IL153833A0 - Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches - Google Patents

Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches

Info

Publication number
IL153833A0
IL153833A0 IL15383301A IL15383301A IL153833A0 IL 153833 A0 IL153833 A0 IL 153833A0 IL 15383301 A IL15383301 A IL 15383301A IL 15383301 A IL15383301 A IL 15383301A IL 153833 A0 IL153833 A0 IL 153833A0
Authority
IL
Israel
Prior art keywords
monomeric
chain
regulation
gene expression
switches
Prior art date
Application number
IL15383301A
Other languages
English (en)
Original Assignee
Novartis Ag
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Scripps Research Inst filed Critical Novartis Ag
Publication of IL153833A0 publication Critical patent/IL153833A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL15383301A 2000-07-18 2001-07-16 Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches IL153833A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61906300A 2000-07-18 2000-07-18
PCT/EP2001/008190 WO2002006463A2 (en) 2000-07-18 2001-07-16 Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches

Publications (1)

Publication Number Publication Date
IL153833A0 true IL153833A0 (en) 2003-07-31

Family

ID=24480304

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15383301A IL153833A0 (en) 2000-07-18 2001-07-16 Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches

Country Status (10)

Country Link
EP (2) EP1908835A3 (https=)
JP (1) JP2004504029A (https=)
AT (1) ATE382691T1 (https=)
AU (2) AU7254401A (https=)
CA (1) CA2415726A1 (https=)
DE (1) DE60132208T2 (https=)
ES (1) ES2299494T3 (https=)
IL (1) IL153833A0 (https=)
NZ (1) NZ523649A (https=)
WO (1) WO2002006463A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329728B1 (en) 1999-10-25 2008-02-12 The Scripps Research Institute Ligand activated transcriptional regulator proteins
US7011972B2 (en) 2000-07-18 2006-03-14 The Scripps Research Institute Fusion polypeptide comprising two ligand binding domains
IL157335A0 (en) 2001-03-13 2004-02-19 Novartis Ag Lentiviral packaging constructs
EP1397382B1 (en) 2001-05-31 2008-08-06 Novartis AG Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions
US7115374B2 (en) 2002-10-16 2006-10-03 Gen-Probe Incorporated Compositions and methods for detecting West Nile virus
US7927840B2 (en) 2006-09-11 2011-04-19 Gen Probe Incorporated Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region
EP4210733B1 (en) * 2020-09-04 2024-11-06 Miltenyi Biotec B.V. & Co. KG System for inducible expression of an adapter in immune cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
EP0935657B1 (en) * 1996-10-29 2007-08-29 Baylor College Of Medicine Modified steroid hormone receptors
JP2003524368A (ja) * 1997-08-26 2003-08-19 アリアド ジーン セラピューティクス インコーポレイテッド ニ量化ドメイン、三量化ドメインまたは四量化ドメインおよび補足的非相同転写活性化ドメイン、転写抑制ドメイン、ｄｎａ結合ドメインまたはリガンド結合ドメインを含む融合蛋白
CA2323064C (en) * 1998-03-17 2011-05-31 Gendaq Limited Nucleic acid binding proteins
US6140081A (en) * 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US7057015B1 (en) * 1999-10-20 2006-06-06 The Salk Institute For Biological Studies Hormone receptor functional dimers and methods of their use
US7329728B1 (en) * 1999-10-25 2008-02-12 The Scripps Research Institute Ligand activated transcriptional regulator proteins

Also Published As

Publication number Publication date
WO2002006463A3 (en) 2002-07-25
AU2001272544B2 (en) 2005-12-01
DE60132208T2 (de) 2008-12-24
EP1908835A3 (en) 2008-06-18
EP1303606B1 (en) 2008-01-02
ATE382691T1 (de) 2008-01-15
DE60132208D1 (de) 2008-02-14
EP1908835A2 (en) 2008-04-09
JP2004504029A (ja) 2004-02-12
CA2415726A1 (en) 2002-01-24
NZ523649A (en) 2005-02-25
AU7254401A (en) 2002-01-30
ES2299494T3 (es) 2008-06-01
EP1303606A2 (en) 2003-04-23
WO2002006463A2 (en) 2002-01-24

Similar Documents

Publication Publication Date Title
IL161016A (en) Polypeptides capable of ang-2 binding
DE69839444D1 (de) Smad 6 und dessen anwendungen
ZA200102908B (en) Zinc finger binding domains for gnn
WO2005044976A3 (en) Oligomeric compounds for use in gene modulation
WO2003012057A3 (en) Antisense modulation of serum amyloid a4 expression
PT1860187E (pt) Receptor apo-2
WO2003018758A3 (en) Reagents and methods for smooth muscle therapies
ATE328896T1 (de) Faktor viii vom schwein und hybriden
WO2003010284A3 (en) Antisense modulation of c-reactive protein expression
WO2001023412A3 (en) Methods of screening for agents which inhibit aggregation of polypeptides
EP0892048A3 (en) XAF genes and polypeptides and their use for modulating apoptosis
EP0960192A4 (en) SYNTHETIC POLYNUCLEOTIDES
WO2002044376A8 (en) Modulation of gene expression using insulator binding proteins
AU7254401A (en) Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches
WO2002066640A3 (en) Zinc finger binding domains for nucleotide sequence ann
AU2002228805A1 (en) Antisense modulation of damage-specific dna binding protein 2, p48 expression
ZA97835B (en) Purified sr-p70 protein
WO2002092765A3 (en) Novel telomerase inhibitors and uses therefor
WO2001066752A3 (en) Reproduction-specific genes
ZA982009B (en) Isolated nucleic acid molecules encoding SSX family members and uses thereof.
WO1998024896A3 (en) Muteins of obese protein
WO1999028465A3 (en) Pias molecules that recognize and bind stat proteins and uses thereof
WO2002070676A3 (en) Use of protein histidine phosphatase
WO2002055659A3 (en) Antisense modulation of integrin beta 4 binding protein expression
AU2002241586A1 (en) Antisense modulation of damage-specific dna binding protein 1, p127 expression