ATE382691T1 - Regulation der genexpression unter verwendung von einkettigen, monomeren, liganden-abhängigen polypeptidschaltern - Google Patents
Regulation der genexpression unter verwendung von einkettigen, monomeren, liganden-abhängigen polypeptidschalternInfo
- Publication number
- ATE382691T1 ATE382691T1 AT01951681T AT01951681T ATE382691T1 AT E382691 T1 ATE382691 T1 AT E382691T1 AT 01951681 T AT01951681 T AT 01951681T AT 01951681 T AT01951681 T AT 01951681T AT E382691 T1 ATE382691 T1 AT E382691T1
- Authority
- AT
- Austria
- Prior art keywords
- regulation
- gene expression
- switches
- dependent polypeptide
- monomeric ligand
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
- C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61906300A | 2000-07-18 | 2000-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE382691T1 true ATE382691T1 (de) | 2008-01-15 |
Family
ID=24480304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01951681T ATE382691T1 (de) | 2000-07-18 | 2001-07-16 | Regulation der genexpression unter verwendung von einkettigen, monomeren, liganden-abhängigen polypeptidschaltern |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP1908835A3 (de) |
JP (1) | JP2004504029A (de) |
AT (1) | ATE382691T1 (de) |
AU (2) | AU2001272544B2 (de) |
CA (1) | CA2415726A1 (de) |
DE (1) | DE60132208T2 (de) |
ES (1) | ES2299494T3 (de) |
IL (1) | IL153833A0 (de) |
NZ (1) | NZ523649A (de) |
WO (1) | WO2002006463A2 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7329728B1 (en) | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
US7011972B2 (en) | 2000-07-18 | 2006-03-14 | The Scripps Research Institute | Fusion polypeptide comprising two ligand binding domains |
NZ527937A (en) | 2001-03-13 | 2005-03-24 | Novartis Ag | Stable cell lines to express high levels of lentiviral Gag/Pol proteins for generation of HIV- or BIV- based lentiviral vectors |
ATE403676T1 (de) | 2001-05-31 | 2008-08-15 | Novartis Ag | Neue östrogenrezeptorligandenbindungsdomänen varianten und neue liganden und pharmazeutische zusammensetzungen |
US7927840B2 (en) | 2006-09-11 | 2011-04-19 | Gen Probe Incorporated | Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region |
EP2366803B8 (de) | 2002-10-16 | 2015-08-19 | Gen-Probe Incorporated | Zusammensetzungen und Verfahren zum Nachweis des West Nil Viruses |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
EP0935657B1 (de) * | 1996-10-29 | 2007-08-29 | Baylor College Of Medicine | Modifizierte steroid-hormon rezeptoren |
JP2003524368A (ja) * | 1997-08-26 | 2003-08-19 | アリアド ジーン セラピューティクス インコーポレイテッド | ニ量化ドメイン、三量化ドメインまたは四量化ドメインおよび補足的非相同転写活性化ドメイン、転写抑制ドメイン、dna結合ドメインまたはリガンド結合ドメインを含む融合蛋白 |
CA2323064C (en) * | 1998-03-17 | 2011-05-31 | Gendaq Limited | Nucleic acid binding proteins |
US6140081A (en) * | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
US7057015B1 (en) * | 1999-10-20 | 2006-06-06 | The Salk Institute For Biological Studies | Hormone receptor functional dimers and methods of their use |
US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
-
2001
- 2001-07-16 AT AT01951681T patent/ATE382691T1/de not_active IP Right Cessation
- 2001-07-16 EP EP07019198A patent/EP1908835A3/de not_active Withdrawn
- 2001-07-16 JP JP2002512356A patent/JP2004504029A/ja not_active Withdrawn
- 2001-07-16 WO PCT/EP2001/008190 patent/WO2002006463A2/en active IP Right Grant
- 2001-07-16 EP EP01951681A patent/EP1303606B1/de not_active Expired - Lifetime
- 2001-07-16 DE DE60132208T patent/DE60132208T2/de not_active Expired - Lifetime
- 2001-07-16 NZ NZ523649A patent/NZ523649A/en unknown
- 2001-07-16 AU AU2001272544A patent/AU2001272544B2/en not_active Ceased
- 2001-07-16 CA CA002415726A patent/CA2415726A1/en not_active Abandoned
- 2001-07-16 AU AU7254401A patent/AU7254401A/xx active Pending
- 2001-07-16 IL IL15383301A patent/IL153833A0/xx unknown
- 2001-07-16 ES ES01951681T patent/ES2299494T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1908835A2 (de) | 2008-04-09 |
EP1303606B1 (de) | 2008-01-02 |
IL153833A0 (en) | 2003-07-31 |
ES2299494T3 (es) | 2008-06-01 |
AU7254401A (en) | 2002-01-30 |
AU2001272544B2 (en) | 2005-12-01 |
NZ523649A (en) | 2005-02-25 |
DE60132208D1 (de) | 2008-02-14 |
EP1908835A3 (de) | 2008-06-18 |
DE60132208T2 (de) | 2008-12-24 |
JP2004504029A (ja) | 2004-02-12 |
WO2002006463A3 (en) | 2002-07-25 |
EP1303606A2 (de) | 2003-04-23 |
WO2002006463A2 (en) | 2002-01-24 |
CA2415726A1 (en) | 2002-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |