IL143666A0 - Prodrug compounds and process for preparation thereof - Google Patents
Prodrug compounds and process for preparation thereofInfo
- Publication number
- IL143666A0 IL143666A0 IL14366699A IL14366699A IL143666A0 IL 143666 A0 IL143666 A0 IL 143666A0 IL 14366699 A IL14366699 A IL 14366699A IL 14366699 A IL14366699 A IL 14366699A IL 143666 A0 IL143666 A0 IL 143666A0
- Authority
- IL
- Israel
- Prior art keywords
- leu
- prodrug
- prodrugs
- therapeutic agent
- ssala
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11179398P | 1998-12-11 | 1998-12-11 | |
| US11931299P | 1999-02-08 | 1999-02-08 | |
| PCT/US1999/030393 WO2000033888A2 (en) | 1998-12-11 | 1999-12-10 | Prodrug compounds and process for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL143666A0 true IL143666A0 (en) | 2002-04-21 |
Family
ID=26809248
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14366699A IL143666A0 (en) | 1998-12-11 | 1999-12-10 | Prodrug compounds and process for preparation thereof |
| IL143666A IL143666A (en) | 1998-12-11 | 2001-06-10 | Prodrug compounds and process for preparation thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL143666A IL143666A (en) | 1998-12-11 | 2001-06-10 | Prodrug compounds and process for preparation thereof |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1144011B1 (pt) |
| JP (1) | JP2003518000A (pt) |
| AT (1) | ATE460180T1 (pt) |
| AU (1) | AU773420B2 (pt) |
| CA (1) | CA2354766A1 (pt) |
| CY (1) | CY1111094T1 (pt) |
| DE (1) | DE69942128D1 (pt) |
| DK (1) | DK1144011T3 (pt) |
| ES (1) | ES2342637T3 (pt) |
| HK (1) | HK1039272A1 (pt) |
| IL (2) | IL143666A0 (pt) |
| NZ (1) | NZ512171A (pt) |
| PT (1) | PT1144011E (pt) |
| WO (1) | WO2000033888A2 (pt) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| DE69900841T2 (de) | 1998-01-23 | 2002-10-02 | Newbiotics Inc | Durch enzymkatalyse erhaltene therapeutische substanzen. |
| US6818213B1 (en) | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
| JP2002520297A (ja) | 1998-07-13 | 2002-07-09 | ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム | アミノリン脂質に結合する治療結合体を用いる癌処置方法 |
| US7425541B2 (en) | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
| US6613879B1 (en) | 1999-05-14 | 2003-09-02 | Boehringer Ingelheim Pharma Kg | FAP-activated anti-tumour compounds |
| CA2370245A1 (en) | 1999-05-14 | 2000-11-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Enzyme-activated anti-tumor prodrug compounds |
| US6683061B1 (en) | 1999-07-22 | 2004-01-27 | Newbiotics, Inc. | Enzyme catalyzed therapeutic activation |
| AU6358900A (en) * | 1999-07-22 | 2001-02-13 | Newbiotics, Inc. | Enzyme catalyzed anti-infective therapeutic agents |
| CN1391486A (zh) * | 1999-07-22 | 2003-01-15 | 新生物公司 | 治疗对治疗有抗性的肿瘤的方法 |
| DE10018617A1 (de) * | 2000-01-13 | 2001-10-31 | Joerg G Moser | Cyclodextrin-Dimere mit Peptid-Spacerstrukturen zur Entgiftung von pharmazeutischen Wirkstoffen hohen Nebenwirkungspotentials |
| CA2401873A1 (en) | 2000-03-15 | 2001-09-20 | Robert A. Copeland | Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use |
| CA2411545A1 (en) | 2000-06-14 | 2002-01-03 | Medarex, Inc. | Tripeptide prodrug compounds |
| AU6685301A (en) * | 2000-06-14 | 2001-12-24 | Corixa Corp | Prodrug compounds with isoleucine |
| CA2411660C (en) * | 2000-06-14 | 2011-03-01 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
| AU2001286727A1 (en) | 2000-08-24 | 2002-03-04 | Coulter Pharmaceutical, Inc. | Prodrugs activated by plasmin and their use in cancer chemotherapy |
