IL150080A0 - Methods of detection of amyloidogenic proteins - Google Patents

Methods of detection of amyloidogenic proteins

Info

Publication number
IL150080A0
IL150080A0 IL15008000A IL15008000A IL150080A0 IL 150080 A0 IL150080 A0 IL 150080A0 IL 15008000 A IL15008000 A IL 15008000A IL 15008000 A IL15008000 A IL 15008000A IL 150080 A0 IL150080 A0 IL 150080A0
Authority
IL
Israel
Prior art keywords
aggregation
assay
amyloid
peptide
amyloid peptide
Prior art date
Application number
IL15008000A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL150080A0 publication Critical patent/IL150080A0/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL15008000A 1999-12-29 2000-12-01 Methods of detection of amyloidogenic proteins IL150080A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/474,970 US6399314B1 (en) 1999-12-29 1999-12-29 Methods of detection of amyloidogenic proteins
PCT/US2000/032693 WO2001050134A2 (en) 1999-12-29 2000-12-01 Methods of detection of amyloidogenic proteins

Publications (1)

Publication Number Publication Date
IL150080A0 true IL150080A0 (en) 2002-12-01

Family

ID=23885720

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15008000A IL150080A0 (en) 1999-12-29 2000-12-01 Methods of detection of amyloidogenic proteins
IL150080A IL150080A (en) 1999-12-29 2002-06-06 Methods for detecting amyloidogenic proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL150080A IL150080A (en) 1999-12-29 2002-06-06 Methods for detecting amyloidogenic proteins

Country Status (21)

