IL141719A0 - Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors - Google Patents

Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors

Info

Publication number
IL141719A0
IL141719A0 IL14171999A IL14171999A IL141719A0 IL 141719 A0 IL141719 A0 IL 141719A0 IL 14171999 A IL14171999 A IL 14171999A IL 14171999 A IL14171999 A IL 14171999A IL 141719 A0 IL141719 A0 IL 141719A0
Authority
IL
Israel
Prior art keywords
optionally substituted
group
optionally
alkyl
hydroxy
Prior art date
Application number
IL14171999A
Other languages
English (en)
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of IL141719A0 publication Critical patent/IL141719A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL14171999A 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors IL141719A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002319A IT1303272B1 (it) 1998-10-29 1998-10-29 Derivati triciclici inibitori della fosfodiesterasi 4
PCT/EP1999/007304 WO2000026218A1 (en) 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors

Publications (1)

Publication Number Publication Date
IL141719A0 true IL141719A0 (en) 2002-03-10

Family

ID=11380959

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14171999A IL141719A0 (en) 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors

Country Status (10)

Country Link
US (1) US6525055B1 (ja)
EP (1) EP1124829B1 (ja)
JP (1) JP2002528549A (ja)
AT (1) ATE272638T1 (ja)
AU (1) AU766129B2 (ja)
CA (1) CA2345337A1 (ja)
DE (1) DE69919192D1 (ja)
IL (1) IL141719A0 (ja)
IT (1) IT1303272B1 (ja)
WO (1) WO2000026218A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224316A1 (en) 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
AU2003277562B2 (en) * 2002-11-06 2009-03-26 Aska Pharmaceutical Co., Ltd. Pyrazolonaphthyridine derivative
JP4671104B2 (ja) * 2003-01-09 2011-04-13 アステラス製薬株式会社 ピロロピリダジン誘導体
CA2578368C (en) * 2004-09-02 2013-07-02 Altana Pharma Ag Triazolophthalazines
ATE508130T1 (de) * 2004-09-08 2011-05-15 Nycomed Gmbh 3-oxa-10-aza-phenanthrene als pde4- oder pde3/4- inhibitoren
US7589205B2 (en) * 2004-09-08 2009-09-15 Nycomed Gmbh 3-thia-10-aza-phenanthrene derivatives
BRPI0606379A2 (pt) * 2005-01-05 2009-06-23 Nycomed Gmbh triazolftalazinas
JP5130053B2 (ja) * 2005-01-05 2013-01-30 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング トリアゾロフタラジン
MX2008014713A (es) 2006-05-19 2009-04-17 Helicon Therapeutics Inc Inhibidores de fosfodiesterasa 4 para rehabilitacion cognitiva y motora.
AR066016A1 (es) * 2007-04-11 2009-07-15 Alcon Res Ltd Uso de un inhibidor del tnf alfa junto con una antihistamina para tratar la rinitis alergica y la conjuntivitis alergica
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
CA2773483A1 (en) * 2009-10-01 2011-04-07 Alcon Research, Ltd. Olopatadine compositions and uses thereof
GB2575490A (en) * 2018-07-12 2020-01-15 Recordati Ind Chimica E Farmaceutica Spa P2X3 receptor antagonists
MX2021007938A (es) 2018-12-28 2022-01-24 Regeneron Pharma Tratamiento de trastornos respiratorios con inhibidores de la araquidonato 15-lipooxigenasa (alox15).

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3704300A (en) * 1971-04-09 1972-11-28 Sandoz Ag Imidazo(2,1-a)phthalazines
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
HUT66969A (en) * 1991-10-09 1995-01-30 Syntex Inc Benzo- and pyrido-pyridazinone- and pyridazin-thion derivatives, pharmaceutical compositions containing the same and process for the production of thereof
TW211013B (ja) * 1991-12-27 1993-08-11 Takeda Pharm Industry Co Ltd
CA2120997A1 (en) 1993-04-12 1994-10-13 Akio Miyake Triazolopyridazine derivatives, their production and use
HU219864B (hu) 1994-08-09 2001-08-28 Eisai Co., Ltd. cGMP-PDE inhibitor kondenzált piridazinszármazékok és alkalmazásuk
DE19617862A1 (de) 1996-04-23 1997-10-30 Schering Ag Phthalazinderivate, deren Herstellung und Verwendung als Arzneimittel
EA002436B1 (ru) 1996-07-25 2002-04-25 Мерк Шарп Энд Домэ Лимитед Замещенные производные триазоло-пиридазина в качестве лигандов рецепторов гамк
AU722710B2 (en) * 1996-08-20 2000-08-10 Eisai Co. Ltd. Remedies for erectile dysfunction containing fused pyridazine compounds
WO1998021208A1 (en) * 1996-11-11 1998-05-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridines as bronchial therapeutics
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4

Also Published As

Publication number Publication date
ITMI982319A1 (it) 2000-04-29
JP2002528549A (ja) 2002-09-03
DE69919192D1 (de) 2004-09-09
AU766129B2 (en) 2003-10-09
AU6332499A (en) 2000-05-22
ITMI982319A0 (it) 1998-10-29
CA2345337A1 (en) 2000-05-11
WO2000026218A1 (en) 2000-05-11
US6525055B1 (en) 2003-02-25
IT1303272B1 (it) 2000-11-06
EP1124829A1 (en) 2001-08-22
ATE272638T1 (de) 2004-08-15
EP1124829B1 (en) 2004-08-04

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