| JP2004517821A (ja) * | 2000-10-27 | 2004-06-17 | アベンティス・ファーマ・ソシエテ・アノニム | 癌治療のためのカンプトセシン及びスチルベン誘導体からなる組合せ |
| CA2428971A1 (en) * | 2000-11-14 | 2003-05-01 | New River Pharmaceuticals Inc. | Conjugates of a therapeutic agent and a peptide carrier |
| EP1355675A1 (en) * | 2001-01-30 | 2003-10-29 | Universite Catholique De Louvain | Anti-tumor compounds |
| MXPA03011094A (es) | 2001-05-31 | 2004-12-06 | Medarex Inc | Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello. |
| ES2364452T3 (es) * | 2001-06-11 | 2011-09-02 | Medarex, Inc. | Método para diseñar compuestos profármacos activados por cd10. |
| FR2825928B1 (fr) * | 2001-06-18 | 2004-04-02 | Ecole Norm Superieure Cachan | Composition pharmaceutique pour le diagnostic, la prevention ou le traitement d'une pathologie tumorale, comprenant un agent modulateur de l'etat polymerisation de l'actine |
| AU2003233238A1 (en) * | 2002-05-10 | 2003-11-11 | Boehringer Ingelheim Pharma Gmbh And Co Kg | Fap-activated anti-tumor prodrugs |
| US7678386B2 (en) | 2002-07-15 | 2010-03-16 | Board Of Regents The University Of Texas | Liposomes coated with selected antibodies that bind to aminophospholipids |
| US7378386B2 (en) | 2002-07-15 | 2008-05-27 | Board Of Regents, The University Of Texas System | Anti-viral treatment methods using phosphatidylethanolamine-binding peptide derivatives |
| US7879801B2 (en) * | 2002-07-15 | 2011-02-01 | Board Of Regents, The University Of Texas System | Compositions comprising cell-impermeant duramycin derivatives |
| US7384909B2 (en) | 2002-07-15 | 2008-06-10 | Board Of Regents, The University Of Texas System | Anti-viral treatment methods using phosphatidylethanolamine-binding peptides linked to anti-viral agents |
| US7511124B2 (en) | 2002-07-15 | 2009-03-31 | Board Of Regents, The University Of Texas System | Compositions comprising phosphatidylethanolamine-binding peptides linked to anti-viral agents |
| EP1684816B1 (en) | 2003-10-28 | 2009-05-06 | Medtronic, Inc. | Methods of preparing crosslinked materials and bioprosthetic devices |
| WO2005072061A2 (en) | 2004-02-02 | 2005-08-11 | Biosight Ltd. | Conjugates for cancer therapy and diagnosis |
| WO2006095345A2 (en) | 2005-03-08 | 2006-09-14 | Ramot At Tel-Aviv University Ltd. | Targeted drug-carrying bacteriophages |
| WO2007105027A1 (en) * | 2006-03-10 | 2007-09-20 | Diatos | Anticancer drugs conjugated to antibody via an enzyme cleavable linker |
| CN101626782B (zh) | 2006-12-01 | 2013-03-27 | 梅达雷克斯公司 | 结合cd22的人抗体及其用途 |
| CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| AU2007333098A1 (en) | 2006-12-14 | 2008-06-19 | Medarex, Inc. | Human antibodies that bind CD70 and uses thereof |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
| CN101616911A (zh) | 2007-02-21 | 2009-12-30 | 梅达莱克斯公司 | 具有单个氨基酸的化学连接物及其偶联物 |
| EP1977765A1 (en) * | 2007-04-03 | 2008-10-08 | Diatos | Peptide prodrugs |
| EA031986B1 (ru) | 2012-04-04 | 2019-03-29 | Галозим, Инк. | Способ и комбинация для лечения солидной раковой опухоли и набор, содержащий комбинацию |
| CN113476616A (zh) | 2012-12-28 | 2021-10-08 | 科比欧尔斯公司 | 最低毒性的药物前体 |
| WO2014147129A1 (en) | 2013-03-21 | 2014-09-25 | Sanofi-Aventis Deutschland Gmbh | Synthesis of cyclic imide containing peptide products |
| SG11201506804VA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of hydantoin containing peptide products |
| US20140364368A1 (en) * | 2013-06-06 | 2014-12-11 | Massachusetts Institute Of Technology | Stimulus responsive nanocomplexes and methods of use thereof |
| US11058701B2 (en) | 2015-12-03 | 2021-07-13 | Biosight Ltd. | Cytarabine conjugates for cancer therapy |
| BR112018011178A2 (pt) | 2015-12-03 | 2018-11-21 | Biosight Ltd | sais de conjugados para terapia de câncer |
| CN109021065B (zh) * | 2017-06-08 | 2021-10-01 | 复旦大学 | 一种制备海兔毒素Dolastatin10的方法 |
| AU2021405744A1 (en) | 2020-12-22 | 2023-08-03 | Cobiores Nv | Compounds comprising a tetrapeptidic moiety |
| WO2022167664A1 (en) | 2021-02-07 | 2022-08-11 | Cobiores Nv | Compounds comprising a tetrapeptidic moiety |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0037388B1 (fr) * | 1980-03-31 | 1984-12-12 | Institut International De Pathologie Cellulaire Et Moleculaire | Formes pharmaceutiques, leur préparation et les compositions qui les contiennent |
| US5155210A (en) * | 1990-09-11 | 1992-10-13 | Brunswick Corporation | Methods of conjugating actinomycin d |
| EP0640622B1 (en) * | 1993-02-26 | 2000-08-09 | Drug Delivery System Institute, Ltd. | Polysaccharide derivative and drug carrier |
| PT769967E (pt) * | 1994-08-19 | 2008-02-18 | Univ Catholique Louvain | Conjugados que compreendem um agente antitumoral e a sua utilização |
| AU715632B2 (en) * | 1996-09-12 | 2000-02-03 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| HRP970566A2 (en) * | 1996-10-30 | 1998-08-31 | Jones Deborah Defeo | Conjugates useful in the treatment of prostate canser |
| AU7582298A (en) * | 1997-05-19 | 1998-12-11 | Johns Hopkins University School Of Medicine, The | Tissue specific prodrug |
| ATE256473T1 (de) * | 1997-07-10 | 2004-01-15 | Merck & Co Inc | Konjugate welche bei der behandlung von prostatakrebs nützlich sind |
| HUP0100350A3 (en) * | 1997-12-02 | 2001-09-28 | Merck & Co Inc | Conjugates useful in the treatment of prostate cancer, pharmaceutical compositions comprising thereof, process for their preparation and their use |
-
1999
- 1999-12-10 NZ NZ512171A patent/NZ512171A/en not_active IP Right Cessation
- 1999-12-10 WO PCT/US1999/030393 patent/WO2000033888A2/en active IP Right Grant
- 1999-12-10 PT PT99967462T patent/PT1144011E/pt unknown
- 1999-12-10 ES ES99967462T patent/ES2342637T3/es not_active Expired - Lifetime
- 1999-12-10 IL IL14366699A patent/IL143666A0/xx active IP Right Grant
- 1999-12-10 DK DK99967462.5T patent/DK1144011T3/da active
- 1999-12-10 DE DE69942128T patent/DE69942128D1/de not_active Expired - Lifetime
- 1999-12-10 AU AU23733/00A patent/AU773420B2/en not_active Ceased
- 1999-12-10 CA CA002354766A patent/CA2354766A1/en not_active Abandoned
- 1999-12-10 AT AT99967462T patent/ATE460180T1/de active
- 1999-12-10 EP EP99967462A patent/EP1144011B1/en not_active Expired - Lifetime
- 1999-12-10 JP JP2000586378A patent/JP2003518000A/ja active Pending
-
2001
- 2001-06-10 IL IL143666A patent/IL143666A/en not_active IP Right Cessation
- 2001-12-06 HK HK01108566.6A patent/HK1039272A1/xx not_active IP Right Cessation
-
2010
- 2010-06-10 CY CY20101100510T patent/CY1111094T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1111094T1 (el) | 2015-10-07 |
| DK1144011T3 (da) | 2010-07-05 |
| JP2003518000A (ja) | 2003-06-03 |
| WO2000033888A3 (en) | 2001-11-08 |
| AU773420B2 (en) | 2004-05-27 |
| WO2000033888A9 (en) | 2001-05-10 |
| CA2354766A1 (en) | 2000-06-15 |
| HK1039272A1 (en) | 2002-04-19 |
| DE69942128D1 (de) | 2010-04-22 |
| NZ512171A (en) | 2004-07-30 |
| PT1144011E (pt) | 2010-06-16 |
| IL143666A (en) | 2009-02-11 |
| WO2000033888A2 (en) | 2000-06-15 |
| AU2373300A (en) | 2000-06-26 |
| EP1144011A2 (en) | 2001-10-17 |
| ES2342637T3 (es) | 2010-07-09 |
| ATE460180T1 (de) | 2010-03-15 |
| EP1144011B1 (en) | 2010-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |