IL142103A0 - Receptor based antagonists and methods of making and using - Google Patents

Receptor based antagonists and methods of making and using

Info

Publication number
IL142103A0
IL142103A0 IL14210399A IL14210399A IL142103A0 IL 142103 A0 IL142103 A0 IL 142103A0 IL 14210399 A IL14210399 A IL 14210399A IL 14210399 A IL14210399 A IL 14210399A IL 142103 A0 IL142103 A0 IL 142103A0
Authority
IL
Israel
Prior art keywords
making
methods
receptor based
based antagonists
fusion polypeptides
Prior art date
Application number
IL14210399A
Other languages
English (en)
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of IL142103A0 publication Critical patent/IL142103A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL14210399A 1998-09-25 1999-09-22 Receptor based antagonists and methods of making and using IL142103A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10185898P 1998-09-25 1998-09-25
US09/313,942 US6472179B2 (en) 1998-09-25 1999-05-19 Receptor based antagonists and methods of making and using
PCT/US1999/022045 WO2000018932A2 (fr) 1998-09-25 1999-09-22 Antagonistes a base de recepteurs, modes d'elaboration et d'utilisation

Publications (1)

Publication Number Publication Date
IL142103A0 true IL142103A0 (en) 2002-03-10

Family

ID=26798712

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14210399A IL142103A0 (en) 1998-09-25 1999-09-22 Receptor based antagonists and methods of making and using
IL142103A IL142103A (en) 1998-09-25 2001-03-19 Receptor based antagonists and methods of making and using them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL142103A IL142103A (en) 1998-09-25 2001-03-19 Receptor based antagonists and methods of making and using them

Country Status (19)

