophene carboxylic acid amides with potassium channel blocking effect IL156314A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10061876A DE10061876A1 (de) 2000-12-12 2000-12-12 Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013958 WO2002048131A1 (de) 2000-12-12 2001-11-29 Arylierte furan- und thiophencarbonsäureamide mit kalium kanal blockierender wirkung

Publications (1)

Publication Number Publication Date
IL156314A0 true IL156314A0 (en) 2004-01-04

Family

ID=7666837

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15631401A IL156314A0 (en) 2000-12-12 2001-11-29 Arylated furane and thiophene carboxylic acid amides with potassium channel blocking effect
IL156314A IL156314A (en) 2000-12-12 2003-06-04 Amylation of carboxylic acids Poren and typhoon that have been aerated with a blocking effect on potassium channels

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL156314A IL156314A (en) 2000-12-12 2003-06-04 Amylation of carboxylic acids Poren and typhoon that have been aerated with a blocking effect on potassium channels

Country Status (30)

Country Link
US (1) US6982279B2 (zh)
EP (1) EP1349846B1 (zh)
JP (1) JP4252798B2 (zh)
KR (1) KR20030061846A (zh)
CN (1) CN1225463C (zh)
AR (1) AR032781A1 (zh)
AT (1) ATE288906T1 (zh)
AU (2) AU2002235743B2 (zh)
BR (1) BR0116084A (zh)
CA (1) CA2431095A1 (zh)
CZ (1) CZ20031633A3 (zh)
DE (2) DE10061876A1 (zh)
DK (1) DK1349846T3 (zh)
EE (1) EE05306B1 (zh)
ES (1) ES2236335T3 (zh)
HK (1) HK1061850A1 (zh)
HR (1) HRP20030469A2 (zh)
HU (1) HUP0303665A3 (zh)
IL (2) IL156314A0 (zh)
MX (1) MXPA03004770A (zh)
NO (1) NO329163B1 (zh)
NZ (1) NZ526383A (zh)
PL (1) PL362410A1 (zh)
PT (1) PT1349846E (zh)
RS (1) RS50336B (zh)
RU (1) RU2275366C2 (zh)
SK (1) SK287464B6 (zh)
TW (1) TWI288134B (zh)
WO (1) WO2002048131A1 (zh)
ZA (1) ZA200304091B (zh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
JP4544857B2 (ja) * 2001-06-11 2010-09-15 ヴァイロケム ファーマ インコーポレイテッド Ｆｌａｖｉｖｉｒｕｓ感染の治療または予防のための化合物および方法
US7402608B2 (en) * 2002-12-10 2008-07-22 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of Flavivirus infections
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
EP1493739A1 (fr) * 2003-07-03 2005-01-05 Warner-Lambert Company LLC Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
KR20080016597A (ko) * 2005-05-13 2008-02-21 바이로켐 파마 인코포레이티드 플라비바이러스 감염의 예방 또는 치료용 화합물 및 그의예방 또는 치료 방법
US8278317B2 (en) * 2005-07-22 2012-10-02 Merck Sharp & Dohme Corp. Potassium channel inhibitors
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
CN101636154B (zh) * 2006-04-27 2011-12-14 塞诺菲-安万特德国有限公司 Task-1和task-3离子通道抑制剂
KR20090086081A (ko) * 2006-11-15 2009-08-10 바이로켐 파마 인코포레이티드 플라비바이러스 감염의 치료 또는 예방용 티오펜 유사체
US8263641B2 (en) 2007-09-10 2012-09-11 Calcimedica, Inc. Compounds that modulate intracellular calcium
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
US8389567B2 (en) 2007-12-12 2013-03-05 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN102256969A (zh) 2008-08-27 2011-11-23 钙医学公司 调节胞内钙的化合物
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
PE20120003A1 (es) * 2009-01-30 2012-02-12 Glaxosmithkline Llc Hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil)etil}-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino
US8618307B2 (en) 2009-09-16 2013-12-31 Calcimedica, Inc. Compounds that modulate intracellular calcium
MX2012014273A (es) 2010-06-07 2013-03-22 Novomedix Llc Compuestos furanilo y su uso.
CA2809830C (en) 2010-08-27 2019-09-10 Calcimedica, Inc. Compounds comprising n-acyl-2-amino-1,3-thiazole for modulating intracellular calcium
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (zh) 2011-07-01 2018-04-28
NZ627942A (en) 2012-01-27 2016-03-31 Gilead Sciences Inc Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103012381B (zh) * 2013-01-10 2015-01-07 山东大学 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用
KR101721490B1 (ko) * 2014-07-30 2017-03-30 한국생명공학연구원 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물
EP3366683A1 (en) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9214120D0 (en) * 1991-07-25 1992-08-12 Ici Plc Therapeutic amides
DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5670504A (en) 1995-02-23 1997-09-23 Merck & Co. Inc. 2,6-diaryl pyridazinones with immunosuppressant activity
US6083986A (en) 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
US5969017A (en) 1996-10-31 1999-10-19 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US5935945A (en) 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US6013664A (en) * 1996-11-27 2000-01-11 Bayer Aktiengesellschaft Microbicidal agents based on thiophene-2-carboxylic acid derivatives
CN1265643A (zh) * 1997-08-05 2000-09-06 美国家用产品公司 邻氨基苯甲酸类似物
CA2315070A1 (en) * 1997-12-17 1999-07-01 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
US6333337B1 (en) * 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
WO1999041231A1 (fr) * 1998-02-17 1999-08-19 Ono Pharmaceutical Co., Ltd. Derives amidino utilises comme ingredients actifs et medicaments les contenant
EP0960882A1 (en) * 1998-05-19 1999-12-01 Hoechst Marion Roussel Deutschland GmbH Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
EP1082315A1 (en) 1998-06-05 2001-03-14 Icagen, Inc. Potassium channel inhibitors
AU754204B2 (en) 1998-09-01 2002-11-07 Bristol-Myers Squibb Company Potassium channel inhibitors and method
AU5379900A (en) * 1999-06-07 2000-12-28 Shire Biochem Inc. Thiophene integrin inhibitors
EP1419161A1 (en) * 2001-08-24 2004-05-19 PHARMACIA & UPJOHN COMPANY Substituted-heteroaryl-7-aza 2.2.1]bicycloheptanes for the treatment of disease

