IL151550A0 - 3-(diarylmethylene)-8-azabicyclo [3.2.1] octane derivatives - Google Patents
3-(diarylmethylene)-8-azabicyclo [3.2.1] octane derivativesInfo
- Publication number
- IL151550A0 IL151550A0 IL15155001A IL15155001A IL151550A0 IL 151550 A0 IL151550 A0 IL 151550A0 IL 15155001 A IL15155001 A IL 15155001A IL 15155001 A IL15155001 A IL 15155001A IL 151550 A0 IL151550 A0 IL 151550A0
- Authority
- IL
- Israel
- Prior art keywords
- diarylmethylene
- azabicyclo
- octane derivatives
- octane
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18677800P | 2000-03-03 | 2000-03-03 | |
PCT/US2001/005735 WO2001066543A2 (fr) | 2000-03-03 | 2001-02-22 | Derives de 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane |
Publications (1)
Publication Number | Publication Date |
---|---|
IL151550A0 true IL151550A0 (en) | 2003-04-10 |
Family
ID=22686249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15155001A IL151550A0 (en) | 2000-03-03 | 2001-02-22 | 3-(diarylmethylene)-8-azabicyclo [3.2.1] octane derivatives |
Country Status (12)
Country | Link |
---|---|
US (1) | US6552036B2 (fr) |
EP (1) | EP1263758A2 (fr) |
JP (1) | JP2003525938A (fr) |
KR (1) | KR20030009376A (fr) |
CN (1) | CN1426411A (fr) |
AR (1) | AR031556A1 (fr) |
AU (1) | AU2001241676A1 (fr) |
BR (1) | BR0108965A (fr) |
CA (1) | CA2402039A1 (fr) |
CO (1) | CO5280090A1 (fr) |
IL (1) | IL151550A0 (fr) |
WO (1) | WO2001066543A2 (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0101771D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101769D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101766D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101765D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101773D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101770D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
CN100384421C (zh) * | 2002-12-18 | 2008-04-30 | 拜尔农科股份公司 | N-(取代的芳基甲基)-4-(二取代的甲基)哌啶和吡啶 |
SE0300103D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
SE0300105D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
SE0300104D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
ATE474577T1 (de) * | 2003-03-26 | 2010-08-15 | Merck Sharp & Dohme | Bicyclische piperidin-derivate als melanocortin-4 rezeptor-agonisten |
SE0300987D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
CA2522199A1 (fr) * | 2003-04-15 | 2004-10-28 | Pfizer Products Inc. | Derives de 3-benzhydrylidene-8-aza-bicyclo¬3.2.1|octane a activite de recepteur d'opioides |
KR20060010811A (ko) * | 2003-05-16 | 2006-02-02 | 아스트라제네카 아베 | 디아릴메틸리덴 피페리딘 유도체, 그의 제조 및 그의 용도 |
SE0301442D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
SE0301441D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
SE0301443D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
JP4810423B2 (ja) * | 2003-06-27 | 2011-11-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式デルタオピオイド調節剤 |
CA2533812C (fr) * | 2003-07-28 | 2012-12-18 | Smithkline Beecham Corporation | Cycloalkylidenes substitues |
BRPI0415281A (pt) * | 2003-10-17 | 2006-12-19 | Glaxo Group Ltd | antagonistas de receptor de acetilcolina muscarìnico |
SE0400026D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
EP1737853A1 (fr) * | 2004-02-03 | 2007-01-03 | Janssen Pharmaceutica N.V. | Derives de 3-(diheteroarylnethylene)-8-azabicyclo[3.2.1]octane et de 3-(aryl)(heteroaryl)methylene)-8-azabicyclo[3.2.1]octane |
WO2007030089A1 (fr) | 2004-08-05 | 2007-03-15 | Janssen Pharmaceutica N.V. | Modulateurs d’opioïdes delta tricycliques |
CN101065014A (zh) * | 2004-09-23 | 2007-10-31 | 亚历山大·米哈洛 | 通过诱导逆适应调节神经递质系统的方法 |
US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
BRPI0519201A2 (pt) | 2004-12-22 | 2008-12-30 | Janssen Pharmaceutica Nv | moduladores de delta-opiàide tricÍclico |
WO2006069276A2 (fr) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Modulateurs des recepteurs opioides $g(d) tricycliques |
JP2008526878A (ja) | 2005-01-06 | 2008-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式δ−オピオイド調節剤 |
DE602006018604D1 (de) | 2005-06-16 | 2011-01-13 | Janssen Pharmaceutica Nv | Tricyclische opioidmodulatoren |
MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
FR2911874B1 (fr) * | 2007-01-25 | 2009-03-06 | Sanofi Aventis Sa | Derives d'urees de tropane, leur preparation et leur application en therapeutique |
AP2780A (en) | 2006-10-18 | 2013-09-30 | Pfizer Prod Inc | Biaryl ether urea compounds |
MY148880A (en) * | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | 8-氮雜雙環〔3.2.1〕辛烷化合物之結晶型 |
CN109422740B (zh) * | 2017-08-27 | 2020-04-21 | 中南民族大学 | 一类莨菪烷型生物碱及其合成方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
JP3252485B2 (ja) * | 1992-10-21 | 2002-02-04 | 東レ株式会社 | 3環性トリアゾロ誘導体 |
SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
-
2001
- 2001-02-22 EP EP01912949A patent/EP1263758A2/fr not_active Withdrawn
- 2001-02-22 CN CN01808773A patent/CN1426411A/zh active Pending
- 2001-02-22 BR BR0108965-0A patent/BR0108965A/pt not_active IP Right Cessation
- 2001-02-22 CA CA002402039A patent/CA2402039A1/fr not_active Abandoned
- 2001-02-22 US US09/791,246 patent/US6552036B2/en not_active Expired - Lifetime
- 2001-02-22 IL IL15155001A patent/IL151550A0/xx unknown
- 2001-02-22 JP JP2001565359A patent/JP2003525938A/ja active Pending
- 2001-02-22 WO PCT/US2001/005735 patent/WO2001066543A2/fr not_active Application Discontinuation
- 2001-02-22 AU AU2001241676A patent/AU2001241676A1/en not_active Abandoned
- 2001-02-22 KR KR1020027011575A patent/KR20030009376A/ko not_active Application Discontinuation
- 2001-03-02 AR ARP010101010A patent/AR031556A1/es unknown
- 2001-03-05 CO CO01017369A patent/CO5280090A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2001066543A3 (fr) | 2002-03-14 |
WO2001066543A2 (fr) | 2001-09-13 |
CA2402039A1 (fr) | 2001-09-13 |
AR031556A1 (es) | 2003-09-24 |
US6552036B2 (en) | 2003-04-22 |
US20020115662A1 (en) | 2002-08-22 |
CN1426411A (zh) | 2003-06-25 |
EP1263758A2 (fr) | 2002-12-11 |
JP2003525938A (ja) | 2003-09-02 |
AU2001241676A1 (en) | 2001-09-17 |
CO5280090A1 (es) | 2003-05-30 |
BR0108965A (pt) | 2002-11-26 |
KR20030009376A (ko) | 2003-01-29 |
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