Country Link
US (2) US6472179B2 (fr)
EP (3) EP1229047B1 (fr)
JP (1) JP3902728B2 (fr)
CN (1) CN100345970C (fr)
AT (2) ATE336583T1 (fr)
AU (1) AU758970C (fr)
BE (1) BE2010C021I2 (fr)
CA (1) CA2345109C (fr)
DE (3) DE69922269T2 (fr)
DK (1) DK1229047T3 (fr)
ES (2) ES2233733T3 (fr)
FR (1) FR10C0025I2 (fr)
HK (2) HK1035377A1 (fr)
IL (2) IL142103A0 (fr)
NO (2) NO329976B1 (fr)
NZ (1) NZ510720A (fr)
PL (1) PL201246B1 (fr)
PT (1) PT1229047E (fr)
WO (1) WO2000018932A2 (fr)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100071A (en) * 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
AU737592B2 (en) 1998-01-23 2001-08-23 Immunex Corporation Il-18 receptors
US6927044B2 (en) * 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
US7083950B2 (en) * 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. High affinity fusion proteins and therapeutic and diagnostic methods for use
US7083949B2 (en) 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US20040120891A1 (en) * 1998-12-21 2004-06-24 Craig Hill Compounds for intracellular delivery of therapeutic moieties to nerve cells
US20040220103A1 (en) * 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
DE16192152T1 (de) 2000-05-26 2020-08-06 Immunex Corporation Verwendung von interleukin-4 rezeptor (il-4r) antikörpern und zusammensetzungen davon
EP1290170A2 (fr) * 2000-06-16 2003-03-12 Asterion Limited Liant
ATE342980T1 (de) * 2000-08-08 2006-11-15 Zymogenetics Inc Lösliche zcyctor 11 cytokinrezeptoren
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20050112616A1 (en) * 2001-12-10 2005-05-26 William Lee Functionalized materials and libraries thereof
US7795213B2 (en) * 2001-12-13 2010-09-14 Posco Methods of contacting β amyloid protein with VEGF
US6846520B2 (en) * 2002-01-17 2005-01-25 Canon Kabushiki Kaisha Epoxy resin composition, surface treatment method, liquid-jet recording head and liquid-jet recording apparatus
US6811780B2 (en) 2002-05-01 2004-11-02 Regeneron Pharmaceuticals, Inc. Methods of using cytokine antagonists to treat HIV infection and AIDS
US20040223966A1 (en) * 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
KR20050086628A (ko) 2002-11-15 2005-08-30 젠맵 에이/에스 Ｃｄ25에 대한 인간 모노클로날 항체
US6919012B1 (en) 2003-03-25 2005-07-19 Olimex Group, Inc. Method of making a composite article comprising a ceramic coating
PL1606318T3 (pl) 2003-03-26 2010-01-29 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Ulepszone białka fuzyjne FC
WO2004100987A2 (fr) * 2003-05-06 2004-11-25 Regeneron Pharmaceuticals, Inc. Procede d'utilisation d'antagonistes de l'il1 pour le traitement d'hyperplasie neointimale
WO2004098596A1 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprenant roflumilast et il-1 trap
AU2004262637A1 (en) * 2003-06-11 2005-02-17 Wyeth Method for producing a polypeptide
WO2005016968A2 (fr) * 2003-07-28 2005-02-24 Genentech, Inc. Reduction de la lixiviation de la proteine a lors de la chromatographie d'affinite sur la proteine a
JP2007503820A (ja) * 2003-09-05 2007-03-01 ナショナル・リサーチ・カウンシル・オブ・カナダ 細胞レセプタードメインを含むコイルドコイル融合タンパク質
ATE548388T1 (de) 2003-11-07 2012-03-15 Immunex Corp An den interleukin-4-rezeptor bindende antikörper
CA2554596A1 (fr) 2004-02-27 2005-09-15 Regeneron Pharmaceuticals, Inc. Polypeptides specifiques d'il-4/il-13 et utilisations therapeutiques associees
WO2005117945A1 (fr) 2004-06-04 2005-12-15 Regeneron Pharmaceuticals, Inc. Procedes d'utilisation d'antagonistes de l'il-1 dans le traitement de maladies auto-inflammatoires
EP1771470B1 (fr) 2004-07-23 2013-06-26 Acceleron Pharma Inc. Polypeptides du recepteur actrii, procedes et compositions correspondants
CA2576519C (fr) * 2004-08-17 2013-05-21 Regeneron Pharmaceuticals, Inc. Formulations d'un antagoniste il-1
ES2309427T3 (es) * 2004-08-27 2008-12-16 Conaris Research Institute Ag Secuencias de nucleotidos optimizidas que codifican para sgp130.
US7786261B2 (en) * 2004-09-02 2010-08-31 National Research Council Of Canada Coiled-coil fusion proteins comprising cell receptor domains
DK1804835T3 (da) * 2004-09-13 2010-10-11 Genzyme Corp Multimere konstruktioner
RU2007117716A (ru) * 2004-10-12 2008-11-20 Ампротеин Корпорейшн (Us) Химерный белок
ATE474856T1 (de) 2004-10-22 2010-08-15 Zymogenetics Inc Anti-il-22ra-antikörper und bindungspartner und verfahren zur anwendung bei entzündungen
JP2008527981A (ja) * 2005-01-25 2008-07-31 アポロ ライフ サイエンシズ リミテッド 治療目的および診断目的のためにパラメーターにより選択されたｇｍ−ｃｓｆ、ｉｌ−３、ｉｌ−４、ｉｌ−５、ならびにそのキメラ
CA2995971A1 (fr) * 2005-03-25 2006-10-05 Regeneron Pharmaceuticals, Inc. Formulations d'antagonistes du facteur vegf
US7732167B2 (en) * 2005-06-17 2010-06-08 Regeneron Pharmaceuticals, Inc. Interferon-α/β binding fusion proteins and therapeutic uses thereof