Also Published As

Publication number Publication date
US20040068120A1 (en) 2004-04-08
AU3574302A (en) 2002-06-24
EP1349846B1 (de) 2005-02-09
CA2431095A1 (en) 2002-06-20
HUP0303665A2 (hu) 2004-03-01
KR20030061846A (ko) 2003-07-22
WO2002048131A1 (de) 2002-06-20
EE200300240A (et) 2003-08-15
TWI288134B (en) 2007-10-11
RU2275366C2 (ru) 2006-04-27
EE05306B1 (et) 2010-06-15
HK1061850A1 (en) 2004-10-08
NO20032535L (no) 2003-07-29
IL156314A (en) 2008-12-29
AR032781A1 (es) 2003-11-26
AU2002235743B2 (en) 2006-07-20
DE50105337D1 (de) 2005-03-17
CZ20031633A3 (cs) 2003-08-13
ATE288906T1 (de) 2005-02-15
PL362410A1 (en) 2004-11-02
RS50336B (sr) 2009-11-10
NO20032535D0 (no) 2003-06-04
HRP20030469A2 (en) 2005-04-30
MXPA03004770A (es) 2003-09-10
DE10061876A1 (de) 2002-06-20
SK287464B6 (sk) 2010-10-07
US6982279B2 (en) 2006-01-03
EP1349846A1 (de) 2003-10-08
ZA200304091B (en) 2004-04-23
YU42503A (sh) 2006-05-25
JP4252798B2 (ja) 2009-04-08
ES2236335T3 (es) 2005-07-16
SK7252003A3 (en) 2003-12-02
NO329163B1 (no) 2010-08-30
CN1479734A (zh) 2004-03-03
CN1225463C (zh) 2005-11-02
HUP0303665A3 (en) 2005-02-28
NZ526383A (en) 2004-11-26
PT1349846E (pt) 2005-05-31
DK1349846T3 (da) 2005-05-30
BR0116084A (pt) 2003-10-14
JP2004526680A (ja) 2004-09-02

Similar Documents

Publication Publication Date Title
IL156314A0 (en) Arylated furane and thiophene carboxylic acid amides with potassium channel blocking effect
AU2002235743A1 (en) Arylated furane and thiophene carboxylic acid amides with potassium channel blocking effect
IL146269A0 (en) Fet with notched gate
EG23122A (en) Pyrrolcarboxamides and pyrrolcarbothioamides
AU9667901A (en) Mycoattractants and mycopesticides
DE60134697D1 (de) Befestigungselement mit U-förmiger Mutter
AU2486102A (en) Mild cosmetic composition with stabilized retinoids
DE60106923D1 (de) Schutzkappen mit gerollter schürze
AU8439201A (en) Bis-heterocyclic compounds with antitumour and chemosensitising activity
DE60002237T2 (de) Befestigungsvorrichtung mit gestricktem Band
SI1349846T1 (en) Arylated furane and thiophene carboxylic acid amides with potassium channel blocking effect
EP1350090A4 (en) COMBINED OXYGEN AND NOx SENSOR
IL154633A0 (en) Substituted phenylcyclohexane carboxylic acid amides and the use thereof
GB0216544D0 (en) Direct coal-based continuous steelmaking
HK1045908A1 (zh) 具有優化生產並減輕重量的顯像漏斗的顯像管
HU0002560D0 (en) Wine with beer-tasting and curative effect
TW435091U (en) Underpants with dividing structure
TW441394U (en) Scooter with visual and audio effect
WO2002008175A3 (en) Arginine saccharate and use thereof
NO20000794D0 (no) Rundballepresse med integrert ultra-rask wrapping
GB0011720D0 (en) Hydroxamic and carboxylic acid derivatives
HU9801853D0 (en) Construction set with holed straw
HU0002418D0 (en) Motor-sprayer with diving-pump and system
ES1046726Y (es) Dispositivo de adaptacion de barandillas y otros elementos a flataformas rodantes.
GB0030697D0 (en) Computing device with profiles