IL144340A0 - Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands - Google Patents
Diazabicyclic derivatives as nicotinic acetylcholine receptor ligandsInfo
- Publication number
- IL144340A0 IL144340A0 IL14434000A IL14434000A IL144340A0 IL 144340 A0 IL144340 A0 IL 144340A0 IL 14434000 A IL14434000 A IL 14434000A IL 14434000 A IL14434000 A IL 14434000A IL 144340 A0 IL144340 A0 IL 144340A0
- Authority
- IL
- Israel
- Prior art keywords
- acetylcholine receptor
- receptor ligands
- nicotinic acetylcholine
- diazabicyclic
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23983899A | 1999-01-29 | 1999-01-29 | |
PCT/US2000/001620 WO2000044755A1 (fr) | 1999-01-29 | 2000-01-25 | Derives diazabicycliques utiles en tant que ligands du recepteur nicotinique de l'acetylcholine |
Publications (1)
Publication Number | Publication Date |
---|---|
IL144340A0 true IL144340A0 (en) | 2002-05-23 |
Family
ID=22903947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14434000A IL144340A0 (en) | 1999-01-29 | 2000-01-25 | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands |
Country Status (26)
Country | Link |
---|---|
EP (2) | EP1359152B1 (fr) |
JP (1) | JP4676062B2 (fr) |
KR (1) | KR20010101725A (fr) |
CN (2) | CN1345320A (fr) |
AR (1) | AR034538A1 (fr) |
AT (2) | ATE253067T1 (fr) |
AU (1) | AU773795B2 (fr) |
BG (1) | BG105836A (fr) |
BR (1) | BR0007664A (fr) |
CA (1) | CA2361525C (fr) |
CO (1) | CO5150231A1 (fr) |
CZ (1) | CZ20012716A3 (fr) |
DE (2) | DE60038823D1 (fr) |
DK (1) | DK1147112T3 (fr) |
ES (2) | ES2209825T3 (fr) |
HK (1) | HK1043116B (fr) |
HU (1) | HUP0200332A3 (fr) |
IL (1) | IL144340A0 (fr) |
NO (1) | NO20013731L (fr) |
NZ (1) | NZ512884A (fr) |
PT (1) | PT1147112E (fr) |
SK (1) | SK10692001A3 (fr) |
TR (1) | TR200102162T2 (fr) |
TW (1) | TW200300021A (fr) |
WO (1) | WO2000044755A1 (fr) |
ZA (1) | ZA200105835B (fr) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6605610B1 (en) * | 1997-12-31 | 2003-08-12 | Pfizer Inc | Aryl fused azapolycyclic compounds |
CN1324013C (zh) | 1997-12-31 | 2007-07-04 | 辉瑞产品公司 | 芳基稠合氮杂多环化合物 |
US6815438B2 (en) | 1999-12-14 | 2004-11-09 | Neurosearch A/S | Heteroaryl-diazabicycloalkanes |
US6809105B2 (en) | 2000-04-27 | 2004-10-26 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
MY145722A (en) * | 2000-04-27 | 2012-03-30 | Abbott Lab | Diazabicyclic central nervous system active agents |
US6440970B1 (en) | 2000-05-25 | 2002-08-27 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
AU2001274952A1 (en) | 2000-05-25 | 2001-12-03 | Targacept, Inc. | Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands |
EP1301514B1 (fr) | 2000-07-04 | 2005-01-26 | Neurosearch A/S | Diazabicycloalkanes aryle et heteroaryle, elaboration et utilisation |
US6624167B1 (en) | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
WO2002070522A1 (fr) | 2001-03-02 | 2002-09-12 | Neurosearch A/S | Nouveaux derives de 2,5-diazabicyclo[2.2.1]heptane |
US20040147505A1 (en) * | 2001-06-01 | 2004-07-29 | Dan Peters | Novel heteroaryl-diazabicyclo alkanes as cns-modulators |
AR036041A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
EP1472248A1 (fr) | 2002-01-17 | 2004-11-03 | Eli Lilly And Company | Modulateurs de recepteurs de l'acetylcholine |
CN1653068A (zh) * | 2002-05-07 | 2005-08-10 | 神经研究公司 | 新的二氮杂双环联芳基衍生物 |
US7135484B2 (en) | 2002-08-14 | 2006-11-14 | Abbott Laboratories | Azabicyclic compounds are central nervous system active agents |
US20040242641A1 (en) * | 2003-05-27 | 2004-12-02 | Buckley Michael J. | (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent |
US7763618B2 (en) * | 2003-07-29 | 2010-07-27 | Xenon Pharmaceuticals Inc. | Pyridyl derivatives and their use as therapeutic agents |
PT1648874E (pt) | 2003-07-30 | 2011-12-23 | Xenon Pharmaceuticals Inc | Derivados de piperazina e a sua utilização a título de agentes terapêuticos |