Country Link
US (1) US6399314B1 (xx)
EP (1) EP1242822B1 (xx)
JP (1) JP2003519383A (xx)
KR (1) KR20020070470A (xx)
CN (1) CN1211661C (xx)
AT (1) ATE399323T1 (xx)
AU (1) AU774377B2 (xx)
BR (1) BR0016883A (xx)
CA (1) CA2395789C (xx)
DE (1) DE60039310D1 (xx)
DK (1) DK1242822T3 (xx)
EA (1) EA005582B1 (xx)
ES (1) ES2309003T3 (xx)
HK (1) HK1046550B (xx)
IL (2) IL150080A0 (xx)
MX (1) MXPA02006362A (xx)
NO (1) NO20023163L (xx)
NZ (1) NZ519612A (xx)
PL (1) PL356813A1 (xx)
PT (1) PT1242822E (xx)
WO (1) WO2001050134A2 (xx)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179892B2 (en) * 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
US6761888B1 (en) 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US6750324B1 (en) 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
US6913745B1 (en) 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
US6743427B1 (en) 1997-12-02 2004-06-01 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6787523B1 (en) 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
US20030147882A1 (en) * 1998-05-21 2003-08-07 Alan Solomon Methods for amyloid removal using anti-amyloid antibodies
DE19923811C1 (de) * 1999-05-20 2000-12-07 Robert Koch Inst Verfahren zur Diagnose TSE-induzierter Veränderungen in Geweben mittels Infrarotspektroskopie
US6787637B1 (en) 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
US6689753B1 (en) * 1999-11-05 2004-02-10 Axonyx, Inc. β sheet breaker peptide analogs that inhibit β pleated sheet formation in amyloid β-peptide
WO2002016951A2 (en) 2000-08-21 2002-02-28 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
TWI255272B (en) * 2000-12-06 2006-05-21 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
NZ531337A (en) * 2001-04-27 2006-05-26 Gen Hospital Corp Ocular diagnosis of alzheimer's disease
US7166471B2 (en) * 2001-05-31 2007-01-23 Arete Associates Misfolded protein sensor method in body fluids
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
AU2002360696A1 (en) * 2001-12-21 2003-07-30 Ilex Oncology, Inc. Combination comprising anti-cd52 antibodies and other therapeutic agents for treatment for multiple sclerosis
MY139983A (en) * 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US20070003552A1 (en) * 2002-07-09 2007-01-04 Gebbink Martijn F B Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation
EP1380290A1 (en) * 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-beta structure pathway and its therapeutic relevance
TWI374893B (en) 2003-05-30 2012-10-21 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US20050048539A1 (en) * 2003-06-13 2005-03-03 The General Hospital Corporation Methods to monitor molecule conformation and molecule/molecule proximity
SE0401219D0 (sv) * 2004-05-10 2004-05-10 Biochromix Ab Metoder för detektera konformationsförändringar eller aggregering hos proteiner med hjälp av konjugerade polyelektrolyter
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
WO2006066089A1 (en) 2004-12-15 2006-06-22 Neuralab Limited Humanized amyloid beta antibodies for use in improving cognition
PE20061401A1 (es) * 2004-12-15 2006-12-23 Neuralab Ltd ANTICUERPOS Aß PARA MEJORAR LA COGNICION
ES2396555T3 (es) * 2004-12-15 2013-02-22 Janssen Alzheimer Immunotherapy Anticuerpos que reconocen péptido beta amiloide
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
WO2006069697A1 (en) * 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Colorimetrically assessing peptide characteristics
US8372593B2 (en) * 2005-02-15 2013-02-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
US20090202980A1 (en) * 2005-03-21 2009-08-13 Crossbeta Biosciences B.V. Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation
ATE554394T1 (de) * 2005-07-13 2012-05-15 Crossbeta Biosciences Bv Cross-beta-struktur-bindende verbindungen
CA2615020A1 (en) * 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. Adjuvation through cross-.beta. structure
US20070015133A1 (en) * 2005-07-13 2007-01-18 Umc Utrecht Holding B.V. Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein
US8114832B2 (en) * 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
WO2009017467A1 (en) 2007-07-27 2009-02-05 Elan Pharma International Limited Treatment of amyloidogenic diseases
BRPI0714930A2 (pt) * 2006-07-28 2013-05-21 Adlyfe Inc sondas peptÍdicas para fins diagnàsticos e terapÊuticos
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
EP2058001A1 (en) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Enhancement of immunogenicity of antigens
EP2058000A1 (en) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Immunogenic compositions capable of activating T cells
US20100021390A1 (en) * 2008-03-17 2010-01-28 The Research Foundation Of State University Of New York Fluorescent Analogs Of The Islet Amyloid Polypeptide
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
RU2509155C1 (ru) * 2012-10-25 2014-03-10 Федеральное государственное бюджетное учреждение науки Институт биохимии им. А.Н. Баха Российской академии наук Способ детекции белков в амилоидном состоянии и набор для детекции белков в амилоидном состоянии
GB201303507D0 (en) * 2013-02-27 2013-04-10 Hollfelder Florian Assays
US9588129B2 (en) * 2013-03-15 2017-03-07 Amira Medical Technologies Inc. Methods for analyzing blood to detect diseases associated with abnormal protein aggregation
CN104803993B (zh) * 2015-03-01 2017-11-03 四川大学 一种具有Aβ亲和力的荧光化合物及其用途
CN105651752B (zh) * 2016-02-26 2019-04-12 国家纳米科学中心 淀粉样蛋白的检测方法
CN105717182B (zh) * 2016-03-10 2018-05-11 中南大学 一种用于同步检测淀粉样多肽单体和聚集体的生物传感器及其构建方法和应用
WO2018136910A1 (en) * 2017-01-23 2018-07-26 Rensselaer Polytechnic Institute Systems and methods for binding amyloid fibrils using fluorescent protein
CN108489941B (zh) * 2018-01-31 2021-07-27 吉林大学 溴酚蓝在作为检测牛胰岛素淀粉样纤维探针和作为牛胰岛素淀粉样纤维抑制剂方面的应用
US20210165001A1 (en) * 2018-08-03 2021-06-03 The University Of Hong Kong Compositions and methods for detection and imaging of amyloid fibrils, amyloid plaques, rna, and nucleoli
CN111504957B (zh) * 2019-01-31 2021-12-03 吉林大学 一种维多利亚蓝b及其衍生物在制备异构化蛋白的探针或抑制剂中的应用
KR102258048B1 (ko) * 2019-05-30 2021-05-31 주식회사 캔티스 아밀로이드 베타 올리고머의 검출 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2013396A1 (en) * 1989-04-05 1990-10-05 Dennis J. Selkoe Diagnostic method for alzheimer's disease: examination of non-neural tissue
US5276059A (en) 1992-07-10 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of diseases associated with amyloid formation
AU6728396A (en) 1995-08-17 1997-03-12 Ontario Cancer Institute, The Protein fibril assembly assay
JPH0995444A (ja) * 1995-10-02 1997-04-08 Teijin Ltd アミロイド蛋白凝集阻害剤
JP2001515044A (ja) 1997-08-14 2001-09-18 ザ・レジェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 蛍光アミロイドＡβペプチドとその使用
JP4537577B2 (ja) * 1998-03-13 2010-09-01 ユニバーシティ・オブ・ワシントン アルツハイマー病及びプリオン病の治療に関する抗プラーク療法を特定するコンゴ好染性マルタ十字形アミロイドプラークのｉｎｖｉｔｒｏにおける形成

Also Published As

Publication number Publication date
ES2309003T3 (es) 2008-12-16
CN1415074A (zh) 2003-04-30
DK1242822T3 (da) 2008-09-29
NZ519612A (en) 2004-04-30
EP1242822B1 (en) 2008-06-25
JP2003519383A (ja) 2003-06-17
CA2395789A1 (en) 2001-07-12
HK1046550A1 (en) 2003-01-17
WO2001050134A2 (en) 2001-07-12
AU1810301A (en) 2001-07-16
NO20023163L (no) 2002-08-27
EP1242822A2 (en) 2002-09-25
MXPA02006362A (es) 2002-11-29
PT1242822E (pt) 2008-09-29
HK1046550B (zh) 2008-12-19
BR0016883A (pt) 2002-10-01
WO2001050134A3 (en) 2002-06-27
AU774377B2 (en) 2004-06-24
EA200200722A1 (ru) 2002-12-26
CA2395789C (en) 2010-03-30
ATE399323T1 (de) 2008-07-15
US6399314B1 (en) 2002-06-04
KR20020070470A (ko) 2002-09-09
NO20023163D0 (no) 2002-06-28
EA005582B1 (ru) 2005-04-28
CN1211661C (zh) 2005-07-20
PL356813A1 (en) 2004-07-12
IL150080A (en) 2009-02-11
DE60039310D1 (de) 2008-08-07

Similar Documents

Publication Publication Date Title
HK1046550A1 (en) Methods of detection of amyloidogenic proteins
Zareba-Koziol et al. Stress-induced Changes in the S-palmitoylation and S-nitrosylation of Synaptic Proteins*[S]
Solberg et al. A five-year follow-up study of antioxidants, oxidative stress and polyunsaturated fatty acids in schizophrenia
Strucksberg et al. Proteasomal activity in skeletal muscle: a matter of assay design, muscle type, and age
AU5884394A (en) Method and device for assessing the suitability of biopolymers
WO2006076631A3 (en) Methods of in vitro analysis using time-domain nmr spectroscopy
SG126066A1 (en) Inspection method and system using multifrequency phase analysis
ATE443775T1 (de) Hif-prolylhydroxylase-aktivitätstest
PH12020551371A1 (en) Assays to detect neurodegeneration
Zinellu et al. Highly sensitive simultaneous detection of cultured cellular thiols by laser induced fluorescence‐capillary electrophoresis
DE60229303D1 (de) Bioäquivalenztest für eisenhaltige formulierungen
Wang et al. Study of the interaction of proteins with curcumin and SDS and its analytical application
WO2002066982A3 (de) Analyse von modifizierungen und demodifizierungen von proteinen mit ubiquintin-verwandten proteinen mittels fret (fluorescence resonance energy transfer)
ATE487122T1 (de) Vorrichtung zur bestimmung rheologischer eigenschaften
UA94920C2 (ru) Способ быстрого выявления, выделения и подсчета апоптических клеток, который базируется на агглютинации
Chen et al. Scopoletine as fluorescence probe for determination of protein
CN2222352Y (zh) 高分辨率单探头内应力磁测仪的探头
CN201229305Y (zh) 食用菌荧光增白剂检测仪
CN110441457A (zh) 一种检测尿液中同型半胱氨酸的方法
DE60324820D1 (de) Verfahren zum testen des oxidiertes-ldl-beta-2-glycoprotein-i-komplexes in vivo
ATE466285T1 (de) Diagnose von leberzirrhose mittels eines für menschliches protoonkogenes protein spezifischen antikörpers
RU2008132559A (ru) Способ оценки агрегационной способности эритроцитов
SU1746960A1 (ru) Способ определени степени зрелости икры рыб
RU2315998C2 (ru) Способ определения влияния соединений на процесс скачка митохондриальной проницаемости и мембранный потенциал митохондрий
FR2846009B1 (fr) Criblage de molecules a activite anti-prion:kits, methodes et molecules criblees

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed