IL150913A0 - Process for solubilizing glucagon-like peptide 1 (glp-1) compounds - Google Patents
Process for solubilizing glucagon-like peptide 1 (glp-1) compoundsInfo
- Publication number
- IL150913A0 IL150913A0 IL15091301A IL15091301A IL150913A0 IL 150913 A0 IL150913 A0 IL 150913A0 IL 15091301 A IL15091301 A IL 15091301A IL 15091301 A IL15091301 A IL 15091301A IL 150913 A0 IL150913 A0 IL 150913A0
- Authority
- IL
- Israel
- Prior art keywords
- glp
- solution
- compound
- compounds
- peptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17843800P | 2000-01-27 | 2000-01-27 | |
US22405800P | 2000-08-09 | 2000-08-09 | |
PCT/US2001/000010 WO2001055213A2 (en) | 2000-01-27 | 2001-01-16 | Process for solubilizing glucagon-like peptide 1 (glp-1) compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
IL150913A0 true IL150913A0 (en) | 2003-02-12 |
Family
ID=26874307
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15091301A IL150913A0 (en) | 2000-01-27 | 2001-01-16 | Process for solubilizing glucagon-like peptide 1 (glp-1) compounds |
IL189371A IL189371A0 (en) | 2000-01-27 | 2008-02-07 | A method for conversion of insoluble glucagon-like peptide (glp-1) compounds to a soluble glp-1 compound |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL189371A IL189371A0 (en) | 2000-01-27 | 2008-02-07 | A method for conversion of insoluble glucagon-like peptide (glp-1) compounds to a soluble glp-1 compound |
Country Status (17)
Country | Link |
---|---|
US (4) | US7598222B2 (hu) |
EP (1) | EP1257577B1 (hu) |
JP (1) | JP2003523366A (hu) |
KR (1) | KR20020073184A (hu) |
AT (1) | ATE264870T1 (hu) |
AU (1) | AU2001232735A1 (hu) |
BR (1) | BR0107837A (hu) |
CA (1) | CA2396920A1 (hu) |
DE (1) | DE60102899T2 (hu) |
DK (1) | DK1257577T3 (hu) |
ES (1) | ES2218381T3 (hu) |
HU (1) | HUP0204281A3 (hu) |
IL (2) | IL150913A0 (hu) |
MX (1) | MXPA02007231A (hu) |
PT (1) | PT1257577E (hu) |
TR (1) | TR200401142T4 (hu) |
WO (1) | WO2001055213A2 (hu) |
Families Citing this family (72)
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US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US20030119734A1 (en) * | 2001-06-28 | 2003-06-26 | Flink James M. | Stable formulation of modified GLP-1 |
JP5424521B2 (ja) | 2001-12-21 | 2014-02-26 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | アルブミン融合タンパク質 |
EP1894591B1 (en) | 2002-03-20 | 2013-06-26 | MannKind Corporation | Cartridge for an inhalation apparatus |
US7687625B2 (en) * | 2003-03-25 | 2010-03-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CN1816622B (zh) * | 2003-03-28 | 2011-06-22 | 株式会社三和化学研究所 | 高产重组蛋白的植物贮藏器官的生产方法以及新型重组蛋白 |
WO2004105790A1 (en) * | 2003-06-03 | 2004-12-09 | Novo Nordisk A/S | Stabilized pharmaceutical peptide compositions |
ES2375056T3 (es) * | 2003-06-03 | 2012-02-24 | Novo Nordisk A/S | Composiciones pept�?dicas farmacéuticas estabilizadas. |
KR101308912B1 (ko) | 2003-06-03 | 2013-09-23 | 노보 노르디스크 에이/에스 | 안정화된 약학적 펩티드 조성물 |
US8921311B2 (en) | 2003-08-01 | 2014-12-30 | Mannkind Corporation | Method for treating hyperglycemia |
CN1867560A (zh) * | 2003-08-13 | 2006-11-22 | 武田药品工株式会社 | 4-嘧啶酮衍生物及其作为肽基肽酶抑制剂的用途 |
EP1699777B1 (en) * | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2005030751A2 (en) * | 2003-09-08 | 2005-04-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CN104826116A (zh) * | 2003-11-20 | 2015-08-12 | 诺沃挪第克公司 | 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂 |
BRPI0418639B8 (pt) * | 2004-03-15 | 2021-05-25 | Takeda Pharmaceutical | compostos inibidores de dipeptidil peptidase, assim como composição farmacêutica contendo os mesmos |
DK1786784T3 (da) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Katalyse af diketopiperazinsyntese |
ES2543007T3 (es) | 2004-08-23 | 2015-08-13 | Mannkind Corporation | Micropartículas que comprenden sales de dicetopiperazina para la administración de fármacos |
JP4965446B2 (ja) | 2004-08-31 | 2012-07-04 | ノヴォ ノルディスク アー/エス | ペプチド、ポリペプチド及びタンパク質の安定化のためのトリス(ヒドロキシメチル)アミノメタンの使用 |
ES2458991T3 (es) | 2004-11-12 | 2014-05-07 | Novo Nordisk A/S | Formulaciones estables de péptidos insulinotrópicos |
US7601423B2 (en) | 2004-11-19 | 2009-10-13 | Mitsui Chemicals, Inc. | Ethylene-based polymer microparticles, functional group-containing ethylene-based polymer microparticles, and catalyst carriers for manufacture thereof |
EP1828192B1 (en) | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2006069779A1 (en) * | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Preparing of peptides with excellent solubility |
TW200643033A (en) * | 2005-03-08 | 2006-12-16 | Chugai Pharmaceutical Co Ltd | Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue |
TWI448326B (zh) | 2005-04-07 | 2014-08-11 | Mitsui Chemicals Inc | 烯烴系聚合體所構成之膠囊狀微粒子 |
NZ566799A (en) | 2005-09-14 | 2011-04-29 | Takeda Pharmaceutical | Dipeptidyl peptidase inhibitors for treating diabetes |
PE20070622A1 (es) * | 2005-09-14 | 2007-08-22 | Takeda Pharmaceutical | Administracion de inhibidores de dipeptidil peptidasa |
HRP20140091T4 (hr) * | 2005-09-14 | 2021-12-24 | Takeda Pharmaceutical Company Limited | Davanje inhibitora dipeptidil peptidaze |
IN2014DN09128A (hu) | 2005-09-14 | 2015-07-10 | Mannkind Corp | |
CN101360723A (zh) * | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | 制备嘧啶二酮衍生物的方法 |
TW200745079A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
TW200745080A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
ATE507235T1 (de) * | 2006-02-08 | 2011-05-15 | Lonza Ag | Synthese von glucagon-ähnlichen peptiden |
US8039431B2 (en) | 2006-02-22 | 2011-10-18 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
JP2009531456A (ja) * | 2006-03-28 | 2009-09-03 | 武田薬品工業株式会社 | (r)−3−アミノピペリジン二塩酸塩の調製 |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EA017799B1 (ru) * | 2006-09-13 | 2013-03-29 | Такеда Фармасьютикал Компани Лимитед | Применение 2-[6-(3-аминопиперидин-1-ил)-3-метил-2,4-диоксо-3,4-дигидро-2н-пиримидин-1-илметил]-4-фторбензонитрила |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
TW200838536A (en) * | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
EP3281663B8 (en) | 2008-06-13 | 2022-09-21 | MannKind Corporation | Breath powered dry powder inhaler for drug delivery |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
WO2009155581A1 (en) | 2008-06-20 | 2009-12-23 | Mannkind Corporation | An interactive apparatus and method for real-time profiling of inhalation efforts |
TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
JP5918539B2 (ja) | 2009-01-08 | 2016-05-18 | マンカインド コーポレイション | Glp−1を用いる高血糖症の治療方法 |
DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
WO2010144789A2 (en) | 2009-06-12 | 2010-12-16 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
EP2482840A4 (en) * | 2009-08-07 | 2013-06-26 | Mannkind Corp | VAL (8) GLP-1 COMPOSITION AND METHOD FOR THE TREATMENT OF REAGENTS AND / OR IRRITATION SYNDROME |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
JP6385673B2 (ja) | 2010-06-21 | 2018-09-05 | マンカインド コーポレイション | 乾燥粉末薬物送達システム |
CN102718858B (zh) * | 2011-03-29 | 2014-07-02 | 天津药物研究院 | 胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用 |
DK2694402T3 (en) | 2011-04-01 | 2017-07-03 | Mannkind Corp | BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
BR112014009686A2 (pt) | 2011-10-24 | 2018-08-07 | Mannkind Corp | composição analgésica inalável, pó seco e método para tratar dor |
MX354163B (es) | 2012-07-12 | 2018-02-15 | Mannkind Corp | Sistemas y métodos de suministro de fármaco en polvo seco. |
EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
KR102391750B1 (ko) | 2013-03-15 | 2022-04-28 | 맨카인드 코포레이션 | 미세결정성 디케토피페라진 조성물 및 방법 |
WO2014147129A1 (en) | 2013-03-21 | 2014-09-25 | Sanofi-Aventis Deutschland Gmbh | Synthesis of cyclic imide containing peptide products |
EP2976331B1 (en) | 2013-03-21 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Synthesis of hydantoin containing peptide products |
MX2016000739A (es) | 2013-07-18 | 2017-04-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US9969769B2 (en) | 2014-12-19 | 2018-05-15 | Cem Corporation | Coupling method for peptide synthesis at elevated temperatures |
US10308677B2 (en) | 2014-12-19 | 2019-06-04 | Cem Corporation | Coupling method for peptide synthesis at elevated temperatures |
PE20181327A1 (es) | 2015-12-23 | 2018-08-20 | Amgen Inc | Metodo para tratar o mejorar trastornos metabolicos con proteinas de union para el receptor peptidico inhibidor gastrico (gipr) en combinacion con agonistas de glp-1 |
JOP20190177A1 (ar) | 2017-01-17 | 2019-07-16 | Amgen Inc | طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr) |
CN111050750A (zh) | 2017-08-24 | 2020-04-21 | 诺沃挪第克公司 | Glp-1组合物及其用途 |
JP2021514936A (ja) * | 2017-12-19 | 2021-06-17 | ノヴォ ノルディスク アー/エス | Glp−1ペプチドの可溶性 |
KR20220143036A (ko) | 2020-02-18 | 2022-10-24 | 노보 노르디스크 에이/에스 | 약학적 제형 |
WO2022157747A2 (en) | 2021-01-25 | 2022-07-28 | Mylan Ireland Limited | Pharmaceutical peptide compositions and methods of preparation thereof |
WO2022266927A1 (zh) * | 2021-06-24 | 2022-12-29 | 深圳翰宇药业股份有限公司 | 一种利拉鲁肽变构体及其制备方法、应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3419824A1 (de) * | 1984-05-26 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Verfahren und formwerkzeug zum herstellen von formteilen mit grill-, gitter- oder rostartigen bereichen, wie kfz-soft-faces, spoiler, bumper, aus einer fliessfaehigen masse |
HU225496B1 (en) | 1993-04-07 | 2007-01-29 | Scios Inc | Pharmaceutical compositions of prolonged delivery, containing peptides |
US6380357B2 (en) | 1997-12-16 | 2002-04-30 | Eli Lilly And Company | Glucagon-like peptide-1 crystals |
DE69918070T2 (de) * | 1998-03-13 | 2005-08-25 | Novo Nordisk A/S | Stabilisierte, wässrige Glukagonlösungen, enthaltend Detergenzien |
US6844321B2 (en) * | 2000-01-31 | 2005-01-18 | Novo Nordisk A/S | Crystallization of a GLP-1 analogue |
-
2001
- 2001-01-16 DE DE60102899T patent/DE60102899T2/de not_active Expired - Lifetime
- 2001-01-16 JP JP2001561060A patent/JP2003523366A/ja not_active Withdrawn
- 2001-01-16 KR KR1020027009546A patent/KR20020073184A/ko not_active Application Discontinuation
- 2001-01-16 EP EP01904785A patent/EP1257577B1/en not_active Expired - Lifetime
- 2001-01-16 PT PT01904785T patent/PT1257577E/pt unknown
- 2001-01-16 CA CA002396920A patent/CA2396920A1/en not_active Abandoned
- 2001-01-16 AU AU2001232735A patent/AU2001232735A1/en not_active Abandoned
- 2001-01-16 US US10/169,657 patent/US7598222B2/en not_active Expired - Fee Related
- 2001-01-16 DK DK01904785T patent/DK1257577T3/da active
- 2001-01-16 BR BR0107837-2A patent/BR0107837A/pt not_active IP Right Cessation
- 2001-01-16 AT AT01904785T patent/ATE264870T1/de not_active IP Right Cessation
- 2001-01-16 ES ES01904785T patent/ES2218381T3/es not_active Expired - Lifetime
- 2001-01-16 HU HU0204281A patent/HUP0204281A3/hu not_active Application Discontinuation
- 2001-01-16 WO PCT/US2001/000010 patent/WO2001055213A2/en active Application Filing
- 2001-01-16 TR TR2004/01142T patent/TR200401142T4/xx unknown
- 2001-01-16 MX MXPA02007231A patent/MXPA02007231A/es active IP Right Grant
- 2001-01-16 IL IL15091301A patent/IL150913A0/xx unknown
-
2008
- 2008-02-07 IL IL189371A patent/IL189371A0/en unknown
-
2009
- 2009-09-01 US US12/551,841 patent/US8222205B2/en not_active Expired - Fee Related
-
2012
- 2012-04-27 US US13/458,057 patent/US8268780B2/en not_active Expired - Fee Related
- 2012-08-10 US US13/571,443 patent/US8455433B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20130072658A1 (en) | 2013-03-21 |
DE60102899D1 (de) | 2004-05-27 |
PT1257577E (pt) | 2004-08-31 |
BR0107837A (pt) | 2003-01-14 |
US8222205B2 (en) | 2012-07-17 |
ATE264870T1 (de) | 2004-05-15 |
WO2001055213A2 (en) | 2001-08-02 |
US20120101034A9 (en) | 2012-04-26 |
HUP0204281A3 (en) | 2007-03-28 |
US7598222B2 (en) | 2009-10-06 |
KR20020073184A (ko) | 2002-09-19 |
TR200401142T4 (tr) | 2004-07-21 |
MXPA02007231A (es) | 2002-12-09 |
IL189371A0 (en) | 2008-06-05 |
ES2218381T3 (es) | 2004-11-16 |
DK1257577T3 (da) | 2004-08-02 |
JP2003523366A (ja) | 2003-08-05 |
US20030060412A1 (en) | 2003-03-27 |
US20110053838A1 (en) | 2011-03-03 |
US8455433B2 (en) | 2013-06-04 |
EP1257577B1 (en) | 2004-04-21 |
WO2001055213A3 (en) | 2002-02-28 |
HUP0204281A2 (hu) | 2003-04-28 |
AU2001232735A1 (en) | 2001-08-07 |
DE60102899T2 (de) | 2005-03-31 |
CA2396920A1 (en) | 2001-08-02 |
US20120208980A1 (en) | 2012-08-16 |
EP1257577A2 (en) | 2002-11-20 |
US8268780B2 (en) | 2012-09-18 |
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Legal Events
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