CA2415726A1 - Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches - Google Patents
Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches Download PDFInfo
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- CA2415726A1 CA2415726A1 CA002415726A CA2415726A CA2415726A1 CA 2415726 A1 CA2415726 A1 CA 2415726A1 CA 002415726 A CA002415726 A CA 002415726A CA 2415726 A CA2415726 A CA 2415726A CA 2415726 A1 CA2415726 A1 CA 2415726A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
- C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61906300A | 2000-07-18 | 2000-07-18 | |
| US09/619,063 | 2000-07-18 | ||
| PCT/EP2001/008190 WO2002006463A2 (en) | 2000-07-18 | 2001-07-16 | Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2415726A1 true CA2415726A1 (en) | 2002-01-24 |
Family
ID=24480304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002415726A Abandoned CA2415726A1 (en) | 2000-07-18 | 2001-07-16 | Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1908835A3 (https=) |
| JP (1) | JP2004504029A (https=) |
| AT (1) | ATE382691T1 (https=) |
| AU (2) | AU7254401A (https=) |
| CA (1) | CA2415726A1 (https=) |
| DE (1) | DE60132208T2 (https=) |
| ES (1) | ES2299494T3 (https=) |
| IL (1) | IL153833A0 (https=) |
| NZ (1) | NZ523649A (https=) |
| WO (1) | WO2002006463A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329728B1 (en) | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| US7011972B2 (en) | 2000-07-18 | 2006-03-14 | The Scripps Research Institute | Fusion polypeptide comprising two ligand binding domains |
| IL157335A0 (en) | 2001-03-13 | 2004-02-19 | Novartis Ag | Lentiviral packaging constructs |
| EP1397382B1 (en) | 2001-05-31 | 2008-08-06 | Novartis AG | Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions |
| US7115374B2 (en) | 2002-10-16 | 2006-10-03 | Gen-Probe Incorporated | Compositions and methods for detecting West Nile virus |
| US7927840B2 (en) | 2006-09-11 | 2011-04-19 | Gen Probe Incorporated | Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region |
| EP4210733B1 (en) * | 2020-09-04 | 2024-11-06 | Miltenyi Biotec B.V. & Co. KG | System for inducible expression of an adapter in immune cells |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
| EP0935657B1 (en) * | 1996-10-29 | 2007-08-29 | Baylor College Of Medicine | Modified steroid hormone receptors |
| JP2003524368A (ja) * | 1997-08-26 | 2003-08-19 | アリアド ジーン セラピューティクス インコーポレイテッド | ニ量化ドメイン、三量化ドメインまたは四量化ドメインおよび補足的非相同転写活性化ドメイン、転写抑制ドメイン、ｄｎａ結合ドメインまたはリガンド結合ドメインを含む融合蛋白 |
| CA2323064C (en) * | 1998-03-17 | 2011-05-31 | Gendaq Limited | Nucleic acid binding proteins |
| US6140081A (en) * | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US7057015B1 (en) * | 1999-10-20 | 2006-06-06 | The Salk Institute For Biological Studies | Hormone receptor functional dimers and methods of their use |
| US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
-
2001
- 2001-07-16 IL IL15383301A patent/IL153833A0/xx unknown
- 2001-07-16 AU AU7254401A patent/AU7254401A/xx active Pending
- 2001-07-16 CA CA002415726A patent/CA2415726A1/en not_active Abandoned
- 2001-07-16 NZ NZ523649A patent/NZ523649A/en unknown
- 2001-07-16 EP EP07019198A patent/EP1908835A3/en not_active Withdrawn
- 2001-07-16 AU AU2001272544A patent/AU2001272544B2/en not_active Ceased
- 2001-07-16 AT AT01951681T patent/ATE382691T1/de not_active IP Right Cessation
- 2001-07-16 JP JP2002512356A patent/JP2004504029A/ja not_active Withdrawn
- 2001-07-16 EP EP01951681A patent/EP1303606B1/en not_active Expired - Lifetime
- 2001-07-16 WO PCT/EP2001/008190 patent/WO2002006463A2/en not_active Ceased
- 2001-07-16 DE DE60132208T patent/DE60132208T2/de not_active Expired - Lifetime
- 2001-07-16 ES ES01951681T patent/ES2299494T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002006463A3 (en) | 2002-07-25 |
| AU2001272544B2 (en) | 2005-12-01 |
| DE60132208T2 (de) | 2008-12-24 |
| EP1908835A3 (en) | 2008-06-18 |
| EP1303606B1 (en) | 2008-01-02 |
| ATE382691T1 (de) | 2008-01-15 |
| DE60132208D1 (de) | 2008-02-14 |
| EP1908835A2 (en) | 2008-04-09 |
| JP2004504029A (ja) | 2004-02-12 |
| IL153833A0 (en) | 2003-07-31 |
| NZ523649A (en) | 2005-02-25 |
| AU7254401A (en) | 2002-01-30 |
| ES2299494T3 (es) | 2008-06-01 |
| EP1303606A2 (en) | 2003-04-23 |
| WO2002006463A2 (en) | 2002-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |