IL150482A0 - Heteroaromatic carboxamide derivatives and their use as inhibitors of the enzyme ikk-2 - Google Patents
Heteroaromatic carboxamide derivatives and their use as inhibitors of the enzyme ikk-2Info
- Publication number
- IL150482A0 IL150482A0 IL15048201A IL15048201A IL150482A0 IL 150482 A0 IL150482 A0 IL 150482A0 IL 15048201 A IL15048201 A IL 15048201A IL 15048201 A IL15048201 A IL 15048201A IL 150482 A0 IL150482 A0 IL 150482A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibitors
- carboxamide derivatives
- heteroaromatic carboxamide
- ikk
- enzyme
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- -1 heteroaromatic carboxamides Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0003154.2A GB0003154D0 (en) | 2000-02-12 | 2000-02-12 | Novel compounds |
| PCT/SE2001/000248 WO2001058890A1 (en) | 2000-02-12 | 2001-02-07 | Heteroaromatic carboxamide derivatives and their use as inhibitors of the enzyme ikk-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL150482A0 true IL150482A0 (en) | 2002-12-01 |
Family
ID=9885396
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15048201A IL150482A0 (en) | 2000-02-12 | 2001-02-07 | Heteroaromatic carboxamide derivatives and their use as inhibitors of the enzyme ikk-2 |
| IL150482A IL150482A (en) | 2000-02-12 | 2002-06-27 | The traumatic derivatives of carboxamide and their use as inhibitors of the enzyme IKK-2 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL150482A IL150482A (en) | 2000-02-12 | 2002-06-27 | The traumatic derivatives of carboxamide and their use as inhibitors of the enzyme IKK-2 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7358376B2 (de) |
| EP (1) | EP1261600B1 (de) |
| JP (1) | JP4812999B2 (de) |
| KR (1) | KR100738165B1 (de) |
| CN (1) | CN1243747C (de) |
| AT (1) | ATE266019T1 (de) |
| AU (1) | AU781047B2 (de) |
| BR (1) | BR0108143A (de) |
| CA (1) | CA2396824C (de) |
| DE (1) | DE60103132T2 (de) |
| DK (1) | DK1261600T3 (de) |
| ES (1) | ES2218376T3 (de) |
| GB (1) | GB0003154D0 (de) |
| IL (2) | IL150482A0 (de) |
| MX (1) | MXPA02007734A (de) |
| NO (1) | NO327741B1 (de) |
| NZ (1) | NZ519947A (de) |
| PT (1) | PT1261600E (de) |
| TR (1) | TR200401962T4 (de) |
| WO (1) | WO2001058890A1 (de) |
| ZA (1) | ZA200205300B (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6869956B2 (en) | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
| AU2002211663A1 (en) * | 2000-10-12 | 2002-04-22 | Smith Kline Beecham Corporation | Nf-$g(k)b inhibitors |
| ATE392898T1 (de) | 2000-10-26 | 2008-05-15 | Amgen Inc | Antiphlogistische mittel |
| PL364111A1 (en) * | 2001-02-01 | 2004-12-13 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of ikappab kinase (ikk) |
| AU2002344854B2 (en) * | 2001-06-11 | 2008-11-06 | Vertex Pharmaceuticals (Canada) Incorporated | Thiophene derivatives as antiviral agents for flavivirus infection |
| US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| WO2003024935A2 (en) * | 2001-09-19 | 2003-03-27 | Pharmacia Corporation | Substituted pyrazolyl compounds for the treatment of inflammation |
| EP1436279B8 (de) * | 2001-09-21 | 2008-10-29 | Smithkline Beecham Corporation | Chemische verbindungen |
| EP1436265A4 (de) | 2001-09-27 | 2004-12-15 | Smithkline Beecham Corp | Chemische verbindungen |
| EP1448545B1 (de) * | 2001-10-04 | 2008-11-19 | Smithkline Beecham Corporation | Nf-kb-inhibitoren |
| WO2003028731A1 (en) * | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
| AU2002356871A1 (en) * | 2001-10-30 | 2003-05-12 | Pharmacia Corporation | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
| AR037641A1 (es) | 2001-12-05 | 2004-11-17 | Tularik Inc | Moduladores de inflamacion |
| US6974870B2 (en) | 2002-06-06 | 2005-12-13 | Boehringer Ingelheim Phamaceuticals, Inc. | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
| CA2483890C (en) | 2002-06-06 | 2012-12-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
| WO2003104218A1 (en) * | 2002-06-06 | 2003-12-18 | Smithkline Beecham Corporation | Nf-:b inhibitors |
| US7179836B2 (en) | 2002-09-20 | 2007-02-20 | Smithkline Beecham Corporation | Chemical compounds |
| AU2003270701B2 (en) | 2002-10-31 | 2009-11-12 | Amgen Inc. | Antiinflammation agents |
| US7196106B2 (en) | 2002-11-05 | 2007-03-27 | Merck & Co., Inc | Cyanothiophene derivatives, compositions containing such compounds and methods of use |
| WO2004053087A2 (en) * | 2002-12-06 | 2004-06-24 | Smithkline Beecham Corporation | Nf-κb inhibitors |
| CN100413861C (zh) | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
| SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| AU2004265140A1 (en) | 2003-08-15 | 2005-02-24 | Astrazeneca Ab | Substituted thiophenes and uses thereof |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| WO2005035527A1 (en) * | 2003-10-14 | 2005-04-21 | Pharmacia Corporation | Substituted pyrazinone compounds for the treatment of inflammation |
| WO2005037797A1 (en) * | 2003-10-21 | 2005-04-28 | Pharmacia Corporation | Substituted pyrazole urea compounds for the treatment of inflammation |
| WO2005066163A2 (en) * | 2004-01-05 | 2005-07-21 | Astrazeneca Ab | Thiophene derivatives as chk 1 inihibitors |
| AU2005233437A1 (en) * | 2004-04-12 | 2005-10-27 | Sankyo Company, Limited | Thienopyridine derivatives |
| WO2005105777A1 (en) * | 2004-05-05 | 2005-11-10 | Pharmacia & Upjohn Company Llc | Substituted thiophene amide compounds for the treatment of inflammation |
| AR050253A1 (es) | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento |
| TW200626142A (en) | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
| WO2006036031A1 (ja) * | 2004-09-30 | 2006-04-06 | Takeda Pharmaceutical Company Limited | 縮合フラン誘導体およびその用途 |
| WO2006118320A1 (ja) | 2005-04-28 | 2006-11-09 | Takeda Pharmaceutical Company Limited | チエノピリミドン化合物 |
| MX2007016541A (es) | 2005-06-30 | 2008-03-07 | Smithkline Beecham Corp | Compuestos quimicos. |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| US7592353B2 (en) | 2006-06-06 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
| PT2104674E (pt) | 2006-11-15 | 2013-07-26 | Virochem Pharma Inc | Análogos de tiofeno para o tratamento ou prevenção de infeções por flavivírus |
| US8193237B2 (en) * | 2007-01-15 | 2012-06-05 | Santen Pharmaceutical Co., Ltd. | Indole derivative having IκB kinase β inhibitory activity |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| BRPI0910850B1 (pt) | 2008-04-21 | 2022-06-14 | Otonomy, Inc. | Composição intratimpânica compreendendo fator neurotrófico de crescimento derivado do cérebro (bdnf) para o tratamento ou prevenção da perda auditiva |
| JP2010043070A (ja) | 2008-07-14 | 2010-02-25 | Santen Pharmaceut Co Ltd | カルバモイル基、ウレイド基及び置換オキシ基を有する新規インドール誘導体 |
| US8088817B2 (en) * | 2008-08-25 | 2012-01-03 | Santen Pharmaceutical Co., Ltd. | Pyrrole derivative having, as substituents, ureido group, aminocarbonly group and bicyclic group which may have substituent |
| JP2010077119A (ja) * | 2008-08-25 | 2010-04-08 | Santen Pharmaceut Co Ltd | ウレイド基、アミノカルボニル基及び置換フェニル基を置換基として有するピロール誘導体を有効成分として含有する骨・関節疾患の予防又は治療剤 |
| JP5570520B2 (ja) * | 2008-11-14 | 2014-08-13 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 非水和性結晶形を調製する方法 |
| WO2010102968A1 (en) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| JP2012176930A (ja) * | 2010-10-07 | 2012-09-13 | Santen Pharmaceut Co Ltd | ウレイド基とアミノカルボニル基を置換基として有するチオフェン誘導体を有効成分として含有する新規ｊａｋ３阻害剤 |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| EP2520292A1 (de) | 2011-05-06 | 2012-11-07 | Helmholtz-Zentrum für Infektionsforschung GmbH | Verwendung von Spirangienen zur Behandlung oder Prävention von IL-8- oder IL-6-vermittelten Erkrankungen |
| GB201202027D0 (en) | 2012-02-06 | 2012-03-21 | Sareum Ltd | Pharmaceutical compounds |
| DK2634185T3 (en) | 2012-03-02 | 2016-03-21 | Sareum Ltd | Tyk2 kinase inhibitors |
| KR20190024983A (ko) | 2016-06-29 | 2019-03-08 | 오토노미, 인코포레이티드 | 트리글리세라이드 귀 제제 및 이의 용도 |
| GB201617871D0 (en) | 2016-10-21 | 2016-12-07 | Sareum Limited | Pharmaceutical compounds |
| WO2018204775A1 (en) | 2017-05-05 | 2018-11-08 | Hepanova, Inc. | Amino-aryl-benzamide compounds and methods of use thereof |
| GB201816369D0 (en) | 2018-10-08 | 2018-11-28 | Sareum Ltd | Pharmaceutical compounds |
| GB202005114D0 (en) | 2020-04-07 | 2020-05-20 | Sareum Ltd | Crystalline Forms of a Pharmaceutical Compound |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1468012A (en) | 1973-08-09 | 1977-03-23 | Beecham Group Ltd | 2-amino-3-carboxy-thiophene derivatives |
| DE3529247A1 (de) * | 1985-05-17 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung |
| US5258357A (en) * | 1989-10-07 | 1993-11-02 | Basf Aktiengesellschaft | Carboxamides, their preparation and their use as herbicides |
| US5378703A (en) * | 1990-04-09 | 1995-01-03 | Alcon Laboratories, Inc. | Sulfonamides useful as carbonic anhydrase inhibitors |
| US5571810A (en) * | 1990-06-11 | 1996-11-05 | Fujisawa Pharmaceutical Co., Ltd. | Thiophene derivatives |
| CA2260213C (en) * | 1996-07-11 | 2005-03-29 | Pfizer Inc. | Pyridylpyrrole compounds useful as interleukin- and tnf antagonists |
| PT853083E (pt) * | 1997-01-06 | 2001-12-28 | Pfizer | Composto de piridilfurano e piridiltiofeno e sua utilizacao farmaceutica |
| US6037340A (en) | 1997-05-28 | 2000-03-14 | Cadus Pharmaceutical Corporation | Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds |
| DE19744026A1 (de) * | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| WO1999046244A1 (en) | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
| HN2000000051A (es) | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
| US6414013B1 (en) | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
| AU2002211663A1 (en) * | 2000-10-12 | 2002-04-22 | Smith Kline Beecham Corporation | Nf-$g(k)b inhibitors |
| US20040024047A1 (en) * | 2001-10-12 | 2004-02-05 | Callahan James F. | Nf-kb inhibitors |
| SE0102617D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| EP1448545B1 (de) * | 2001-10-04 | 2008-11-19 | Smithkline Beecham Corporation | Nf-kb-inhibitoren |
| SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
-
2000
- 2000-02-12 GB GBGB0003154.2A patent/GB0003154D0/en not_active Ceased
-
2001
- 2001-02-07 DK DK01902951T patent/DK1261600T3/da active
- 2001-02-07 MX MXPA02007734A patent/MXPA02007734A/es active IP Right Grant
- 2001-02-07 EP EP01902951A patent/EP1261600B1/de not_active Expired - Lifetime
- 2001-02-07 AT AT01902951T patent/ATE266019T1/de active
- 2001-02-07 US US09/868,884 patent/US7358376B2/en not_active Expired - Fee Related
- 2001-02-07 DE DE60103132T patent/DE60103132T2/de not_active Expired - Lifetime
- 2001-02-07 KR KR1020027010124A patent/KR100738165B1/ko not_active Expired - Fee Related
- 2001-02-07 CN CNB018046606A patent/CN1243747C/zh not_active Expired - Fee Related
- 2001-02-07 PT PT01902951T patent/PT1261600E/pt unknown
- 2001-02-07 TR TR2004/01962T patent/TR200401962T4/xx unknown
- 2001-02-07 WO PCT/SE2001/000248 patent/WO2001058890A1/en not_active Ceased
- 2001-02-07 IL IL15048201A patent/IL150482A0/xx active IP Right Grant
- 2001-02-07 CA CA2396824A patent/CA2396824C/en not_active Expired - Fee Related
- 2001-02-07 ES ES01902951T patent/ES2218376T3/es not_active Expired - Lifetime
- 2001-02-07 JP JP2001558440A patent/JP4812999B2/ja not_active Expired - Fee Related
- 2001-02-07 NZ NZ519947A patent/NZ519947A/en not_active IP Right Cessation
- 2001-02-07 BR BR0108143-8A patent/BR0108143A/pt not_active Application Discontinuation
- 2001-02-07 AU AU30705/01A patent/AU781047B2/en not_active Ceased
-
2002
- 2002-06-27 IL IL150482A patent/IL150482A/en not_active IP Right Cessation
- 2002-07-02 ZA ZA200205300A patent/ZA200205300B/en unknown
- 2002-08-09 NO NO20023786A patent/NO327741B1/no not_active IP Right Cessation
-
2007
- 2007-12-03 US US11/949,273 patent/US20090181962A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60103132T2 (de) | 2005-05-12 |
| CN1243747C (zh) | 2006-03-01 |
| ATE266019T1 (de) | 2004-05-15 |
| AU781047B2 (en) | 2005-05-05 |
| NO20023786L (no) | 2002-09-23 |
| TR200401962T4 (tr) | 2004-09-21 |
| US20020107252A1 (en) | 2002-08-08 |
| PT1261600E (pt) | 2004-08-31 |
| EP1261600A1 (de) | 2002-12-04 |
| KR100738165B1 (ko) | 2007-07-10 |
| CN1425012A (zh) | 2003-06-18 |
| CA2396824A1 (en) | 2001-08-16 |
| NZ519947A (en) | 2004-05-28 |
| JP4812999B2 (ja) | 2011-11-09 |
| NO20023786D0 (no) | 2002-08-09 |
| BR0108143A (pt) | 2003-01-21 |
| GB0003154D0 (en) | 2000-04-05 |
| NO327741B1 (no) | 2009-09-14 |
| EP1261600B1 (de) | 2004-05-06 |
| US20090181962A1 (en) | 2009-07-16 |
| US7358376B2 (en) | 2008-04-15 |
| WO2001058890A1 (en) | 2001-08-16 |
| ES2218376T3 (es) | 2004-11-16 |
| DK1261600T3 (da) | 2004-08-16 |
| CA2396824C (en) | 2010-11-16 |
| IL150482A (en) | 2006-08-01 |
| JP2003522766A (ja) | 2003-07-29 |
| DE60103132D1 (de) | 2004-06-09 |
| ZA200205300B (en) | 2003-10-02 |
| MXPA02007734A (es) | 2002-10-11 |
| KR20030005183A (ko) | 2003-01-17 |
| AU3070501A (en) | 2001-08-20 |
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