US7608430B2 (en) * 2005-07-08 2009-10-27 Regeneron Pharmaceuticals, Inc. Interferon-γ antagonists and therapeutic uses thereof
PT2298815E (pt) 2005-07-25 2015-07-16 Emergent Product Dev Seattle Moléculas de ligaçao especificas para cd37 e especificas para cd20
US7666622B2 (en) * 2005-10-19 2010-02-23 Regeneron Pharmaceuticals, Inc. Monomeric self-associating fusion polypeptides and therapeutic uses thereof
US8067562B2 (en) 2005-11-01 2011-11-29 Amgen Inc. Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
WO2007061981A2 (fr) 2005-11-21 2007-05-31 Lumera Corporation Detecteur a resonance de plasmon en surface avec mecanisme de balayage d’angle entraine par actionneur
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
KR20190006086A (ko) * 2005-11-23 2019-01-16 악셀레론 파마 인코포레이티드 액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
AR060070A1 (es) 2006-03-24 2008-05-21 Merck Patent Gmbh Dominios proteicos heterodimericos obtenidos por ingenieria
CA3149553C (fr) 2006-06-12 2023-11-21 Aptevo Research And Development Llc Proteines de liaison monocatenaires polyvalentes dotees d'une fonction d'effecteur
JP5216002B2 (ja) 2006-06-16 2013-06-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 硝子体内投与に適したｖｅｇｆアンタゴニスト製剤
RS51544B (en) 2006-06-30 2011-06-30 Conaris Research Institute Ag. POBOLJŠANI SGP 130FC DIMERI
US7666423B2 (en) * 2006-07-28 2010-02-23 Children's Memorial Hospital Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells
US8106004B2 (en) * 2006-07-28 2012-01-31 Children's Memorial Hospital Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells
US7632490B2 (en) * 2006-10-20 2009-12-15 Regeneron Pharmaceuticals, Inc. Use of IL-1 antagonists to treat gout
SI2124997T1 (sl) * 2006-10-20 2012-11-30 Regeneron Pharma Uporaba IL antagonista za zdravljenje putike inpsevdo putike
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
JP5272735B2 (ja) * 2007-01-30 2013-08-28 国立大学法人 新潟大学 生物学的製剤
EP2111229B1 (fr) 2007-02-01 2013-04-10 Acceleron Pharma, Inc. Compositions comprenant des antagonistes Activin-ActRIIA pour leur utilisation dans la prévention ou le traitement de la métastases du cancer du sein ou de la perte osseuse due au cancer du sein
TWI548647B (zh) 2007-02-02 2016-09-11 艾瑟勒朗法瑪公司 衍生自ＡｃｔＲＩＩＢ的變體與其用途
EP2120999B1 (fr) 2007-02-09 2012-08-29 Acceleron Pharma, Inc. Compositions comprenant des antagonistes Activin-ActRIIA et leur utilisation dans la prévention ou le traitement du myélome multiple
US8501678B2 (en) 2007-03-06 2013-08-06 Atara Biotherapeutics, Inc. Variant activin receptor polypeptides and uses thereof
US7947646B2 (en) 2007-03-06 2011-05-24 Amgen Inc. Variant activin receptor polypeptides
EP2578684B1 (fr) 2007-03-19 2016-02-24 National Research Council Of Canada Antagonistes de ligands et leurs utilisations
WO2009010539A2 (fr) * 2007-07-19 2009-01-22 Ablynx. N.V. Recepteur de l'interleukine-6 (il-6) derive de macaca fascicularis
CN103877564A (zh) 2007-09-18 2014-06-25 阿塞勒隆制药公司 活化素-actriia拮抗剂和减少或抑制fsh分泌的用途
WO2009058888A1 (fr) * 2007-10-31 2009-05-07 The Scripps Research Institute Polythérapie pour traiter des infections virales persistantes
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
US8658135B2 (en) * 2008-03-19 2014-02-25 National Research Council Of Canada Antagonists of ligands and uses thereof
CA2719924C (fr) 2008-04-11 2017-10-03 Philip Tan Produits d'immunotherapie de cd37 et combinaison avec un produit chimiotherapique bifonctionnel de celui-ci
LT3750552T (lt) 2008-08-14 2023-06-26 Acceleron Pharma Inc. Gdf gaudyklės
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
CA2997971A1 (fr) 2008-11-26 2010-06-03 Amgen Inc. Variantes des polypeptides du recepteur iib de l'activine et leurs utilisations
BRPI1010587A2 (pt) 2009-06-08 2019-04-09 Acceleron Pharma Inc. métodos para aumentar adipócitos termogênicos
EP2440577A4 (fr) 2009-06-12 2013-01-23 Acceleron Pharma Inc Protéines de fusion actriib-fc tronquées
US8710016B2 (en) 2009-11-17 2014-04-29 Acceleron Pharma, Inc. ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
JP2014502260A (ja) 2010-11-08 2014-01-30 アクセルロン ファーマ， インコーポレイテッド Ａｃｔｒｉｉａ結合剤およびその使用
CA2833147A1 (fr) 2011-04-15 2012-10-18 Anita SESHIRE Inhibiteurs anti-il-1r1 destines a une utilisation dans le cadre du cancer
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
AU2012364736A1 (en) 2011-12-19 2014-07-24 Amgen Inc. Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof
MX366336B (es) 2012-11-02 2019-07-05 Celgene Corp Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros.
EP2928916B1 (fr) * 2012-12-10 2019-03-13 Vib Vzw Nouveaux inhibiteurs interleukine-33
JP2016508504A (ja) 2013-02-01 2016-03-22 サンタ マリア バイオセラピューティクス インコーポレイテッド 対象に対する抗アクチビン−ａ化合物の投与
KR101989551B1 (ko) 2013-02-15 2019-09-30 알-팜 인터내셔널, 엘엘씨. IL-1β 억제제 조성물 및 이의 용도
BR122023023170A2 (pt) 2014-06-13 2024-02-20 Acceleron Pharma Inc. Uso de um antagonista de actrii no tratamento ou prevenção de úlcera cutânea associada com beta-talassemia
DK3170005T3 (da) 2014-07-18 2019-07-08 Sanofi Sa Fremgangsmåde til forudsigelse af resultatet af en behandling med aflibercept hos en patient, der mistænkes for at lide af cancer
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
MA54761A (fr) 2014-12-01 2021-11-24 Ferring Bv Administration d'un inhibiteur de signalisation de trans-signalisation par il-6 sélectif
MA41116A (fr) 2014-12-01 2017-10-10 Ferring Bv Compositions d'inhibiteur de trans-signalisation par l'il-6 sélectif
AU2015358469B2 (en) 2014-12-03 2021-05-27 Acceleron Pharma Inc. Activin-ActRII antagonists and uses for treating anemia
GB201503453D0 (en) 2015-03-01 2015-04-15 Jain Arjun Endothelin-1"sponge"
UA126278C2 (uk) 2015-09-21 2022-09-14 Аптево Рісьорч Енд Девелопмент Ллс Поліпептиди, які зв'язують cd3
CA3038526A1 (fr) 2016-09-27 2018-04-05 Epicentrx, Inc. Proteines de fusion immunomodulatrices
CN110770250A (zh) * 2017-04-21 2020-02-07 金德雷德生物科学股份有限公司 用于兽医用途的il4/il13受体分子
EA202090838A1 (ru) 2017-09-27 2020-08-28 Эписентарикс, Инк. Иммуномодулирующие слитые белки
JP7319992B2 (ja) 2018-03-09 2023-08-02 アジェナス インコーポレイテッド 抗ｃｄ７３抗体およびそれらの使用方法
JP2021530507A (ja) 2018-07-18 2021-11-11 マンザニータ ファーマシューティカルズ，インク． 神経細胞に抗がん剤を送達するためのコンジュゲート、その使用方法及び製造方法
CN110950965B (zh) * 2018-09-26 2021-10-15 重庆精准生物技术有限公司 抗人cd123的嵌合抗原受体及其应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005183A1 (fr) 1988-10-31 1990-05-17 Immunex Corporation Recepteurs d'interleukine-4
AU651596B2 (en) * 1990-06-05 1994-07-28 Immunex Corporation Type II interleukin-1 receptors
ES2251009T3 (es) * 1990-06-28 2006-04-16 Sanofi-Aventis Deutschland Gmbh Proteinas de fusion con partes de inmunoglobulinas, su preparacion y uso.
EP0533006A1 (fr) * 1991-09-18 1993-03-24 F.Hoffmann-La Roche & Co. Aktiengesellschaft Chimères constituées du récepteur de l'interleukine 5 et de polypeptides d'immunoglobulines
AU674292B2 (en) * 1991-10-15 1996-12-19 Immunex Corporation Methods and compositions for treating allergic reactions
US5262522A (en) 1991-11-22 1993-11-16 Immunex Corporation Receptor for oncostatin M and leukemia inhibitory factor
AU669889B2 (en) * 1992-03-09 1996-06-27 Ludwig Institute For Cancer Research Nucleic acid sequences coding for or complementary to nucleic acid sequences coding for interleukin 9 receptor
WO1993019163A1 (fr) * 1992-03-18 1993-09-30 Yeda Research And Development Co, Ltd. Genes de recepteurs chimeres et cellules transformees au moyen desdits genes
US8211422B2 (en) * 1992-03-18 2012-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric receptor genes and cells transformed therewith
ES2197149T3 (es) * 1992-03-30 2004-01-01 Immunex Corporation Proteinas de fusion que comprende receptores para dos factores de necrosis tumoral.
JP3255699B2 (ja) 1992-04-23 2002-02-12 味の素株式会社 ヒトＩＬ−２レセプターγ鎖分子
CA2160011A1 (fr) * 1993-04-06 1994-10-13 Philip D. Greenberg Recepteur chimerique de cytokine dans les lymphocytes
EP0716703A1 (fr) * 1993-09-03 1996-06-19 PRENDERGAST, Kenneth, Francis Compositions proteiques de fusion contenant la proteine de liaison a la glycophorine (gbp 130)
ATE355369T1 (de) * 1993-10-14 2006-03-15 Harvard College Verfahren zur induzierung und zur erhaltung neuronalen zellen
US5470952A (en) 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists
IL114825A0 (en) * 1994-08-04 1995-12-08 Regeneron Pharma Rtk/cytokine receptor chimeras
AU3830895A (en) 1994-10-07 1996-05-02 Amgen Boulder Inc. Dimeric il-4 inhibitors
US5741899A (en) * 1995-02-02 1998-04-21 Cell Genesys, Inc. Chimeric receptors comprising janus kinase for regulating cellular pro liferation
US5837816A (en) * 1995-05-10 1998-11-17 Chiron Corporation Interleukin-2 receptor subunit ectodomain fusion protein comprising a leucine zipper domain
GB9526131D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Recombinant chimeric receptors
US5776731A (en) * 1996-02-21 1998-07-07 Immunex Corporation DNA encoding type-I interleukin-I receptor-like protein designated 2F1
US5710023A (en) * 1996-03-01 1998-01-20 Genetics Institute, Inc. IL-13 cytokine receptor chain
AU3668897A (en) * 1996-07-17 1998-02-09 University Of Medicine And Dentistry Of New Jersey Chimeric receptors for jak-stat signal transduction
AU7011696A (en) * 1996-08-26 1998-03-19 Human Genome Sciences, Inc. Soluble interleukin-1 receptor accessory molecule
GB9625899D0 (en) 1996-12-13 1997-01-29 Glaxo Group Ltd Substances and their uses
US6087116A (en) * 1997-03-12 2000-07-11 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18 (IL-18) receptor polypeptides and their uses
AU737592B2 (en) * 1998-01-23 2001-08-23 Immunex Corporation Il-18 receptors

Also Published As

Publication number Publication date
EP1229047B1 (fr) 2004-11-24
EP1405915A1 (fr) 2004-04-07
EP1229047A3 (fr) 2002-10-02
FR10C0025I2 (fr) 2011-04-01
DE69922269T2 (de) 2005-12-01
US20020012962A1 (en) 2002-01-31
DE69922269D1 (de) 2004-12-30
IL142103A (en) 2007-07-04
AU758970B2 (en) 2003-04-03
ATE283365T1 (de) 2004-12-15
ES2267300T3 (es) 2007-03-01
PT1229047E (pt) 2005-03-31
ATE336583T1 (de) 2006-09-15
EP1115876A2 (fr) 2001-07-18
WO2000018932A9 (fr) 2000-08-31
CA2345109C (fr) 2012-12-18
CA2345109A1 (fr) 2000-04-06
NZ510720A (en) 2003-11-28
WO2000018932A2 (fr) 2000-04-06
CN100345970C (zh) 2007-10-31
NO2011003I2 (fr) 2011-04-11
DE122010000023I1 (de) 2012-04-26
FR10C0025I1 (fr) 2010-05-21
HK1045847B (zh) 2005-03-24
CN1357049A (zh) 2002-07-03
NO20011513L (no) 2001-05-25
NO20011513D0 (no) 2001-03-23
JP2002525119A (ja) 2002-08-13
US20020164690A1 (en) 2002-11-07
DE122010000023I2 (de) 2012-04-26
DE69932832D1 (de) 2006-09-28
JP3902728B2 (ja) 2007-04-11
NO2011003I1 (no) 2011-05-02
DE69932832T2 (de) 2007-02-08
ES2233733T3 (es) 2005-06-16
EP1115876B1 (fr) 2006-08-16
AU758970C (en) 2007-05-03
BE2010C021I2 (fr) 2018-12-04
EP1229047A2 (fr) 2002-08-07
HK1045847A1 (en) 2002-12-13
PL201246B1 (pl) 2009-03-31
WO2000018932A3 (fr) 2000-11-02
DK1229047T3 (da) 2005-02-21
HK1035377A1 (en) 2001-11-23
US6472179B2 (en) 2002-10-29
PL348529A1 (en) 2002-06-03
AU6499499A (en) 2000-04-17
NO329976B1 (no) 2011-01-31

Similar Documents

Publication Publication Date Title
IL142103A0 (en) Receptor based antagonists and methods of making and using
HK1080511A1 (en) Il-1 receptor based antagonists and methods of making and using
IL166659A0 (en) Nogo receptor antagonists
SG149693A1 (en) Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use
PL341524A1 (en) Novel receptor coupled wih g protein
ATE490323T1 (de) Adiponektin-rezeptor und dafür kodierendes gen
MXPA05009913A (es) Proteina enlazadora del receptor nogo.
BRPI0413426A (pt) antagonistas de receptor novo
WO2004043403A3 (fr) Polypeptides synthetiques a domaine unique imitant l'apolipoproteine e et methodes d'utilisation
DK1009817T3 (da) RTD-receptor
WO2003018631A3 (fr) Homologues des recepteurs de nogo et leur utilisation
WO2005042717A3 (fr) Polypeptides de recepteurs de prokineticines et de prokineticines de primates, compositions associees et methodes
EP1377826A4 (fr) Recepteurs d'opiaces
WO2000006733A3 (fr) Proteines des recepteurs des lymphocytes t, molecules d'acide nucleique et utilisation de ces dernieres

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed