IL144867A0 - Method of crystallising n-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide - Google Patents
Method of crystallising n-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamideInfo
- Publication number
- IL144867A0 IL144867A0 IL14486700A IL14486700A IL144867A0 IL 144867 A0 IL144867 A0 IL 144867A0 IL 14486700 A IL14486700 A IL 14486700A IL 14486700 A IL14486700 A IL 14486700A IL 144867 A0 IL144867 A0 IL 144867A0
- Authority
- IL
- Israel
- Prior art keywords
- crystallising
- trifluoromethylphenyl
- isoxazole
- carboxamide
- methyl
- Prior art date
Links
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19908527A DE19908527C2 (de) | 1999-02-26 | 1999-02-26 | Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
PCT/EP2000/001151 WO2000050411A1 (de) | 1999-02-26 | 2000-02-12 | Verfahren zur kristallisation von n- (4-trifluormethylphenyl) -5-methyl- isoxazol- 4-carboxamid |
Publications (1)
Publication Number | Publication Date |
---|---|
IL144867A0 true IL144867A0 (en) | 2002-06-30 |
Family
ID=7899073
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14486700A IL144867A0 (en) | 1999-02-26 | 2000-02-12 | Method of crystallising n-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide |
IL144867A IL144867A (en) | 1999-02-26 | 2001-08-13 | Method of crystallising n -(4 - trifluoromethylphenyl)- 5-methyl-isoxazole-4 carboxamide |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL144867A IL144867A (en) | 1999-02-26 | 2001-08-13 | Method of crystallising n -(4 - trifluoromethylphenyl)- 5-methyl-isoxazole-4 carboxamide |
Country Status (22)
Country | Link |
---|---|
US (1) | US6303792B1 (ko) |
EP (1) | EP1155004B1 (ko) |
JP (1) | JP4625187B2 (ko) |
KR (1) | KR100626110B1 (ko) |
CN (1) | CN1127491C (ko) |
AR (1) | AR022737A1 (ko) |
AT (1) | ATE257828T1 (ko) |
AU (1) | AU762394B2 (ko) |
BR (1) | BR0008566B1 (ko) |
CA (1) | CA2363875C (ko) |
DE (2) | DE19908527C2 (ko) |
DK (1) | DK1155004T3 (ko) |
ES (1) | ES2214259T3 (ko) |
HK (1) | HK1043787B (ko) |
HU (1) | HU228918B1 (ko) |
IL (2) | IL144867A0 (ko) |
NO (1) | NO319830B1 (ko) |
NZ (1) | NZ513777A (ko) |
PL (1) | PL199365B1 (ko) |
PT (1) | PT1155004E (ko) |
WO (1) | WO2000050411A1 (ko) |
ZA (1) | ZA200106973B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19610955A1 (de) * | 1996-03-20 | 1997-09-25 | Hoechst Ag | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
ATE207065T1 (de) * | 1997-08-08 | 2001-11-15 | Aventis Pharma Gmbh | Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid |
KR20020067545A (ko) * | 1999-12-16 | 2002-08-22 | 테바 파마슈티컬 인더스트리즈 리미티드 | 레플루노마이드의 신규 제조 방법 및 이의 신규 결정형 |
PL366088A1 (en) * | 2000-02-15 | 2005-01-24 | Teva Pharmaceutical Industries Ltd. | A method for synthesizing leflunomide |
CN107311954B (zh) * | 2017-05-17 | 2020-04-07 | 力赛生物医药科技(厦门)有限公司 | 来氟米特晶型化合物、制备方法及其应用 |
CN114436894A (zh) * | 2020-11-04 | 2022-05-06 | 欣凯医药化工中间体(上海)有限公司 | 泰瑞米特钠晶型及制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2854439A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
DE3534440A1 (de) * | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
HU222234B1 (hu) * | 1990-05-18 | 2003-05-28 | Aventis Pharma Deutschland Gmbh. | Eljárás izoxazol-4-karbonsav-amidok és hidroxi-alkilidén-cián-ecetsav-amidok, a vegyületeket tartalmazó gyógyászati készítmények és az ismert vegyületeket tartalmazó rákellenes hatású gyógyszerkészítmények előállítására |
DE4127737A1 (de) * | 1991-08-22 | 1993-02-25 | Hoechst Ag | Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen |
US5519042A (en) * | 1994-01-13 | 1996-05-21 | Hoechst Aktiengesellschaft | Method of treating hyperproliferative vascular disease |
ATE207065T1 (de) | 1997-08-08 | 2001-11-15 | Aventis Pharma Gmbh | Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid |
DE19734438A1 (de) * | 1997-08-08 | 1999-02-11 | Hoechst Marion Roussel De Gmbh | Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid |
-
1999
- 1999-02-26 DE DE19908527A patent/DE19908527C2/de not_active Expired - Lifetime
-
2000
- 2000-02-12 KR KR1020017010843A patent/KR100626110B1/ko active IP Right Grant
- 2000-02-12 CN CN00804234A patent/CN1127491C/zh not_active Expired - Lifetime
- 2000-02-12 DE DE50005025T patent/DE50005025D1/de not_active Expired - Lifetime
- 2000-02-12 PL PL350422A patent/PL199365B1/pl unknown
- 2000-02-12 CA CA002363875A patent/CA2363875C/en not_active Expired - Fee Related
- 2000-02-12 HU HU0200058A patent/HU228918B1/hu unknown
- 2000-02-12 ES ES00916829T patent/ES2214259T3/es not_active Expired - Lifetime
- 2000-02-12 NZ NZ513777A patent/NZ513777A/xx not_active IP Right Cessation
- 2000-02-12 JP JP2000600994A patent/JP4625187B2/ja not_active Expired - Lifetime
- 2000-02-12 AU AU38038/00A patent/AU762394B2/en not_active Expired
- 2000-02-12 BR BRPI0008566-9A patent/BR0008566B1/pt not_active IP Right Cessation
- 2000-02-12 PT PT00916829T patent/PT1155004E/pt unknown
- 2000-02-12 EP EP00916829A patent/EP1155004B1/de not_active Expired - Lifetime
- 2000-02-12 IL IL14486700A patent/IL144867A0/xx active IP Right Grant
- 2000-02-12 DK DK00916829T patent/DK1155004T3/da active
- 2000-02-12 AT AT00916829T patent/ATE257828T1/de active
- 2000-02-12 WO PCT/EP2000/001151 patent/WO2000050411A1/de active IP Right Grant
- 2000-02-22 US US09/510,157 patent/US6303792B1/en not_active Expired - Lifetime
- 2000-02-24 AR ARP000100788A patent/AR022737A1/es active IP Right Grant
-
2001
- 2001-08-13 IL IL144867A patent/IL144867A/en not_active IP Right Cessation
- 2001-08-22 NO NO20014077A patent/NO319830B1/no not_active IP Right Cessation
- 2001-08-23 ZA ZA200106973A patent/ZA200106973B/en unknown
-
2002
- 2002-05-31 HK HK02104056.1A patent/HK1043787B/zh not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed |