IL147195A0 - C-pyrazole a2a receptor agonists - Google Patents

C-pyrazole a2a receptor agonists

Info

Publication number
IL147195A0
IL147195A0 IL14719500A IL14719500A IL147195A0 IL 147195 A0 IL147195 A0 IL 147195A0 IL 14719500 A IL14719500 A IL 14719500A IL 14719500 A IL14719500 A IL 14719500A IL 147195 A0 IL147195 A0 IL 147195A0
Authority
IL
Israel
Prior art keywords
pyrazole
receptor agonists
agonists
receptor
Prior art date
Application number
IL14719500A
Other languages
English (en)
Original Assignee
Cv Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc
Publication of IL147195A0 publication Critical patent/IL147195A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL14719500A 1999-06-22 2000-06-21 C-pyrazole a2a receptor agonists IL147195A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/338,327 US6214807B1 (en) 1999-06-22 1999-06-22 C-pyrazole 2A A receptor agonists
PCT/US2000/017095 WO2000078778A2 (fr) 1999-06-22 2000-06-21 Agonistes de recepteurs a2a c-pyrazole

Publications (1)

Publication Number Publication Date
IL147195A0 true IL147195A0 (en) 2002-08-14

Family

ID=23324355

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14719500A IL147195A0 (en) 1999-06-22 2000-06-21 C-pyrazole a2a receptor agonists
IL147195A IL147195A (en) 1999-06-22 2001-12-19 Derivatives 2 – C - adenosine cleavage with agonist activity for A2A receptors, the pharmacological compositions containing them and their use in coronary diagnosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL147195A IL147195A (en) 1999-06-22 2001-12-19 Derivatives 2 – C - adenosine cleavage with agonist activity for A2A receptors, the pharmacological compositions containing them and their use in coronary diagnosis

Country Status (23)

Country Link
US (6) US6214807B1 (fr)
EP (1) EP1192169B1 (fr)
JP (1) JP4795591B2 (fr)
KR (1) KR100511733B1 (fr)
CN (1) CN1152041C (fr)
AR (1) AR033794A1 (fr)
AT (1) ATE240341T1 (fr)
AU (1) AU766712B2 (fr)
BR (1) BR0011854A (fr)
CA (1) CA2375430C (fr)
DE (1) DE60002722T2 (fr)
DK (1) DK1192169T3 (fr)
ES (1) ES2193969T3 (fr)
HK (1) HK1044953A1 (fr)
IL (2) IL147195A0 (fr)
MX (1) MXPA01013350A (fr)
NO (1) NO323163B1 (fr)
NZ (1) NZ516335A (fr)
PT (1) PT1192169E (fr)
TR (1) TR200200320T2 (fr)
TW (1) TW589321B (fr)
WO (1) WO2000078778A2 (fr)
ZA (1) ZA200200298B (fr)

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US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
CA2671940A1 (fr) * 2000-02-23 2001-08-30 Cv Therapeutics, Inc. Procede permettant d'identifier des agonistes partiels du recepteur a2a
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US20050059068A1 (en) * 2001-05-23 2005-03-17 Stratagene California Compositions and methods using dendrimer-treated microassays
US7262176B2 (en) * 2001-08-08 2007-08-28 Cv Therapeutics, Inc. Adenosine A3 receptor agonists
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CA2460911C (fr) * 2001-10-01 2011-08-30 University Of Virginia Patent Foundation Analogues de 2-propynyle adenosine presentant une activite agoniste de a2a et compositions en contenant
KR20040097126A (ko) * 2002-02-15 2004-11-17 씨브이 쎄러퓨틱스, 인코포레이티드 의료 장치용 중합체 코팅
WO2003099769A1 (fr) * 2002-05-24 2003-12-04 Pharmacia Corporation Modulateurs des recepteurs x du foie a structure anilino
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US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
US8470801B2 (en) * 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
JP2005538190A (ja) * 2002-07-29 2005-12-15 シーブイ・セラピューティクス・インコーポレイテッド 心筋潅流イメージング
EP1537135B1 (fr) 2002-09-09 2009-11-25 Cv Therapeutics, Inc. Agonistes du recepteur de l'adenosine a3
DK1708721T3 (da) 2004-01-27 2013-09-08 Gilead Sciences Inc Billeddannelse af myokardieperfusion under anvendelse af adenosin-receptor-agonister
TWI346109B (en) * 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
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US7605143B2 (en) * 2004-08-02 2009-10-20 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity
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CA2583185A1 (fr) 2004-10-20 2006-04-27 Cv Therapeutics, Inc. Utilisation d'agonistes du recepteur de l'adenosine a2a
GT200500281A (es) * 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
AU2006320578B2 (en) 2005-11-30 2013-01-31 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
KR101494125B1 (ko) 2006-02-03 2015-02-16 길리애드 사이언시즈, 인코포레이티드 Ａ2ａ-아데노신 수용체 효능제 및 이의 다형체의 제조 방법
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ES2440317T3 (es) * 2006-04-21 2014-01-28 Novartis Ag Derivados de purina para su uso como agonistas del receptor de adenosina A2A
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US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
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EP2066232A1 (fr) * 2006-09-29 2009-06-10 Cv Therapeutics, Inc. Procédés d'imagerie myocardique chez des patients ayant un historique de maladie pulmonaire
AU2007316715A1 (en) * 2006-11-10 2008-05-15 Novartis Ag Cyclopentene diol monoacetate derivatives
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US8058259B2 (en) 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
MX2011003168A (es) * 2008-09-29 2011-05-19 Gilead Sciences Inc Combinaciones de un agente de control de cantidad y un antagonista del receptor a-2-alfa para utilizarse en metodos de tomografia computarizada de detectores multiples.
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Also Published As

Publication number Publication date
JP4795591B2 (ja) 2011-10-19
TR200200320T2 (tr) 2002-05-21
US7553823B2 (en) 2009-06-30
US20040198692A1 (en) 2004-10-07
NO20016351D0 (no) 2001-12-21
MXPA01013350A (es) 2002-07-09
US7109180B2 (en) 2006-09-19
BR0011854A (pt) 2002-06-11
CN1152041C (zh) 2004-06-02
NZ516335A (en) 2003-10-31
AU766712B2 (en) 2003-10-23
ATE240341T1 (de) 2003-05-15
US20070207978A1 (en) 2007-09-06
US6855818B2 (en) 2005-02-15
AR033794A1 (es) 2004-01-07
WO2000078778A2 (fr) 2000-12-28
CA2375430C (fr) 2006-03-14
JP2003506460A (ja) 2003-02-18
KR20020028911A (ko) 2002-04-17
NO20016351L (no) 2002-02-18
DK1192169T3 (da) 2003-08-04
CA2375430A1 (fr) 2000-12-28
US6770634B1 (en) 2004-08-03
HK1044953A1 (zh) 2002-11-08
DE60002722T2 (de) 2004-04-08
NO323163B1 (no) 2007-01-08
IL147195A (en) 2007-10-31
US6214807B1 (en) 2001-04-10
CN1358189A (zh) 2002-07-10
US20010018428A1 (en) 2001-08-30
TW589321B (en) 2004-06-01
EP1192169A2 (fr) 2002-04-03
US20100081810A1 (en) 2010-04-01
EP1192169B1 (fr) 2003-05-14
KR100511733B1 (ko) 2005-08-31
AU5755800A (en) 2001-01-09
WO2000078778A3 (fr) 2001-05-10
ZA200200298B (en) 2003-04-30
PT1192169E (pt) 2003-09-30
DE60002722D1 (de) 2003-06-18
ES2193969T3 (es) 2003-11-16

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