US20050065178A1 (en) * | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
US7399765B2 (en) | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
BRPI0416206A (pt) | 2003-11-20 | 2006-12-26 | Janssen Pharmaceutica Nv | 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose) |
SG150534A1 (en) | 2003-11-20 | 2009-03-30 | Janssen Pharmaceutica Nv | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp- ribose) polymerase inhibitors |
DK1697378T3 (da) * | 2003-12-22 | 2008-03-17 | Memory Pharm Corp | Indoler, 1H-indazoler, 1,2-benzisoxazoler og 1,2-benzisothiazoler og fremstilling og anvendelser deraf |
US20050171079A1 (en) * | 2004-02-04 | 2005-08-04 | Schrimpf Michael R. | Amino-substituted tricyclic derivatives and methods of use |
EP1713487B1 (fr) | 2004-02-04 | 2009-12-02 | Neurosearch A/S | Derives d'aryle diazabicycliques constituant des modulateurs des recepteurs cholinergiques |
US7365193B2 (en) | 2004-02-04 | 2008-04-29 | Abbott Laboratories | Amino-substituted tricyclic derivatives and methods of use |
DE602005024677D1 (de) | 2004-04-22 | 2010-12-23 | Memory Pharm Corp | Indole, 1h-indazole, 1,2-benzisoxazole, 1,2-benzoisothiazole, deren herstellung und verwendungen |
ITMI20040954A1 (it) * | 2004-05-12 | 2004-08-12 | Univ Degli Studi Milano | Derivati del 3,6-diazabiciclo 3.1.i.eptano ad attivita' analgesica |
AU2005259192C1 (en) | 2004-06-30 | 2012-03-01 | Janssen Pharmaceutica N.V. | Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors |
CN1980674B (zh) * | 2004-06-30 | 2011-05-25 | 詹森药业有限公司 | 作为parp抑制剂的2,3-二氮杂萘衍生物 |
BRPI0512938A (pt) | 2004-06-30 | 2008-04-15 | Janssen Pharmaceutica Nv | derivados da quinazolinediona como inibidores parp |
CA2580329C (fr) | 2004-09-13 | 2015-01-06 | Chrono Therapeutics Inc. | Administration de medicament transdermique biosynchrone |
CA2580857A1 (fr) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et leur utilisation en tant qu'agents therapeutiques |
BRPI0515505A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e sua utilização como inibidores da estearoil-coa desaturase |
EP1799668A1 (fr) | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et leur utilisation en tant que modulateurs de stearoyle-coa desaturase |
CA2580845A1 (fr) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et leur utilisation en tant qu'agents therapeutiques |
CA2580787A1 (fr) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et utilisation de ceux-ci comme agents therapeutiques |
TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
EP1799664A1 (fr) | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et leur utilisation en tant qu'inhibiteurs de la stearoyl-coa desaturase |
ATE495178T1 (de) | 2005-02-16 | 2011-01-15 | Neurosearch As | Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin- acetylcholin-rezeptoren |
JP2008530171A (ja) | 2005-02-16 | 2008-08-07 | ノイロサーチ アクティーゼルスカブ | 新規なジアザ二環系アリール誘導体及びそれらの医療上の使用 |
US8541457B2 (en) | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
ATE473978T1 (de) | 2005-12-06 | 2010-07-15 | Neurosearch As | Neue diazabicyclische arylderivate und medizinische verwendung dafür |
US7687517B2 (en) | 2006-02-10 | 2010-03-30 | Neurosearch A/S | 3,9-Diazabicyclo [3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US7687523B2 (en) | 2006-02-10 | 2010-03-30 | Neurosearch A/S | 3-heteroaryl-3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
CA2641678A1 (fr) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | Derives de 3,9-diazabicyclo[3.3.1]nonane et leur utilisation en tant qu'inhibiteurs du recaptage de neurotransmetteur monoamine |
CN101448828B (zh) * | 2006-02-10 | 2011-12-07 | 神经研究公司 | 作为烟碱性乙酰胆碱受体激动剂的3-杂芳基-3,9-二氮杂双环[3.3.1]壬烷衍生物 |
CA2641767A1 (fr) * | 2006-02-14 | 2007-08-23 | Neurosearch A/S | Nouveaux derives de diazabicycloalkane et leur utilisation medicale |
EP1987032A1 (fr) * | 2006-02-14 | 2008-11-05 | NeuroSearch A/S | Dérivés de 3, 9-diazabicyclo(3.3.1)non-3-yl-aryl méthanone en tant qu'agonistes du récepteur nicotinique de l'acétylcholine |
ATE529423T1 (de) | 2006-05-19 | 2011-11-15 | Abbott Lab | Cns-aktivierte kondensierte bi- und heterocyclisch substituierte azabicyklische alkanderivate |
JP2009537599A (ja) | 2006-05-23 | 2009-10-29 | ノイロサーチ アクティーゼルスカブ | 新規8,10−ジアザ−ビシクロ[4.3.1]デカン誘導体及びそれらの医学的使用 |
AU2007272854B2 (en) | 2006-07-14 | 2013-08-01 | Merck Sharp & Dohme Corp. | Bridged diazepan orexin receptor antagonists |
US8076350B2 (en) | 2006-12-22 | 2011-12-13 | Abbott Laboratories | Spirocyclic azaadamantane derivatives and methods of use |
SI2134691T1 (sl) | 2007-03-08 | 2012-06-29 | Janssen Pharmaceutica Nv | Derivati kvinolina kot PARP in TANK inhibitorji |
GB2461412B (en) | 2007-04-02 | 2010-09-29 | Parkinson S Inst | Methods and compositions for reduction of side effects of therapeutic treatments |
US8263586B2 (en) | 2007-05-18 | 2012-09-11 | Merck Sharp & Dohme Corp. | OXO bridged diazepan orexin receptor antagonists |
US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
WO2009081246A2 (fr) * | 2007-12-19 | 2009-07-02 | Pfizer Inc. | Diamines bicycliques en tant qu'agonistes de récepteur nicotinique |
US8168644B2 (en) | 2008-03-27 | 2012-05-01 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as tubulin polymerization inhibitors |
CN101981013B (zh) | 2008-03-27 | 2013-05-29 | 詹森药业有限公司 | 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮 |
US8148408B2 (en) * | 2008-05-09 | 2012-04-03 | Abbott Laboratories | Selective substituted pyridine ligands for neuronal nicotinic receptors |
TW201004963A (en) * | 2008-07-03 | 2010-02-01 | Targacept Inc | Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands |
WO2010045212A2 (fr) * | 2008-10-14 | 2010-04-22 | Psychogenics, Incstatuts | Ligands des récepteurs cholinergiques nicotiniques et leurs utilisations |
KR101925971B1 (ko) * | 2011-01-28 | 2018-12-06 | 에스케이바이오팜 주식회사 | 피리돈 유도체 및 이를 포함하는 약학적 조성물 |
WO2013016160A1 (fr) * | 2011-07-26 | 2013-01-31 | Merck Sharp & Dohme Corp. | Dérivés inédits d'imidazo[1,2-a]pyrazine utilisables en tant qu'inhibiteurs de mtor |
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US20150031675A1 (en) * | 2012-02-02 | 2015-01-29 | Targacept, Inc. | Diazabicyclo[3.3.1]nonanes, methods of synthesis, and uses thereof |
CN102952134B (zh) * | 2012-12-05 | 2015-01-07 | 苏州药明康德检测检验有限责任公司 | 含二氟甲基的金雀花碱衍生物及制备方法和抗癌作用研究 |
WO2016054123A1 (fr) | 2014-09-30 | 2016-04-07 | Lightner Derek | Procédés de production d'hétéropolycycles par bis-époxydation |
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US11285306B2 (en) | 2017-01-06 | 2022-03-29 | Morningside Venture Investments Limited | Transdermal drug delivery devices and methods |
US20180311238A1 (en) * | 2017-04-28 | 2018-11-01 | Saniona A/S | Selective Agonist Of a6 Containing nAChRs |
US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
AR117169A1 (es) | 2018-11-28 | 2021-07-14 | Bayer Ag | (tio)amidas de piridazina como compuestos fungicidas |
JP2022514651A (ja) | 2018-12-20 | 2022-02-14 | バイエル、アクチエンゲゼルシャフト | 殺真菌化合物としてのヘテロシクリルピリダジン |
JP2023527036A (ja) | 2020-05-27 | 2023-06-26 | バイエル、アクチエンゲゼルシャフト | 活性化合物の組合せ物 |
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US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
EP0984966B1 (fr) * | 1997-05-30 | 2003-01-29 | Neurosearch A/S | Derives de 9-azabicyclo(3.3.1)non-2-ene et nonane utilises comme ligands cholinergiques de recepteurs nicotiniques de l'ach. |
AU745964B2 (en) * | 1997-05-30 | 2002-04-11 | Neurosearch A/S | 8-Azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ACh receptors |
FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
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