IL149715A0 - MICROBIAL 9α-HYDROXYLATION OF STEROIDS - Google Patents

MICROBIAL 9α-HYDROXYLATION OF STEROIDS

Info

Publication number
IL149715A0
IL149715A0 IL14971500A IL14971500A IL149715A0 IL 149715 A0 IL149715 A0 IL 149715A0 IL 14971500 A IL14971500 A IL 14971500A IL 14971500 A IL14971500 A IL 14971500A IL 149715 A0 IL149715 A0 IL 149715A0
Authority
IL
Israel
Prior art keywords
hydroxylation
steroids
microbial
Prior art date
Application number
IL14971500A
Other languages
English (en)
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of IL149715A0 publication Critical patent/IL149715A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL14971500A 1999-10-22 2000-10-17 MICROBIAL 9α-HYDROXYLATION OF STEROIDS IL149715A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99203470 1999-10-22
EP99204449 1999-12-22
PCT/EP2000/010223 WO2001031050A1 (en) 1999-10-22 2000-10-17 MICROBIAL 9α-HYDROXYLATION OF STEROIDS

Publications (1)

Publication Number Publication Date
IL149715A0 true IL149715A0 (en) 2002-11-10

Family

ID=26153382

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14971500A IL149715A0 (en) 1999-10-22 2000-10-17 MICROBIAL 9α-HYDROXYLATION OF STEROIDS

Country Status (11)

Country Link
EP (1) EP1232278A1 (cs)
CN (1) CN1224716C (cs)
AR (1) AR026186A1 (cs)
AU (1) AU775476B2 (cs)
CA (1) CA2396879A1 (cs)
CZ (1) CZ20021784A3 (cs)
IL (1) IL149715A0 (cs)
NO (1) NO20022449L (cs)
NZ (1) NZ519039A (cs)
RU (1) RU2268935C2 (cs)
WO (1) WO2001031050A1 (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1478742B1 (en) 2002-02-21 2010-04-21 N.V. Organon Identification of 3-ketosteroid 9-alfa-hydroxylase genes and microorganisms blocked in 3-ketosteroid 9-alfa-hydroxylase activity
AU2003302151A1 (en) * 2002-12-03 2004-07-09 N.V. Organon New expression system from rhodococcus
AT503486B1 (de) * 2006-04-11 2008-05-15 Iep Gmbh Verfahren zur enantioselektiven reduktion von steroiden
RU2351645C1 (ru) * 2007-07-20 2009-04-10 Наталия Евгеньевна Войшвилло ШТАММ Rhodococcus erythropolis ВКПМ Ac-1740 ДЛЯ ПОЛУЧЕНИЯ 9 АЛЬФА-ГИДРОКСИСТЕРОИДОВ
WO2009024572A1 (en) * 2007-08-21 2009-02-26 N.V. Organon Method for the production of modified steroid degrading microorganisms and their use
RU2011138954A (ru) 2009-02-23 2013-03-27 Рейксюниверситейт Гронинген Фармацевтическая композиция и способы лечения туберкулеза
CN103361394B (zh) * 2013-08-07 2016-08-17 中国科学院上海高等研究院 利用微生物转化制备9α-羟基-雄烯二酮的方法
CN103805577A (zh) * 2013-08-14 2014-05-21 济南环亿生物科技有限公司 一种采用睾丸酮丛毛单胞菌高效生产羟基类固醇脱氢酶的方法
WO2015128534A1 (es) 2014-02-27 2015-09-03 Consejo Superior De Investigaciones Científicas MUTANTES RECOMBINANTES SELECTIVOS DE MYCOBACTERIUM SMEGMATIS mc2 155 Y SU USO PARA LA PRODUCCIÓN DE 1,4-ANDROSTADIEN-3,17-DIONA O 4-ANDROSTEN-3,17-DIONA A PARTIR DE ESTEROLES NATURALES
CN107586762A (zh) * 2017-09-18 2018-01-16 天津科技大学 一种3‑甾酮‑δ1‑脱氢酶突变体及其应用
US11001871B2 (en) 2017-12-15 2021-05-11 Jiangnan University Method for producing 9alpha-hydroxy androstane-4-alkene-3,17-diketone by enzymatic conversion
CN107955827B (zh) * 2017-12-15 2019-07-02 江南大学 一种酶法转化生产9α-羟基雄甾-4-烯-3,17-二酮的方法
GB2577037A (en) * 2018-08-09 2020-03-18 Cambrex Karlskoga Ab Genetically-modified bacteria and uses thereof
KR20210125490A (ko) * 2019-02-08 2021-10-18 사노피 스테로이드의 1,2-탈수소화를 위한 미생물의 생명공학적 최적화
CN110229838B (zh) * 2019-05-28 2021-01-08 浙江理工大学 一种生物转化类固醇类化合物获取羟基化化合物的方法
CN114621965B (zh) * 2022-02-15 2023-10-03 复旦大学 一种3-甾酮-δ1-脱氢酶突变体及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196627B (en) * 1986-11-18 1988-12-28 Gyogyszerkutato Intezet Microbiological process for producing y alpha-hydroxy-4-androstene-3,17-dione
RU2039824C1 (ru) * 1993-06-22 1995-07-20 Институт биохимии и физиологии микроорганизмов РАН Способ получения андроста-1,4-диен-3,17-диона

Also Published As

Publication number Publication date
EP1232278A1 (en) 2002-08-21
RU2268935C2 (ru) 2006-01-27
NO20022449L (no) 2002-06-19
CZ20021784A3 (cs) 2002-08-14
CN1413260A (zh) 2003-04-23
AR026186A1 (es) 2003-01-29
WO2001031050A1 (en) 2001-05-03
CN1224716C (zh) 2005-10-26
NO20022449D0 (no) 2002-05-23
NZ519039A (en) 2004-09-24
CA2396879A1 (en) 2001-05-03
RU2002113373A (ru) 2004-02-27
AU775476B2 (en) 2004-08-05
AU1514501A (en) 2001-05-08

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